Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Human+EGF+upregulates+aquaporin+3+expression+via+extracellular+signal-regulated+kinase+%28ERK%29signal+transduction+pathways+in+gastric+cancer+cells. assertion.
- assertion asSentence miR-200bc%2F429+cluster+targets+PLCgamma1+and+differentially+regulates+proliferation+and+EGF-driven+invasion+than+miR-200a%2F141+in+breast+cancer. assertion.
- assertion asSentence TGFbeta+and+EGF+signaling+pathways+synergistically+induce+epithelial-mesenchymal+transition+and+render+epithelial+ovarian+cancer+cells+a+more+invasive+phenotype. assertion.
- assertion asSentence Cells+derived+from+subventricular+zone+type-B+cells+actively+respond+to+epidermal+growth+factor+%28EGF%29+stimulation+becoming+highly+migratory+and+proliferative. assertion.
- assertion asSentence Disulfide+bonds+in+EGF+domains+of+beta3+affect+structure+and+function+of+alphaIIbbeta3+and+alphavbeta3+integrins+in+different+manner. assertion.
- assertion asSentence EGF-mediated+CYR61+upregulation+in+HES+cells+involves+STAT3+and+is+counter-regulated+by+the+EGFR%2FMAPK%2FERK+pathway. assertion.
- assertion asSentence A+truncated+form+of+the+hEGFR+ectodomain+comprising+residues+1-501%2C+unlike+the+full-length+hEGFR+ectodomain+%28residues+1-621%29%2C+binds+hEGF+and+hTGF-alpha+with+high+affinity+and+is+a+competitive+inhibitor+of+EGF-stimulated+mitogenesis. assertion.
- assertion asSentence Antisense+epidermal+growth+factor+receptor+RNA+transfection+in+human+glioblastoma+cells+down-regulates+telomerase+activity+and+telomere+length. assertion.
- assertion asSentence Caveolin-1%2FEGFR+association+and+is+critical+for+the+EGF-induced+tyrosine+phosphorylation+of+caveolin-1+that+is+associated+with+its+inhibition+of+EGFR+activation. assertion.
- assertion asSentence Hydrogen+peroxide+increases+cPLA%282%29+activity+through+its+phosphorylation+utilizing+an+epithelial+growth+factor%2FRas%2Fextracellular+signal-regulated+kinase+and+p38+pathway. assertion.
- assertion asSentence Levels+of+this+receptor+are+lowered+in+cryptorchism. assertion.
- assertion asSentence The+mechanism+of+attenuated+ERK+signaling+in+EGFR-overexpressing+cells+is+a+sequestration+of+ERKs+at+the+cell+membrane+in+EGFR-containing+complexes. assertion.
- assertion asSentence Nitric+oxide+and+nitric+oxide+donors+induce+EGF+receptor+phosphorylations%2C+in+A431+tumor+cells. assertion.
- assertion asSentence PLSCR1%2C+through+its+interaction+with+Shc%2C+promotes+Src+kinase+activation+through+the+EGF+receptor. assertion.
- assertion asSentence Mitogenic+effects+of+gastrin-releasing+peptide+in+head+and+neck+squamous+cells+are+mediated+by+activation+of+EGFR. assertion.
- assertion asSentence Endothelial+cell+vessel+assembly+requires+EGFR+signaling+transduction+pathways. assertion.
- assertion asSentence The+timing+of+lethality+caused+by+homozygosity+for+a+null+allele+of+the+epidermal+growth+factor+receptor+in+mice+is+strongly+dependent+on+genetic+background. assertion.
- assertion asSentence The+reduction+in+EGFR+levels+and+EGF-induced+signaling+in+SOCS5-expressing+cells+requires+both+the+Src+homology-2+and+SOCS+box+domains+of+SOCS5. assertion.
- assertion asSentence The+patients+with+mutations+of+EGFR+to+have+a+more+favorable+prognosis+than+those+with+wild+type+%28p%3D0.033%29. assertion.
- assertion asSentence EGFR+expression+is+not+stable+during+metastatic+progression+in+a+significant+proportion+of+non-small-cell-lung+cancer+patients. assertion.
- assertion asSentence EGFR+depletion+induced+enhancement+of+IGF1R+ubiquitylation+and+degradation. assertion.
- assertion asSentence Downregulation+of+E-cadhedrin+expression+is+associataed+with+increased+EGFR+downstream+signalling+and+a+subsequent+increase+in+expression+of+Th2-attracting+chemokine+TARC. assertion.
- assertion asSentence CK5%2F6+and%2For+EGFR+expressing+tumor+types+have+a+persistently+poorer+prognosis+over+the+longer+term. assertion.
- assertion asSentence Reduction+of+sperm+motility+by+tryptase+through+the+PAR-2+receptor+involves+epidermal+growth+factor+receptor+pathways. assertion.
- assertion asSentence Hydrocortisone+and+indomethacin+negatively+modulate+EGF-R+signaling+in+human+fetal+intestine. assertion.
- assertion asSentence The+Egfr%2B2073+A%2FT+polymorphism+is+not+associated+with+an+increased+risk+of+endometriosis+in+a+Japanese+population. assertion.
- assertion asSentence Amphiregulin+is+a+specific+ligand+of+the+EGFR+and+a+potent+mitogen+for+epithelial+cells+such+as+breast+cancer+cell+lines. assertion.
- assertion asSentence The+activation+of+PAR-2+expressed+by+human+intestinal+epithelial+cells+enhances+mucin+secretion%2C+a+component+of+the+intestinal+innate+defence%2C+via+a+pathway+involving+EGFR+transactivation. assertion.
- assertion asSentence AP-1+and+NF-kappaB+transcription+factors+are+activated+and+EGF-R+is+expressed+in+these+cells+and+associated+with+COX-2+and+VEGF+production. assertion.
- assertion asSentence Genomic+alteration+of+the+HER2-neu+and+EGFR+genes+is+frequent+%2825%25%29+in+ovarian+cancer. assertion.
- assertion asSentence Silibinin+impairs+constitutively+active+TGFalpha-EGFR+autocrine+loop+in+advanced+human+prostate+carcinoma+cells. assertion.
- assertion asSentence Lysophosphatidic+acid-induced+transactivation+of+epidermal+growth+factor+receptor+regulates+cyclo-oxygenase-2+expression+and+prostaglandin+E%282%29+release+via+C%2FEBPbeta+in+human+bronchial+epithelial+cells. assertion.
- assertion asSentence siRNA-mediated+knockdown+is+effective+in+lung+adenocarcinomas+with+EGFR+mutation+and+those+with+resistance+to+gefitinib+by+acquired+mutation+in+EGFR. assertion.
- assertion asSentence Coordinated+overexpression+of+the+EGFR+pathway+predicts+susceptibility+to+EGFR+inhibitors+in+pancreatic+cancer+transplanted+into+nude+mice. assertion.
- assertion asSentence The+p-EGFR%3Ap-AKT+ratio+deserves+further+investigation+as+a+predictive+parameter+for+clinical+response+to+erlotinib+in+NSCLC+tumors+expressing+wild-type+EGFR+gene. assertion.
- assertion asSentence EGF+contributes+to+differentiation+and+migration+of+myofibroblasts+induced+by+TGF-beta1+through+EGF-receptor+activation+and+is+important+modulator+of+wound+healing+and+scar+tissue+formation. assertion.
- assertion asSentence In+vascular+smooth+muscle+cells+shedding+of+membrane-bound+epidermal+growth+factor+%28EGF%29+receptor+ligands+and+activation+of+the+nonreceptor+tyrosine+kinases+Pyk2+and+Src+contributed+to+the+thrombin-induced+ERK1%2F2+phosphorylation. assertion.
- assertion asSentence Clathrin-mediated+endocytosis+of+the+EGFR+unexpectedly+has+a+greater+impact+on+receptor+signaling+than+on+receptor+degradation. assertion.
- assertion asSentence In+human+gingival+fibroblasts%2C+enamel+matrix+derivative-induced+extracellular+regulated+kinase+activation+and+proliferation+are+partially+due+to+a+Src-dependent%2C+metalloproteinase-mediated+transactivation+of+epidermal+growth+factor+receptor. assertion.
- assertion asSentence EGFR+gene+amplification%2C+protein+over-expression+and+no+mutation+in+tyrosine+kinase+domain+is+associated+with+recurrent+glioblastoma. assertion.
- assertion asSentence Lung+epithelial+cells+secrete+AMCase+via+an+EGFR-dependent+pathway+that+is+activated+by+ADAM17+and+mediates+its+effects+via+Ras. assertion.
- assertion asSentence EGFR+mutations+are+associated+with+non-small+cell+lung+cancer. assertion.
- assertion asSentence Epidermal+growth+factor+receptor+intron-1+polymorphism+is+associated+with+gefitinib+response+in+advanced+non-small+cell+lung+cancer. assertion.
- assertion asSentence Somatic+mutations+in+the+EGFR+have+emerged+as+important+biomarkers+in+predicting+the+likelihood+of+tumor+response+to+the+EGFR+tyrosine+kinase+inhibitor+gefitinib+in+patients+with+advanced+NSCLC. assertion.
- assertion asSentence p38+MAP+kinase+controls+EGF+receptor+downregulation+via+phosphorylation+at+Ser1046%2F1047. assertion.
- assertion asSentence Epiregulin+is+a+marker+of+advanced+disease+in+non-small+cell+lung+cancer+patients+and+confers+invasive+properties+on+EGFR-mutant+cells. assertion.
- assertion asSentence High+coexpression+of+both+insulin-like+growth+factor+receptor-1+%28IGFR-1%29+and+epidermal+growth+factor+receptor+%28EGFR%29+is+associated+with+shorter+disease-free+survival+in+resected+non-small-cell+lung+cancer+patients. assertion.
- assertion asSentence EGFR+mutations+in+the+tyrosine+kinase+domain+is+a+rare+event+in+salivary+gland+carcinomas. assertion.
- assertion asSentence Filamin+A+modulates+kinase+activation+and+intracellular+trafficking+of+epidermal+growth+factor+receptors+in+human+melanoma+cells. assertion.
- assertion asSentence Epidermal+growth+factor+receptor+vIII+enhances+tumorigenicity+and+resistance+to+5-fluorouracil+in+human+hepatocellular+carcinoma. assertion.
- assertion asSentence Overexpression+of+EGFR+is+associated+with+thymic+carcinoma. assertion.
- assertion asSentence Regulation+of+estrogen-mediated+fibronectin+matrix+assembly+and+epidermal+growth+factor+receptor+transactivation+by+GPR30. assertion.
- assertion asSentence Enediyne+lidamycin+enhances+the+effect+of+epidermal+growth+factor+receptor+tyrosine+kinase+inhibitor%2C+gefitinib%2C+in+epidermoid+carcinoma+A431+cells+and+lung+carcinoma+H460+cells. assertion.
- assertion asSentence In+patients+with+non-small+cell+lung+cancer%2C+there+is+a+higher+frequency+of+epithelial+markers+in+patients+with+EGFR+mutation. assertion.
- assertion asSentence EGFR%2FKRAS+mutation+testing+of+multiple+lung+adenocarcinomas+can+assist+in+differentiating+multiple+primary+lung+adenocarcinomas+from+metastatic+lesions. assertion.
- assertion asSentence EGFR+mutation+is+associated+with+metastatic+in+non-small+cell+lung+cancer. assertion.
- assertion asSentence EGFR+mutation+up-regulates+EGR1+expression+through+the+ERK+pathway. assertion.
- assertion asSentence EGFR+expression+is+different+between+primary+nasopharygeal+carcinoma+and+lymph+node+metastases. assertion.
- assertion asSentence EGFR+mutations+are+associated+with+good+response+to+gefitinib+therapy. assertion.
- assertion asSentence EGFR+protein+overexpression+and+increased+EGFR+gene+copy+number+is+associated+with+sarcomatoid+carcinomas+of+the+lung. assertion.
- assertion asSentence EGFR+mutations+are+associated+with+lung+adenocarcinomas. assertion.
- assertion asSentence Autophagy+promoted+via+troglitazone+is+correlated+with+AMPKalpha+activation+and+independent+of+PPARgamma+activation+and+EGFR+transactivation. assertion.
- assertion asSentence Adhesion-induced+EphA2+expression+is+dependent+upon+activation+of+the+epidermal+growth+factor+receptor+%28EGFR%29%2C+mitogen+activated+protein+kinase+kinase+%28MEK%29+and+Src+family+kinases+%28SRC%29. assertion.
- assertion asSentence EGFR+plays+an+essential+role+in+the+immunopathobiology+of+HCMV+by+mediating+viral+entry+into+monocytes+and+stimulating+the+aberrant+biological+activity+that+promotes+hematogenous+dissemination. assertion.
- assertion asSentence Slow+physical+deformation+of+the+lateral+intercellular+space+in+response+to+a+step+increase+in+loading+leads+to+synchronous+activation+of+the+EGFR. assertion.
- assertion asSentence Hyaluronan+can+serve+as+a+signal+integrator+by+facilitating+TGF-beta1-mediated+CD44-EGF-R-ERK+interactions+and+ultimately+fibroblast+phenotype. assertion.
- assertion asSentence Features+of+KRAS+mutations+in+lung+cancer+and+contrast+these+with+the+features+of+EGFR+mutations. assertion.
- assertion asSentence Elevated+expression+level+of+EGFR+is+associated+with+a+low+response+to+chemoradiation+in+rectal+cancer. assertion.
- assertion asSentence Simultaneously+blocking+EGFR+and+COX-2+mediated+pathways+would+significantly+inhibit+the+growth+of+the+CNE-2+cell+line%2C+increase+G1+arrest+and+reduce+the+expression+levels+of+p-EGFR+and+COX-2. assertion.
- assertion asSentence In+amnion+cells+EGFR+clustering+induced+by+50-Hz+MF+depends+on+acid+sphingomyelinase+activity. assertion.
- assertion asSentence Mutations+in+TP53%2C+KRAS%2C+or+EGFR+are+not+major+contributors+to+the+RCC+development+even+in+the+absence+of+VHL+inactivation. assertion.
- assertion asSentence E5+and+the+EGF-receptor+cooperate+to+enhance+cell+cycle+entry+and+progression+through+regulating+p27%28Kip1%29+expression+at+protein+level. assertion.
- assertion asSentence Alterations+in+the+EGFR-PTEN+signaling+pathway+are+present+in+a+third+of+prostate+adenocarcinomas%2C+particularly+affecting+the+more+advanced+cases. assertion.
- assertion asSentence EGFR+mutations+are+associated+with+HLA-A2+in+female+patients+with+adenocarcinoma+of+the+lung. assertion.
- assertion asSentence EGFR+gene+mutations+are+not+associated+with+non-small+cell+lung+cancer. assertion.
- assertion asSentence HB-EGF+participate+in+transactivation+of+EGF+receptor+under+oxidative+stress. assertion.
- assertion asSentence EGFR+mutation+is+associated+with+high+chemotherapy+response+rate+of+non-small+cell+lung+cancer. assertion.
- assertion asSentence The+EGFR%2FERK+pathway+is+activated+in+high-grade+MECs+with+aggressive+behaviour. assertion.
- assertion asSentence Activating+epidermal+growth+factor+receptor+mutations+are+associated+with+response+to+gefitinib+in+non-small+cell+lung+cancer. assertion.
- assertion asSentence Epidermal+growth+factor+receptor+mutations+are+associated+with+better+response+to+therapy+in+non-small+cell+lung+cancer. assertion.
- assertion asSentence Epidermal+growth+factor+receptor+mutation+is+associated+with+lung+cancer. assertion.
- assertion asSentence EGFR+gene+mutation+is+associated+with+non-small+cell+lung+cancer. assertion.
- assertion asSentence TGFA%2FEGFR+signaling+contributes+to+the+proliferation+of+papillary+thyroid+carcinomas+cells. assertion.
- assertion asSentence Mutations+in+EGFR+is+associated+with+adenocarcinoma+of+the+lung. assertion.
- assertion asSentence Cbl+ubiquitin+ligase+plays+a+critical+role+in+the+maintenance+of+AJs+and+suppression+of+cell+migration+through+down-regulation+of+EGFR-Vav2+signaling. assertion.
- assertion asSentence Elevated+plasma+levels+of+epidermal+growth+factor+receptor+are+associated+with+breast+cancer+among+hormone+therapy+users. assertion.
- assertion asSentence Gefitinib+and+Erlotinib+induce+responses+in+over+70%25+of+non-small+cell+lung+carcinoma+patients+harboring+EGFR+mutations%2C+with+progression-free+survival. assertion.
- assertion asSentence The+PI3+kinase%2FmTOR+blocker+NVP-BEZ235+overrides+resistance+against+irreversible+ErbB+inhibitors+in+breast+cancer+cells. assertion.
- assertion asSentence Calcium-induced+apoptosis+in+bladder+cancer+cells+is+delayed+by+HER1+receptor+activation+involving+the+Akt+and+PLCgamma+signalling+pathways. assertion.
- assertion asSentence Epidermal+growth+factor+receptor+exon+19+deletion+is+associated+with+Miliary+never-smoking+adenocarcinoma+of+the+lung. assertion.
- assertion asSentence There+is+a+positive+correlation+between+the+EGFR+and+c-Met+protein+expression+and+the+differentiation+of+non-small+cell+lung+cancer. assertion.
- assertion asSentence TIP30+complex+regulates+EGFR+endocytosis+by+facilitating+the+transport+of+V-ATPases+from+trans-Golgi+network+to+early+endosomes. assertion.
- assertion asSentence EGFR+T790M+mutation+resistance+to+EGFR-tyrosine+kinase+inhibitors+is+overcome+by+vascular+endothelial+growth+factor+inhibitors. assertion.
- assertion asSentence EGFR+mutations+are+associated+with+drug+resistance+in+non-small+cell+lung+cancer. assertion.
- assertion asSentence Galectin-3+regulates+MUC1+and+epidermal+growth+factor+receptor+%28EGFR%29+internalization+and+subcellular+localization%2C+ERK1%2C2+activation+downstream+of+the+EGFR+and+EGFR+nuclear+translocation+in+pancreatic+cancer+cells. assertion.
- assertion asSentence A+high+frequency+of+Q787Q+mutation+and+a+less+prevalent+active+EGFR+mutation+in+oral+cavity+squamous+cell+carcinoma+patients+in+Taiwan+where+betel+nut+is+commonly+chewed. assertion.
- assertion asSentence Nuclear+translocation+of+epidermal+growth+factor+receptor+by+Akt-dependent+phosphorylation+enhances+breast+cancer-resistant+protein+expression+in+gefitinib-resistant+cells. assertion.
- assertion asSentence Mutations+in+EGFR+is+associated+with+drug+resistance+and+epithelial+to+mesenchymal+transition+in+lung+cancer. assertion.
- assertion asSentence Epithelial+growth+factor+receptor+mutations+in+cerebrospinal+fluid+is+associated+with+lung+adenocarcinoma+suspected+of+neoplastic+meningitis. assertion.
- assertion asSentence Epidermal+growth+factor+receptor+mutation+is+associated+with+treatment+response+in+non-small+cell+lung+cancer. assertion.