Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence CHOP-dependent+DR5+up-regulation+is+a+key+event+mediating+SHetA2-induced+apoptosis. assertion.
- assertion asSentence Two+CCAAT%2Fenhancer-binding+protein+%28C%2FEBP%29+family+members+%5BC%2FEBP-homologous+protein+%28CHOP%29+and+C%2FEBPbeta%5D+enhanced+V2+transcription+via+different+pathways. assertion.
- assertion asSentence Aberrant+methylation+of+DNA-damage-inducible+transcript+3+promoter+is+associated+with+myelodysplastic+syndrome. assertion.
- assertion asSentence Coxsackievirus+B3+infection+induces+apoptosis+through+downregulation+of+p58IPK+and+activation+of+CHOP+and+SREBP1. assertion.
- assertion asSentence Endoplasmic+reticulum+stress-induced+transcription+factor%2C+CHOP%2C+is+crucial+for+dendritic+cell+IL-23+expression. assertion.
- assertion asSentence Cadmium+chloride+can+induce+DNA+damage+and+increase+expression+levels+of+the+gadd153+and+gadd45beta+promoters+in+HepG2+cells. assertion.
- assertion asSentence D-dopachrome+tautomerase+%28D-DT%29+and+macrophage+migration+inhibitory+factor%2C+individually+and+additively%2C+promote+vascular+endothelial+growth+factor+and+CXCL8+expression+in+human+lung+adenocarcinoma+cell+lines. assertion.
- assertion asSentence DDX1+interacts+with+coronavirus+nonstructural+protein+14+and+enhances+viral+replication. assertion.
- assertion asSentence DEAD+box+helicase+is+involved+in+TBK1%2FIKKepsilon-mediated+IRF+activation+and+Ifnb+promoter+induction. assertion.
- assertion asSentence Replication+of+HCV+is+significantly+suppressed+in+cells+expressing+green+fluorescent+protein+fusions+to+HCV+core+protein+residues+16-36. assertion.
- assertion asSentence The+role+of+DDX3+in+antiviral+immunity+and+its+inhibition+or+exploitation+by+different+viruses. assertion.
- assertion asSentence Patient+with+chronic+hepatitis+C+carrying+DDX5+haplotypes+are+at+an+increased+risk+of+developing+advanced+liver+fibrosis. assertion.
- assertion asSentence RHA+interacts+with+NF-kappa+B+p65+and+functions+as+a+transcriptional+coactivator. assertion.
- assertion asSentence HNP1+%28human+neutrophil+protein+1%29+inhibited+diphtheria+toxin+%28DT%29-+or+Pseudomonas+exotoxin+A+%28ETA%29-mediated+ADP-ribosylation+of+eEF2+%28eukaryotic+elongation+factor+2%29+and+protected+HeLa+cells+against+DT-+or+ETA-induced+cell+death. assertion.
- assertion asSentence Alpha-defensin+human+neutrophil+protein+1+%28HNP1%29+and+human+alpha-defensin+5+%28HD5%29+inhibit+BKV+infection+by+targeting+an+early+event+in+the+viral+lifecycle. assertion.
- assertion asSentence Upregulation+of+HNP1+is+associated+with+colorectal+adenomas+and+carcinomas. assertion.
- assertion asSentence A+population+of+immature+dysplastic+granulocytes+contributes+to+the+chronic+myelomonocytic+leukemia+phenotype+through+production+of+alpha-defensins+HNP1-3+that+suppress+the+differentiation+capabilities+of+monocytes. assertion.
- assertion asSentence Upregulation+of+HNP3+is+associated+with+colorectal+adenomas+and+carcinomas. assertion.
- assertion asSentence A+population+of+immature+dysplastic+granulocytes+contributes+to+the+chronic+myelomonocytic+leukemia+phenotype+through+production+of+alpha-defensins+HNP1-3+that+suppress+the+differentiation+capabilities+of+monocytes. assertion.
- assertion asSentence Crystal+structure+of+HNP-4. assertion.
- assertion asSentence Oxidation+and+reduction+modulate+the+activity+of+human+beta-defensin+1. assertion.
- assertion asSentence Activation+of+a+Src-dependent+Raf-MEK1%2F2-ERK+signaling+pathway+is+required+for+IL-1alpha-induced+upregulation+of+beta-defensin+2+in+human+middle+ear+epithelial+cells. assertion.
- assertion asSentence Malignant+transformation+induces+alteration+of+hBD-2+expression+and+leads+to+a+reduced+hBD-2+expression+and+subsequentially+to+Candida+colonization+on+oral+squamous+cell+carcinoma. assertion.
- assertion asSentence Francisella+tularensis+LVS+infection+induced+elevated+levels+of+hBD-2+mRNA+in+human+airway+epithelial+cells. assertion.
- assertion asSentence In+periodontally+healthy+subjects%2C+salivary+beta-defensin+2+levels+are+not+influenced+by+stress. assertion.
- assertion asSentence Extraplacental+membranes+can+react+differentialy+to+the+arrival+of+E.+coli%2C+secreting+HBD2+and+HBD3+mainly+in+the+choriodecidua+region. assertion.
- assertion asSentence Platelets+display+potent+antimicrobial+activity+and+release+human+beta-defensin+2. assertion.
- assertion asSentence A+highly+size-specific%2C+TLR4-dependent%2C+innate+defense+response+to+fragmented+HA+contributes+to+intestinal+epithelium+barrier+defense+through+the+induction+of+intracellular+HbetaD2+protein. assertion.
- assertion asSentence Desmin+E245D+mutation+interferes+with+the+ability+of+nebulin+to+precisely+regulate+thin+filament+lengths. assertion.
- assertion asSentence Anti+factor+D+Fab+fragment+inhibits+FD+proteolytic+function+by+interfering+with+macromolecular+substrate+access+rather+than+by+inhibiting+FD+catalysis. assertion.
- assertion asSentence Hypoxia-induced+cleavage+of+caspase-3+and+DFF45%2FICAD+in+human+failed+cardiomyocytes. assertion.
- assertion asSentence Hsp70+binds+free+CAD+in+TCR-stimulated+T+cells+to+stabilize+and+augment+its+activity. assertion.
- assertion asSentence C-terminal+region+of+each+subunit%2C+DFF40+%28RLKRK%29+and+DFF45+%28KRAR%29%2C+is+essential+for+nuclear+accumulation+of+the+DFF+complex. assertion.
- assertion asSentence All+affected+family+members+with+a+COCH+mutation+in+the+vWFA2+domain+shared+sensorineural+hearing+loss+with+full+penetrance+starting+between+the+second+and+fifth+decade+of+life. assertion.
- assertion asSentence DHCR7+gene+mutations+is+associated+with+Smith-Lemli-Opitz+syndrome. assertion.
- assertion asSentence LBR+mutant+variants+and+sterol+reductases+can+severely+interfere+with+the+regular+organization+of+the+nuclear+envelope+and+the+endoplasmic+reticulum. assertion.
- assertion asSentence DHCR24+is+elevated+in+response+to+HCV+infection+and+inhibits+the+p53+stress+response+by+stimulating+the+accumulation+of+the+MDM2-p53+complex+in+the+cytoplasm+and+by+inhibiting+the+acetylation+of+p53+in+the+nucleus. assertion.
- assertion asSentence Activation+of+Sp1+by+oxidative+stress+is+involved+in+the+promotion+of+expression+of+DHCR24+by+Hepatitis+C+virus. assertion.
- assertion asSentence RNA+polymerase+II+accumulates+in+the+promoter-proximal+region+of+the+dihydrofolate+reductase+and+gamma-actin+genes. assertion.
- assertion asSentence Dihydrofolate+reductase+deficiency+is+associated+with+inborn+error+of+metabolism. assertion.
- assertion asSentence Human+dihydrofolate+reductase+is+bound+to+NADP. assertion.
- assertion asSentence DHODH+recessively+causes+Miller+syndrome. assertion.
- assertion asSentence Dia1+is+required+for+the+formation+of+the+actin+coat+around+endosomes+downstream+of+RhoB%2C+connecting+membrane+trafficking+with+the+regulation+of+actin+dynamics. assertion.
- assertion asSentence Lack+of+NQO1+induction+in+human+tumors+is+not+due+to+changes+in+promoter+region. assertion.
- assertion asSentence The+association+between+oral+contraceptives+use+and+breast+cancer+risk+is+dependent+on+NQO1+genotype%2C+age+and+menopausal+status. assertion.
- assertion asSentence NQO1+has+an+important+role+as+a+mediator+of+neutrophil+elastase-regulated+oxidant+stress+and+MUC5AC+mucin+gene+expression. assertion.
- assertion asSentence In+Burkitt%27s+lymphoma+cell+lines+the+NQO1+gene+is+not+efficiently+translated+and+this+effect+is+not+related+to+%28C609T%29+polymorphism. assertion.
- assertion asSentence Resveratrol+can+prevent+breast+cancer+initiation+by+blocking+multiple+sites+in+the+estrogen+genotoxicity+pathway. assertion.
- assertion asSentence Increased+risk+for+acute+lymphoblastic+leukemia+in+children+with+cytochrome+P450A1+%28CYP1A1%29-+and+NAD%28P%29H%3Aquinone+oxidoreductase+1+%28NQO1%29-inherited+gene+variants. assertion.
- assertion asSentence LXA%284%29+upregulates+Nrf%2C+NQO1+and+HO-1+to+protect+HUVEC+against+the+oxidative+stress+induced+by+LPS. assertion.
- assertion asSentence The+Ser+allele+of+NQO1+Pro187Ser+significantly+contributed+to+the+increased+risks+of+colorectal+adenoma+and+cancer+in+Caucasians. assertion.
- assertion asSentence mDia1+and+WAVE2+are+important+Src+homology+3+domain+partners+of+IRSp53+in+forming+filopodia. assertion.
- assertion asSentence Single+nucleotide+polymorphism+is+associated+with+greater+insulin+resistance+in+type+2+diabetes+mellitus+patients+and+with+lower+D2+velocity+in+tissue+samples. assertion.
- assertion asSentence The+Ala92+allele+of+the+type+2+iodothyronine+deiodinase+increases+risk+for+the+development+of+hypertension. assertion.
- assertion asSentence There+is+a+combined+effect+of+DIO2+T92A+and+PPARgamma2+P12A+polymorphisms+on+insulin+resistance-related+features+in+non-diabetic+whites. assertion.
- assertion asSentence Genetic+variations+of+type+II+deiodinase+are+associated+with+bipolar+disorder+in+a+subset+of+a+Chinese+Han+population. assertion.
- assertion asSentence hDIO2+promoter+is+down-regulated+at+the+transcriptional+level+by+both+LXR+and+RXR+signal+pathway. assertion.
- assertion asSentence The+D2+Thr92Ala+polymorphism+is+associated+with+a+decreased+femoral+neck+bone+mineral+density+and+higher+bone+turnover. assertion.
- assertion asSentence Intact+dyskerin+levels%2C+in+the+absence+of+coding+mutations%2C+are+critical+for+telomerase+RNA+stability+and+for+in+vivo+telomere+maintenance. assertion.
- assertion asSentence Crystal+structure+of+the+second+PDZ+domain+of+SAP97+in+complex. assertion.
- assertion asSentence MARCH2+is+co-localized+with+DLG1+at+sites+of+cell-cell+contact. assertion.
- assertion asSentence Dlg1%2C+through+the+interaction+with+GLUT1+and+Env%2C+plays+a+positive+role+in+the+syncytium+formation+induced+by+HTLV-1. assertion.
- assertion asSentence DLG1+participates+in+the+control+of+TGFalpha+bioavailability+through+its+dynamic+interaction+with+the+growth+factor+precursor+and+TACE. assertion.
- assertion asSentence Dlg1+has+a+distinct+oncogenic+function+in+the+context+of+HPV+induced+malignancy%2C+one+of+the+outcomes+of+which+is+increased+RhoG+activity+and+increased+invasive+capacity. assertion.
- assertion asSentence E6AP+is+extensively+involved+in+the+ubiquitin-mediated+degradation+of+Dlg+%28an+HPV+E6-dependent+substrate%29+as+a+cellular+E3+ubiquitin-protein+ligase. assertion.
- assertion asSentence GABARAP+and+DLG4+genes+are+involved+in+the+etiology+of+nicotine+dependence+in+European-American+smokers. assertion.
- assertion asSentence The+DLG4+protein+enhances+the+resensitization+of+the+D1+DA+receptor+by+accelerating+D1+receptor+recycling+to+the+cell+membrane. assertion.
- assertion asSentence An+altered+association+between+membrane-associated+guanylate+kinases+%28such+as+PSD-95%29+and+NMDA+receptors+in+mutant+huntingtin-expressing+cells+contributes+to+increased+susceptibility+to+excitotoxicity. assertion.
- assertion asSentence Phosphorylation+of+a+PDZ+domain+extension+modulates+binding+affinity+and+interdomain+interactions+in+postsynaptic+density-95+%28PSD-95%29+protein%2C+a+membrane-associated+guanylate+kinase+%28MAGUK%29. assertion.
- assertion asSentence 2-oxoglutarate+dehydrogenase+complex+%28OGDHC%29%2C+the+key+regulatory+enzyme+of+Krebs+cycle. assertion.
- assertion asSentence Dlx3+triggers+p63+protein+degradation+by+a+proteasome-dependent+pathway. assertion.
- assertion asSentence SUMOylation+of+DLX3+by+SUMO1+promotes+its+transcriptional+activity. assertion.
- assertion asSentence Activation+of+placenta-specific+transcription+factor+distal-less+homeobox+5+predicts+clinical+outcome+in+primary+lung+cancer+patients. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+in+intron+1+of+the+DLX6+gene+and+in+exon+4+of+the+PCLO+gene+are+not+in+linkage+disequilibrium+with+autism. assertion.
- assertion asSentence p63+binds+to+an+enhancer+element+in+the+SHFM1+locus+and+this+element+controls+expression+of+DLX6+and+DLX5+which+are+important+for+limb+development. assertion.
- assertion asSentence gp340-mediated+aggregation+reduced+bacterial+adhesion+to+human+epithelial+cells. assertion.
- assertion asSentence DMBT1+functions+as+pattern-recognition+molecule+for+poly-sulfated+and+poly-phosphorylated+ligands+providing+a+molecular+basis+for+its+broad+bacterial-binding+specificity+and+its+inhibitory+effects+on+LPS-induced+TLR4-mediated+NF-kappaB+activation. assertion.
- assertion asSentence Dystrophin+expression+is+disrupted+in+viral+myocarditis+and+dilated+cardiomyopathy. assertion.
- assertion asSentence The+induction+of+exon+skipping+by+the+most+effective+2%27-O-Me+RNA%2FENA+chimeras+led+to+the+expression+of+dystrophin+in+dystrophin-deficient+myocytes+by+correcting+the+translational+reading+frames. assertion.
- assertion asSentence Absence+of+members+of+the+dystrophin-associated+glycoprotein+complex+constitutes+a+permissive+environment+for+spontaneous+development+of+embryonal+rhabdomyosarcoma+associated+with+mutation+of+p53+and+mutation+or+altered+splicing+of+Mdm2. assertion.
- assertion asSentence DMP1+is+expressed+in+salivary+gland+ducts. assertion.
- assertion asSentence mRNA+of+DMP1+involved+in+the+pathogenesis+of+hypophosphataemic+rickets+is+highly+expressed+in+cells+of+the+osteoblasts%2Fosteocyte+lineage. assertion.
- assertion asSentence Herpes+simplex+virus+type+1+can+enter+human+keratinocytes+by+alternative+entry+pathways+that+require+dynamin+and+host+cholesterol. assertion.
- assertion asSentence Steinert%27s+disease+caused+by+a+dynamic+mutation+of+%28CTG%29+trinucleotide+repeats+in+the+3%27+untranslated+region+of+the+myotonic+dystrophy+protein+kinase+gene+%28DMPK%29. assertion.
- assertion asSentence Replication+protein+A+stimulates+the+5%27-+to+3%27-nuclease+activity+of+Dna2+and+inhibits+the+3%27-+to+5%27-exo%2Fendonuclease+activity+of+Dna2. assertion.
- assertion asSentence Low+DNase1+activity+is+associated+to+the+active+phase+of+type+III+or+IV+lupus+erythromatosus+nephropathy. assertion.
- assertion asSentence Modified+DNase1+can+efficiently+eliminate+apoptosis-resistant+cancer+cells+through+apoptosis. assertion.
- assertion asSentence Dyn2+is+a+Nef-associated+protein+required+for+the+infectivity+enhancement+of+progeny+virions+by+Nef. assertion.
- assertion asSentence DNM2+has+an+etiologic+role+in+axonal+Charcot-Marie-Tooth+disease+type+2+neuropathy. assertion.
- assertion asSentence %7Balpha%7DV%7Bbeta%7D3-integrin+routes+herpes+simplex+virus+to+an+entry+pathway+dependent+on+cholesterol-rich+lipid+rafts+and+dynamin2. assertion.
- assertion asSentence DNMT1+is+necessary+for+proper+PcG+body+assembly+independent+of+DNMT-associated+histone+deacetylase+activity. assertion.
- assertion asSentence Breast+cancer+cells+have+a+prominent+loss+of+DNA+methylation+accompanied+by+altered+expression+of+maintenance+DNA+methyltransferase+DNMT1. assertion.
- assertion asSentence DNMT1+is+essential+for+the+maintenance+of+DNA+methylation+patterns+in+human+cells. assertion.
- assertion asSentence DNMT1+is+required+for+faithfully+maintaining+DNA+methylation+patterns+in+human+cancer+cells+and+is+essential+for+their+proliferation+and+survival. assertion.
- assertion asSentence The+association+between+sequence+variants+of+DNMT1+and+3B+and+mutagen+sensitivity+induced+by+BPDE+supports+the+involvement+of+these+DNMTs+in+protecting+the+cell+from+DNA+damage. assertion.
- assertion asSentence Higher+expression+of+DNMT1+and+HDAC1+correlated+with+advanced+stages+of+the+disease+and+reflect+the+malignancy+of+pancreatic+carcinoma. assertion.
- assertion asSentence No+association+between+DNMT1+polymorphisms+and+gastric+cancer. assertion.
- assertion asSentence Different+binding+properties+and+function+of+CXXC+zinc+finger+domains+in+Dnmt1+and+Tet1. assertion.
- assertion asSentence Elevated+expression+of+DNMT1+or+DNMT3B+alone+is+not+required+to+maintain+restricted+latency. assertion.
- assertion asSentence Regulation+of+human+RNA+polymerase+III+transcription+by+DNMT1+and+DNMT3a+DNA+methyltransferases. assertion.