Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _4 value "hFOG-2 Co-activates the p45 NF-E2 Promoter via GATA-1-- It was previously demonstrated that mFOG-1 functions with GATA-1 to co-activate the p45 NF-E2 promoter (10). A similar activity is also observed with hFOG-2 (Fig. 4). GATA-1 alone has little effect when co-transfected with a reporter harboring 7 kb of the p45 NF-E2 promoter upstream of growth hormone (GH). However, co-expression of both GATA-1 and hFOG-2 (from pcDNA3) activates this promoter approximately 3-fold. " provenance.
- _4 value "The combination of the inflammatory cytokines IL-1 beta, TNF-alpha, and IFN-gamma, synergized with Tat to promote the development of angioproliferative KS-like lesions in nude mice that are not observed with each factor alone. Injection of inflammatory cytokines IL-1beta, TNF-alpha and IFN-gamma was found to cause an increase in the expression of bFGF and VEGF. However, bFGF, but not VEGF, synergizes with Tat in vivo and induces endothelial cells to migrate, to adhere, and to grow in response to Tat in vitro. Tat angiogenic effects correlate with the expression of the alpha v beta 3 integrin that is induced by bFGF and binds the arginine-glycine-aspartic acid (RGD) region of Tat." provenance.
- _3 value "Modified assertion" provenance.
- _3 value "Modified assertion" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _6 value "The KRML (MAFB) transcriptional regulator plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription" provenance.
- _4 value "Transport processes along the nephron are regulated in part by hormone stimulation of adenylyl cyclases mediated by the heterotrimeric G protein G(s). To assess the role of this pathway in the regulation of Na-K-2Cl cotransporter abundance in the renal thick ascending limb (TAL), we studied mice with heterozygous disruption of the Gnas gene, which codes for the alpha-subunit of G(s). Outer medullary G(s)alpha protein abundance (as assessed by semiquantitative immunoblotting) and glucagon-stimulated cAMP production were significantly reduced in the heterozygous G(s)alpha knockout mice (GSKO) relative to their wild-type (WT) littermates. Furthermore, Na-K-2Cl cotransporter protein abundance in the outer medulla was significantly reduced (band density, 48% of WT). In addition, GSKO mice had a significantly reduced (72% of WT) urinary osmolality in response to a single injection of 1-deamino-[8-D-arginine]vasopressin (DDAVP), a vasopressin analog. In contrast, outer medullary protein expression of the type 3 Na/H exchanger (NHE-3) or Tamm-Horsfall protein did not differ between the GSKO mice and their WT littermates. However, abundance of type VI adenylyl cyclase was markedly decreased in the outer medullas of GSKO mice, suggesting a novel feed-forward regulatory mechanism. We conclude that expression of the Na-K-2Cl cotransporter of the TAL is dependent on G(s)alpha-mediated hormone stimulation, most likely due to long-term changes in cellular cAMP levels." provenance.
- _6 value "glucagon-stimulated cAMP production were significantly reduced in the heterozygous G(s)alpha knockout" provenance.
- _8 value "FAK also combines with, and may activate, phosphoinositide 3-OH kinase (PI 3-kinase), either directly or through the Src kinase (13). Finally, there is evidence that Src phosphorylates FAK at Tyr925, creating a binding site for the complex of the adapter Grb2 and Ras guanosine 5'-triphosphate exchange factor mSOS (10). These interactions link FAK to signaling pathways that modify the cytoskeleton and activate mitogen-activated protein kinase (MAPK) cascades (Fig. 3A)." provenance.
- _5 value "FAK also combines with, and may activate, phosphoinositide 3-OH kinase (PI 3-kinase), either directly or through the Src kinase (13). Finally, there is evidence that Src phosphorylates FAK at Tyr925, creating a binding site for the complex of the adapter Grb2 and Ras guanosine 5'-triphosphate exchange factor mSOS (10). These interactions link FAK to signaling pathways that modify the cytoskeleton and activate mitogen-activated protein kinase (MAPK) cascades (Fig. 3A)." provenance.
- _4 value "Rac promotes cell cycle progression, an effect that correlates with its ability to organize the cytoskeleton and promote spreading, rather than with its ability to activate MAP kinases (63)." provenance.
- _6 value "The FAK and Shc pathways are regulated both positively and negatively by tyrosine phosphatases. Integrin-mediated activation of ERK is suppressed in cells that lack the re- ceptor-type protein tyrosine phosphatase a or the cytosolic phosphatase SHP-2 (19). These enzymes dephosphorylate the negative regulatory site in Src-family kinases and thus, presumably, amplify both FAK and Shc signaling." provenance.
- _8 value "The a5b1 integrin, which binds to fibronectin, induces expression of the antiapoptotic protein Bcl-2, protecting cells from apoptosis from stresses such as the lack of growth factors (55). Other integrins, including another fibronectin receptor, avb1, do not provide this survival effect. The avb3 integrin promotes endothelial and melanoma cell survival; this effect correlates with suppression of the p53 pathway and activation of the nuclear factor kappa B transcription factor (56). The activation of Shc by a1b1, a5b1, and avb3 may also contribute to protection from apoptosis (4, 17). Thus, integrinmediated attachment to ECM is a general requirement for cell survival, but survival under special circumstances may require a particular integrin." provenance.
- _8 value "The receptors for insulin, plateletderived growth factor (PDGF), epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF) are optimally activated by their ligands only under appropriate cell attachment conditions (24-28). Although a systematic analysis has not been conducted, certain integrins appear to be preferentially associated with specific growth factor receptors. Thus, the avb3 integrin can be immunoprecipitated in complexes with the insulin, PDGF, and VEGF receptors (26, 28), whereas a5b1 and perhaps other b1 integrins associate with the EGF receptor (25, 27)." provenance.
- _5 value "Modified assertion" provenance.
- _4 value "Modified assertion" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "Interleukin-1 receptor-associated kinase, IRAK, has been shown to activate NFkappaB in response to interleukin-1." provenance.
- _5 value "interleukin-17 induces time-dependent stimulation of tyrosine phosphorylation of JAK 1, 2 and 3, Tyk 2 and STAT 1, 2, 3 and 4 within 0.5 to 30 min" provenance.
- _5 value "Moreover, the mutated MAZ was unable to enhance the expression of luciferase encoded by a c-myc promoter/luciferase reporter gene in HeLa cells in the presence of CKII." provenance.
- _5 value "ncoa1 potentiated transcription by ligand-activated PGR, whereas it had no effect on transcription in the absence of ligands" provenance.
- _5 value "ncoa1 potentiated transcription by ligand-activated PGR, whereas it had no effect on transcription in the absence of ligands" provenance.
- _5 value "The low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) is phosphorylated by Src and Src-related kinases both in vitro and in vivo; in Jurkat cells, and in NIH-3T3 cells, it becomes tyrosine-phosphorylated upon stimulation by PDGF. In this study we show that pp60Src phosphorylates in vitro the enzyme at two tyrosine residues, Tyr131 and Tyr132," provenance.
- _5 value "Activation of PKB alpha and beta is then achieved at the plasma membrane by phosphorylation of Thr308/309 in the A-loop of the kinase domain and Ser473/474 in the carboxy-terminal regulatory region, respectively. The upstream kinase that phosphorylates PKB on Thr308, termed PI-dependent protein kinase-1, has been identified and extensively characterised. A candidate for the Ser473/474 kinase, termed the integrin-linked kinase, has been identified recently." provenance.
- _5 value "Activation of PKB alpha and beta is then achieved at the plasma membrane by phosphorylation of Thr308/309 in the A-loop of the kinase domain and Ser473/474 in the carboxy-terminal regulatory region, respectively. The upstream kinase that phosphorylates PKB on Thr308, termed PI-dependent protein kinase-1, has been identified and extensively characterised. A candidate for the Ser473/474 kinase, termed the integrin-linked kinase, has been identified recently." provenance.
- _5 value "Activation of PKB alpha and beta is then achieved at the plasma membrane by phosphorylation of Thr308/309 in the A-loop of the kinase domain and Ser473/474 in the carboxy-terminal regulatory region, respectively. The upstream kinase that phosphorylates PKB on Thr308, termed PI-dependent protein kinase-1, has been identified and extensively characterised. A candidate for the Ser473/474 kinase, termed the integrin-linked kinase, has been identified recently." provenance.
- _4 value "Here we show that NF-kappaB activation suppresses mitochondrial release of cytochrome c through the activation of the Bcl-2 family member A1/Bfl-1" provenance.
- _6 value "demonstrate that ligand stimulation of the chimeric receptor results in activation of the mitogen-activated protein kinase pathway." provenance.
- _4 value "Modified assertion" provenance.
- _4 value "Modified assertion" provenance.
- _5 value "Increases in [Ca2+]i caused by ET-1(1-31), big ET-1 and ET-2(1-31) were completely inhibited by 10(-4)M phosphoramidon, a dual neutral endopeptidase (NEP)/endothelin-converting enzyme (ECE) inhibitor, and 10(-5)M thiorphan, a NEP inhibitor. These results suggest that ET-1(1-31), big ET-1 and ET-2(1-31) cause an increase in [Ca2+]i by being converted into the corresponding ET-1 and ET-2 by NEP, but this did not occur with big ET-2 in human BSMC. ET-2(1-31), produced by human chymase from big ET-2 might be important for the generation of ET-2 in human bronchial tissue." provenance.
- _3 value "Remyelination in the adult central nervous system (CNS) is preceded by the generation of new oligodendrocytes (ODCs) but the source of the new ODCs has not been resolved. Adult galactocerebroside positive (O1+)ODCs proliferate when cultured with purified sensory neurons (Wood and Bunge, Nature 320:756-758, 1999), implying that differentiated ODCs could be an important source of new myelinating ODCs. To test this possibility purified O1+ODCs (>96% purity) were plated at low density (20-50 cells/culture) into cultures of purified dorsal root ganglion neurons. Three days after plating, single O1+ODCs were located (209 ODCs/43 cultures) and sequentially observed for 4 weeks. The ODCs began to proliferate by the fifth day after plating and formed large colonies by the third week. Most cells in these colonies were 01- but positive for another ODC antigen, O4. A few O1+, myelin basic protein (MBP)+ODCs, and glial fibrillary acidic protein (GFAP)+cells with astrocytic morphology were observed in some colonies. In similar cultures plated with cell-sorted O1+ODCs (>99.5% purity), ciliary neurotrophic factor (CNTF, 1ng/ml) increased the number and size of colonies, the number of O1+MBP+ODCs (including ODCs producing myelin-like profiles in association with axons) and the number of GFAP+ astrocytes, relative to untreated controls. The results are evidence that CNTF exerts a trophic effect on adult O1+ODCs, and/or their progeny, and that cells generated by division of O1+ODCs can become either new myelin-producing ODC, or astrocytes. This plasticity in regenerative potential of adult O1+ODCs has not been previously demonstrated." provenance.
- _8 value "BK increased cPLA(2) mRNA eightfold by 15 min, and this increase was inhibited by pretreatment with the PKC inhibitors." provenance.
- _6 value "BK-induced enhancement of PGI(2) synthesis was observed in a dose- and time-dependent manner, and it also increased [Ca(2+)](i) followed by enhancement of cytosolic phospholipase A(2) (cPLA(2)) activity." provenance.
- _7 value "The PKC inhibitors GF109203X and H7 attenuated the BK-induced increase in [Ca(2+)](i) and inhibited the BK-induced PGI(2) synthesis. Phorbol 12-myristate 13-acetate increased cPLA(2) activity and PGI(2) synthesis but failed to alter [Ca(2+)](i)." provenance.
- _9 value "The PKC inhibitors GF109203X and H7 attenuated the BK-induced increase in [Ca(2+)](i) and inhibited the BK-induced PGI(2) synthesis. Phorbol 12-myristate 13-acetate increased cPLA(2) activity and PGI(2) synthesis but failed to alter [Ca(2+)](i)." provenance.
- _3 value "Furthermore, high oxygen levels induce S-phase arrest and increased expression of p53 and p21(WAF1/CIP1)." provenance.
- _4 value "Cyclical RGD peptide, the specific inhibitor of alphav integrin, also exhibited a dose-dependent effect of increasing NO levels (thru TNF)" provenance.
- _7 value "Here, we report that Pbx-Meis1/Prep1 binds DNA cooperatively with heterodimers of E2a and MyoD, myogenin, Mrf4 or Myf5." provenance.
- _7 value "IL-1alpha, IL-1beta and IL-6 increased both metallothionein-1 (MT-1) and metallothionein-2 (MT-2) mRNA in HepG2 cells." provenance.
- _6 value "IQGAP1, a target of Cdc42 and Rac1 small GTPases, directly interacts with beta-catenin and negatively regulates E-cadherin-mediated cell-cell adhesion by dissociating alpha-catenin from the cadherin-catenin complex in vivo" provenance.
- _6 value "Betacellulin activated EGFR and erbB2 phosphorylation and significantly increased beta1-integrin-dependent adhesion of the MDA-MB-435 cells to type IV collagen." provenance.
- _4 value "Figure 6. PPARs downregulate human ET-1 gene promoter activity by interfering negatively with the AP-1 signaling pathway." provenance.
- _7 value "Figure 6. PPARs downregulate human ET-1 gene promoter activity by interfering negatively with the AP-1 signaling pathway." provenance.
- _6 value "In endothelial cells, ET-1 secretion is detectable under basal conditions, whereas thrombin induces its secretion." provenance.
- _5 value "TNFR-associated factor 2 recruitment, which in turn recruits and activates apoptosis signal-regulating kinase-1, leading to downstream activation of c-Jun N-terminal/stress-activated protein kinases (JNK/SAPK)" provenance.
- _7 value "TNFR-associated factor 2 recruitment, which in turn recruits and activates apoptosis signal-regulating kinase-1, leading to downstream activation of c-Jun N-terminal/stress-activated protein kinases (JNK/SAPK)" provenance.
- _6 value "GRK2, -3, -5, -6a, and -6b inhibit the FSH-R-mediated signaling" provenance.
- _5 value "beta-arrestins 1 or 2 also decrease the FSH action when overexpressed" provenance.
- _5 value "These results suggest that activation of PI 3-K is an early signal induced by TSP-1 and is critical for chemotaxis. Activation of this kinase precedes and may occur upstream from FAK phosphorylation, although the nature of the interaction between these 2 enzymes remains obscure." provenance.
- _5 value "Modified assertion" provenance.
- _5 value "Modified assertion" provenance.
- _6 value "Modified assertion" provenance.
- _3 value "Twist expression bypassed p53-induced growth arrest. These effects correlated with an ability of Twist to interfere with activation of a p53-dependent reporter and to impair induction of p53 target genes in response to DNA damage." provenance.
- _3 value "We find that mice develop functional and morphologic characteristics of chronic renal failure after partial renal ablation, including glomerular sclerosis, systemic hypertension, and reduced glomerular filtration. However, we now report that littermates with a homozygous deletion of the gene for the cyclin-dependent kinase inhibitor, p21(WAF1/CIP1), do not develop chronic renal failure after ablation. " provenance.
- _4 value "BDNF, NT-3, and NT-4 caused rapid tyrosine phosphorylation of ERK and SNT. " provenance.
- _3 value "In rats, estradiol down-regulates 11betaHSD1 expression." provenance.
- _5 value "% Entrez Gene GeneRifs summary: Human: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3." provenance.
- _6 value "In the nucleus, HDAC4 associates with the myocyte enhancer factor MEF2A. Binding of HDAC4 to MEF2A results in the repression of MEF2A transcriptional activation, a function that requires the deacetylase domain of HDAC4." provenance.
- _6 value "Axin formed a complex with plakoglobin in COS cells and SW480 cells. Axin directly bound to plakoglobin, and this binding was inhibited by beta-catenin." provenance.
- _5 value "IFNalpha induces JAK1 auto phosphorylation." provenance.
- _5 value "Phosphorylation of IRS-1 by JAK1 leads to generation of interaction sites for SH2 domain containing proteins." provenance.
- _7 value "Here we describe a Raf-1-interacting protein, isolated using a yeast two-hybrid screen. This protein inhibits the phosphorylation and activation of MEK by Raf-1 and is designated RKIP (Raf kinase inhibitor protein)." provenance.
- _6 value "Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK)" provenance.
- _5 value "Borg3 also inhibited Jun kinase activity by a mechanism that was independent of Cdc42 binding." provenance.
- _7 value "Surprisingly, Borg3 bound only to Cdc42." provenance.
- _5 value "Modified assertion" provenance.
- _6 value "Modified assertion" provenance.
- _6 value "Modified assertion" provenance.
- _3 value "We injected a monoclonal antibody directed against the SH3 domain of Ras-GAP (mAb200) that has been shown to block Ras-GAP downstream signalling into various human normal and tumour cell lines. When mAb200 was microinjected into lung carcinoma H460 cells, cervix carcinoma HeLa cells and colon carcinoma HCT116 cells, massive cell death occurred. Breast carcinoma SKBR3 cells, non small lung H322 and colon HT29 carcinoma cells were also sensitive to the mAb200 antibody, although to a lesser extent (data not shown)." provenance.
- _4 value "Treatment of jurkat cells with intact TSP1 in the presence of anti-CD3 enhanced the CD-3 dependent phosphorylation of a 36-KDa protein, identified as LAT. Intact TSP1 did not reproducibly enhance its phosphorylation, except in the presence of anti-CD3." provenance.
- _4 value "Resveratrol was found to act as a competitive inhibitor of purified 5-lipoxygenase and 15-lipoxygenase and prostaglandin H synthase" provenance.
- _4 value "A specific inhibitor of phosphoinositide 3-kinase (PI3K), LY294002, negated the effect of the monoclonal antibodies on the morphology of the Matrigel-embedded cells and on production of MMP-2." provenance.
- _7 value "In addition, TGFbeta(1)- and BMP-2-induced increases in alpha1(I) collagen mRNA levels were both dependent on protein kinase C and protein tyrosine kinase activities." provenance.
- _7 value "In addition, TGFbeta(1)- and BMP-2-induced increases in alpha1(I) collagen mRNA levels were both dependent on protein kinase C and protein tyrosine kinase activities." provenance.
- _6 value "Treatment with the selective Src kinase inhibitor PP-2 inhibited both FAK activation and phosphorylation of FAK at Tyr(577) induced by bombesin in intact cells." provenance.
- _5 value "Treatment with the selective Src kinase inhibitor PP-2 inhibited both FAK activation and phosphorylation of FAK at Tyr(577) induced by bombesin in intact cells." provenance.
- _5 value "high glucose concentration also activated the insulin receptor kinase toward the endogenous insulin receptor substrates IRS1 and IRS2" provenance.
- _5 value "inhibition of PKCalpha expression caused an increase in IRS phosphorylation by the insulin receptor this effect was independent of insulin" provenance.
- _4 value "The results showed that intracerebroventricular administration of NPY stimulated feeding and increased immunostaining of c-Fos, a product of the immediate early gene c-fos" provenance.
- _4 value "The activation of human platelets by thrombin is mediated primarily by protease-activated receptors (PARs). PAR1 and PAR4 are present on human platelets and are activated by the hexapeptides SFLLRN and GYPGQV, respectively." provenance.
- _4 value "In cultures of cerebellar granule cells, BDNF, NT-3, and NT-4/5 triggered the phosphorylation of Shc, PI 3-K, and ERK/MAPKs, and the expression of c-fos, whereas only BDNF and NT-4/5 seemed to activate PLCgamma (Lindholm et al., 1993 ; Zirrgiebel et al., 1995 ; Nonomura et al., 1996 ; Zirrgiebel and Lindholm, 1996 )." provenance.
- _4 value "BMP6 induced the phosphorylation of Smad5 and Smad1 in C2C12 cells and MC3T3-E1 cells." provenance.
- _3 value "# sentences for pubmedID=10506130: # Ariadne: Results showed that forskolin also inhibited the expression of alkaline phosphatase, bone sialoprotein, osteopontin, and osteocalcin genes (Fig. 2 C ). [Expression]" provenance.
- _3 value "# sentences for pubmedID=10506130: # Ariadne: Results showed that forskolin also inhibited the expression of alkaline phosphatase, bone sialoprotein, osteopontin, and osteocalcin genes (Fig. 2 C ). [Expression]" provenance.
- _3 value "# sentences for pubmedID=10506130: # Ariadne: Results showed that forskolin also inhibited the expression of alkaline phosphatase, bone sialoprotein, osteopontin, and osteocalcin genes (Fig. 2 C ). [Expression]" provenance.
- _5 value "Met-mediated invasive growth requires autophosphorylation of the receptor on tyrosines located in the kinase activation loop (Tyr(1234)-Tyr(1235)) and in the carboxyl-terminal tail (Tyr(1349)-Tyr(1356))" provenance.
- _5 value "Met-mediated invasive growth requires autophosphorylation of the receptor on tyrosines located in the kinase activation loop (Tyr(1234)-Tyr(1235)) and in the carboxyl-terminal tail (Tyr(1349)-Tyr(1356))" provenance.
- _5 value "Met-mediated invasive growth requires autophosphorylation of the receptor on tyrosines located in the kinase activation loop (Tyr(1234)-Tyr(1235)) and in the carboxyl-terminal tail (Tyr(1349)-Tyr(1356))" provenance.
- _5 value "In this study, we examined the cell cycle-dependent phosphorylation of PP1alpha in vivo using three different antibodies. PP1alpha was phosphorylated at Thr-320 during M-phase and again in late G(1)- through early S-phase. Inhibition of Cdk2 led to a small increase in PP1 activity and also prevented PP1alpha phosphorylation. In vitro, PP1alpha was a substrate for Cdk2 but not Cdk4." provenance.
- _4 value "# sentences for pubmedID=10508159: # Pubmed:gene: Cathepsin D targeted by acid sphingomyelinase-derived ceramide. # Ariadne: In both cases, D - erythro -ceramide, but not D - erythro -dihydroceramide, enhanced CTSD proteolytic activity. [Regulation]" provenance.
- _5 value "Ectopic expression of Myc induces Cdk2 kinaseactivity in quiescent cells and antagonizes association of p27(kip1) with Cdk2." provenance.
- _8 value "Ectopic expression of Myc induces Cdk2 kinaseactivity in quiescent cells and antagonizes association of p27(kip1) with Cdk2." provenance.
- _6 value "Another PDGF binding protein was isolated from a rat neural retina cell line and called PDGF-associated protein (PAP) (124). PAP binds PDGF with low affinity and was found to enhance the activity of PDGF-AA but depress the activity of PDGF-BB." provenance.
- _5 value "Both the alpha -receptor and the beta -receptor mediate an increase in intracellular Ca2+ concentration, albeit the beta -receptor more efficiently than the alpha -receptor; pretreatment with PDGF-AA depressed the Ca2+ mobilization after PDGF-BB stimulation (100)." provenance.
- _9 value "Both the alpha -receptor and the beta -receptor mediate an increase in intracellular Ca2+ concentration, albeit the beta -receptor more efficiently than the alpha -receptor; pretreatment with PDGF-AA depressed the Ca2+ mobilization after PDGF-BB stimulation (100)." provenance.
- _2 value "and the activation of the apoptotic pathway." provenance.
- _4 value "Modified assertion" provenance.
- _4 value "Treatment of HT29-D4 cells with antibodies to alphaV, alpha-6 and beta-1 integrins significantly inhibited the des (1-3)-IGF1 (analogue of IGF-1) induced cell migration. Incubation with a mixture containing anti-alphaV, anti-alpha6 and anti-beta1antibodies together totally abolished migration, indicating that these integrin subunits are involved in the IGF-1 induced cell migration." provenance.
- _5 value "Fig. 4 shows the results of the Northern blot analysis, which indicate that endogenous HNF-3? mRNA (indicated with an arrow) was decreased 50% in the CCl4-injured liver compared with the normal rat. However, the transduced HNF-3gamma mRNA (indicated with an arrowhead) was increased dose-dependently by the AxCAHNF3gamma infection in spite of CCl4 treatment. HNF-3alpha and HNF-3beta were up-regulated in the CCl4-treated livers of mock- and AxCALacZ-infected rats. Conversely, These mRNAs in the AxCAHNF3gamma-infected liver were not observed to be induced by CCl4 treatment." provenance.