Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Beta-catenin-independent+WNT+signaling+is+associated+with+basal-like+breast+cancer+and+brain+metastasis. assertion.
- assertion asSentence High+CTNNB1+is+associated+with+non-small+cell+lung+cancer+after+surgery. assertion.
- assertion asSentence RNAi+directly+against+beta-catenin+markedly+decreased+beta-catenin+gene+expression+and+inhibited+cellular+proliferation+as+reflected+in+the+reduced+growth+of+tongue+cancer+cells+both+in+vitro+and+in+nude+mice. assertion.
- assertion asSentence Wnt%2Fbeta-catenin+signaling+regulates+MAPK+and+Akt1+expression+and+growth+of+hepatocellular+carcinoma+cells. assertion.
- assertion asSentence The+cell-type-specific+presence+of+MITF+in+melanoma+affects+beta-catenin%27s+pro-invasive+properties+otherwise+active+in+colon+or+liver+cancer. assertion.
- assertion asSentence Beta-catenin+plays+a+central+role+in+regulating+osteogenic+differentiation+of+mesenchymal+stem+cells+in+inflammatory+microenvironments. assertion.
- assertion asSentence Immunohistochemical+and+histologic+features+supporting+the+diagnosis+of+SPNs+over+PanNETs+include+CD10+and+nuclear+beta-catenin+labeling. assertion.
- assertion asSentence miR-1826+plays+an+important+role+as+tumor+suppressor+via+CTNNB1%2FMEK1%2FVEGFC+downregulation+in+bladder+cancer. assertion.
- assertion asSentence Smad4-mediated+signaling+inhibits+intestinal+neoplasia+by+inhibiting+expression+of+beta-catenin. assertion.
- assertion asSentence Beta-catenin+inhibits+promyelocytic+leukemia+protein+tumor+suppressor+function+in+colorectal+cancer+cells. assertion.
- assertion asSentence Beta-Catenin+controls+YAP+expression+in+colorectal+carcinoma+cells. assertion.
- assertion asSentence KLF4+inhibits+beta-catenin+expression+and+regulates+the+beta-catenin-mediated+biological+behaviors+of+gastric+cancer+cells. assertion.
- assertion asSentence P-cadherin+cooperates+with+insulin-like+growth+factor-1+receptor+to+promote+metastatic+signaling+of+gonadotropin-releasing+hormone+in+ovarian+cancer+via+p120+catenin. assertion.
- assertion asSentence p120-catenin+isoform+3+regulates+the+nuclear+export+of+Kaiso+and+promotes+invasion+in+lung+cancer+cells+via+a+phosphorylation-dependent+mechanism. assertion.
- assertion asSentence p120ctn+Expression+Is+Lost+or+Reduced+in+Esophageal+Cancer+Tissues+and+Cell+Linessuppressor+gene. assertion.
- assertion asSentence Selective+activation+of+p120ctn-Kaiso+signaling+to+unlock+contact+inhibition+of+ARPE-19+cells+without+epithelial-mesenchymal+transition. assertion.
- assertion asSentence The+interaction+of+scaffolding+proteins+with+cadherin-NPRAP+complexes+anchors+diverse+signaling+and+adhesion+molecules+at+cadherins. assertion.
- assertion asSentence Introduction+of+a+fluorine+atom+at+C3+of+3-deazauridine+shifts+its+antimetabolic+activity+from+inhibition+of+CTP+synthetase+to+inhibition+of+orotidylate+decarboxylase%2C+an+early+event+in+the+de+novo+pyrimidine+nucleotide+biosynthesis+pathway. assertion.
- assertion asSentence In+normal+conditions+and+in+the+presence+of+IL-1beta%2C+cathepsin+B+is+involved+in+the+activation+of+plasminogen+activator+in+osteoblasts. assertion.
- assertion asSentence The+expression+of+cathepsin+B+in+non-small+cell+lung+cancer+should+be+considered+as+a+significant+prognostic+parameter. assertion.
- assertion asSentence Cathepsin+B+specifically+cleaves+off+four+C-terminally+located+amino+acids+of+human+CCL20+and+generates+a+CCL20%281-66%29+isoform+with+full+functional+activity. assertion.
- assertion asSentence Cyclosporine+down+regulated+Cathepsin+B. assertion.
- assertion asSentence Imbalanced+serum+concentration+between+cathepsin+B+and+cystatin+C+in+patients+with+pelvic+inflammatory+disease. assertion.
- assertion asSentence Cathepsin+B+activities+are+increased+in+acromegaly. assertion.
- assertion asSentence High+expression+of+cathepsin+B+is+closely+associated+with+tumor+infiltration+and+lymphatic+metastasis+of+cervical+cancer. assertion.
- assertion asSentence Cathepsin+B+endopeptidase+specificity+is+primarily+guided+by+a+strong+selectivity+for+glycine. assertion.
- assertion asSentence Stringent+regulation+of+cathepsins+S+and+D%2C+two+proteases+involved+in+antigen+presentation%2C+is+crucial+to+engage+cell+commitment+to+either+route. assertion.
- assertion asSentence Induction+of+cathepsin+D+plays+a+previously+unrecognized+role+in+lipid+processing+for+CD1d+antigen-restricted+lipid+presentation+by+dendritic+cells. assertion.
- assertion asSentence Three-dimensional+structure+of+cathepsin-E. assertion.
- assertion asSentence CatE+is+important+in+the+processing+of+tetanus+toxin+C-fragment+in+primary+human+B+cells. assertion.
- assertion asSentence RANKL-induced+cathepsin+K+gene+expression+is+cooperatively+regulated+by+the+combination+of+the+transcription+factors+and+p38+MAP+kinase+in+a+gradual+manner. assertion.
- assertion asSentence Possiable+role+in+homeostasis+of+dermal+extracellular+matrix+and+dynamic+equilibrium+between+matrix+synthesis+and+proteolytic+degradation%2C+by+counteracting+deposition+of+matrix+proteins+during+scar+formation+with+its+matrix-degrading+activity. assertion.
- assertion asSentence Cathepsin+K+expression+is+of+predictive+prognostic+value+for+patients+with+high-grade+osteosaromas+and+metastasis+at+diagnosis. assertion.
- assertion asSentence Cathepsin+X+causes+cytoskeletal+rearrangements+and+stimulates+migration+of+T+lymphocytes. assertion.
- assertion asSentence Cathepsin+L+is+over-expressed+in+human+AAA+and+atherosclerotic+lesions+and+its+expression+in+vascular+cell+types+found+in+these+lesions+is+regulated+by+pro-inflammatory+cytokines. assertion.
- assertion asSentence Caspase-3+activation+triggers+extracellular+cathepsin+L+release+and+endorepellin+proteolysis. assertion.
- assertion asSentence CTSL+and+CTSB+are+capable+of+directly+processing+both+alpha-+and+beta-protryptases+from+human+mast+cells+to+their+mature+enzymatically+active+products. assertion.
- assertion asSentence Associated+with+type+1+diabetes+and+early-onset+myasthenia+gravis. assertion.
- assertion asSentence Fractalkine-induced+activation+of+CX3CR1+by+endothelial+cells+leads+to+in+vivo+angiogenesis. assertion.
- assertion asSentence One+function+of+the+CX3CR1-CX3CL1+pathway+is+to+recruit+and+sustain+divergent+immune+cell+populations+implicated+in+the+pathogenesis+of+cigarette+smoke-induced+emphysema. assertion.
- assertion asSentence CX3CR1+expression+is+a+frequent+event+in+gliomas%2C+irrespective+of+tumor+classification+and+clinical+severity. assertion.
- assertion asSentence High+CX3CR1+expression+is+associated+with+dlioma. assertion.
- assertion asSentence In+the+setting+of+CX3CR1+deficiency+and+reduced+numbers+of+Gr-1+antigen-positive+macrophages%2C+transgenic+mice+have+enhanced+response+to+ozone. assertion.
- assertion asSentence The+expression+of+CAR+mRNA+and+protein+in+cancer+tissue+samples+are+significantly+higher+than+that+in+the+normal+and+paraneoplastic+samples. assertion.
- assertion asSentence ZEB1+represses+CAR+expression+in+both+PANC-1+%28pancreatic%29+and+MDA-MB-231+%28breast%29+human+cancer+cells. assertion.
- assertion asSentence Sp1+is+involved+in+regulation+of+CAR+expression. assertion.
- assertion asSentence Anaplasma+phagocytophila+causes+a+change+in+p22phox. assertion.
- assertion asSentence Genetic+variation+in+CYBA+is+not+a+risk+factor+for+small+vessel+cerebrovascular+disease. assertion.
- assertion asSentence The+C242T+CYBA+single+nucleotide+polymorphism+is+associated+with+altered+NADPH+oxidase+activity+in+lymphoblastoid+cells+of+patients+with+cardiovascular+disease. assertion.
- assertion asSentence Platelet+CD40L+expression+occurs+via+arachidonic+acid-mediated+gp91phox+activation. assertion.
- assertion asSentence Src+homology-containing+tyrosine+phosphatase+2+activation+blocks+IFN+consensus+sequence-binding+protein+%28ICSBP%29+induced+CYBB+transcription. assertion.
- assertion asSentence Aged+transgenic+mice+overexpressing+the+Swedish+mutation+of+amyloid+precursor+protein+and+lacking+the+catalytic+subunit+Nox2+of+NADPH+oxidase+do+not+develop+oxidative+stress%2C+cerebrovascular+dysfunction%2C+or+behavioral+decline. assertion.
- assertion asSentence None+of+the+CYBB+SNPs+serve+as+good+surrogates+for+the+microsatellite+alleles%2C+previously+associated+with+mild+malaria. assertion.
- assertion asSentence NF-kappaB+is+necessary+for+CYBB+and+NCF1+gene+expression+and+activation+of+the+phagocyte+NADPH+oxidase+normal+and+anhidrotic+ectodermal+dysplasia+leukocytes. assertion.
- assertion asSentence Phosphodiesterase+2+mediates+redox-sensitive+endothelial+cell+proliferation+and+angiogenesis+by+thrombin+via+Rac1+and+NADPH+oxidase+2. assertion.
- assertion asSentence NADPH+oxidase+assembly+process+and+FAD+incorporation+are+closely+related+events+essential+for+the+diaphorase+activity+of+Nox2. assertion.
- assertion asSentence Glucan+increases+IL-12+production+through+NADPH+oxidase-unrelated+mechanisms. assertion.
- assertion asSentence In+resting+neutrophils%2C+a+substantial+proportion+of+p22-phox+from+HIV-positive+patients+is+distributed+in+regions+close+to+the+cytoplasmic+membrane%2C+sediment+in+high+density+sucrose+fractions+and+is+located+in+the+cytoplasmic+insoluble+fraction. assertion.
- assertion asSentence Somatic+mutation+of+CYLD+gene+is+rare+in+hematologic+and+solid+malignancies. assertion.
- assertion asSentence CYP1a1+polymorphism+does+not+independently+confer+risk+to+OSCC. assertion.
- assertion asSentence T6235C+CYP1A1+polymorphism+is+a+risk+factor+for+the+development+of+cerebral+infarct. assertion.
- assertion asSentence Genetic+polymorphisms+in+CYP1A1+are+associated+with+lung+cancer+risk+in+Asian+smokers. assertion.
- assertion asSentence Heat+shock+protein+90+inhibitors+suppress+aryl+hydrocarbon+receptor-mediated+activation+of+CYP1A1+and+CYP1B1+transcription+and+DNA+adduct+formation. assertion.
- assertion asSentence The+CYP1A1+Ile462Val+polymorphism+is+associated+with+platinum+resistance+of+epithelial+ovarian+neoplasms. assertion.
- assertion asSentence Combined+effects+of+cigarette+smoke+and+CYP1A1+Polymorphisms+are+associated+with+non+small+cell+lung+cancer. assertion.
- assertion asSentence CYP1A1+gene+polymorphisms+are+associated+with+lung+cancer. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+of+CYP1A1+is+associated+with+colorectal+cancer. assertion.
- assertion asSentence Single+Nucleotide+Polymorphism+in+CYP1A1+is+associated+with+endometrial+cancer. assertion.
- assertion asSentence Polymorphisms+of+the+CYP1A1%2C+CYP2E1+and+XRCC1+genes+are+not+asociated+with+cancer. assertion.
- assertion asSentence CYP1A1+downregulation+is+associated+with+head+and+neck+cancer+progression. assertion.
- assertion asSentence Transgenic+enzyme+metabolizes+4-n-nonylphenol+in+tobacco+cultures. assertion.
- assertion asSentence Used+shuffled+CYP1A2library+to+examine+genotype%2Fphenotype+of+mutant+forms. assertion.
- assertion asSentence Differential+mechanisms+for+the+inhibition+of+human+cytochrome+P450+1A2+by+apigenin+and+genistein. assertion.
- assertion asSentence Methanol+is+the+suitable+solvent+and+has+no+significant+effects+on+CYP1A2-mediated+phenacetin+O-deethylation. assertion.
- assertion asSentence Benzo%28k%29fluoranthene+and+benzo%28a%29pyrene+induced+CYP1A1+and+CYP1B1+in+T-47D+human+breast+cancer+cells. assertion.
- assertion asSentence Mexican+patients+with+PCG+%28primary+congenital+glaucoma%29+are+rarely+%28less+than+10%25%29+due+to+CYP1B1+mutations. assertion.
- assertion asSentence CYP1B1+mutations+causing+primary+congenital+glaucoma+can+act+by+either+reducing+enzymatic+activity+%28p.G61E+and+p.N203S%29%2C+reducing+the+abundance+of+the+enzyme+%28p.Y81N+and+p.E229+K%29%2C+or+both+%28p.L343del%29. assertion.
- assertion asSentence CYP1B1+variants+are+associated+with+prostate+cancer. assertion.
- assertion asSentence Heat+shock+protein+90+inhibitors+suppress+aryl+hydrocarbon+receptor-mediated+activation+of+CYP1A1+and+CYP1B1+transcription+and+DNA+adduct+formation. assertion.
- assertion asSentence Allelic+polymorphism+of+CYP1B1+L432V+increases+the+risk+of+endometrial+cancer+and+has+a+positive+correlation+with+ERalpha+expression. assertion.
- assertion asSentence The+homozygote+variant+genotype+of+AHR+Lys554Lys+is+associated+with+a+significantly+lower+AHR%2C+ARNT+and+CYP1B1+mRNA+expression. assertion.
- assertion asSentence Benzyl+butyl+phthalate-induces+granulosa+cell+necrosis+is+AhR+and+CYP1B1+dependent. assertion.
- assertion asSentence A+meta-analysis+found+no+association+between+the+CYP1B1+Leu432Val+polymorphism+and+risk+of+colorectal+cancer+among+Caucasians. assertion.
- assertion asSentence CYP2A6%2A1B+is+associated+with+the+number+of+cigarettes+smoked+per+day. assertion.
- assertion asSentence CYP2A6%2A1B+genotype+is+associated+with+faster+nicotine+clearance+in+vivo. assertion.
- assertion asSentence CYP2A6+is+directly+induced+by+estradiol+in+an+ERalpha-dependent+manner%2C+implying+a+biological+role+of+CYP2A6+in+estrogen-responsive+tissues. assertion.
- assertion asSentence Heavy+smoking+is+significantly+associated+with+type+2+diabetes+mellitus%2C+an+association+that+is+moderated+by+the+CYP2A6+genotype. assertion.
- assertion asSentence Expression+of+CYP3A7+in+the+endometrium+is+significantly+greater+in+the+proliferative+phase+compared+with+the+secretory+phase+of+the+menstrual+cycle. assertion.
- assertion asSentence The+expression+level+of+CYP3A7+messenger+RNA+is+highest+in+chorion%2Fdecidua+at+a+level+which+is+about+3-fold+of+placenta+and+amnion%2C+with+the+metabolic+function+to+protect+the+fetus+from+exposure+to+drugs. assertion.
- assertion asSentence Recombinant+CYP3A4%2C+CYP3A5+and+CYP3A7+metabolized+R-+and+S-warfarin+to+10-+and+4%27-hydroxywarfarin+with+efficiencies+that+depended+on+the+individual+enzymes. assertion.
- assertion asSentence CYP2B6-G516T+polymorphisms+significantly+affect+the+CL%2FF+rate+of+EFV+in+children. assertion.
- assertion asSentence Distribution+of+functional+CYP2B+haplotypes+among+HIV+infected+African+American+patients+is+significant+different+from+that+among+control+subjects. assertion.
- assertion asSentence CYP2B6-516G%3ET+polymorphisms+significantly+affect+the+drug+metabolism+of+efavirenz+in+children. assertion.
- assertion asSentence The+CYP2B6%2A6+allele+is+associated+with+altered+binding+affinity+and%2For+catalytic+activity. assertion.
- assertion asSentence Polymorphism+of+CYP2C19+gene+is+involved+in+the+metabolism+of+various+drugs+used+clinically. assertion.
- assertion asSentence The+constructs%2C+CYP2C9%2FBMR%2C+CYP2C19%2FBMR+and+CYP3A4%2FBMR+are+well+expressed+in+Escherichia+coli+as+holo+proteins. assertion.
- assertion asSentence The+poor+metabolizers+phenotype+and+the+frequencies+of+CYP2C19+defective+alleles%2C+particularly+CYP2C19%2A3+among+these+three+Southeast+Asian+ethnics+appeared+to+be+lower+than+other+Asian+populations. assertion.
- assertion asSentence CYP2c19+and+CYP2d6+genotypes+can+be+used+to+predict+imipramine%2Bdesipramine+plasma+levels+in+in+depressed+patients. assertion.
- assertion asSentence Individuals+of+the+Korean+population+carrying+CYP2C19%2A26+variant+have+lower+activity+for+metabolizing+CYP2C19+substrate+drugs. assertion.
- assertion asSentence CYP2C19-mediated+clearance+of+S-citalopram+occurs+via+N-desmethylation+and+the+fomration+of+a+propionic+acid+metabolite. assertion.