Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence sTNFR1+levels+are+higher+in+children+with+IDDM%2C+correlate+with+anthropometric+parameters+and+do+not+depend+on+the+kind+of+insulin+therapy. assertion.
- assertion asSentence The+disease-related+protein+modifications+alter+Ca%282%2B%29+binding+by+influencing+both+the+association+and+dissociation+rates+of+thin+filament+Ca%282%2B%29+exchange. assertion.
- assertion asSentence Elevations+of+troponin+I+and+N-terminal+pro-B-type+natriuretic+peptide+%28NT-proBNP%29+are+common+in+patients+with+atrial+fibrillation+and+independently+related+to+increased+risks+of+stroke+and+mortality. assertion.
- assertion asSentence Structure+and+dynamics+of+the+C-domain+of+human+cardiac+troponin+C+in+complex+with+the+inhibitory+region+of+human+cardiac+troponin+I. assertion.
- assertion asSentence Impairment+in+the+regulatory+function+of+cardiac+troponin+TnI+by+the+mutation+Arg145Gly+leads+to+modulations+in+crossbridge+kinetics+that+significantly+alter+the+dynamics+of+myofibrillar+contraction+and+relaxation. assertion.
- assertion asSentence The+regulatory+N-terminal+domain+of+cardiac+TnI+is+a+dominant+factor+for+the+incompatibility+in+bacterial+cells%2C+supporting+its+role+in+modulating+the+overall+molecular+conformation. assertion.
- assertion asSentence Postmortem+cardiac+troponin-I+levels+predict+intramyocardial+damage+at+autopsy. assertion.
- assertion asSentence At+8+hours+postoperatively%2C+cardiac+troponin+I+led+to+an+earlier+diagnosis+of+perioperative+myocardial+infarction+in+coronary+artery+bypass+patients. assertion.
- assertion asSentence Patients+with+lower+limb+ischemia+often+have+elevated+troponin+I+without+a+primary+cardiac+source. assertion.
- assertion asSentence Cardiac+troponin+I+is+associated+with+a+risk+of+premature+cardiovascular+death. assertion.
- assertion asSentence Postoperative+cardiac+troponin+I+is+an+independent+predictor+of+in-hospital+death+after+coronary+artery+bypass+grafting. assertion.
- assertion asSentence Deletion+of+a+genomic+segment+containing+the+cardiac+troponin+I+gene+knocks+down+expression+of+the+slow+troponin+T+gene+and+impairs+fatigue+tolerance+of+diaphragm+muscle. assertion.
- assertion asSentence cTnI+participates+in+proper+stabilization+of+tropomyosin+in+the+%22Ca%282%2B%29-activated+state%22+or+%22C-state%22+on+actin+filaments. assertion.
- assertion asSentence Troponin+elevations+are+frequent+among+patients+receiving+molecular+targeted+therapies. assertion.
- assertion asSentence Elevated+serum+troponin+T+levels+are+associated+with+different+conditions+related+to+the+severity+of+hypertrophic+cardiomyopathy. assertion.
- assertion asSentence Infantile+case+of+restrictive+cardiomyopathy+caused+by+a+de+novo+mutation+of+the+cardiac+troponin+T+gene. assertion.
- assertion asSentence Higher+levels+of+CRP%2FBNP%2Ftroponin+T+are+strong%2C+independent+predictors+of+mortality+in+community+patients+with+heart+failure. assertion.
- assertion asSentence The+combined+use+of+high-sensitivity+cardiac+troponin+T+at+presentation+and+its+early+absolute+change+discriminates+between+patients+with+myocardial+infarction+and+those+with+cardiac+noncoronary+artery+disease. assertion.
- assertion asSentence The+expression+of+tensin+is+increased+in+mesangial+cells+with+stimulating+of+high+concentrations+of+glucose. assertion.
- assertion asSentence Topoisomerase+I+and+mutants+lacking+tryptophane-205+relax+positive+supercoils+faster+than+negative+supercoils+under+both+processive+and+distributive+conditions. assertion.
- assertion asSentence The+C-terminal+CK18+fragment+exerts+an+effect+in+the+nucleolus+by+stimulating+rRNA+transcription+and+processing+via+modulation+of+enzymatic+activity+of+topoisomerase+I. assertion.
- assertion asSentence Elevated+expression+of+Topo-I+and+Topo-II+beta+is+found+in+Lewis%28y%29+antigen-overexpressing+ovarian+tumor+cells. assertion.
- assertion asSentence Clinical+samples+demonstrated+increased+TOP1+gene+copy+number+and+increased+TOP1%2Fchromosome+20+centromere+ratio. assertion.
- assertion asSentence The+role+of+topoisomerase+II+in+the+excision+of+DNA+loop+domains+during+apoptosis. assertion.
- assertion asSentence TOP2A+deletion+is+associated+with+poor+prognosis+in+ERBB2-amplified+breast+carcinomas. assertion.
- assertion asSentence Significantly+higher+DNA+topoisomerase+IIalpha+is+associated+with+relapse+in+acute+lymphocytic+leukemia. assertion.
- assertion asSentence Enhanced+expression+of+TOP-2alpha+is+positively+associated+with+a+high+rate+of+recurrence+and+progression+in+Non-Muscle-Invasive+Bladder+Cancer. assertion.
- assertion asSentence High+DNA+topoisomerase+II+alpha+in+metastatic+cells+are+associated+with+response+to+therapy+in+small+cell+lung+cancer. assertion.
- assertion asSentence Loss+of+topoisomerase+%28DNA%29+II+alpha+is+associated+with+liposarcoma. assertion.
- assertion asSentence Amplification+of+Her-2%2Fneu+and%2For+topoisomerase+IIalpha+is+associated+with+poor+overall+survival+in+breast+cancer. assertion.
- assertion asSentence The+active+DNA+topoisomerase+II+alpha+is+significantly+less+abundant+at+the+centromeres+of+BLM-deficient+cells+and+PICH-deficient+cells+than+at+those+of+control+cells. assertion.
- assertion asSentence NRF-1+can+also+directly+interact+with+poly%28ADP-ribose%29+polymerase+1+%28PARP-1%29+and+co-purify+the+PARP-1.DNA-PK.Ku80.Ku70.topoisomerase+IIbeta-containing+protein+complex. assertion.
- assertion asSentence Tyrosine+656+in+topoisomerase+II+beta+is+important+for+the+catalytic+activity+of+the+enzyme. assertion.
- assertion asSentence Restoration+of+wt-p53+activity+in+Hep3B+leads+to+sensitiveness+to+chemotherapeutic+agents+because+of+the+decrease+of+p-glycoprotein+expression. assertion.
- assertion asSentence TP53-mutated+tumors+need+fewer+additional+genetic+alterations+to+develop+metastases+in+primary+head+and+neck+tumors+compared+with+TP53+wild-type+primary+tumors. assertion.
- assertion asSentence The+low-molecular-weight+compound+PRIMA-1+restored+sequence-specific+DNA+binding+and+the+active+conformation+to+mutant+p53+proteins+in+vitro+and+in+living+cells. assertion.
- assertion asSentence The+first+direct+demonstration+of+p53+mutations+in+pleuropulmonary+blastomas+%28PPB%29suggests+p53+inactivation+can+occur+as+a+nonrandom+genetic+change+involving+the+pathogenesis+and+outcome+of+PPB. assertion.
- assertion asSentence Akt+enhances+Mdm2-mediated+ubiquitination+and+degradation+of+p53. assertion.
- assertion asSentence The+point+mutation+of+p53+gene+exon7+in+hepatocellular+carcinoma+from+Anhui+Province%2C+a+non+HCC+prevalent+area+in+China. assertion.
- assertion asSentence Recognition+of+DNA+by+p53+core+domain+and+location+of+intermolecular+contacts+of+cooperative+binding. assertion.
- assertion asSentence UVB-mediated+activation+of+p38+mitogen-activated+protein+kinase+enhances+resistance+of+normal+human+keratinocytes+to+apoptosis+by+stabilizing+cytoplasmic+p53. assertion.
- assertion asSentence Sequential+extension+of+proliferative+lifespan+in+human+fibroblasts+is+induced+by+over-expression+of+CDK4+or+6+and+loss+of+p53+function. assertion.
- assertion asSentence MDMX-mediated+regulation+of+p53+activity+during+development. assertion.
- assertion asSentence The+lack+of+Bcl2+accompanied+by+p53+overexpression+affects+the+distribution+of+cells+among+the+cell+cycle+phases+and+modifies+the+sensitivity+to+cytotoxic+drugs+and+the+type+of+cell+death. assertion.
- assertion asSentence Wild-type+p53+protein+conformation+is+stabilized+upon+CP-31398+exposure. assertion.
- assertion asSentence Affects+relative+biological+effectiveness+of+light+ions+in+human+tumoural+cell+lines. assertion.
- assertion asSentence Selection+pressures+of+TP53+mutation+and+microenvironmental+location+influence+epidermal+growth+factor+receptor+gene+amplification+in+human+glioblastomas. assertion.
- assertion asSentence The+complement+inhibitor+CD59+and+the+lymphocyte+function-associated+antigen-3+%28LFA-3%2C+CD58%29+genes+possess+functional+binding+sites+for+the+p53+tumor+suppressor+protein. assertion.
- assertion asSentence Expression+of+p53R2%2C+newly+p53+target+in+oral+normal+epithelium%2C+epithelial+dysplasia+and+squamous+cell+carcinoma. assertion.
- assertion asSentence Cooperation+of+two+mutant+p53+alleles+contributes+to+Fas+resistance+of+prostate+carcinoma+cells. assertion.
- assertion asSentence HIPK2-mediated+enhancement+of+p53-dependent+transcription%2C+p53+serine+46+phosphorylation+and+the+antiproliferative+function+of+HIPK2+strictly+rely+on+the+presence+of+PML. assertion.
- assertion asSentence The+p53+tumor+suppressor+pathway+is+disrupted+in+most+oral+squamous+cell+carcinomas+at+the+cellular+levels%2C+due+to+either+an+abnormality+in+p53+itself+or+loss+of+expression+of+p53+regulatory+factors. assertion.
- assertion asSentence Plays+a+role+in+breast+cancer+in+conjunction+with+BRCA1. assertion.
- assertion asSentence Nitric+oxide+depletion+reduces+the+presence+of+p53-DNA+complexes+after+cisplatin+treatment. assertion.
- assertion asSentence Loss+of+p53%2C+directly+or+indirectly%2C+perturbs+the+normal+regulation+of+phosphorylation+of+serine+10+in+histone+H3. assertion.
- assertion asSentence Crucial+role+of+p53+C-terminal+phosphorylation+in+the+regulation+of+its+DNA-binding+activity. assertion.
- assertion asSentence MNNG+induces+apoptosis+in+lymphoblastoid+cells+by+activating+the+p53-dependent+Fas+receptor-driven+pathway. assertion.
- assertion asSentence Inactivation+of+p53+is+a+protective+mechanism+utilized+by+cells+to+adapt+to+ER+stress. assertion.
- assertion asSentence ATR-p53+pathway+is+suppressed+in+noncycling+lymphocytes+via+ATR+downregulation. assertion.
- assertion asSentence Basal+p53+expression+in+WI38+human+embryonic+lung+fibroblasts+restricts+growth+rate+and+mediates+density-dependent+inhibition+of+growth+and+the+associated+G1+phase+arrest+of+the+cell+cycle+by+affecting+the+density-dependent+regulation+of+p16%2FINK4a. assertion.
- assertion asSentence p53+disruption+has+a+dramatic+effect+on+how+glioblastoma+cells+process+topoisomerase+I+inhibitor-mediated+DNA+damage. assertion.
- assertion asSentence Irinotecan+resistant+colorectal+cancer+lines+are+resistanst+both+in+the+presence+or+absence+of+p53. assertion.
- assertion asSentence BRCA1-BARD1+complexes+act+as+an+adaptor+to+mediate+phosphorylation+of+p53%2C+influencing+G%281%29%2FS+cell+cycle+progression+after+DNA+damage. assertion.
- assertion asSentence Disruption+of+p53-p21%2FWAF1+cell+cycle+pathways+contributes+to+tumor+progression+and+worse+clinical+outcome+of+hepataocellular+hepatoma. assertion.
- assertion asSentence No+association+between+p53+status+and+overall+survival+in+human+glioma. assertion.
- assertion asSentence Integrin+alphav+controls+melanoma+cell+survival+in+3D-collagen+through+a+pathway+involving+p53+regulation+of+MEK1+signaling. assertion.
- assertion asSentence Mutated+in+choroid+plexus+carcinoma. assertion.
- assertion asSentence Epigallocatechin-3-gallate+increased+expression+of+tumor+suppressor+protein+p53+in+brest+cancer+cells. assertion.
- assertion asSentence Effect+of+hibuscus+polyphenol+extracs+in+human+gastric+carcinoma+cells+is+mediated+via+p53+signaling+and+p38+MAPK%2FFasL+cascade+pathway. assertion.
- assertion asSentence p53+is+an+effective+repressor+of+snRNA+gene+transcription+by+RNA+polymerases+II+and+III. assertion.
- assertion asSentence Clear+need+in+human+melanoma+cell+lines+to+disrupt+both+RB+and+p53+pathways+and+recurrent+mechanisms+which+play+into+the+unique+genetic+vulnerabilities+of+this+tumor+type. assertion.
- assertion asSentence Overexpression+of+BAG-1+and+p53+plays+an+important+role+in+the+process+laryngeal+squamous+cell+carcinoma+development. assertion.
- assertion asSentence Polymorphisms+in+some+insulin-related+genes+are+associated+with+an+increased+risk+of+colon+cancer+with+specific+KRAS2+and+TP53+mutations%2C+implying+a+link+between+these+genetic+changes+and+specific+mutational+pathways+in+carcinogenesis. assertion.
- assertion asSentence The+MAPK+cascade+pathway+and+P53+pathway+can+protect+hepatocytes+by+different+mechanisms+after+liver+transplantation. assertion.
- assertion asSentence Expression+predicts+response+to+anticancer+drugs+in+advanced+hepatocellular+carcinoma. assertion.
- assertion asSentence p53+codon+72+polymorphisms+do+not+serve+as+a+susceptibility+factor+affecting+the+chances+of+miscarriage+in+an+unselected+population. assertion.
- assertion asSentence Fatty+acid+synthase+%28FAS%29+gene%2C+encoding+for+a+key+enzyme+involved+in+the+biogenesis+of+membrane+lipids+in+rapidly+proliferating+cells%2C+is+a+conserved+target+of+the+p53+family+throughout+the+evolution. assertion.
- assertion asSentence In+the+absence+of+telomerase%2C+transgenic+p53+mice+aged+with+the+same+kinetics+and+pathological+spectrum+as+p53+wild+type+mice. assertion.
- assertion asSentence DeltaNp63alpha+would+downregulate+p53+in+response+to+DNA+damage. assertion.
- assertion asSentence Finds+a+corrrelation+between+the+p53+codon+72+polymorphism+and+location+of+gastric+cancer+in+Korea. assertion.
- assertion asSentence GAS41+plays+a+role+in+repressing+the+p53+tumor+suppressor+pathway+during+the+normal+cell+cycle+by+a+TIP60-independent+mechanism. assertion.
- assertion asSentence The+multiple+biological+activities+of+p53+are+orchestrated+and+deciphered+by+different+%22p53+cassettes%2C%22+each+containing+combination+patterns+of+posttranslational+modifications+and+protein-protein+interactions. assertion.
- assertion asSentence Defective+DNA+mismatch+repair+and+TP53+defects+are+common+early+events+in+carcinosarcoma+tumorigenesis. assertion.
- assertion asSentence Tumour+protein+p53+plays+a+role+in+facilitating+histone+H2AX+phosphorylation%2C+an+important+step+in+the+mobilization+of+the+DNA+repair+machinery+at+the+site+of+DNA+double-strand+breaks. assertion.
- assertion asSentence p53+expression+is+not+an+independent+prognostic+predictor+of+progression-free+survival+or+overall+survival+in+ovarian+cancer. assertion.
- assertion asSentence RNPC1a+is+required+to+maintain+the+stability+of+p21+transcript+induced+by+p53. assertion.
- assertion asSentence PCNA+is+not+significally+increased+in+proliferative+endometrial+carcinoma. assertion.
- assertion asSentence MDMX+is+an+important+regulator+of+p53+response+to+ribosomal+stress+and+RNA-targeting+chemotherapy+agents. assertion.
- assertion asSentence Smad7+plays+a+crucial+role+upstream+of+ATM+and+p53+to+protect+the+genome+from+insults+evoked+by+extracellular+stress. assertion.
- assertion asSentence Cytoplasmic+monoubiquitylated+p53%2C+generated+by+Mdm2-type+ligases%2C+is+subject+to+a+binary+switch+from+inactivation+via+subsequent+polyubiquitylation+and+degradation+in+unstressed+cells%2C+to+activation+via+mitochondrial+trafficking. assertion.
- assertion asSentence No+siatistically+significant+value+in+assocation+with+survival+or+event-free+survival+in+head+and+neck+squamous+cell+carcinoma. assertion.
- assertion asSentence Cancer-associated+mutant+p53+can+augment+the+induction+of+nuclear+factor+kappaB+%28NFkappaB%29+transcriptional+activity+in+response+to+the+cytokine+tumor+necrosis+factor+alpha+%28TNFalpha%29. assertion.
- assertion asSentence A+complex+between+tetrameric+p53+and+p300+in+which+four+domains+of+p300+wrap+around+the+four+transactivation+domains+of+p53. assertion.
- assertion asSentence The+ability+of+mutant+p53+to+prevent+arrest+induced+by+replicational+stress+per+se+is+primarily+dependent+on+preventing+p21CIP1+up-regulation. assertion.
- assertion asSentence Alterations+in+TGF-betaRII%2C+BAX%2C+IGFIIR%2C+caspase-5%2C+hMSH3+and+hMSH6+genes+of+microsatellite+instability+are+rare+in+urinary+bladder+carcinoma+and+they+are+not+associated+with+microsatellite+instability+or+the+presence+of+p53+mutations. assertion.
- assertion asSentence HPV18+E6+oncoprotein+contributes+to+tumor+angiogenesis+by+inducing+VEGF+transcription+from+the+promoter+in+a+p53-independent+manner. assertion.
- assertion asSentence Azurin+binds+to+the+flexible+L%281%29+and+s%287%29-s%288%29+loops+of+the+p53+DBD+and+stabilizes+them+through+protein-protein+tight+packing+interactions. assertion.
- assertion asSentence p53+codon-249+mutations+are+associated+with+X-ray+repair+cross+complementing+protein+1+polymorphism+Arg399Gln+among+the+Guangxi+population+of+China. assertion.
- assertion asSentence Wip1+acts+as+a+gatekeeper+in+the+Mdm2-p53+regulatory+loop+by+stabilizing+Mdm2+and+promoting+Mdm2-mediated+proteolysis+of+p53. assertion.
- assertion asSentence The+acetylation+of+two+lysine+residues+in+p53+promotes+recruitment+of+the+TFIID+subunit+TAF1+to+the+p21+promoter+through+its+bromodomains. assertion.