Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence The+association+of+thrombospondin-1+and+FRP1+is+primarily+mediated+by+the+amino-terminal+N-module+of+thrombospondin-1+and+the+netrin+domain+of+FRP1. assertion.
- assertion asSentence Regulation+of+intervertebral+disc+ECM+metabolism+by+the+THBS2-MMP+system+plays+an+essential+role+in+the+etiology+and+pathogenesis+of+LDH. assertion.
- assertion asSentence Common+variants+in+the+TCHH+gene+are+associated+with+straight+hair+in+Europeans. assertion.
- assertion asSentence Jak-Stat+and+PI+3-kinase+activation+pathways+regulate+the+TPO-induced+survival+of+megakaryocytic+cells+via+Bcl-xL+gene+expression. assertion.
- assertion asSentence A+sensitive+index+of+thombopoiesis+activity+in+colorectal+cancer. assertion.
- assertion asSentence A+family+with+segregation+of+G185T+TPO+mutation+in+the+5%27+UTR+region+in+4+subjects+with+thrombocythemia. assertion.
- assertion asSentence Furin+overexpression+in+some+types+of+hepatocellular+carcinomas+is+TR+dependent. assertion.
- assertion asSentence Affected+receptor+amino+acid+sequences.lost+their+trans-activation+function+and+exhibited+dominant+negative+activity. assertion.
- assertion asSentence A+point+mutation%2C+not+anticipated+to+occur+in+resistance+to+thyroid+hormone%2C+causes+variable+phenotypes. assertion.
- assertion asSentence Furin+overexpression+in+some+types+of+hepatocellular+carcinomas+is+TR+dependent. assertion.
- assertion asSentence Transcriptional+regulation+by+TR+is+mainly+mediated+by+an+exchange+of+corepressor+proteins+and+coactivator+proteins. assertion.
- assertion asSentence The+natural+TH+3%2C5%2C3%27-triodothyroacetic+acid+%28Triac%29+exhibits+a+previously+unrecognized+mechanism+of+TRbeta+selectivity. assertion.
- assertion asSentence Fibroblast+Thy-1+display+pre-determines+lineage+to+a+contractile+or+lipid-like+phenotype+in+the+human+myometrium+and+orbit. assertion.
- assertion asSentence Loss+of+Thy-1+in+human+lung+fibroblasts+induces+a+fibrogenic+phenotype. assertion.
- assertion asSentence Dual+role+for+TIA-1+in+shuttling+between+DNA+and+RNA+ligands+to+co-regulate+COL2A1+expression+at+the+level+of+transcription+and+pre-mRNA+alternative+splicing. assertion.
- assertion asSentence The+carboxyl-terminal+domain+of+TIA-1+is+responsible+for+its+recruitment+into+inclusions+containing+mutant+huntingtin+protein. assertion.
- assertion asSentence Down-regulation+of+the+IGFBP-3+transcripts+correlated+with+the+up-regulation+of+the+TIA-1+transcripts+in+primary+HCC+biopsies. assertion.
- assertion asSentence A+role+for+TIA+proteins+as+growth%2Ftumour-suppressor+genes. assertion.
- assertion asSentence TIA1+and+TIAR+proteins+are+intron-associated+positive+regulators+of+SMN2+exon+7+splicing. assertion.
- assertion asSentence Distinct+phosphoinositides+regulate+different+functions+of+Tiam1. assertion.
- assertion asSentence Overexpression+of+Tiam1+is+associated+with+lymphangiogenesis+in+colorectal+carcinoma. assertion.
- assertion asSentence Increased+TIAM1+is+associated+with+vascular+invasion+and+intrahepatic+metastasis+hepatocellular+carcinoma. assertion.
- assertion asSentence High+Tiam1+protein+expression+is+associated+with+lung+cancer+development+and+metastasis. assertion.
- assertion asSentence TIMP-1+expression+is+regulated+by+IL-10+and+IL-10+receptor+signaling+in+primary+human+prostate+tumor+cell+lines. assertion.
- assertion asSentence Overexpressed+in+ulcerative+colitis+and+serve+as+biological+markers. assertion.
- assertion asSentence STAT3+directly+contributes+to+the+high+level+of+TIMP1+expression+in+anaplastic+lymphoma+kinase-positive+anaplastic+large+cell+lymphoma. assertion.
- assertion asSentence Homozygous+familial+hypercholesterolemia+patients+exhibited+significantly+elevated+level+of+active+TIMP-1. assertion.
- assertion asSentence Increase+in+serum+levels+eight+days+after+IVIG+treatment+in+neuromuscular+disease. assertion.
- assertion asSentence Atorvastatin+does+not+alter+interferon+Beta-induced+changes+of+serum+matrix+metalloproteinase+9+and+tissue+inhibitor+of+metalloproteinase+1+in+patients+with+multiple+sclerosis. assertion.
- assertion asSentence TIMP1+functions+as+a+differentiating+and+survival+factor+of+GC+B+cells+by+modulating+CD44+and+SHP1+in+the+late+centrocyte%2Fpost-GC+stage%2C+regardless+of+EBV+infection. assertion.
- assertion asSentence Overexpression+of+TIMP-1+is+associated+with+gastric+cancer. assertion.
- assertion asSentence TIMP-1+interaction+with+alphavbeta3+integrin+confers+resistance+to+human+osteosarcoma+cell+line+MG-63+against+TNF-alpha-induced+apoptosis. assertion.
- assertion asSentence Short-term+use+of+statins+is+not+associated+in+reducing+levels+of+TIMP+1+in+areas+of+low+and+peak+wall+stress+in+patients+with+abdominal+aortic+aneurysms. assertion.
- assertion asSentence Increased+serum+TIMP1+is+associated+with+chemoradiation+therapy+in+rectal+cancer. assertion.
- assertion asSentence TIMP-1+and+RECK%2C+are+expressed+in+a+reproducible%2C+specific+pattern+and+if+the+profiles+are+related+to+prognosis+and+clinical+outcome+in+prostate+cancer+%28PC%29. assertion.
- assertion asSentence TIMP-2+expression+in+breast+cancer+is+related+to+survival. assertion.
- assertion asSentence The+expression+of+TIMP2+is+significantly+decreased+in+floppy+valves+compared+to+normal+valves. assertion.
- assertion asSentence Incidental+clear+cell+renal+cell+carcinomas+strongly+expressing+MMP-9+and+TIMP-2+have+a+higher+nulclear+grade%28worse+prognosis%29. assertion.
- assertion asSentence TIMP-2+G-418C+polymorphism+increases+risk+of+gastric+cancer+in+a+Chinese+population%2C+especially+in+younger+subjects+and+smokers. assertion.
- assertion asSentence The+TIMP-2+-418G%3EC+polymorphism+is+significantly+associated+with+an+increased+susceptibility+to+atrial+fibrillation+in+Chinese+Han+patients+with+hypertensive+heart+disease. assertion.
- assertion asSentence TIMP-2+protein+level+also+increased+significantly+in+the+hypoxia%2Freoxygenation+groups%2C+compared+with+the+normoxic+group. assertion.
- assertion asSentence The+TIMP-2+gene+is+a+disease-modifier+gene+of+thoracic+adolescent+idiopathic+scoliosis. assertion.
- assertion asSentence TIMP-2+integrin-binding+peptides+retain+anti-mitogenic+activity+in+vascular+endothelial+growth+factor+A+stimulated+human+microvascular+endothelial+cells. assertion.
- assertion asSentence In+hepatocellular+carcinoma+miR-519d+is+up-regulated+by+p53+and+DNA+hypomethylation+and+targets+CDKN1A%2Fp21%2C+PTEN%2C+AKT3+and+TIMP2. assertion.
- assertion asSentence TIMP-3+promotes+apoptosis+in+melanoma+cells+through+stabilization+of+three+distinct+death+receptors+and+activation+of+their+apoptotic+signaling+cascade+through+caspase-8. assertion.
- assertion asSentence TIMP-3+has+a+role+in+the+pericyte-induced+stabilization+of+newly+formed+vascular+networks+that+are+predisposed+to+undergo+regression+and+reveal+specific+molecular+targets+of+the+inhibitors+regulating+these+events. assertion.
- assertion asSentence Increased+mesenchymal+stem+cell+culture+confluence+impairs+migration+and+is+related+to+an+upregulation+of+TIMP-3. assertion.
- assertion asSentence The+C-terminal+domains+of+ADAMTS-4+and+ADAMTS-5+affect+the+structure+around+the+active+site%2C+favouring+interaction+with+TIMP-3. assertion.
- assertion asSentence Overexpression+of+TIMP3+mRNA+is+associated+with+head+and+neck+cancer. assertion.
- assertion asSentence Systemic+insulin+resistance+and+subclinical+atherosclerosis+are+associated+with+decreased+IRS2+and+TIMP3+expression+in+circulating+monocytes. assertion.
- assertion asSentence Peroxynitrite-induced+nitration+and+oligomerization+of+TIMP-4+attenuated+its+inhibitory+activity+against+MMP-2+activity+and+endothelial+or+tumor+cell+invasiveness. assertion.
- assertion asSentence A+cardiopulmonary+vasculature-specific+role+of+TIMP-4+activation+in+systemic+sclerosis. assertion.
- assertion asSentence MMP-10+and+-7+abundance+increased%2C+accompanied+by+decreased+TIMP-4+in+dilated+cardiomyopathy+failing+hearts+compared+with+non-failing+hearts. assertion.
- assertion asSentence Thyroid+transcription+factor-1+expression+in+four+cases+of+mammary+ductal+carcinoma. assertion.
- assertion asSentence ZO-1+accumulated+at+cell-to-cell+junctions+of+the+breast+neoplasm+cell+line. assertion.
- assertion asSentence DEP-1+interacts+with+the+tight+junction+proteins+occludin+and+ZO-1+in+a+tyrosine+phosphorylation-dependent+manner. assertion.
- assertion asSentence Compared+with+healthy+individuals%2C+zo-1+gene+in+acute+leukemia+patients+is+hypermethylated+and+with+different+degrees+in+various+phases+of+leukemia. assertion.
- assertion asSentence Activity+of+thymidine+kinase%2C+thymidine+phosphorylase+and+thymidilate+synthase+in+human+cancer+xenografts+to+investigate+the+contribution+of+these+enzymes+to+the+sensitivity+of+TAS-102. assertion.
- assertion asSentence Elevated+serum+thymidine+kinase+1+is+associated+with+pre%2Fearly+cancerous+progression. assertion.
- assertion asSentence F0F1+domain+is+essential+for+talin-induced+activation+of+integrin+alphaLbeta2+%28LFA-1%29. assertion.
- assertion asSentence FAK+promotes+talin+recruitment+to+nascent+adhesions+occurring+independently+of+talin+binding+to+beta1+integrins. assertion.
- assertion asSentence Presence+of+TLR1+239G+%3E+C+%28Arg80+%3E+Thr%29+or+the+presence+of+both+TLR1+743A+%3E+G+%28Asn248+%3E+Ser%29+and+TLR6+745C+%3E+T+%28Ser249+%3E+Pro%29+single+nucleotide+polymorphism+is+associated+with+invasive+aspergillosis+following+allogeneic+stem+cell+transplantation. assertion.
- assertion asSentence Notably%2C+among+myeloid+differentiation+transgene+MyD88-dependent+TLR%2C+only+stimulation+via+TLR1%2F2+consistently+educates+spleen+dendritic+cells+with+gut-homing+imprinting+capacity. assertion.
- assertion asSentence 3+TLR1+polymorphisms+are+associated+with+an+increased+susceptibility+for+candidemia+in+white+patients. assertion.
- assertion asSentence Glucocorticoids+synergistically+enhance+nontypeable+Haemophilus+influenzae-induced+Toll-like+receptor+2+expression+via+a+negative+cross-talk+with+p38+MAP+kinase. assertion.
- assertion asSentence Non-LPS+components+of+Chlamydia+pneumoniae+stimulate+cytokine+production+through+Toll-like+receptor+2-dependent+pathways. assertion.
- assertion asSentence TLR2+serves+as+a+costimulatory+receptor+for+antigen-specific+T+cell+development+and+participates+in+the+maintenance+of+T+cell+memory. assertion.
- assertion asSentence Innate+immune+responses+mediated+through+TLR2+play+a+role+in+augmenting+allergic+reactions%2C+in+part+by+modulating+basophil+cytokine+secretion+and+mediator+release+independently+of+NFkappaB+activation. assertion.
- assertion asSentence H.+pylori+LPS-induced+cell+activation+is+mediated+through+TLR2. assertion.
- assertion asSentence Microcrystals+of+calcium+pyrophosphate+dihydrate+and+monosodium+urate+use+TLR2-mediated+signaling+in+chondrocytes+to+trigger+NO+generation. assertion.
- assertion asSentence TLR2+is+specifically+recruited+to+the+bacterial+or+inclusion+membrane+during+a+productive+infection+with+chlamydia. assertion.
- assertion asSentence Arg753Gln+polymorphism+impacts+herpes+and+other+viral+infecions+after+transplantation. assertion.
- assertion asSentence Ganglioside+GD1a+is+an+essential+coreceptor+for+Toll-like+receptor+2+signaling+in+response+to+the+B+subunit+of+type+IIb+enterotoxin. assertion.
- assertion asSentence Homozygous+TLR2+Arg753Gln+polymorphism+is+associated+with+allograft+failure+and+mortality+after+liver+transplantation+for+chronic+hepatitis+C+virus. assertion.
- assertion asSentence Dissociation+of+Toll-like+receptor+2-mediated+innate+immune+response+to+Zymosan+by+organic+solvent-treatment+without+loss+of+Dectin-1+reactivity. assertion.
- assertion asSentence The+TLR2-+and+TLR4-stimulating+activity+of+supragingival+plaque+is+associated+with+clinical+parameters+for+gingivitis+and+periodontitis. assertion.
- assertion asSentence HSV-1-infected+monocytes+exhibit+downregulated+TLR-2+and+TLR-4. assertion.
- assertion asSentence TLR2+and+TLR3+signaling+leads+to+ras+homolog+gene+family+member+A+%28RhoA%29+activity+at+distinct+cellular+compartments. assertion.
- assertion asSentence Mal+specifically+connects+TLR2%2F6+to+PI3K+activation%2C+PIP%283%29+generation+and+macrophage+polarization. assertion.
- assertion asSentence TLR-2+polymorphisms+are+not+increased+in+Henoch+Schonlein+purpura+patients+with+and+without+renal+involvement. assertion.
- assertion asSentence TLR2+gene+Arg753Gln+polymorphism+is+not+associated+with+Behcet+disease+nor+with+rheumatic+heart+disease. assertion.
- assertion asSentence Isolated+Behcet+disease+neutrophils+do+not+overexpress+TLR2+neither+overreact+to+lipoteichoic+acid. assertion.
- assertion asSentence Schistosoma+mansoni+antigens+exert+potent+regulatory+effects+on+both+dendritic+cells+and+B+cells+through+TLR2+regulation+conducted+via+different+signaling+pathways+in+infected+multiple+sclerosis+patients. assertion.
- assertion asSentence Toll-like+receptor+2-mediated+peptidoglycan+uptake+by+immature+intestinal+epithelial+cells+from+apical+side+and+exosome-associated+transcellular+transcytosis. assertion.
- assertion asSentence TLR2+and+TLR4+expression+and+signaling+are+increased+in+Type+1+diabetics+with+microvascular+complications+as+compared+with+levels+in+Type+1+diabetics+without+microvascular+complications. assertion.
- assertion asSentence The+Arg753Gln+TLR2+polymorphism+occurred+in+2+out+of+38+severe+sepsis+patients. assertion.
- assertion asSentence Substance+P+primes+TLR2-mediated+activation+of+human+mast+cells+by+up-regulating+TLR+expression+and+potentiating+signalling+pathways+associated+with+TLR. assertion.
- assertion asSentence TLR2+is+developmentally+expressed+from+the+early+pseudoglandular+stage+of+lung+development+to+the+canalicular+stage. assertion.
- assertion asSentence Direct+binding+of+beta+2-glycoprotein+I+on+the+endothelial+cell+surface+occurs+through+direct+interaction+with+TLR2. assertion.
- assertion asSentence PAUF+induces+extracellular+signal-regulated+kinase+phosphorylation+and+activates+the+IKK-b-mediated+TPL2%2FMEK%2FERK+signaling+pathway+through+TLR2. assertion.
- assertion asSentence High+TLR2+is+associated+with+renal+diseases. assertion.
- assertion asSentence TLR2+and+TLR4+expression+is+increased+in+dendritic+cells+from+HIV-1-coinfected+patients+with+opportunistic+infections. assertion.
- assertion asSentence Notably%2C+among+myeloid+differentiation+transgene+MyD88-dependent+TLR%2C+only+stimulation+via+TLR1%2F2+consistently+educates+spleen+dendritic+cells+with+gut-homing+imprinting+capacity. assertion.
- assertion asSentence TLR2+stimulation%2C+in+combination+with+TCR+activation+and+costimulation%2C+promotes+the+differentiation+of+distinct+subsets+of+human+naive+and+memory%2Feffector+Tregs+into+a+Th17-like+phenotype+and+their+expansion. assertion.
- assertion asSentence A+rare+polymorphism+in+the+gene+for+Toll-like+receptor+2+is+associated+with+systemic+sclerosis+phenotype+and+increases+the+production+of+inflammatory+mediators. assertion.
- assertion asSentence TLR2+agonist+bacterial+lipoprotein+%28BLP%29+significantly+enhances+proinflammatory+cytokine+release+in+response+to+monocyte+or+peripheral+blood+mononuclear+leukocyte+stimulation+by+BLP. assertion.
- assertion asSentence Toll-like+receptor+%28TLR%29+2+is+upregulated+on+peripheral+blood+monocytes+of+patients+with+psoriatic+arthritiS. assertion.
- assertion asSentence Expression+of+TLR2+and+TLR4+in+peripheral+blood+mononuclear+cells+are+markedly+elevated+in+patients+with+late+onset+Alzheimer%27s+disease. assertion.
- assertion asSentence Herpes+simplex+virus+1+glycoproteins+gH%2FgL+and+gB+bind+Toll-like+receptor+2+to+activate+NF-kappaB. assertion.
- assertion asSentence TLR3+is+induced+on+human+astrocytes+upon+inflammation+and+when+activated%2C+mediates+a+comprehensive+neuroprotective+response+rather+than+a+polarized+pro-inflammatory+reaction. assertion.