Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence DNMT1+hypermethylation+is+a+late+part+of+glioma+progression. assertion.
- assertion asSentence CG+dinucleotide+recognized+by+the+Dnmt3a+and+Dnmt3L+complex+are+distinctive+at+retroelements+and+imprinted+domains. assertion.
- assertion asSentence The+mRNA+of+the+DNA+methyltransferase+DNMT3A+is+expressed+temporally+in+the+endometrium+across+the+menstrual+cycle. assertion.
- assertion asSentence A+structural+mechanism+for+the+regulation+of+DNMT3A+activity+and+epigenetic+imprinting. assertion.
- assertion asSentence DNMT3A+mutations+are+associated+with+acute+myeloid+leukemia. assertion.
- assertion asSentence Regulation+of+human+RNA+polymerase+III+transcription+by+DNMT1+and+DNMT3a+DNA+methyltransferases. assertion.
- assertion asSentence The+human+de+novo+enzymes+hDNMT3a+and+hDNMT3b+form+complexes+with+the+major+maintenance+enzyme+hDNMT1. assertion.
- assertion asSentence Transfection+with+the+antisense+DNMT3b+gene+eukaryotic+expression+plasmid+can+significantly+reduce+the+expression+level+of+the+DNMT3b+gene+in+the+human+biliary+tract+carcinoma+cell+line+QBC-939. assertion.
- assertion asSentence Dnmt3b-Dnmt3L+interactions+play+an+important+role+in+the+regulation+of+DNA+methylation+during+mammalian+development. assertion.
- assertion asSentence DeltaDNMT3B+is+the+predominant+form+of+DNMT3B+in+non-small+cell+lung+cancer. assertion.
- assertion asSentence Expression+of+microRNA+is+inversely+correlated+with+DNMT3B+in+non-small+cell+lung+cancer. assertion.
- assertion asSentence Down-regulation+of+CXCR4+expression+by+tamoxifen+is+associated+with+DNA+methyltransferase+3B+up-regulation+in+MCF-7+breast+cancer+cells. assertion.
- assertion asSentence Role+of+deltaDNMT3B4%2F2+in+regulating+RASSF1A+promoter-specific+DNA+methylation+in+non-small+cell+lung+cancer. assertion.
- assertion asSentence DNMT3b+overexpression+is+an+independent+prognostic+factor+for+predicting+shortened+survival+of+patients+with+diffuse+large+B-cell+lymphomas. assertion.
- assertion asSentence Increased+DNMT3B+gene+expression+is+associated+with+carcinogenesis+in+pancreatic+ductal+adenocarcinoma. assertion.
- assertion asSentence Dock180+ELMO+complex+functions+as+an+unconventional+two-part+exchange+factor+for+Rac. assertion.
- assertion asSentence DOCK2+is+needed+for+efficient+chemokine-stimulated+lymphocyte+attachment+to+VCAM-1+under+shear+stress. assertion.
- assertion asSentence PI3K+and+Src-ELMO-Dock2+pathways+work+in+parallel+to+activate+Rac2+and+modulate+chemotaxis+in+response+to+a+CXCL8+gradient+in+neutrophils. assertion.
- assertion asSentence Dok1+negatively+regulates+Dok2-mediated+CD200R+signaling+through+the+recruitment+of+CrkL. assertion.
- assertion asSentence DPEP1+is+expressed+in+the+early+stages+of+colon+carcinogenesis+and+affects+cancer+cell+invasiveness. assertion.
- assertion asSentence CD26+interferes+with+transduction+pathway%28s%29+needed+for+the+maturation+of+T+cells+and+plays+an+important+role+in+T+lymphocyte+homeostasis+in+peripheral+blood. assertion.
- assertion asSentence Increased+adhesion+of+ovarian+carcinoma+cells+to+mesothelial+cells+by+overexpression+of+dipeptidyl+peptidase+IV. assertion.
- assertion asSentence Adenosine+down-regulates+the+surface+expression+of+DPP4+on+HT29+cells. assertion.
- assertion asSentence The+dipeptidyl+peptidase+IV+gene+family+contains+the+four+peptidases+dipeptidyl+peptidase+IV%2C+fibroblast+activation+protein%2C+dipeptidyl+peptidase+8+and+dipeptidyl+peptidase+9. assertion.
- assertion asSentence Selective+inhibition+of+DPP-IV+does+not+impair+T+dependent+immune+responses+to+antigenic+challenge. assertion.
- assertion asSentence Higher+serum+DPP-4+activity+and+decreased+CD26+lymphocyte+expression+on+all+lymphocyte+subpopulations+in+T1DM. assertion.
- assertion asSentence Loss+of+DPP4+activity+affects+the+anti-thrombogenic+nature+of+the+endothelium. assertion.
- assertion asSentence KV4.2+channel+fast+inactivation+induced+by+DPP10a+or+DPP6a+is+mediated+by+a+common+N-terminal+inactivation+motif+via+a+pore-blocking+mechanism. assertion.
- assertion asSentence Gene+expression+is+a+predictor+for+the+efficacy+of+fluoropyrimidine-based+chemotherapy+for+metastatic+colorectal+cancer. assertion.
- assertion asSentence At+least+in+distinct+tumor+types%2C+a+common+DPYD+polymorphism+strongly+contributes+to+the+occurrence+of+fluoropyrimidine-related+drug+adverse+effects. assertion.
- assertion asSentence Genomic+deletion+affecting+DPYD+and+a+deep+intronic+mutation+affecting+pre-mRNA+splicing+can+cause+severe+5FU-associated+toxicity. assertion.
- assertion asSentence Variants+in+the+dihydropyrimidine+dehydrogenase%2C+methylenetetrahydrofolate+reductase+and+thymidylate+synthase+genes+predict+early+toxicity+of+5-fluorouracil+in+colorectal+cancer+patients. assertion.
- assertion asSentence Hemizygous+deletions+of+the+dihydropyrimidine+dehydrogenase+%28DPYD%29+locus+contribute+to+intellectual+disability+phenotypes. assertion.
- assertion asSentence Aberrant+expression+of+dihydropyrimidinase+related+proteins-2%2C-3+and+-4+in+fetal+Down+syndrome+brain. assertion.
- assertion asSentence Functional+coupling+of+the+downregulated+in+adenoma+Cl-%2Fbase+exchanger+DRA+and+the+apical+Na%2B%2FH%2B+exchangers+NHE2+and+NHE3+in+intestinal+epithelial+cells. assertion.
- assertion asSentence Patterns+of+cyclic+AMP+formation+by+coexpressed+D1+and+D2L+dopamine+receptors+in+HEK+293+cells. assertion.
- assertion asSentence Genetic+polymorphism+of+the+gene+is+substantially+involving+in+individual+variation+of+susceptibility+to+alcohol+dependence. assertion.
- assertion asSentence Individual+differences+in+caudate+D1+receptor+density+are+positively+associated+with+individual+differences+in+dorsolateral+prefrontal+connectivity+to+right+parietal+cortex+and+negatively+with+medial+prefrontal+connectivity+to+right+parietal+cortex. assertion.
- assertion asSentence Protein+4.1N%2Fdopamine+receptor+interaction+is+required+for+localization+or+stability+of+dopamine+receptors+at+the+neuronal+plasma+membrane. assertion.
- assertion asSentence The+human+D2+dopamine+receptor+synergizes+with+the+A2A+adenosine+receptor+to+stimulate+adenylyl+cyclase+in+PC12+cells. assertion.
- assertion asSentence Significantly+stronger+stress-induced+cigarette+craving+is+found+for+individuals+carrying+the+DRD2+%28D2+dopamine+receptor%29+gene+A1+allelic+variants+compared+to+subjects+without+allelic+variants. assertion.
- assertion asSentence The+-141C+del+polymorphism+in+the+dopamine+D2+receptor+gene+is+associated+with+schizophrenia. assertion.
- assertion asSentence No+support+for+an+association+between+early+onset+alcohol+use+disorders+and+the+DRD2+TaqIA+polymorphism. assertion.
- assertion asSentence A+DRD2+polymorphic+TaqIA+restriction+endonuclease+site+is+associated+with+increase+risk+of+violence+or+serious+delinquency+in+male+adolescents+and+young+adults+%28ages+12+to+23%29. assertion.
- assertion asSentence SNP+in+DRD2+gene+is+associated+with+continuous+performance+task+phenotypes+in+ADHD+children+and+their+families. assertion.
- assertion asSentence Nicotine+replacement+therapy+reduced+negative+affect+to+a+greater+extent+in+DRD2+A1+carriers+than+in+A2A2+individuals+during+the+1st+2+weeks+of+treatment. assertion.
- assertion asSentence Genotype+is+not+related+with+alterations+in+baseline+D2+receptor+availability+in+vivo+in+the+cortex+or+the+striatum. assertion.
- assertion asSentence The+presence+of+the+D2LR-5-HT2AR+heteromer+in+discrete+brain+regions+is+postulated+based+on+the+existence+of+D2LR-5-HT2A+receptor-receptor+interactions+in+living+cells+and+their+codistribution+inter+alia+in+striatal+regions. assertion.
- assertion asSentence Activation+of+cloned+dopamine+D2+receptors+in+cerebral+cortex+leads+to+phosphorylation+of+proto-oncogene+protein+c-Akt+and+glycogen+synthase+kinase+3beta. assertion.
- assertion asSentence Subjects+with+the+DRD2%2FANKK1+TaqI+Al+allele+exhibit+decreased+corticostriatal+activity+in+response+to+negatively+charged+affective+stimuli+compared+with+subjects+homozygous+for+the+A2+allele. assertion.
- assertion asSentence Chinese+Han+patients+with+schizophrenia+assessed+for+abnormal+involuntary+movements+and+DRD3+polymorphism. assertion.
- assertion asSentence A+shared+variance+of+at+least+17%25+%28p%3D0.016%29+between+DRD3+mRNA+expression+in+peripheral+blood+lymphocytes+and+the+personality+trait+of+persistence+is+found. assertion.
- assertion asSentence A+single+nucleotide+polymorphism+in+the+dopamine+D3+receptor+causes+a+shift+from+cAMP+to+a+PGE2+signal+transduction+pathway. assertion.
- assertion asSentence Multiple+variants+of+the+DRD3+influence+age-at-onset+of+schizophrenia. assertion.
- assertion asSentence Variation+in+DRD3+is+implicated+as+risk+factor+for+schizophrenia. assertion.
- assertion asSentence No+involvement+is+found+between+dopamine+D3+receptor+polymorphisms+and+schizophrenia+susceptibility. assertion.
- assertion asSentence The+crystal+structure+of+the+human+dopamine+D3+receptor+%28D3R%29+in+complex+with+the+small+molecule+D2R%2FD3R-specific+antagonist+eticlopride+reveals+important+features+of+the+ligand+binding+pocket+and+extracellular+loops. assertion.
- assertion asSentence Dopamine+receptor+D3+regulates+endocytic+sorting+by+a+Prazosin-sensitive+interaction+with+the+coatomer+COPI. assertion.
- assertion asSentence Genetic+variation+within+the+DRD4+promoter+and+gender+differences+contribute+to+variation+in+Novelty+Seeking+behaviors+such+as+Extraversion. assertion.
- assertion asSentence Link+between+the+DRD4+gene+and+human+temperament+in+3+year+old+infants. assertion.
- assertion asSentence Children+with+ADHD+possessing+the+7-repeat+allele+of+the+DRD4+gene+VNTR+polymorphism+require+higher+doses+of+methylphenidate+for+symptom+improvement+treatment+outcomes. assertion.
- assertion asSentence There+is+an+association+between+DAT1+and+DRD4+and+increased+response+variability+in+ADHD. assertion.
- assertion asSentence Children+with+one+or+two+copies+of+the+short+allele+of+the+5-HTT+gene+and+the+long+allele+version+of+the+DRD4+gene+exhibited+significantly+more+internalizing+and+externalizing+behaviors+at+age+7. assertion.
- assertion asSentence Absence+of+the+7-repeat+allele+in+DRD4+VNTR+in+children+with+ADHD+is+associated+with+a+neurocognitive+profile+of+drifting+sustained+attention+that+gives+rise+to+variable+and+inconsistent+performance. assertion.
- assertion asSentence Elevated+DA+receptor+gene+expression+in+depressive+subjects+further+implicates+altered+dopaminergic+transmission+in+the+amygdala+in+depression. assertion.
- assertion asSentence DRD4+protein+is+associated+with+ADHD. assertion.
- assertion asSentence The+DRD5+expression+in+the+temporal+lobe+of+Alzheimer%27s+disease+patients+is+decressed. assertion.
- assertion asSentence E2FBP1+modulates+cell+growth+through+down-regulation+of+promyelocytic+leukemia+bodies. assertion.
- assertion asSentence Bright+is+not+expressed+in+all+human+B+lymphocyte+subpopulations. assertion.
- assertion asSentence Status+epilepticus+during+sleep+caused+by+an+expansion+of+the+CAG+repeat+in+the+DRPLA+gene. assertion.
- assertion asSentence Repression+of+the+desmocollin+2+gene+expression+in+human+colon+cancer+cells+is+relieved+by+the+homeodomain+transcription+factors+Cdx1+and+Cdx2. assertion.
- assertion asSentence Both+the+binding+of+desmocollin+3+%28Dsc3%29+to+plakoglobin+and+Dsc3+phosphorylation+are+involved+in+Dsc3+binding+to+desmoglein+3+%28Dsg3%29+during+Ca2%2B+-induced+desmosome+assembly. assertion.
- assertion asSentence The+specificity+of+Drosophila+Dscam+is+due+to+complementarity+of+variable+residues+in+epitope+I. assertion.
- assertion asSentence DSCR1-L1+is+constitutively+expressed+in+endothelial+cells+and+acts+similar+to+DSCR1+in+inhibiting+calcineurin+activity+and+restraining+VEGF-mediated+angiogenesis. assertion.
- assertion asSentence Dsg1+promotes+the+formation+of+intercellular+adhesion+complexes. assertion.
- assertion asSentence Mutations+in+DSG2+and+DSC2+are+less+prevalent+than+PKP2+mutations+in+Dutch+arrhythmogenic+right+ventricular+dysplasia%2Fcardiomypath+patients. assertion.
- assertion asSentence Implication+of+the+transcription+factor+GILZ+in+the+pathophysiology+of+glucocorticoid-induced+osteoporosis+by+regulating+osteoblast+maturation+and+bone+turnover. assertion.
- assertion asSentence Dominant+mutation+in+desmoplakin+that+causes+left-sided+arrhythmogenic+left+ventricular+cardiomyopathywith+arrhythmias+of+left+ventricular+origin. assertion.
- assertion asSentence This+is+the+first+description+of+a+phenotype+caused+by+a+mutation+affecting+only+one+DSP+isoform. assertion.
- assertion asSentence Mutations+in+desmoplakin+protein+is+associated+with+cardiomyopathy. assertion.
- assertion asSentence Desmoplakin+is+a+promising+candidate+for+supportive+CSF+marker+to+rule+out+14-3-3+false+positive+cases+in+sporadic+Creutzfeldt-Jakob+disease+differential+diagnosis. assertion.
- assertion asSentence Dentin+sialophosphoprotein+expressed+by+transgenic+presecretory+ameloblasts+contributes+to+the+unique+properties+of+the+dentino-enamel+junction. assertion.
- assertion asSentence Diminished+DTDST+expression+through+epigenetic+silencing+is+associated+with+colon+cancer. assertion.
- assertion asSentence During+a+cycle+of+regeneration+in+tibialis+anterior+muscle+following+myonecrosis%2C+alpha-dystrobrevin+reaches+50%25+of+the+protein+level+on+day+28+by+6.6+days%2C+regenerating+more+slowly+than+dystrophin. assertion.
- assertion asSentence Bronchial+epithelial+compression+regulates+MAP+kinase+signaling+and+HB-EGF-like+growth+factor+expression. assertion.
- assertion asSentence HB-EGF+has+a+function+in+endometrial+maturation+in+mediating+decidualization+and+attenuating+TNF+alpha-+and+TGF+beta-induced+apoptosis+of+endometrial+stromal+cells. assertion.
- assertion asSentence HB-EGF+carboxyl-terminal+fragment+is+a+potent+regulator+of+gene+expression+via+its+interaction+with+the+transcriptional+repressor+Bcl6. assertion.
- assertion asSentence HB-EGF+regulates+endothelial+cell+function+via+stimulation+of+eNOS+and+nitric+oxide+production+to+promote+eNOS+dependent+angiogenesis. assertion.
- assertion asSentence Increased+serum+HB-EGF+is+associated+with+heart+hypertrophy+and+elevated+blood+cholesterol. assertion.
- assertion asSentence Anandamide-induced+rapid+MKP-1+expression+switches+off+MAPK+signal+transduction+in+microglial+cells+activated+by+stimulation+of+pattern+recognition+receptors. assertion.
- assertion asSentence The+MAP+kinase+phosphatase-1+MKP-1%2FDUSP1+is+a+regulator+of+human+liver+response+to+transplantation. assertion.
- assertion asSentence KLF5+promotes+breast+cell+survival+partially+through+fibroblast+growth+factor-binding+protein+1-pERK-mediated+dual+specificity+MKP-1+protein+phosphorylation+and+stabilization. assertion.
- assertion asSentence Molecular+cross-talk+between+the+MKP-1%2C+p38+MAPK+and+PI3K+pathways+promotes+resistance+to+PI3K+inhibitors+in+hilar+cholangiocarcinoma+cells. assertion.
- assertion asSentence Tauroursodeoxycholate+inhibits+neointimal+hyperplasia+by+reducing+proliferation+and+inducing+apoptosis+of+smooth+muscle+cells+by+suppression+of+ERK+via+PKCalpha-mediated+MKP-1+induction. assertion.
- assertion asSentence DUSP5+is+a+direct+target+of+p53. assertion.
- assertion asSentence DUSP5+inactivates+ERK2+and+causes+both+nuclear+translocation+and+sequestration+of+inactive+ERK2. assertion.
- assertion asSentence Regulation+of+ERK1%2F2+by+MKP-3+is+countered+by+the+complex+regulation+of+MKP-3+by+ERK1%2F2. assertion.
- assertion asSentence DUSP6+plays+an+important+role+in+the+pathogenesis+of+bipolar+disorder%2C+particularly+in+women. assertion.
- assertion asSentence Decreased+expression+of+DUSP-9+is+associated+with+poor+prognosis+in+ccRCC. assertion.
- assertion asSentence Dishevelled+2+%28Dvl2%29%2C+a+key+component+of+the+Wnt+signaling+pathway%2C+is+overexpressed+in+human+gliomas. assertion.