Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence CP-31398+induced+mitochondrial+translocation+of+p53%2C+leading+to+changes+in+mitochondrial+membrane+permeability+pore+transition+%28MPT%29+and+consequent+cytochrome+c+release+in+these+cells. assertion.
- assertion asSentence The+culture+of+cells+in+the+Cl%28-%29-replaced+medium+significantly+increased+expressions+of+p21+mRNA+and+protein+without+any+effects+on+p53. assertion.
- assertion asSentence There+is+heterogeneity+in+the+requirement+for+transactivation+subdomains+1+and+2+of+p53+without+any+subdomain-specific+contribution+to+p53-induced+gene+expression. assertion.
- assertion asSentence p53+mutation+spectra+and+differences+with+histology+in+lung+cancers. assertion.
- assertion asSentence P53+mutations+are+associated+with+higher+levels+of+Intratumoral+T+cells. assertion.
- assertion asSentence p53+is+of+limited+value+only%2C+being+largely+overshadowed+by+the+prognostic+capability+of+FIGO+stage+and+extent+of+residual+disease. assertion.
- assertion asSentence Tubal+p53+signature+merits+serious+consideration+as+an+important+early+event+in+serous+carcinogenesis+in+BRCA%2B+women. assertion.
- assertion asSentence p53+single-nucleotide+polymorphism+is+associated+with+the+early+development+of+hepatocellular+carcinoma+in+Korean+patients+with+chronic+HBV+infection. assertion.
- assertion asSentence Fbw7+regulates+the+activity+of+endoreduplication+mediators+and+the+p53+pathway+to+prevent+drug-induced+polyploidy. assertion.
- assertion asSentence Expressed+in+most+dysmorphic+neurons+in+focal+cortical+dysplasia+type+II. assertion.
- assertion asSentence Damage+of+exon+5+of+p53+gene+by+arsenic+is+associated+with+precarcinomas+and+carcinomas. assertion.
- assertion asSentence Its+loss+of+function+is+critical+for+the+molecular+pathogenesis+of+uterine+papillary+serous+carcinoma. assertion.
- assertion asSentence p53-independent+events+regulating+expression+of+protein-coding+genes+and+microRNAs+within+the+network+can+define+the+cellular+outcome+of+p53+activation. assertion.
- assertion asSentence STX6+can+be+induced+by+DNA+damage+and+Mdm2+inhibitor+Nutlin-3+in+a+p53-dependent+manner. assertion.
- assertion asSentence The+protein+structure+prediction+of+CP2+family+in+order+to+elucidate+the+molecular+mechanism+of+the+CP2-directed+regulation+of+gene+expression. assertion.
- assertion asSentence Knockdown+of+endogenous+MBP-1+is+involved+in+cellular+senescence+of+HFF+through+p53-p21+pathway. assertion.
- assertion asSentence Mdm2+regulates+p53+levels+also+by+targeting+ribosomal+protein+L26+for+polyubiquitylation+and+proteasomal+degradation. assertion.
- assertion asSentence JS-K+inhibits+E1+activity+and+kills+transformed+cells+harboring+wild-type+p53. assertion.
- assertion asSentence E6+F47R-induced+cellular+senescence+is+strongly+dependent+on+p53+signaling+pathway. assertion.
- assertion asSentence The+inactivation+of+TP53+is+similar+in+familial+pancreatic+adenocarcinomas+as+in+sporadic+pancreatic+adenocarcinomas. assertion.
- assertion asSentence Alterations+in+both+the+p53+and+p16-Rb+pathways+are+associated+with+squamous+cell+carcinoma+arising+in+mature+cystic+teratoma. assertion.
- assertion asSentence Additional+inactivation+of+p53+in+malignant+primaries+and+benign+recurrences+contributes+to+myoepithelial+neoplastic+transformation+and+aggressive+tumour+growth. assertion.
- assertion asSentence The+switch+from+Mnt-Max+to+Myc-Max+during+bile+duct+ligation+%28cholestasis%29+and+in+hepatocytes+treated+with+lithocholic+acid+is+responsible+for+the+induction+in+p53+and+cyclin+D1+expression+and+contributes+to+apoptosis. assertion.
- assertion asSentence The+essential+role+of+p53+in+hyperpigmentation+of+the+skin+via+the+regulation+of+paracrine-cytokine+signaling%2C+both+in+keratinocytes+and+in+melanocytes. assertion.
- assertion asSentence Up-regulation+of+p53+gene+expression+is+associated+with+virus-mediated+induction+of+type-I+interferons. assertion.
- assertion asSentence A+role+for+p53+in+mediating+altered+trophoblast+cell+turnover+in+response+to+oxidative+stress. assertion.
- assertion asSentence Only+a+small+fraction+of+naturally+occurring+sequence+variations+of+TP53+cause+measurable+perturbation+of+p53+function. assertion.
- assertion asSentence TBX2+is+a+cell+type-dependent+survival+factor+under+a+p53-negative+background. assertion.
- assertion asSentence Depletion+of+the+outer+kinetochore+protein+hBub1+upon+activation+of+SAC+primarily+triggers+early+cell+death+mediated+by+p53. assertion.
- assertion asSentence P53+gene+mutations+are+significantly+correlated+with+p53+protein+over-expression+in+adenocarcinoma+of+gastric+cancer+patients+from+India. assertion.
- assertion asSentence AP-1+binds+to+the+p53+gene+promoter+region+and+regulates+its+expression+in+A549+cells. assertion.
- assertion asSentence Artemis+and+DNA-PKcs+participate+in+a+new%2C+signaling+pathway+to+modulate+p53+function+in+response+to+oxidative+stress+produced+by+mitochondrial+respiration. assertion.
- assertion asSentence Both+Forkhead+Transcription+Factor+3a+and+Tumor+Suppressor+Protein+p53+gene+expression+change+under+various+stresses%2C+leading+to+diverse+physiological+functions. assertion.
- assertion asSentence p53+is+primarily+protective+against+ultraviolet+rays-induced+apoptosis+in+primary+human+fibroblasts+and+this+activity+of+p53+does+not+require+DDB2. assertion.
- assertion asSentence The+expressions+of+p53%2C+p21+and+Ki67+proteins+are+closely+related+with+the+pathogenesis+and+progression+of+nasal+NK%2FT-cell+lymphoma. assertion.
- assertion asSentence A+method+developed+to+predict+the+effects+of+mutations+in+the+p53+cancer+suppressor+gene%2C+a+protein+that+is+involved+in+over+50%25+of+all+human+cancers. assertion.
- assertion asSentence A+proline+in+position+72+of+p53+increases+the+risk+of+cervical+carcinoma+in+Chinese+population. assertion.
- assertion asSentence miR-34a+contributes+to+megakaryocytic+differentiation+of+K562+cells+independently+of+p53. assertion.
- assertion asSentence Allelic+imbalance+at+p53+and+microsatellite+instability+are+associated+with+resistance+to+chemotherapy+in+gastric+carcinoma. assertion.
- assertion asSentence GPR87+knockdown+sensitized+cancer+cells+to+DNA+damage-induced+growth+suppression+via+enhanced+p53+stabilization+and+activation. assertion.
- assertion asSentence SIK1+links+LKB1+to+p53-dependent+anoikis+and+suppresses+metastasis. assertion.
- assertion asSentence Alemtuzumab+is+effective+irrespective+of+genetic+high-risk+subgroups+with+TP53+mutations. assertion.
- assertion asSentence TP53+increased+in+high-grade+invasive+ductal+breast+carcinoma+compared+to+DCIS. assertion.
- assertion asSentence The+levels+of+transcriptionally+inactive+native+protein+with+inactivating+mutations+in+the+transactivation+domain+correlated+strongly+with+p53+stability. assertion.
- assertion asSentence The+prolyl+cis%2Ftrans+isomerase+cyclophilin+18+interacts+with+the+tumor+suppressor+p53+and+modifies+its+functions+in+cell+cycle+regulation+and+apoptosis. assertion.
- assertion asSentence p53+repression+of+SHP-1+expression+leads+to+trkA-Y674%2FY675+phosphorylation+and+trkA-dependent+suppression+of+breast-cancer+cell+proliferation. assertion.
- assertion asSentence Sgk1+activates+MDM2-dependent+p53+ubiquitylation. assertion.
- assertion asSentence TP53+mutations+in+myeloid+malignancies+are+either+homozygous+or+hemizygous+due+to+copy+number-neutral+loss+of+heterozygosity+or+deletion+of+17p. assertion.
- assertion asSentence Mutation+at+K351N+of+transformation+suppressor+p53+has+a+reduced+ability+to+bind+DNA+and+to+trans-activate+its+specific+target+gene+promoters%2C+such+as+bax. assertion.
- assertion asSentence p53+Mutation+is+associated+with+pathological+response+to+chemoradiotherapy+in+locally+advanced+esophageal+cancer. assertion.
- assertion asSentence MDM2+binding+region+in+p53TAD+%28residues+S15+to+N29%29+is+responsible+for+Bcl-XL+binding. assertion.
- assertion asSentence The+genes+that+induced+their+mRNAs+at+the+highest+levels+compared+to+the+baseline+tended+to+be+synthesized+better+by+the+p53-arginine+protein+than+the+p53-proline+protein. assertion.
- assertion asSentence Nuclear+p53+protein+expression+is+strongly+associated+with+TP53+deletion+in+chronic+lymphocytic+leukemia. assertion.
- assertion asSentence CTCF+protects+the+p53+gene+promoter+against+repressive+histone+marks. assertion.
- assertion asSentence Wild-type+p53-induced+phosphatase+1+dephosphorylates+histone+variant+gamma-H2AX+and+suppresses+DNA+double+strand+break+repair. assertion.
- assertion asSentence Changes+of+P53+transcriptional+activity+play+an+important+role+in+the+development+of+gastric+cancer. assertion.
- assertion asSentence TP53+gene+mutations+occur+in+some+of+endometrioid+endometrial+cancers+in+the+presence+of+PTEN+gene+mutations. assertion.
- assertion asSentence Tp53+mutations+are+associated+with+high-grade+gliomas. assertion.
- assertion asSentence Both+p53+and+p73+have+distinct+and+cooperative+roles+in+mediating+cell+cycle+arrest+and+apoptosis+in+response+to+aurora+kinase+inhibition. assertion.
- assertion asSentence Loss+of+p53%2C+rather+than+beta-catenin+overexpression%2C+induces+survivin-mediated+resistance+to+apoptosis+in+an+esophageal+cancer+cell+line. assertion.
- assertion asSentence ATDC+increases+cell+proliferation+via+inhibition+of+p53+nuclear+activities. assertion.
- assertion asSentence p53+is+both+indispensable+and+sufficient+for+the+radiation+effect+inducing+synergistic+activation+of+PAI-1+by+radiation+and+TGF-beta. assertion.
- assertion asSentence The+increased+expression+of+p53+mediates+silica-induced+cell+cycle+change+and+inhibits+silica-induced+DNA+double+strand+breaks+repair+in+lung+fibroblasts. assertion.
- assertion asSentence TP53+mutations+are+associated+with+subgroups+of+early-onset+breast+cancer. assertion.
- assertion asSentence In+p53-deficient+hepatoma%2C+there+are+no+significant+changes+in+cell+proliferation+and+survival. assertion.
- assertion asSentence 37%25+of+the+myeloma+patients+with+del%2817p%29+present+a+TP53+mutation+versus+0%25+in+patients+lacking+the+del%2817p%29. assertion.
- assertion asSentence Gain+of+cellular+adaptation+due+to+prolonged+p53+impairment+leads+to+functional+switchover+from+p53+to+p73+during+DNA+damage+in+acute+myeloid+leukemia+cells. assertion.
- assertion asSentence High+TP53+is+associated+with+endometrial+cancer. assertion.
- assertion asSentence Differences+in+expression+levels+of+apoptosis-+and+proliferation-controlling+proteins+define+distinct+prognostic+subgroups+of+chronic+lymphocytic+leukemia+and+uncover+a+correlation+of+levels+of+CDK4%2C+P27+and+P53+proteins+with+higher+hierarchical+risk. assertion.
- assertion asSentence NPM%2FB23+plays+an+important+role+in+protecting+cells+from+radiation-induced+apoptosis+and+increasing+polyploidy+formation+via+either+a+p53+or+non-p53+pathway. assertion.
- assertion asSentence Histone+deacetylase+inhibitors+valproic+acid+and+depsipeptide+sensitize+retinoblastoma+cells+to+radiotherapy+by+increasing+H2AX+phosphorylation+and+p53+acetylation-phosphorylation. assertion.
- assertion asSentence Arg72Pro+TP53+polymorphism+is+associated+with+cancer+susceptibility. assertion.
- assertion asSentence For+diagnosis+of+BK+virus+infection+in+renal+allograft+biopsies%2C+p53+staining+is+a+sensitive+and+specific+method+when+used+along+with+SV40+staining. assertion.
- assertion asSentence SPARC+regulates%2C+in+a+cell-autonomous+manner%2C+cell+cycle+progression+and+proliferation+through+the+p53%2Fp21%28Cip1%2FWaf1%29+pathway. assertion.
- assertion asSentence CHIP-dependent+p53+regulation+occurs+specifically+during+senescence. assertion.
- assertion asSentence p53+accumulates+selectively+in+the+erythroid+lineage+in+primary+human+hematopoietic+progenitor+cells+after+expression+of+shRNAs+targeting+RPS14%2C+the+ribosomal+protein+gene+deleted+in+the+5q-syndrome%2C+or+RPS19. assertion.
- assertion asSentence The+p53+inhibits+transcriptional+elongation+from+the+HIV-1+promoter+by+preventing+ther+phosphorylation+of+the+CTD+of+polII+on+serine+2. assertion.
- assertion asSentence TP53+polymorphism+with+carriers+of+the+MDM2+SNP309+G+allele+is+associated+with+non-melanoma+skin+cancer. assertion.
- assertion asSentence TP53+codon+72+polymorphism+is+associated+with+cancer. assertion.
- assertion asSentence The+association+between+BMI+and+diabetes+depends+on+p53+polymorphism. assertion.
- assertion asSentence The+primate-specific+Alu+repeats+play+an+important+role+in+shaping+the+p53+regulatory+network+in+the+context+of+chromatin. assertion.
- assertion asSentence The+researchers+found+that+the+TP53+polymorphism+Pro72Arg+is+associated+with+the+development+of+coronary+artery+disease+in+a+population+of+Chilean+individuals. assertion.
- assertion asSentence TP53+gene+polymorphisms+is+associated+with+sporadic+breast+cancer. assertion.
- assertion asSentence The+DNA-binding+domain+of+human+p53%2C+usually+defined+as+residues+94-292%2C+extends+beyond+these+domain+boundaries. assertion.
- assertion asSentence TP53+mutation+does+not+necessarily+lead+to+a+loss+of+p53+protein+response. assertion.
- assertion asSentence Hsp90+interacts+with+p53+by+multiple+transient+interactions%2C+forming+a+dynamic+heterogeneous+manifold+of+conformational+states+that+resembles+a+molten+globule. assertion.
- assertion asSentence p53+mutations+contribute+to+multipolar+mitoses+in+esophageal+cancer+cells. assertion.
- assertion asSentence Cathepsin+L+is+present+in+the+nucleus+and+regulates+the+transcription+of+effector+caspases+3+and+7%2C+in+a+p53+dependent+manner. assertion.
- assertion asSentence Epirubicin+and+its+cellular+effectors+p53+and+E2F1+modulate+FOXM1+transcription+through+an+E2F-binding+site+located+within+the+proximal+promoter+region. assertion.
- assertion asSentence Maslinic+acid+induces+apoptosis+in+human+HT29+colon-cancer+cells+through+the+JNK-Bid-mediated+mitochondrial+apoptotic+pathway+via+the+activation+of+p53. assertion.
- assertion asSentence Silencing+of+frataxin+gene+expression+triggers+p53-dependent+apoptosis+in+human+neuron-like+cells. assertion.
- assertion asSentence S27a+plays+a+non-redundant+role+in+mediating+p53+activation+in+response+to+ribosomal+stress+via+interplaying+with+MDM2. assertion.
- assertion asSentence MdmX+protein+is+essential+for+Mdm2+protein-mediated+p53+polyubiquitination. assertion.
- assertion asSentence HER-2+and+p53+have+important+prognostic+value+in+breast+cancer+and+should+be+considered+collectively. assertion.
- assertion asSentence Mutations+in+TP53+is+associated+with+ulcerative+colitis-associated+colon+cancer. assertion.
- assertion asSentence Polymorphisms+in+TP53+gene+is+associated+with+lung+squamous+cell+carcinoma. assertion.
- assertion asSentence p53-Inducible+DHRS3+is+an+endoplasmic+reticulum+protein+associated+with+lipid+droplet+accumulation. assertion.
- assertion asSentence A+restricted+pattern+of+p53+overexpression+is+preferentially+associated+with+microsatellite+instability+high+phenotype. assertion.
- assertion asSentence ProteIn+p53+is+involved+late+in+the+process+of+tumour+progression+and+is+predictive+of+a+poor+prognosis+in+squamous+cell+carcinoma+of+the+uterine+cervix. assertion.
- assertion asSentence Penta-O-galloyl-alpha-D%3A-glucopyranose+treatment+elevated+p53+levels%2C+induced+p53+phosphorylation+and+nuclear+translocation+in+RKO+cels. assertion.