Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Histone+deacetylase-2+is+a+key+regulator+of+diabetes-+and+transforming+growth+factor-beta1-induced+renal+injury. assertion.
- assertion asSentence Adenovirus+E1A+oncoprotein+is+sufficient+to+induce+Smad7+expression%2C+an+inhibitor+of+TGF-beta+signalling. assertion.
- assertion asSentence TGF-beta%281%29+decreased+sGC+and+PKGI+expression+in+pulmonary+artery+and+aortic+smooth+muscle+cells+from+adult+rats+and+mice. assertion.
- assertion asSentence High+TGFB1+serum+levels+are+associated+with+locally+advanced+non-small+cell+lung+cancer. assertion.
- assertion asSentence CCN3+counter-regulates+positive+signals+from+TGF-beta+and+Wnt+for+fibrillin+fibrillogenesis+and+profibrotic+gene+expression. assertion.
- assertion asSentence Generation+of+ROS+by+Nox4+mediates+TGF-beta1-induced+PAI-1+gene+expression+at+least+in+part+through+oxidative+modification+and+inhibition+of+MKP-1+leading+to+a+sustained+activation+of+JNK+and+p38+MAPKs. assertion.
- assertion asSentence Agrin+binds+BMP2%2C+BMP4+and+TGFbeta1+with+relatively+high+affinity. assertion.
- assertion asSentence TGF-beta%2C+leading+the+tissue+invasion+mediated+by+MMP-2%2C+is+a+strong+promoter+of+tumor+progression. assertion.
- assertion asSentence CD4%28%2B%29CD25%28%2B%29+Treg+cell+level+and+the+serum+level+of+IL-2+and+TGF-beta+all+are+related+to+incidence+and+severity+of+acute+graft-versus+host+disease. assertion.
- assertion asSentence Elevated+TGFbeta1+levels+are+associated+with+viral+clearance+following+therapy+in+patients+with+hepatitis+C+virus. assertion.
- assertion asSentence Loss+of+beta1-integrin+enhances+TGF-beta1-induced+collagen+expression+in+epithelial+cells+via+increased+alphavbeta3-integrin+and+Rac1+activity. assertion.
- assertion asSentence Level+of+TGF-beta+and+IL-10+inversely+correlated+with+malaria+vaccine+immunogenicity. assertion.
- assertion asSentence TGF-beta1+activates+beta-catenin+signalling%2C+increases+beta-catenin+nuclear+translocation+and+interacts+with+LEF%2FTCF+to+regulate+gene+expression+in+dental+pulp+cells. assertion.
- assertion asSentence Smad2%2F3+and+p38+MAPK+differentially+regulate+TGFB1-induced+epithelial-mesenchymal+transition+in+pulmonary+epithelial+cells. assertion.
- assertion asSentence Microbe-associated+neuraminidases+can+directly+activate+LTGF-beta+and+TGF-beta+plays+a+pivotal+role+protecting+the+host+from+influenza+pathogenesis. assertion.
- assertion asSentence The+culture+supernatant+of+mesenchymal+stem+cells+isolated+from+stage+III+breast+cancer+patients+induced+upregulation+of+the+mRNA+expression+levels+of+IL-4%2C+TGF-beta1%2C+IL-10%2C+CCR4+and+CD25+in+peripheral+blood+T+lymphocytes. assertion.
- assertion asSentence The+establishment+of+the+self-sustaining+TGF-beta+and+SDF-1+autocrine+signaling+gives+rise+to+tumor-promoting+carcinoma-associated+fibroblasts+myofibroblasts+during+tumor+progression. assertion.
- assertion asSentence The+TGF-beta1+mediated+secretion+of+endothelin-1+and+TGF-beta2+is+mediated+by+Rho+kinase+activation+in+hepatic+stellate+cells. assertion.
- assertion asSentence Oxidative+stress-mediated+decorin+GAG+chain+synthesis+triggers+TGF-beta+signaling+and+mineralization+of+vascular+smooth+muscle+cells+in+vitro. assertion.
- assertion asSentence High+TGFB1+is+associated+with+ovarian+cancer. assertion.
- assertion asSentence Link+between+heterogeneity+in+TGF-beta+signaling+and+tumor+promotion+by+tumor+stromal+cells. assertion.
- assertion asSentence Thrombophlebitis+accelerates+activation+of+TGF-beta1+and+activity+of+its+receptor+in+the+varicose+vein+wall. assertion.
- assertion asSentence Adenosine+monophosphate-activated+protein+kinase+%28AMPK%29+inhibits+TGF-beta-induced+fibrogenic+property+of+hepatic+stellate+cells+by+regulating+transcriptional+coactivator+p300. assertion.
- assertion asSentence The+development+of+osteoradionecrosis+is+related+to+the+presence+of+the+T+variant+allele+at+-509+within+the+TGF-beta1+gene. assertion.
- assertion asSentence Combined+strength+and+aerobic+training+increases+transforming+growth+factor-beta1+in+patients+with+type+2+diabetes. assertion.
- assertion asSentence Over+expression+of+TGF-beta+and+CTLA-4+leads+to+T+cell+hyporesponsiveness%2C+a+major+hallmark+of+leprosy%2C+by+increasing+the+expression+of+Cbl-b. assertion.
- assertion asSentence The+TbetaR-I+pre-helix+extension+is+structurally+ordered+in+the+unbound+form+and+its+flanking+prolines+are+essential+for+binding. assertion.
- assertion asSentence Snail+transcription+factor+plays+a+critical+role+in+TGF-beta1-induced+epithelial-mesenchymal+transition+in+human+retinal+pigment+epithelium+cells. assertion.
- assertion asSentence TGF-beta1+expression+is+diminished+in+activated+arteries+and+vascular+cells+which+limits+a+protective+role+for+this+cytokine+in+the+pathogenesis+of+arteriosclerosis. assertion.
- assertion asSentence CD109+is+an+important+regulator+of+SMAD7%2FSmurf2-mediated+degradation+of+TGFBR1. assertion.
- assertion asSentence TGF-beta-induced+TG2+enhances+ovarian+tumor+metastasis+by+inducing+epithelial-to-mesenchymal+transition+and+a+cancer+stem+cell+phenotype. assertion.
- assertion asSentence Vascular+phenotype+with+regard+to+VEGFR2+expression+and+TGF-beta+signaling+in+endothelial+cells+varies+with+malignancy+in+human+glioma. assertion.
- assertion asSentence TGFbeta1-Endo180-dependent+collagen+deposition+is+dysregulated+at+the+tumour-stromal+interface+in+bone+metastasis. assertion.
- assertion asSentence High+serum+transforming+Growth+Factor+beta+is+associated+with+virus+infection+in+liver+carcinogenesis. assertion.
- assertion asSentence Man-6-P-dependent+effects+on+latent+TGF-beta1+activation+are+not+mediated+by+direct+modification+of+its+latency-associated+peptide. assertion.
- assertion asSentence Menin+mutant+exhibits+selective+loss+of+the+TGF-beta+signaling+pathway+and+loss+of+cell+proliferation+control+contributing+to+the+development+of+MEN1. assertion.
- assertion asSentence COM+stimulates+the+expression+of+MCP-1+and+TGFbeta1+in+renal+epithelial+cells. assertion.
- assertion asSentence Chelators+inhibit+the+TGF-beta-induced+EMT+via+a+process+consistent+with+NDRG1+up-regulation+and+elucidates+the+mechanism+of+their+activity. assertion.
- assertion asSentence TGFbeta1+has+endogenous+anti-progestational+effects+in+stromal+cells+and+the+opposing+effects+of+progesterone+and+TGFbeta1+are+important+in+regulation+of+matrix+integrity+in+human+endometrium. assertion.
- assertion asSentence Transforming+growth+factor-beta1+%28TGF-beta1%29+plays+a+key+role+in+the+tissue+remodeling+processes+involved+in+chronic+rhinosinusitis. assertion.
- assertion asSentence Ablation+of+TGF-beta+signaling+in+T+cells+does+not+confer+resistance+in+transgenic+mice+to+Heligmosomoides+polygyrus+infection. assertion.
- assertion asSentence Silencing+Hic-5+in+hypertrophic+scar+fibroblasts+reduces+TGF-beta1+production%2C+decreases+generation+of+supermature+focal+adhesions%2C+reduces+expression+of+smooth-muscle+cell+alpha-actin+and+decreases+collagen+contraction+and+extracellular+matrix+synthesis. assertion.
- assertion asSentence A+transcriptional+target+for+Akt%2Fprotein+kinase+B+via+forkhead+transcription+factor. assertion.
- assertion asSentence PRDX6+attenuates+oxidative+stress-+and+TGFbeta-induced+abnormalities+of+human+trabecular+meshwork+cells. assertion.
- assertion asSentence A+variant+in+the+fibrillin-3+gene+is+associated+with+TGF-beta+and+inhibin+B+levels+in+women+with+polycystic+ovary+syndrome. assertion.
- assertion asSentence Autocrine+stimulation+of+myeloid+progenitors+by+Tgfbeta2+as+one+mechanism+by+which+HoxA10+expands+this+population. assertion.
- assertion asSentence Regulation+of+TGF-beta3+promoter+activity+by+HIF-1+represents+a+mechanism+for+trophoblast+differentiation+during+hypoxia. assertion.
- assertion asSentence Addition+of+recombinant+LEFTY-A+to+explants+induced+MMP-9+in+most+samples%2C+a+response+prevented+by+ovarian+steroids. assertion.
- assertion asSentence Blood+levels+are+higher+in+coronary+artery+disease+patients+compared+with+normal+values. assertion.
- assertion asSentence The+deduced+structure+of+the+TGFBIp+monomer+consists+of+four+FAS1+domains+in+a+simple+%22beads-on-a-string%22+arrangement%2C+constructed+by+the+superimposition+of+four+consecutive+Drosophila+fasciclin+domains. assertion.
- assertion asSentence The+mRNA+expressions+of+TGFbeta+receptor+type+I+%28TGFbetaRI%29+in+hMSCs+increased+with+the+length+of+cell+culture. assertion.
- assertion asSentence Common+variants+in+TGFBR1+gene+do+not+strongly+influence+genetic+susceptibility+to+diabetic+nephropathy+in+an+Irish+Caucasian+population. assertion.
- assertion asSentence Somatic+acquisition+of+TGFBR1%2A6A+by+epithelial+and+stromal+cells+during+head+and+neck+and+colon+cancer+development. assertion.
- assertion asSentence The+expression+of+TGF-betaR+I+increased+in+CD8%2B+T+cells+of+oral+lichen+planus+compared+to+controls. assertion.
- assertion asSentence Mutations+in+TGFBR1+and+TGFBR2+rarely+cause+sporadic+BAV. assertion.
- assertion asSentence Upon+TGF-beta1+stimulation+ALK5+phosphorylates+Smad2+and+3+with+a+negative+impact+on+ALK2-Smad1%2C+5+and+8+signaling+in+prostate+cancer+cells. assertion.
- assertion asSentence TGFBR1+has+a+specific+role+in+TGFbeta+mediated+tumor+invasion. assertion.
- assertion asSentence Mutations+of+TGFBR1+are+associated+with+Skin+tumors+induced+by+sorafenib. assertion.
- assertion asSentence TGFBR1+intralocus+epistatic+interaction+as+a+risk+factor+for+colorectal+cancer. assertion.
- assertion asSentence Prostate+cancer+cells+mediate+growth+inhibition+and+differentiation+of+bone+marrow+endothelial+cells+through+alteration+of+TGFbetaRII-mediated+signal+transduction. assertion.
- assertion asSentence The+human+TbetaRII+overexpressed+in+highly+malignant+K-ras-transformed+thyroid+cell+clones+is+a+functional+receptor+essential+for+a+strong+reduction+of+adhesive+%26+migratory+behaviour+of+these+cells. assertion.
- assertion asSentence Genetic+testing+revealed+in+patient+with+diffuse+and+rapidly+progressing+vascular+disease+a+de+novo+mutation+in+transforming+growth+factor+receptor+2. assertion.
- assertion asSentence Mutations+in+TGFBR1+and+TGFBR2+rarely+cause+sporadic+BAV. assertion.
- assertion asSentence DHT+decreases+the+level+of+TGF-beta+receptor+II+%28TbetaRII%29+through+a+transcriptional+mechanism. assertion.
- assertion asSentence Genetic+variations+in+TGFBR2+associate+with+abdominal+aortic+aneurysm+in+a+Dutch+population. assertion.
- assertion asSentence The+researchers+found+an+association+between+a+common+TGFRB2+polymorphism+and+the+risk+of+sudden+cardiac+arrest+coupled+with+ventricular+arrhythmias+in+the+presence+of+coronary+artery+disease. assertion.
- assertion asSentence Mutation+in+transforming+growth+factor+beta+receptor+II+is+associated+with+colorectal+cancer. assertion.
- assertion asSentence TbetaRII+alone+is+able+to+mediate+TGFbeta+signaling+to+ERK1%2F2+without+participation+of+TbetaRI. assertion.
- assertion asSentence TGFBR2+mutations+are+not+associated+with+the+microsatellite+instability-high+colorectal+cancer. assertion.
- assertion asSentence Type+III+transforming+growth+factor-beta+protein+expression+is+decreased+in+human+multiple+myeloma+specimens. assertion.
- assertion asSentence A+Brazilian+boy+with+lobar+holoprosencephaly+has+a+K44N+mutation+in+the+TGIF+gene. assertion.
- assertion asSentence Beta-actin+is+a+target+for+the+activity+of+recombinant+human+transglutaminase+1+in+cultured+chick+telecephalon+cell+cultures. assertion.
- assertion asSentence Iintramolecular+crosslinking+of+the+cytoplasmic+soluble+phospho-Ser+alpha-synuclein+monomer+is+initially+catalyzed+by+tissue+transglutaminase. assertion.
- assertion asSentence Overexpression+of+TGM2+accelerates+the+erythroid+differentiation+of+chronic+myeloid+leukemia+cell+line+through+PI3K%2Fakt+signaling+pathway. assertion.
- assertion asSentence tTG+protein+and+mRNA+express+in+stromal+cells+and+trophoblast+in+first+trimester+and+at+term%2C+with+higher+levels+later+in+pregnancy. assertion.
- assertion asSentence Tissue+transglutaminase-2+and+matrix+metalloproteinase-2+expression+are+significantly+correlated+in+vivo%2C+in+peritoneal+xenografts+and+in+human+ovarian+tumors. assertion.
- assertion asSentence TGase+2-mu-calpain+system+is+significant+in+the+NF-kappaB+pathway+via+I-kappaBalpha+polymerization+and+subsequent+degradation. assertion.
- assertion asSentence RGD-independent+cell+adhesion+via+a+tissue+transglutaminase+2-fibronectin+matrix+promotes+fibronectin+fibril+deposition+and+requires+syndecan-4%2F2+and+%7Balpha%7D5%7Bbeta%7D1+integrin+co-signaling. assertion.
- assertion asSentence Activation+of+extracellular+transglutaminase+2+by+thioredoxin. assertion.
- assertion asSentence A+single+conformational+transglutaminase+2+epitope+contributed+by+three+domains+is+critical+for+antibody+binding+in+celiac+disease. assertion.
- assertion asSentence Structure+and+regulation+of+type+2+transglutaminase+in+relation+to+its+physiological+functions+and+pathological+roles. assertion.
- assertion asSentence Upstream+sequence+of+Ets+core+motif+is+critical+for+the+expression+of+TGM3+in+cells+cultured+in+vitro. assertion.
- assertion asSentence Lack+of+TGM3+expression+is+associated+with+oral+squamous+cell+carcinoma. assertion.
- assertion asSentence Tyrosine+hydroxylase+neurons+constitute+a+subpopulation+of+non-pyramidal+cells+that+are+morphologically+and+neurochemically+heterogenous. assertion.
- assertion asSentence Physiological+effects+of+four+mutations+%28T245P%2C+T283M%2C+R306H%2C+T463M%29+in+human+TyrH+that+cause+a+mild+form+of+DOPA-responsive+dystonia+are+primarily+due+to+the+decreased+stability+of+the+mutant+proteins+rather+than+decreases+in+their+intrinsic+activities. assertion.
- assertion asSentence Reduced+striatal+tyrosine+hydroxylase+in+incidental+Lewy+body+disease. assertion.
- assertion asSentence The+C-824T+SNP+in+the+proximal+TH+promoter+influences+BP+and+prevalence+of+hypertension+in+the+general+population. assertion.
- assertion asSentence Behcet%27s+disease+with+vascular+complications+involves+higher+levels+of+thrombomodulin. assertion.
- assertion asSentence Impaired+binding+of+thrombin+to+thrombomodulin+is+associated+with+risk+of+deep+vein+thrombosis. assertion.
- assertion asSentence The+roles+of+selected+arginine+and+lysine+residues+of+TAFI+%28Pro-CPU%29+in+its+activation+to+TAFIa+by+the+thrombin-thrombomodulin+complex. assertion.
- assertion asSentence Paclitaxel+downregulates+thrombomodulin+expression+in+aortic+endothelial+cells. assertion.
- assertion asSentence TSP1+is+expressed+in+tumor+stroma+in+colorectal+cancer%2C+inhibits+tumor+angiogenesis+and+suppresses+tumor+growth+by+activating+TGF+beta-1. assertion.
- assertion asSentence Ras+modulates+myc+activity+to+repress+TSP1+expression+and+increase+tumor+angiogenesis. assertion.
- assertion asSentence Increased+expression+of+TSP1+is+associated+with+an+aggressive+angiogenic+phenotype+in+melanoma. assertion.
- assertion asSentence IL-18+plays+a+key+role+in+thrombospondin-1+expression+involving+JNK. assertion.
- assertion asSentence Upregulation+of+thrombospondin-1%28TSP-1%29in+sporadic+inclusion+body+myositis. assertion.
- assertion asSentence TSP-1+A2210G+variant+has+a+dramatically+lower+prevalence+in+the+Chinese+Han+population+and+fail+to+associate+with+myocardial+infarction. assertion.
- assertion asSentence HuR+plays+an+important+role+in+translation+of+the+TSP1+mRNA. assertion.
- assertion asSentence Metformin+decreases+angiogenesis+via+NF-kappaB+and+Erk1%2F2%2FErk5+pathways+by+increasing+the+antiangiogenic+thrombospondin-1. assertion.
- assertion asSentence Anti-angiogenic+effects+of+resveratrol+mediated+by+decreased+VEGF+and+increased+TSP1+expression. assertion.