Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Omeprazole+inactivated+CYP2C19+with+K%28I%29+values+of+1.7+to+9.1+muM+and+k%28inact%29+values+of+0.041+to+0.046+min%28-1%29. assertion.
- assertion asSentence Voriconazole+therapy+failure+in+a+homozygous+ultrarapid+CYP2C19%2A17%2F%2A17+patient+comedicated+with+carbamazepine. assertion.
- assertion asSentence Association+of+CYP2C9+genotypes+leading+to+high+enzyme+activity+and+colorectal+cancer+risk. assertion.
- assertion asSentence Patients+with+diabetes+mellitus+who+are+carriers+of+a+CYP2C9%2A3+allele+require+lower+doses+of+tolbutamide+to+regulate+their+serum+glucose+levels+compared+to+patients+with+the+wild-type+genotype. assertion.
- assertion asSentence Cyp2C9+genotype+affects+coumarin+metabolism. assertion.
- assertion asSentence Pharmacogenetic+variation+at+CYP2C9+in+different+population+groups. assertion.
- assertion asSentence CYP2C9+gene+mutation+is+associated+with+warfarin+hypersensitivity. assertion.
- assertion asSentence CYP2C9+and+VKORC1+gene+polymorphism+is+not+associated+with+the+development+of+severe+hypocoagulation+episodes+in+patients+treated+with+acenocoumarol. assertion.
- assertion asSentence Hypothetically%2C+cytochrome+P450+2D6+influences+the+transport+of+taurine+across+the+blood-brain+barrier. assertion.
- assertion asSentence In+pregnant+women+with+chronic+arterial+hypertension+receiving+antihypertensive+therapy+with+bisoprolol+and+nifedipine+polymorphic+marker+CYP2D6+of+CYP2D6+gene+is+not+associated+with+prognostically+unfavorable+hemodynamic+changes. assertion.
- assertion asSentence CYP2D6+gene+polymorphisms+are+not+associated+with+cervical+cancer. assertion.
- assertion asSentence The+CYP2D6+gene+mutation+is+associated+with+a+high+risk+of+heroin+spongiform+leucoencephalopathy. assertion.
- assertion asSentence Genetic+polymorphisms+of+CYP2D6+is+not+associated+with+gastric+carcinoma. assertion.
- assertion asSentence CYP2D6+is+responsible+for+the+metabolism+of+most+beta-blockers. assertion.
- assertion asSentence CYP2D6+plays+a+significant+role+in+tramadol+analgesic+efficacy. assertion.
- assertion asSentence There+is+an+association+between+CYP2D6+%281846G%2FA%29+genotype+and+rapid+liver+cirrhosis+development. assertion.
- assertion asSentence Transcriptional+activity+of+the+mutant+allele+of+the+tandem+repeat+polymorphism+in+the+5%27-flanking+region+of+the+CYP2E1+gene+is+greater+than+that+of+the+wild+type. assertion.
- assertion asSentence Polymorphisms+of+the+alcohol+metabolism-related+CYP2E1+gene+are+significantly+different+in+Korean+patients+with+alcoholism+and+Korean+control+subjects+without+alcoholism. assertion.
- assertion asSentence Ethanol+induced+CYP2E1+generates+oxidative+stress+that+is+responsible+for+the+decrease+in+proteasome+activity. assertion.
- assertion asSentence Alcohol+consumption+and+polymorphisms+in+the+CYP2E1%2C+ADH1B+and+ALDH2+genes+are+important+risk+factors+for+esophageal+squamous+cell+carcinoma+in+Chinese+males+living+in+Gansu+Province%2C+China. assertion.
- assertion asSentence Bax+inhibitor+1+regulates+ER-stress-induced+ROS+accumulation+through+the+regulation+of+cytochrome+P450+2E1. assertion.
- assertion asSentence Protein-bound+4-HNE+and+etheno-DNA+adducts+both+strongly+correlate+with+cytochrome+P450+2E1+expression+in+patients+with+alcoholic+liver+disease. assertion.
- assertion asSentence An+indigenous+population+from+western+Mexico%2C+the+Huichols%2C+are+found+to+have+an+unusually+high+frequency+of+CYP2E1%2Ac2+allelic+polymorphisms. assertion.
- assertion asSentence CYP2E1+polymorphisms+are+associated+with+colorectal+cancer. assertion.
- assertion asSentence Acrylamide+is+able+to+affect+its+own+metabolism+by+influencing+the+expression+levels+of+CYP2E1+and+Glutathione+S-Transferase+isozymes. assertion.
- assertion asSentence CYP2E1+contributes+to+ethanol-induced+and+obesity-induced+oxidant+stress+and+liver+injury. assertion.
- assertion asSentence Transgenic+mice+overexpressing+human+CYP2J2+have+improved+postischemic+recovery+of+left+ventricular+function. assertion.
- assertion asSentence Haplotypes+of+CYP2J2+are+associated+with+myocardial+infarction+in+a+Chinese+Han+population. assertion.
- assertion asSentence CYP3A+isoforms+play+a+major+role+in+ecteinascidin+743+rat+and+human+metabolism. assertion.
- assertion asSentence CYP3A+phenotypes+and+genotypes+in+North+Indians. assertion.
- assertion asSentence Ginkgolide+A+and+ginkgolide+B+can+induce+CYP3A+protein+expression+and+enzyme+activity+in+primary+cultures+of+human+hepatocytes+at+higher+doses. assertion.
- assertion asSentence Efavirenz+enhances+omeprazole+metabolism+in+a+nonstereoselective+manner+through+induction+of+CYP3A+and+CYP2C19+activity. assertion.
- assertion asSentence Transcriptional+regulation+of+the+human+CYP3A4+gene+by+the+constitutive+androstane+receptor. assertion.
- assertion asSentence CYP3A4+expression+in+the+endometrium+of+premenopausal+women+is+comparable+between+the+secretory+and+proliferative+phases. assertion.
- assertion asSentence No+difference+in+CYP3A4+activity+in+kidney+transplant+patients+taking+either+FK506+or+Rapamyicn+and+healthy+controls. assertion.
- assertion asSentence CYP3A5%2A1%2F%2A3+polymorphisms+are+associated+with+tacrolimus+pharmacokinetics+and+dose+requirements+in+renal+transplant+recipients. assertion.
- assertion asSentence Tramadol+disposition+can+be+used+as+a+probe+to+assess+CYP2D6%2FCYP3A4+ontogeny+in+the+first+months+of+life. assertion.
- assertion asSentence CYP3A4+is+the+main+CYP3A+expressed+in+the+gastrointestinal+tract. assertion.
- assertion asSentence Concomitant+treatment+with+a+CYP3A4+inhibitor+and+a+CCB+increases+the+risk+of+an+ADR+by+53%25%2C+compared+with+CCB+monotherapy. assertion.
- assertion asSentence Clopidogrel+patients+presenting+with+repeat+acute+coronary+syndrome+do+not+have+higher+frequency+of+CYP3A4+variant+alleles+compared+to+a+control+group. assertion.
- assertion asSentence CYP3A4+is+a+major+isoform+responsible+for+testosterone+6+beta-hydroxylase+activity+in+amnion%2C+chorion%2Fdecidua+and+placenta%2C+with+the+metabolic+function+to+protect+the+fetus+from+exposure+to+drugs. assertion.
- assertion asSentence POR+variants+affect+CYP3A4+activities. assertion.
- assertion asSentence CYP3A4+is+a+highly+active+AA+epoxygenase+that+promotes+Stat3-mediated+breast+cancer+cell+growth+in+part+through+%28%2B%2F-%29-14%2C15-EET+biosynthesis. assertion.
- assertion asSentence The+CYP3A4+expression+also+altered+protein+secretion+in+human+mammary+epithelial+cells+and+C10+mouse+lung+cells. assertion.
- assertion asSentence Pregnane+X+receptor+and+yin+yang+1+contribute+to+the+differential+tissue+expression+and+induction+of+CYP3A5+and+CYP3A4. assertion.
- assertion asSentence Genetic+variation+in+noncoding+sequences+flanking+the+CYP3A+locus+contributes+to+variance+in+premenopausal+E1G+levels+and+is+associated+with+the+risk+of+breast+cancer+in+younger+patients. assertion.
- assertion asSentence Transcription+of+CYP3A5+gene+in+leukemia+cells+directly+induces+resistance+to+anthracyclines+and+alkaloids%2C+the+cells+are+still+sensitive+to+epipodophyllotoxins. assertion.
- assertion asSentence The+CYP3A5%2A1+genotype+is+associated+with+increased+saquinavir+oral+clearance. assertion.
- assertion asSentence Common+polymorphisms+on+CYP3A4+and+CYP3A5+genes+do+not+modify+the+risk+of+developing+digestive+cancers+in+Western+Europe. assertion.
- assertion asSentence Patients+carrying+a+CYP3A5%2A1+allele+require+a+twofold+higher+tacrolimus+dose+compared+with+homozygous+carriers+of+the+CYP3A5%2A3+variant+allele+to+maintain+the+target+dnAUC%280-12%29. assertion.
- assertion asSentence No+pharmacogenomic+associations+are+found+between+the+most+common+cytochrome+P4503A5+haplotypes+and+acute+kidney+injury+or+chronic+kidney+disease+following+myeloablative+allogeneic+hematopoietic+cell+transplantation. assertion.
- assertion asSentence Polymorphism+of+CYP3A5+gene+is+not+related+with+the+morbidity+of+acute+leukemia. assertion.
- assertion asSentence A+role+for+CYP3A5+and+DRD3+gene+variants+on+refractoriness+to+neuroleptic+treatment+in+Brazilians+with+schizophrenia. assertion.
- assertion asSentence Renal+transplant+recipients+with+CYP3A5%2A1+allele+%28CYP3A5+expressers%29+are+more+susceptible+to+diltiazem+induced+inhibition+of+tacrolimus+metabolism+in+comparison+to+CYP3A5%2A3%2F%2A3+carriers+%28CYP3A5+nonexpressers%29. assertion.
- assertion asSentence Aignificant+effects+of+CYP3A5+polymorphism+on+the+achievement+of+target+tacrolimus+trough+levels+and+the+development+of+acute+rejection+on+graft+function+in+renal+allograft+transplantation. assertion.
- assertion asSentence CYP3A5+polymorphism+plays+an+important+role+in+influencing+tacrolimus+blood+levels+for+Chinese+renal+transplant+recipients. assertion.
- assertion asSentence Single+Nucleotide+Polymorphisms+in+CYP3A5+gene+is+associated+with+prostate+cancer. assertion.
- assertion asSentence The+formation+of+the+major+metabolite+of+ilaprazole%2C+ilaprazole+sulfone%2C+is+predominantly+catalysed+by+CYP3A4%2F5. assertion.
- assertion asSentence Pregnane+X+receptor+and+yin+yang+1+contribute+to+the+differential+tissue+expression+and+induction+of+CYP3A5+and+CYP3A4. assertion.
- assertion asSentence CYP4B1+is+a+senescene-associated+gene+in+normal+human+oral+keratinocytes. assertion.
- assertion asSentence P450+side-chain+cleavage+deficiency--a+rare+cause+of+congenital+adrenal+hyperplasia. assertion.
- assertion asSentence Molecular+variant+in+CYP11B2+is+in+linkage+disequilibrium+%28LD%29+with+a+key+quantitative+trait+in+CYP11B1. assertion.
- assertion asSentence Inter-individual+variation+of+blood+pressure+and+plasma+aldosterone+is+affected+by+the+interaction+of+C%28-344%29T+polymorphism+and+ageing. assertion.
- assertion asSentence Molecular+variant+in+CYP11B2+is+in+linkage+disequilibrium+%28LD%29+with+a+key+quantitative+trait+in+CYP11B1. assertion.
- assertion asSentence Compared+to+CC+genotype%2C+CT+and+TT+CYP11B2+genotypes+are+independently+associated+with+increased+stroke+index. assertion.
- assertion asSentence Aldosterone+synthase+C-344T+polymorphism+is+irrelavant+for+the+development+of+hypertension. assertion.
- assertion asSentence Demonstrates+interaction+between+the+CYP11B2+genotype+and+alcohol+consumption+on+the+risk+of+hypertension+in+Chinese+Mongolian+population. assertion.
- assertion asSentence SMAD3+dependent+inactivation+of+CYP17+promoter+activity+and+repression+of+SF-1+expression. assertion.
- assertion asSentence CYP17A1+single+nucleotide+polymorphism+is+not+associated+with+the+risk+of+breast+cancer+or+fibrocystic+breast+disease+in+Chinese+women. assertion.
- assertion asSentence CYP17A1+gene+is+associated+with+autistic+traits%2C+empathy+and+Asperger+syndrome. assertion.
- assertion asSentence Direct+regulation+of+androgen+receptor+activity+by+potent+CYP17+inhibitors+in+prostate+cancer+cells. assertion.
- assertion asSentence Aromatase+and+COX-2+expression+in+human+breast+cancers. assertion.
- assertion asSentence Aromatase+in+atherosclerotic+lesions+of+human+aorta. assertion.
- assertion asSentence Molecular+pharmacology+of+aromatase+and+its+regulation+by+endogenous+and+exogenous+agents. assertion.
- assertion asSentence Regulation+of+aromatase+by+nuclear+receptors. assertion.
- assertion asSentence Estradiol+upregulates+aromatase+expression+by+a+nongenomic+action+of+estrogen+receptor+alpha+via+cross-talk+with+growth+factor-mediated+pathways. assertion.
- assertion asSentence Brain+P-450arom-ir+and+the+relationship+of+its+regulation+with+plasma+sex+steroid+levels%2C+estrogen+and+androgen+receptors+in+the+human+hypothalamus+and+basal+forebrain+are+region-specific. assertion.
- assertion asSentence A+common+haplotype+of+aromatase+associated+with+gene+expression+is+also+associated+with+the+risk+of+osteoporotic+vertebral+fractures+in+postmenopausal+women. assertion.
- assertion asSentence Mullerian-inhibiting+substance+inhibits+FSH+augmentation+of+CYP19+enzyme+activity+and+CYP19+gene+expression+in+granulosa+lutein+cells. assertion.
- assertion asSentence Loss+of+aromatase+is+associated+with+breast+cancer. assertion.
- assertion asSentence Aromatase+expression+by+endometrial+epithelial+and+stromal+cells+is+an+important+part+in+pahtogenesis+of+endometriosis. assertion.
- assertion asSentence Women+with+polycystic+ovary+syndrome+tend+to+have+more+frequently+short+%28TTTA%29n+alleles+of+CYP19+compared+to+controls. assertion.
- assertion asSentence The+combination+of+the+TTTA+long+repeats+and+the+minor+alleles+of+rs10046+in+CYP19A1+is+associated+with+risk+for+prostate+cancer. assertion.
- assertion asSentence Polymorphisms+in+CYP19+predispose+towards+Madurella+mycetomatis-induced+mycetoma+susceptibility. assertion.
- assertion asSentence CYP19+tetranucleotide+TTTA+repeat+polymorphism+is+an+ethnic+and+racial+variant+and+moderately+contributes+to+the+pathogenesis+of+PCOS+in+the+population+of+Han+Chinese+women. assertion.
- assertion asSentence CYP19A1+polymorphisms+are+involved+in+the+risk+for+lung+atypical+adenomatous+hyperplasia+%28AAH%29and+bronchioloalveolar+carcinoma+%28BAC%29+in+the+lungs+by+causing+differences+in+estrogen+levels. assertion.
- assertion asSentence A+common+polymorphism+in+the+human+aromatase+gene+alters+the+risk+for+polycystic+ovary+syndrome+and+modifies+aromatase+activity+in+vitro. assertion.
- assertion asSentence Dienogest+inhibits+aromatase+and+cyclooxygenase-2+expression+and+prostaglandin+E+production+in+human+endometriotic+stromal+cells+in+spheroid+culture. assertion.
- assertion asSentence Cortisol+induces+aromatase+expression+in+human+placental+syncytiotrophoblasts+through+the+cAMP%2FSp1+pathway. assertion.
- assertion asSentence V281%2BI172N%2FV281L+genotype+should+be+included+in+the+panel+of+mutations+associated+with+the+non-classical+forms+of+21-hydroxylase+deficiency. assertion.
- assertion asSentence Psychiatric+disorders+are+somewhat+increased%2C+especially+in+patients+with+severe+degrees+of+congenital+adrenal+hyperplasia. assertion.
- assertion asSentence P.His38Leu+is+a+severe+mutation+causing+a+classical+simple+virilizing+phenotype. assertion.
- assertion asSentence Genetic+variants+in+CYP24A1+is+not+associated+with+breast+cancer. assertion.
- assertion asSentence A+significant+association+with+breast+cancer+found+with+the+rs6013897+genotypes+in+CYP24A1+protein. assertion.
- assertion asSentence The+promoter+region+of+CYP26A1+is+significantly+hypermethylated+in+allergic+asthmatic+subjects. assertion.
- assertion asSentence Sterol+27-hydroxylase+cytochrome+P450+27A1+%28CYP27A1%29+is+involved+in+elimination+of+7-ketocholesterol+from+the+retinal+pigment+epithelium. assertion.
- assertion asSentence CYP1alpha+intron+6+polymorphism+appears+not+to+be+associated+with+type+1+diabetes+mellitus%2C+Graves%27+disease+and+Hashimoto%27s+thyroiditis. assertion.
- assertion asSentence Expression+and+activity+of+25-hydroxyvitamin+D-1+alpha-hydroxylase+are+restricted+in+cultures+of+human+syncytiotrophoblast+cells+from+preeclamptic+pregnancies. assertion.
- assertion asSentence The+common+presence+of+the+%22b%22%2C+%22a%22+and+%22u%22+alleles+in+the+vitamin+D+receptor+greatly+increases+the+probability+of+insulin-dependent+diabetes+in+girls. assertion.
- assertion asSentence Dab1+immunoreactivity+is+found+in+certain+populations+of+amacrine+cells+of+the+retina%2C+with+lobular+appendages+in+the+outer+half+of+the+inner+plexiform+layer+%28IPL%29+and+a+bushy%2C+smooth+dendritic+tree+in+the+inner+half+of+the+IPL. assertion.