Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence The+nuclear+exporter%2C+Crm1%2C+is+regulated+by+NFY+and+Sp1+in+cancer+cells+and+repressed+by+p53+in+response+to+DNA+damage. assertion.
- assertion asSentence The+TP53+PIN3+polymorphism+has+a+sex-specific+effect+on+the+risk+of+cancer+in+TP53+mutation+carriers. assertion.
- assertion asSentence Resveratrol+induces+p53-independent%2C+X-linked+inhibitor+of+apoptosis+protein+%28XIAP%29-mediated+Bax+protein+oligomerization+on+mitochondria+to+initiate+cytochrome+c+release+and+caspase+activation. assertion.
- assertion asSentence Suppression+of+Polo+like+kinase+1+%28PLK1%29+by+p21%28Waf1%29+mediates+the+p53-dependent+prevention+of+caspase-independent+mitotic+death. assertion.
- assertion asSentence The+expression+levels+of+PCNA%2C+Ki-67%2C+Bcl-2+and+mP53+are+significantly+increased+in+the+pterygium+samples+as+compared+to+the+normal+conjunctiva+samples. assertion.
- assertion asSentence MIB-1+and+p53+immunohistochemistry+do+not+correlate+with+aggressive+features+in+the+most+common+type+of+giant+pituitary+adenoma. assertion.
- assertion asSentence Arsenic+pollution+caused+by+coal-burning+can+cause+the+hypermethylation+of+p53+gene+in+promoter+region%2C+hypomethylation+and+mutation+of+p53+gene. assertion.
- assertion asSentence High+Tp53+is+associated+with+prostate+cancer+recurrence. assertion.
- assertion asSentence In+the+absence+of+the+G1+checkpoint%2C+mitotic+catastrophe+occurs+in+p53-null+cells. assertion.
- assertion asSentence Increased+expression+of+14-3-3+gamma+in+lung+cancer+coincides+with+loss+of+functional+p53. assertion.
- assertion asSentence Viral+capture+of+an+ankyrin-like+domain+in+Epstein-Barr+virus+BZLF1+ZEBRA+protein+provides+a+mechanism+for+binding+to+proteins+in+the+NF-kappaB+and+p53+transcription+factor+families. assertion.
- assertion asSentence p53-independent+epigenetic+repression+of+the+p21%28WAF1%29+gene+in+T-cell+acute+lymphoblastic+leukemia. assertion.
- assertion asSentence Mutant+p53+drives+multinucleation+and+breast+cancer+invasion+through+a+process+that+is+suppressed+by+ANKRD11. assertion.
- assertion asSentence Reactive+oxygen+species+accumulation+and+G2%2FM+cell+cycle+arrest+contributed+to+the+apoptosis+process+through+the+TNF-alpha%2C+NF-kappaB%2C+JNK+and+p53+regulation+pathway+in+HepG2+cells+treated+with+tubeimoside-1. assertion.
- assertion asSentence High+expression+of+the+p53+gene+is+associated+with+chronic+lymphocytic+leukemia. assertion.
- assertion asSentence TP53+codon+72+polymorphisms+is+not+associated+with+recurrence+in+Wilms+tumors. assertion.
- assertion asSentence RAD6+can+form+a+ternary+complex+with+MDM2+and+p53+that+contributes+to+the+degradation+of+p53. assertion.
- assertion asSentence Mutations+of+TP53+are+associated+with+Skin+tumors+induced+by+sorafenib. assertion.
- assertion asSentence p53+binding+sites+reside+in+distinct+genomic+landscapes+in+normal+and+cancer-derived+human+cells. assertion.
- assertion asSentence Promoter-localized+deacetylation+of+H3+tails+is+a+prerequisite+for+VprBP+to+tether+and+act+as+a+bona+fide+inhibitor+at+p53+target+genes. assertion.
- assertion asSentence Polymorphism+R72P+of+TP53+gene+is+associated+with+human+aging+and+longevity. assertion.
- assertion asSentence A+favorable+role+of+Delta40p53+in+patients+with+mucinous+ovarian+cancer. assertion.
- assertion asSentence TRIM8+is+a+p53+direct+target+gene+that+induces+p53+stabilization+and+promotes+the+degradation+of+MDM2+protein. assertion.
- assertion asSentence BRCA1+and+BRCA2+mutations+correlate+with+TP53+abnormalities+and+presence+of+immune+cell+infiltrates+in+ovarian+high-grade+serous+carcinoma. assertion.
- assertion asSentence Genetic+variations+in+the+cell+cycle+genes+encoding+p53+and+p21+are+associated+with+idiopathic+pulmonary+fibrosis+disease+development+and+progression. assertion.
- assertion asSentence Mutations+and+polymorphisms+in+TP53+gene+are+associated+with+colorectal+cancer. assertion.
- assertion asSentence Piwil2+plays+a+role+in+anti-apoptosis+in+tumor+cells+possessing+P53+as+a+positive+regulator+of+STAT3+signaling+pathway. assertion.
- assertion asSentence Wild-type+tumor+repressor+protein+53+%28Trp53%29+promotes+ovarian+cancer+cell+survival. assertion.
- assertion asSentence High+TP53+is+associated+with+african+American+in+women+with+breast+cancer. assertion.
- assertion asSentence Furthermore%2C+the+combination+strategy+for+disruption+of+the+p53-MDM2+interaction+with+RT+demonstrated+enhanced+anti-tumor+effects+both+in+vitro+and+in+vivo. assertion.
- assertion asSentence Germline+nonsense+mutation+in+exon+8+at+codon+306+of+the+codified+region+of+the+TP53+gene+is+associated+with+Li-Fraumeni.+syndrome. assertion.
- assertion asSentence Mutations+in+TP53+is+associated+with+medulloblastomas. assertion.
- assertion asSentence Overexpression+of+Tat+protein+decreases+both+the+deacetylase+and+promoter+activity+of+SIRT1%2C+%282%29+SIRT1+inhibition+by+Tat+involves+increased+levels+of+acetylated+p53+and+%283%29+The+activation+of+p53+leads+to+subsequent+increases+in+the+expression+of+p53+target+genes%2C+p21+and+BAX. assertion.
- assertion asSentence Transcription+factor+NFAT1+activates+the+mdm2+oncogene+independent+of+p53. assertion.
- assertion asSentence DNA+damage-induced+Pc2+activation+to+the+p53+transcriptional+co-activation+through+hnRNP+K+sumoylation. assertion.
- assertion asSentence Constitutive+gamma-H2AX+and+53BP1+staining+reveals+a+subset+of+patients+with+triple+negative+breast+tumors+that+have+a+significantly+poorer+prognosis. assertion.
- assertion asSentence Mdm2+and+mdmx+prevent+ASPP1+and+ASPP2+from+stimulating+the+apoptotic+function+of+p53+by+binding+and+inhibiting+the+transcriptional+activity+of+p53. assertion.
- assertion asSentence No+associations+of+p73+G4C14-to-A4T14+at+exon+2+and+p53+Arg72Pro+polymorphisms+with+the+risk+of+digestive+tract+cancers+in+Japanese. assertion.
- assertion asSentence p53+DNA-binding+domain+plays+a+role+in+p73+interaction. assertion.
- assertion asSentence p73+regulates+transcription+of+IL-4Ralpha+through+the+unique+p73-binding+site. assertion.
- assertion asSentence PML+plays+a+crucial+role+in+modulating+p73+function. assertion.
- assertion asSentence Expression+of+RanBPM+regulates+stability+of+p73+protein. assertion.
- assertion asSentence Upregulation+of+MDR1+by+DeltaNp73alpha+is+mediated+by+interaction+with+p53+at+the+MDR1+promoter. assertion.
- assertion asSentence Kpm%2FLats2+is+involved+in+the+fate+of+p73+through+the+phosphorylation+of+YAP2+by+Kpm%2FLats2+and+the+induction+of+p73+target+genes+that+underlie+chemosensitivity+of+leukemic+cells. assertion.
- assertion asSentence Polymorphisms+in+the+P73+gene+is+associated+with+significantly+poorer+response+to+treatment+in+pancreatic+cancer+patients. assertion.
- assertion asSentence Increased+risk+of+head+and+neck+cancer+among+individuals+with+combined+p73+exon+2+G4A+and+p53+intron+3+variant+alleles+and+a+protective+effect+for+those+carrying+the+p53+exon+4-p53+intron+6+diplotype+combination. assertion.
- assertion asSentence C16orf35+can+modulate+differentially+the+specific+activities+of+selected+p73+isoforms. assertion.
- assertion asSentence p73+G4C14-A4T14+polymorphism+has+no+significant+relationship+to+the+cisplatin-based+chemosensitivity+in+human+lung+adenocarcinoma. assertion.
- assertion asSentence Gain+of+cellular+adaptation+due+to+prolonged+p53+impairment+leads+to+functional+switchover+from+p53+to+p73+during+DNA+damage+in+acute+myeloid+leukemia+cells. assertion.
- assertion asSentence p73+are+widely+detected+in+pyramidal+neurons+of+the+adult+human+cortex+and+hippocampus+at+protein+and+mRNA+levels. assertion.
- assertion asSentence MFG-E8+is+a+p63%2Fp73+target+gene+in+breast+cancer. assertion.
- assertion asSentence Aurora-A+phosphorylation+of+p73+at+serine235+abrogates+its+transactivation+function+and+causes+cytoplasmic+sequestration+in+a+complex+with+the+chaperon+protein+mortalin. assertion.
- assertion asSentence Mammary+epithelial+cell+polarity+is+regulated+differentially+by+p73+isoforms+via+epithelial-to-mesenchymal+transition. assertion.
- assertion asSentence The+mRNA+expression+of+trophoblast+glycoprotein+is+up-regulated+in+cells+circulating+within+blood+from+women+with+preeclampsia. assertion.
- assertion asSentence The+positive+heterosis+effects+with+respect+to+nicotine+addiction+and+personality+support+the+idea+that+the+TPH1+gene+exerts+pleiotropic+effects. assertion.
- assertion asSentence The+A218C+SNP+in+TPH1+is+not+associated+with+completed+suicide. assertion.
- assertion asSentence TPH1+gene+is+implicated+in+depression. assertion.
- assertion asSentence Allele+frequencies+of+three+TPH2+variants+and+a+TPH1+variant+vary+significantly+among+four+ethnic+groups+with+heroid+adddiction. assertion.
- assertion asSentence The+effect+of+TPH+gene+polymorphism+on+TMD+development+and+whether+AA+genotype+or+A+allele+are+preventive+factors+for+TMD+remains+unclear. assertion.
- assertion asSentence Loss+of+expression+of+TPM1+induces+anoikis+in+primary+breast+tumors. assertion.
- assertion asSentence KRAS+mutations+correlate+with+expression+of+DCN+and+TPM1+in+colorectal+cancer. assertion.
- assertion asSentence Conserved+noncanonical+residue+Gly-126+confers+instability+to+the+middle+part+of+the+tropomyosin+molecule. assertion.
- assertion asSentence The+destabilizing+effect+of+the+disease-causing+arginine91glycine+mutation+spreads+along+the+coiled-coil%2C+reflecting+the+high+extent+of+cooperativity+within+this+part+of+the+beta-tropomyosin+molecule. assertion.
- assertion asSentence De+novo+missense+mutation+in+a+constitutively+expressed+exon+of+the+slow+alpha-tropomyosin+gene+TPM3+associated+with+an+atypical%2C+sporadic+case+of+nemaline+myopathy. assertion.
- assertion asSentence Thiopurine+S-methyltransferase+gene+polymorphism+is+associated+with+less+6-mercaptopurine+dose+intensity+in+acute+lymphoblastic+leukemia. assertion.
- assertion asSentence Organification+of+radioiodide+into+proteins+of+thyroid+cancer+cells+exogenously+co-expressing+TPO+and+the+sodium%2Fiodide+symporter+%28NIS%29+is+strictly+dependent+of+TPO+and+not+of+NIS. assertion.
- assertion asSentence The+autoimmune+response+to+TPO+regions+outside+the+IDR+%28A+%2B+B%29+epitopes+is+stronger+then+previously+assumed+and+this+response+is+also+conformation+dependent. assertion.
- assertion asSentence siHTbeta+is+for+the+most+part+an+inactive+species+and+any+active+monomer+is+a+consequence+of+heparin+binding+to+siHTbeta+under+dilute+conditions+where+unfavorable+thermodynamics+and%2For+kinetics+restrict+formation+of+active+tetramer. assertion.
- assertion asSentence Up-regulates+interleukin-8+expression+in+airway+smooth+muscle+cells+through+a+protease-activated+receptor%28PAR%29-2-independent+proteolytic+mechanism. assertion.
- assertion asSentence SPAG11B%2FD+is+both+a+substrate+and+a+potent+inhibitor+of+TPSAB1+activity. assertion.
- assertion asSentence Proteolytic+cleavage+of+cathelicidin+LL-37+by+mast+cells+%28MC%29+is+mediated+by+beta-tryptase%2C+the+the+major+LL-37+processing+enzyme+in+MC. assertion.
- assertion asSentence Both+IgE+and+chymase+associate+with+diabetes+status. assertion.
- assertion asSentence Human+recombinant+histamine-releasing+factor+can+partially+inhibit+the+secretion+of+IL-2+and+IL-13+protein+in+a+dose-dependent+manner+from+both+purified+peripheral+blood+T+cells+and+Jurkat+T+cells. assertion.
- assertion asSentence TPT1+is+regulated+by+CREB+transcription+factors. assertion.
- assertion asSentence Polymorphisms+within+the+CRISP2+gene+have+no+significant+association+with+male+infertility. assertion.
- assertion asSentence The+NF1-A+transcription+factor+plays+an+important+role+in+the+transcriptional+activation+of+the+TR2+gene+expression+via+a+promoter+activating+cis-element. assertion.
- assertion asSentence Human+testicular+orphan+receptor+4+enhances+thyroid+hormone+receptor+signaling. assertion.
- assertion asSentence Expression+of+GRP94+suppressed+A23187-induced+apoptosis+and+stabilized+calcium+homeostasis. assertion.
- assertion asSentence Silencing+of+GRP94+expression+promotes+apoptosis+in+pancreatic+cancer+cells. assertion.
- assertion asSentence The+endoplasmic+reticulum+stress+response+chaperone+Gp96+is+strongly+expressed+on+the+apical+surface+of+ileal+epithelial+cells+in+Crohn+disease+patients%2C+promoting+adherent-invasive+Escherichia+coli+invasion. assertion.
- assertion asSentence Autoimmunity+to+endoplasmic+reticulum+molecular+chaperone+GRP94+is+associated+with+a+subset+of+myasthenia+gravis+patients+who+have+additional+autoimmune+diseases. assertion.
- assertion asSentence Lymphocytes+and+lymphoma+cells+from+lymphoma-associated+NF-kappaB2+mutant+transgenic+mice+express+high+levels+of+TRAF1. assertion.
- assertion asSentence A+polymorphism+in+the+TRAF1%2FC5+region+increases+the+susceptibility+to+and+severity+of+rheumatoid+arthritis. assertion.
- assertion asSentence STAT4+and+the+TRAF1%2FC5+loci+are+associated+with+rheumatoid+arthritis+susceptibility. assertion.
- assertion asSentence TRAF2+plays+an+important+role+as+regulator+of+IAP+nucleocytoplasmic+localization%2C+by+preventing+nuclear+translocation+of+cIAP1+and+cIAP2. assertion.
- assertion asSentence TNF-alpha+induces+MMP-9+expression+via+the+TNFR1%2FTRAF2%2FPKCalpha-dependent+JNK1%2F2%2Fc-Jun+and+c-Src%2FEGFR%2FPI3K%2FAkt+pathways. assertion.
- assertion asSentence Interaction+of+TRAF1+with+I-kappa+B+kinase-2+and+TRAF2+is+important+for+regulation+of+NF-kappa+B+activity. assertion.
- assertion asSentence TRAF3%2C+like+Cardif%2C+is+required+for+type+I+interferon+production+in+response+to+intracellular+double-stranded+RNA. assertion.
- assertion asSentence TRAF2%2F3+binding+affinity+and+TRAF2%2F3+binding+site+sequence+dictate+a+distinct+subset+of+CD40+antigen+versus+latent+membrane+protein+1+%28LMP1%29+signaling+properties. assertion.
- assertion asSentence Triad3A+represents+a+versatile+E3+ubiquitin+ligase+that+negatively+regulates+RIG-like+receptor+signaling+by+targeting+TRAF3+for+degradation+following+RNA+virus+infection. assertion.
- assertion asSentence Genetic+lesions+of+the+TRAF3+and+MAP3K14+genes+in+classical+Hodgkin+lymphoma. assertion.
- assertion asSentence TRAF6+acts+as+a+critical+adapter+of+both+the+Src%2FERK1%2F2+kinases+and+IkappaB+kinase%2FNF-kappaB+proinflammatory+signaling+pathways+in+monocytes+and+macrophages. assertion.
- assertion asSentence MyD88%2C+IRAK1+and+TRAF6+proteins+are+crucial+early+mediators+for+the+IL-1-induced+MMP-13+regulation+through+MAPK+pathways+and+AP-1+activity. assertion.
- assertion asSentence TRAF6-caspase-4+interaction%2C+triggered+by+LPS%2C+leads+to+NF-kappaB-dependent+transcriptional+up-regulation+and+secretion+of+important+cytokines+and+chemokines+in+innate+immune+signaling+in+human+monocytic+cells. assertion.
- assertion asSentence The+binding+of+TRAF2+and+TRAF6+to+TICAM-1+cooperatively+activates+the+IFN-inducing+pathway+through+ubiquitination+of+TICAM-1. assertion.
- assertion asSentence A+cytoplasmic+ATM-TRAF6-cIAP1+module+links+nuclear+DNA+damage+signaling+to+ubiquitin-mediated+NF-kappaB+activation. assertion.
- assertion asSentence Pattern+recognition+scavenger+receptor+CD204+attenuates+Toll-like+receptor+4-induced+NF-kappaB+activation+by+directly+inhibiting+ubiquitination+of+tumor+necrosis+factor+%28TNF%29+receptor-associated+factor+6. assertion.
- assertion asSentence TRIO+amplification+is+associated+with+invasive+tumor+growth+and+rapid+tumor+cell+proliferation+in+bladder+neoplasms. assertion.
- assertion asSentence GEF+Trio+is+responsible+for+lamellipodia+formation+through+its+N-terminal+DH-PH+domain+in+a+Rac1-dependent+manner+during+fibronectin-mediated+spreading+and+migration. assertion.
- assertion asSentence ZRP-1+plays+a+crucial+role+in+coupling+the+cell-matrix%2Fcell-cell-contact+signals+with+Rho+GTPase-mediated+actin+remodeling+by+localizing+at+cell-matrix+and+cell-cell+contact+sites. assertion.