Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence The+expression+of+Dishevelleds+in+mammalian+cells+provide+an+estimate+of+the+relative+cellular+abundance+of+each+Dvl. assertion.
- assertion asSentence An+extra+copy+of+the+DYRK1A+gene+in+Down+syndrome+%28DS%29+is+associated+with+gene+dosage-proportional+increases+in+the+levels+of+DYRK1A+in+nuclear+and+cytoplasmic+fractions+and+contributes+to+a+complex+DS+phenotype. assertion.
- assertion asSentence Phosphorylation+of+SRp55+by+Dyrk1A+suppressed+its+ability+to+promote+Tau+exon+10+inclusion. assertion.
- assertion asSentence The+DYT1+carrier+state+increases+energy+demand+in+the+olivocerebellar+network. assertion.
- assertion asSentence Increased+ppRb+and+E2FI+immunoreactivity+in+Alzheimer+disease+brain%2C+with+ppRb+predominately+located+in+the+nucleus+and+E2F1+in+the+cytoplasm. assertion.
- assertion asSentence Human+telomerase+accelerates+growth+of+lens+epithelial+cells+through+regulation+of+the+genes+mediating+RB%2FE2F+pathway. assertion.
- assertion asSentence During+thyroid+hormone-induced+differentiation+of+embryonic+carcinoma+cells+and+of+oligodendrocyte+precursor+cells%2C+levels+of+E2F-1+mRNA+and+E2F-1+protein+decrease%2C+caused+by+thyroid+hormone+receptor+regulating+the+transcription+of+the+E2F-1+gene. assertion.
- assertion asSentence E2F1%2Fp53+interaction+regulates+the+transcriptional+activity+of+p53+throughout+the+cell+cycle. assertion.
- assertion asSentence There+is+a+mutual+regulation+between+E2F1+and+SirT1+that+affects+cellular+sensitivity+to+DNA+damage. assertion.
- assertion asSentence p53+family+proteins+are+potent+therapeutic+agents+for+human+papilomavirus-associated+uterine+cervical+cancers+carrying+the+E2F1+promoter. assertion.
- assertion asSentence Proliferation-promoting+E2F+transcription+factor+E2F-1+plays+a+pivotal+role+in+the+tumor+biology+of+ovarian+cancer. assertion.
- assertion asSentence Expression+of+the+transcription+factor+E2F1+is+upregulated+by+addition+of+Clonorchis+sinensis+excretory-secretory+products+in+HEK293+cells. assertion.
- assertion asSentence Myc+is+required+to+allow+the+interaction+of+the+E2F1+protein+with+the+E2F+gene+promoters. assertion.
- assertion asSentence PTPRO+gene+is+co-regulated+by+both+E2F1+and+miR-17-92. assertion.
- assertion asSentence Bortezomib+arrests+the+proliferation+of+hepatocellular+carcinoma+cells+HepG2+and+JHH6+by+differentially+affecting+E2F1+level. assertion.
- assertion asSentence The+release+of+PCAF+from+hSirT1+repression+favors+the+assembly+of+transcriptionally+active+PCAF%2FE2F1+complexes+onto+the+P1p73+promoter+and+p53-independent+apoptosis. assertion.
- assertion asSentence Overexpression+of+E2F-1+significantly+inhibits+cell+growth+and+proliferation%2C+blocking+entry+into+the+S-phase+of+the+cell+cycle. assertion.
- assertion asSentence miR-330+induces+apoptosis+in+prostate+cancer+cells+through+E2F1-mediated+suppression+of+Akt+phosphorylation. assertion.
- assertion asSentence Low+E2F1+is+associated+with+lymph+node+metastases+in+breast+carcinoma. assertion.
- assertion asSentence Lactoferrin+exploits+the+control+mechanism+of+E2F1-regulated+target+genes+or+Bcl-2+family+gene+networks+involved+in+the+apoptotic+process+in+Jurkat+human+leukemia+T+lymphocytes. assertion.
- assertion asSentence E2F1+is+a+critical+regulator+of+dendritic+cell+maturation. assertion.
- assertion asSentence E2F-1+associated+pRB+is+modified+by+O-GlcNAc. assertion.
- assertion asSentence CEBPD+reverses+RB%2FE2F1-mediated+gene+repression+and+participates+in+HMDB-induced+apoptosis+of+cancer+cells. assertion.
- assertion asSentence The+transcription+factor+E2F1+negatively+regulates+the+basal+transcriptional+activity+of+IRF-3+and+deregulates+IRF-3+expression+at+the+mRNA+level. assertion.
- assertion asSentence Decreased+expression+of+E2F2+is+associated+with+Increased+expression+of+HER2+in+breast+tumors. assertion.
- assertion asSentence E2F3+mRNA+and+protein+are+overexpressed+in+retinoblastoma. assertion.
- assertion asSentence E2F3+levels+have+a+critical+role+in+modifying+cellular+proliferation+rate+in+human+bladder+and+prostate+cancer. assertion.
- assertion asSentence E2F3+gain+is+associated+with+the+late+stage+of+retinoblastoma. assertion.
- assertion asSentence miR-128+can+inhibit+proliferation+of+glioma+cells+through+one+of+its+targets%2C+E2F3a. assertion.
- assertion asSentence EBV+LMP1+blocks+p16INK4+pathway+by+promoting+nuclear+export+of+E2F-4. assertion.
- assertion asSentence Evolutionarily+conserved+multisubunit+protein+complex+that+contains+p130+and+E2F4+mediates+the+repression+of+cell+cycle-dependent+genes+in+quiescence. assertion.
- assertion asSentence Overexpression+of+E2F-5+correlates+with+a+pathological+basal+phenotype+and+a+worse+clinical+outcome. assertion.
- assertion asSentence Short+hairpin+RNA-mediated+depletion+of+E4F1+induced+mitochondrial+defects+and+ROS-mediated+death+in+several+myeloid+leukemia+cell+lines. assertion.
- assertion asSentence Sp1+transcription+factor+contributes+to+its+expression+in+human+colon+carcinoma+cells. assertion.
- assertion asSentence TP+enhances+the+invasion+of+tumor+cells+through+the+induction+of+invasion-related+genes. assertion.
- assertion asSentence Expression+of+thymidylate+synthase+and+thymidine+phosphorylase+mRNA+is+a+useful+predictive+parameter+for+the+survival+of+postoperative+gastric+cancer+patients+after+5-fluorouracil-based+adjuvant+chemotherapy. assertion.
- assertion asSentence The+lack+of+TP+protein+expression+in+basal+cell+carcinoma+tumoral+cells+is+linked+to+transcriptional+regulatory+mechanisms. assertion.
- assertion asSentence PLSCR1+interacts+with+the+tandem+repeat+region+of+ECM1a+in+the+dermal+epidermal+junction+zone+of+human+skin. assertion.
- assertion asSentence Ect2+regulates+the+activation+and+function+of+Cdc42+in+mitosis. assertion.
- assertion asSentence In+mitotic+cells+Ect2+localizes+to+the+central+spindle+and+to+the+cell+cortex. assertion.
- assertion asSentence An+amino+acid+substitution+in+ectodysplasin+A+is+associated+with+X-linked+dominant+incisor+hypodontia. assertion.
- assertion asSentence A+crucial+role+of+the+EDA-A2%2Fectodysplasin+A2+%28XEDAR%29+interaction+is+revealed+in+the+p53-signaling+pathway. assertion.
- assertion asSentence The+constitutively+active+endogenous+S1P1+receptor+enhances+PDGF-induced+cell+migration. assertion.
- assertion asSentence S1P+promotes+lymphangiogenesis+by+stimulating+S1P1%2FG%28i%29%2Fphospholipase+C%2FCa%282%2B%29+signaling+pathways. assertion.
- assertion asSentence Akt-mediated+transactivation+of+the+S1P1+receptor+in+caveolin-enriched+microdomains+regulates+endothelial+barrier+enhancement+by+oxidized+phospholipids. assertion.
- assertion asSentence Downregulation+of+S1P%281%29+expression+enhances+the+malignancy+of+glioblastoma+by+increasing+cell+proliferation+and+correlates+with+the+shorter+survival+of+patients+with+glioblastoma. assertion.
- assertion asSentence Down-regulation+of+EDG2+is+functionally+important+to+suppression+of+tumor+metastasis+in+breast+neoplasms. assertion.
- assertion asSentence CD97+functioned+to+mediate+invasion+in+prostate+cancer+cells%2C+by+associating+with+lysophosphatidic+acid+receptor+1+%28LPAR1%29%2C+leading+to+enhanced+LPA-dependent+RHO+and+extracellular+signal-regulated+kinase+activation. assertion.
- assertion asSentence Expression+of+the+sphingosine+1+phosphate+receptor+in+primary+endothelial+cells+is+both+sufficient+and+necessary+for+the+expression+of+Akt3. assertion.
- assertion asSentence Activated+human+neutrophils+express+prepro-ET-1+mRNA+and+secrete+appreciable+levels+of+mature+peptide+into+the+culture+medium+in+the+presence+of+various+neutrophil+stimulants. assertion.
- assertion asSentence Endothelin+receptor+remodeling+induces+the+portal+venous+hyper-response+to+endothelin-1+following+endotoxin+pretreatment. assertion.
- assertion asSentence Endothelin-1+gene+polymorphism+in+combination+with+environmental+factors+influence+blood+pressure+reactivity. assertion.
- assertion asSentence Catabolic+role+of+ET-1+in+osteoarthritis+cartilage+via+MMP-1+and+MMP-13+up-regulation. assertion.
- assertion asSentence Role+of+ET-1+in+the+pathogenesis+of+post-renal+transplantation+hypertension+in+cyclosporine-treated+recipients. assertion.
- assertion asSentence In+endothelium-restricted+human+preproET-1+overexpression%2C+ET-1+caused+structural+remodeling+%26+endothelial+dysfunction+of+resistance+vessels%2C+via+a+direct+nonhemodynamic+effect+of+ET-1+on+the+vasculature%2C+thru+vascular+NAD%28P%29H+oxidase+activation. assertion.
- assertion asSentence Explanation+for+the+co-expression+between+ET-1+and+protein+kinase+C+in+the+pathogenesis+of+diabteic+retinopaathy. assertion.
- assertion asSentence ET-1+and+its+receptors+are+differentially+expressed+by+hypoxia+and+after+transplantation. assertion.
- assertion asSentence PlGF-induced+expression+of+ET-1+and+its+cognate+ET-BR+receptor+occur+via+activation+of+HIF-1+alpha%2C+independent+of+hypoxia. assertion.
- assertion asSentence Human+neutrophil+peptides+upregulate+expression+of+COX-2+and+endothelin-1+by+inducing+oxidative+stress. assertion.
- assertion asSentence Endothelin-1+stimulation+of+endogenously+expressed+endothelin+b+receptors+leads+to+ARF6+activation+in+endothelial+cells. assertion.
- assertion asSentence The+significantly+increased+maternal+plasma+levels+of+NKB+and+ET-1+of+patients+with+preeclampsia+occur+at+early+pregnancy%2C+before+the+onset+of+clinical+symptoms. assertion.
- assertion asSentence ET-1+rapidly+activates+the+prosurvival+phosphatidylinositol+3%27-OH+kinase+%28PI3K%29%2FAKT+signaling+pathway+in+normal+and+fibrotic+human+lung+fibroblasts. assertion.
- assertion asSentence Synergistic+induction+of+endothelin-1+by+tumor+necrosis+factor+alpha+and+interferon+gamma+is+due+to+enhanced+NF-kappaB+binding+and+histone+acetylation+at+specific+kappaB+sites. assertion.
- assertion asSentence Higher+plasma+levels+of+endothelin-1+are+associated+with+worse+left+ventricular+diastolic+performance+and+poorer+long-term+clinical+outcomes+in+patients+with+chronic+systolic+heart+failure. assertion.
- assertion asSentence Beta-arrestin-1+is+involved+in+a+distinct+signalling+mechanism+linking+the+endothelin-1+%2FET+A+receptor+axis+to+phosphoinositide+3-kinase+%2Fintegrin-linked+kinase+%2FAkt+in+HEY+ovarian+cancer+cells. assertion.
- assertion asSentence ECE-1+influences+prostate+cancer+cell+invasion+via+both+ET-1-mediated+FAK+phosphorylation+and+ET-1+independent+mechanisms. assertion.
- assertion asSentence Long-term+exposure+to+a+physiological+shear+stress+in+the+retinal+arterioles+up-regulated+eNOS+and+thrombomodulin+mRNA+expressions+and+downregulated+ET-1+mRNA+expression+in+retinal+endothelial+cells. assertion.
- assertion asSentence An+impaired+role+of+epoxyeicosatrienoic+acids+contributes%2C+together+with+an+alteration+in+NO%2Freactive+oxygen+species+balance+and+endothelin-1+pathway%2C+to+conduit+artery+endothelial+dysfunction+in+essential+hypertension. assertion.
- assertion asSentence Endothelin+signaling+axis+activates+osteopontin+expression+through+PI3+kinase+pathway+in+A375+melanoma+cells. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+in+EDNRA+gene+is+associated+with+breast+cancer. assertion.
- assertion asSentence Augmented+synthesis+and+altered+expression+of+ET%28B%29+receptors+in+the+peripheral+vasculature+contribute+to+the+increased+incidence+of+hypertension+and+related+complications+in+African+American+patient+populations. assertion.
- assertion asSentence Transfected+into+mice%2C+implicating+endothelin+as+a+major+modifying+factor+for+cystic+disease+progression+in+human+autosomal+dominant+polycystic+kidney+disease. assertion.
- assertion asSentence In+transgenic+Ednrb-deficient+mice%2C+sacral+crest-derived+cells+diminish+in+number+from+fetal+to+postnatal+stages. assertion.
- assertion asSentence Loss+of+EDNRB+is+associated+with+metastasis+in+clear-cell+renal+cell+carcinoma. assertion.
- assertion asSentence Cathepsin+D+and+eEF1+are+promising+markers+for+the+detection+of+cellular+senescence+induced+by+a+variety+of+treatments. assertion.
- assertion asSentence High+eEF1A1+is+associated+with+metastatic+progression+of+prostate+cancer. assertion.
- assertion asSentence Overexpression+of+eukaryotic+translation+elongation+factor+1+alpha+1+is+associated+with+nonepithelial+ovarian+cancer. assertion.
- assertion asSentence Regulates+oncogenesis+through+Akt-dependent+cytoskeletal+remodeling. assertion.
- assertion asSentence Multiple+oncogenic+signalling+pathways+are+affected+by+ephrin-A1%2C+from+the+promotion+of+a+specific+pathway+in+one+cell+or+cancer+type+to+the+inhibition+of+the+same+pathway+in+another+type+of+cell+or+cancer. assertion.
- assertion asSentence On+ephrinB1+stimulation%2C+the+small+GTPases+Rho+and+Ras+are+activated+and+Rap1+is+inactivated. assertion.
- assertion asSentence EphB%2Fephrin-B+molecules+play+a+role+in+restricting+dental+pulp+stem+cell+attachment+and+migration+to+maintain+Dthesse+cells+within+their+stem+cell+niche+under+steady-state+conditions. assertion.
- assertion asSentence Silencing+of+EphB+expression+is+associated+with+colorectal+tumorigenesis. assertion.
- assertion asSentence EphB4+and+ephrin-B2+are+instrumental+in+the+establishment+of+a+functional+placental+structure+and+of+the+utero-placental+circulation. assertion.
- assertion asSentence The+ephrin-B2+ectodomain+binds+to+EphB2+with+a+K%28d%29+of+22.3+nM+to+form+a+tight+complex+in+which+the+tip+of+the+C-D+loop+and+the+C-terminus+still+remain+largely+flexible. assertion.
- assertion asSentence Ephrin-B2+signaling+influence+cell-to+cell+fusion+and+virus+entry+by+the+ratio+between+the+NiV+envelope+glycoproteins+and+surface+receptors. assertion.
- assertion asSentence EGF-mediated+induction+of+fibronectin+expression+occurs+at+the+post-transcriptional+level+and+involves+PKCdelta+signaling+pathway. assertion.
- assertion asSentence Downregulated+by+cetrorelix+in+cultured+leiomyoma+cells. assertion.
- assertion asSentence In+the+absence+of+EGF%2C+p38MAPK-activated+AKT+is+necessary+for+HER-2+overexpressing+human+breast+cancer+cells+to+survive+and+to+form+colonies+in+soft+agar. assertion.
- assertion asSentence EGF+activates+PI3K-Akt+and+NF-kappaB+via+distinct+pathways+in+salivary+gland+epithelial+cells+in+Sjogren%27s+syndrome. assertion.
- assertion asSentence The+Egf%2B61+G%2FA+polymorphism+is+not+associated+with+an+increased+risk+of+endometriosis+in+a+Japanese+population. assertion.
- assertion asSentence EGF+prevents+the+acquisition+of+a+neuroendocrine+phenotype+by+an+ERbB2-independent+and+ERK1%2F2-dependent+mechanism+requiring+Akt+activation. assertion.
- assertion asSentence Sef+plays+a+positive+role+in+the+EGF%2FEGFR-mediated+MAPK+signaling+pathway. assertion.
- assertion asSentence The+time-dependent+EGF-induced+increase+in+AR+transcriptional+activity+by+MAGE-11+is+mediated+through+AR+activation+functions+1+and+2+in+association+with+the+increased+turnover+of+AR+and+MAGE-11. assertion.
- assertion asSentence Pre-formed+EGFR+dimers+are+critical+to+the+initial+EGF+binding+and+the+extent+of+the+pre-formed+dimers+is+not+affected+by+receptor+density. assertion.
- assertion asSentence Effects+of+different+CMV-heat-inactivation-methods+on+EGF+in+human+breast+milk. assertion.
- assertion asSentence EGF-mediated+migration+signaling+activated+by+N-acetylglucosaminyltransferase-V+via+receptor+protein+tyrosine+phosphatase+kappa. assertion.
- assertion asSentence Epidermal+growth+factor+A61G+gene+polymorphism+is+associated+with+gastroesophageal+reflux+disease+and+esophageal+adenocarcinoma. assertion.
- assertion asSentence Enhanced+multipotent+stromal+cells+osteogenic+differentiation+corresponds+to+a+sustained+combination+of+receptor+expression+and+ligand+presentation%2C+both+of+which+are+maintained+by+tethered+epidermal+growth+factor. assertion.
- assertion asSentence EGF+polymorphism+is+associated+with+gastric+cancer+and+esophageal+cancer. assertion.
- assertion asSentence The+common+regenerative+and+neuroprotective+effects+of+epidermal+growth+factor+%28EGF%29+and+growth+hormone+releasing+hormone+peptide%28GHRP%29-6+are+associated+with+their+versatile+pro-survival+and+pro-regenerative+mechanisms. assertion.