Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence TRIP6+is+engaged+in+cell+proliferation%2C+differentiation%2C+transcription+regulation+and+contributes+to+genome+stability. assertion.
- assertion asSentence Caveolin-1+contributes+to+assembly+of+store-operated+Ca2%2B+influx+channels+by+regulating+plasma+membrane+localization+of+TRPC1. assertion.
- assertion asSentence Caveolin-1+scaffold+domain+interacts+with+TRPC1+and+IP3R3+to+regulate+Ca2%2B+store+release-induced+Ca2%2B+entry+in+endothelial+cells. assertion.
- assertion asSentence This+structure+implies+that+the+TRP+superfamily+has+diversely+evolved+as+sensors+specialized+for+various+signals%2C+rather+than+as+simple+ion-conducting+apparatuses. assertion.
- assertion asSentence The+TRPC3+alternative+promoter+is+a+methylation+quantitative-trait+locus+associated+with+the+ataxia+phenotype. assertion.
- assertion asSentence TRPC5+channel+sensitivities+to+antioxidants+and+hydroxylated+stilbenes. assertion.
- assertion asSentence Two+calcium2%2B-permeable+members+of+the+TRPC+family+of+cation+channels%2C+TRPC3+and+TRPC6%2C+can+interact+with+the+pore-forming+subunits+of+BKCa+channels+in+podocytes+and+in+heterologous+systems+in+which+both+classes+of+channels+are+transiently+expressed. assertion.
- assertion asSentence The+cysteine+residues+increase+TRPC6+channel+protein+expression+in+humans. assertion.
- assertion asSentence Tyrosine+phosphorylation+of+TRPM2+by+PTPL1+controls+activation%2Ffunction. assertion.
- assertion asSentence TRPM2+mediates+H2O2-induced+increase+in+endothelial+permeability+through+the+activation+of+Ca2%2B+entry+via+TRPM2. assertion.
- assertion asSentence Mutated+in+suberous+sclerosis+%28REVIEW%29. assertion.
- assertion asSentence Inflammation-associated+signaling+pathway+involving+TSC1+is+activated+in+Barret%27s+esophagus+esophaggeeal+adenocarcinoma. assertion.
- assertion asSentence TSC2+is+phosphorylated+and+inhibited+by+Akt+and+suppresses+mTOR+signalling. assertion.
- assertion asSentence Cyst-like+cortical+tubers+in+the+brain+are+strongly+associated+with+TSC2+gene+mutation+in+tuberous+sclerosis+complex. assertion.
- assertion asSentence Tuberin-null+cells+become+nonadherent+and+invasive+and+these+nonadherent+cells+express+cleaved+forms+of+beta-catenin. assertion.
- assertion asSentence One+of+the+targets+of+HtrA1+activity+during+fetal+development+is+the+TSC2-TSC1+pathway. assertion.
- assertion asSentence Perivascular+epithelioid+cell+tumors+with+TFE3+gene+fusions+demonstrated+intact%2C+robust+tuberin+protein+labeling+and+no+TSC2+loss+of+heterozygosity. assertion.
- assertion asSentence Negative+regulation+of+cell+growth+and+differentiation+by+TSG101+through+association+with+p21%28Cip1%2FWAF1%29. assertion.
- assertion asSentence A+familial+case+of+congenital+hypothyroidism+caused+by+a+homozygous+mutation+of+the+thyrotropin+receptor+gene. assertion.
- assertion asSentence Activation+of+the+cAMP+pathway+by+the+TSH+receptor+involves+switching+of+the+ectodomain+from+a+tethered+inverse+agonist+to+a+true+agonist. assertion.
- assertion asSentence Alpha+helical+motifs+in+intracellular+loops+of+TSHR+are+responsible+for+G-protein+mediated+stimulation+of+TSHR. assertion.
- assertion asSentence Isoleucine+691+is+changed+to+phenylalanine+in+a+Chinese+family+and+is+the+first+germline+mutation+in+TSHR+intracellular+C-terminal+domain. assertion.
- assertion asSentence In+Japan%2C+TSHR+mutations+are+relatively+common+among+patients+with+congenital+hypothyroidism+and+a+founder+mutation+accounts+for+about+70%25+of+mutants. assertion.
- assertion asSentence High+TSHR+expression+is+associated+with+papillary+thyroid+microcarcinoma. assertion.
- assertion asSentence Mutations+in+the+allosteric+binding+site+of+the+thyrotropin+receptor+lead+to+a+decrease+of+cAMP+signaling+activity. assertion.
- assertion asSentence A+family+is+diagnosed+with+congenital+hypothyroidism+caused+by+a+combination+of+loss-of-function+mutations+in+the+thyrotropin+receptor+and+adenylate+cyclase-stimulating+G+alpha-protein+subunit+genes. assertion.
- assertion asSentence Deletion+of+ectodomain+residue+Asp403+in+TSHR+is+associated+with+thyroid+toxic+adenoma. assertion.
- assertion asSentence 8%25+of+Japanese+CH+patients+with+high+radioiodine+uptake+%28two+in+24%29+has+inactivating+TSHR+mutations+in+nonclassic+TSH+resistance. assertion.
- assertion asSentence PHLDA2+gene+is+imprinted%2C+with+preferential+expression+from+the+maternal+allele+in+placenta+and+liver. assertion.
- assertion asSentence Up-regulation+of+TSSC3+occurred+in+Dicer+knockdown+cells. assertion.
- assertion asSentence TPR2+combines+two+TPR+domains+and+a+J+domain+to+regulate+the+Hsp70%2FHsp90+chaperone+system. assertion.
- assertion asSentence The+endogenous+Mps1+in+mitotic+HeLa+cells+is+phosphorylated+on+T676%2C+a+residue+in+the+activation+loop. assertion.
- assertion asSentence MPS1+phosphorylates+borealin+to+control+aurora+kinase+activity+and+chromosome+alignment. assertion.
- assertion asSentence Mps1+mutant+without+the+unstructured+tail+region+is+defective+in+mediating+spindle+assembly+checkpoint+activation. assertion.
- assertion asSentence Release+of+Mps1+from+kinetochores+is+essential+for+mitotic+checkpoint+silencing+and+a+fast+metaphase-to-anaphase+transition. assertion.
- assertion asSentence Hypophosphorylation+of+the+Stiff+N2B+titin+isoform+raises+cardiomyocyte+resting+tension+in+failing+human+myocardium. assertion.
- assertion asSentence Total+deletion+of+the+TTPA+gene+is+expected+to+be+associated+with+severe+phenotype+in+AVED+patients. assertion.
- assertion asSentence Hydrophobic+features+of+alpha-TTP+dominating+the+binding+energy+between+protein+and+membrane. assertion.
- assertion asSentence Crystal+structure+of+the+core+domain+of+the+mouse+Tubby+protein. assertion.
- assertion asSentence Tubby+and+Tulp1+are+bridging+molecules+with+their+N-terminal+region+as+MERTK-binding+domain+and+C-terminal+region+as+phagocytosis+prey-binding+domain. assertion.
- assertion asSentence TTR%28105-115%29+adopts+an+extended+beta-strand+conformation+that+is+similar+to+that+found+in+the+native+protein+except+for+substantial+differences+in+the+vicinity+of+the+proline+residue. assertion.
- assertion asSentence Transthyretin+intronic+open+reading+frames+are+not+independently+expressed+in+vivo+or+part+of+functional+transcripts. assertion.
- assertion asSentence Destabilization+of+the+dimer-dimer+interface+and+the+monomer+core+is+important+for+the+amyloidogenesis+of+transthyretin. assertion.
- assertion asSentence Extended+high-temperature+incubation+of+the+highly+amyloidogenic+transthyretin+mutant+TTR+G53S%2FE54D%2FL55S+successfully+removes+heterogeneities+and+allows+the+reproducible+growth+of+well+diffracting+crystals. assertion.
- assertion asSentence In+patients+with+renal+disease%2C+serum+transthyretin+is+positively+and+independently+related+to+body+mass+index+and+is+significantly+lower+in+malnourished+than+well-nourished+patients. assertion.
- assertion asSentence DNA+testing+for+transthyretin+is+the+most+reliable+test+for+transthyretin+familial+amyloid+polyneuropathy+in+patient+of+Russian+family. assertion.
- assertion asSentence Stability+and+fibril+formation+properties+of+human+transthyretin. assertion.
- assertion asSentence TTR+genotyping+should+be+considered+for+any+patient+with+cardiomyopathy+of+this+phenotype. assertion.
- assertion asSentence In+a+group+of+patients+with+familial+amyloid+neuropathy%2C+skin+denervation+is+associated+with+a+missense+mutation+in+amyloidogenic+transthyretin+%28Ala97Ser%29. assertion.
- assertion asSentence The+site-directed+mutagenesis+of+HNF-4+binding+sites+in+the+transthyretin+proximal+promoter+dramatically+decreases+transthyretin+gene+expression. assertion.
- assertion asSentence Recurrence+of+amyloid+deposition+only+occurred+in+nonextensive+vitrectomized+eyes+and+represents+a+false+recurrence+associated+with+incomplete+vitrectomy. assertion.
- assertion asSentence Electrocardiographic+voltages+meet+the+criteria+for+LVH+in+one+quarter+of+patients+with+ATTR+V122I+cardiac+amyloidosis. assertion.
- assertion asSentence The+axial+elastic+modulus+of+tubulin+diminishes+as+the+length+of+the+monomer+increases. assertion.
- assertion asSentence SADB+kinase+activity+controls+centrosome+homeostasis+by+regulating+phosphorylation+of+gamma-tubulin. assertion.
- assertion asSentence Mutation+in+the+TULP1+gene+is+a+rare+cause+of+LCA%2FEORD+%28Leber+congenital+amaurosis+or+early-onset+retinal+degeneration. assertion.
- assertion asSentence Deficience+causes+skull+osteoblast+apoptosis+due+to+increased+TNFalpha+expression+and+caspase-2+activation. assertion.
- assertion asSentence One+variant+is+associated+with+Robinow-Sorauf+syndrome. assertion.
- assertion asSentence Some+TWIST1+mutations+in+the+RUNX2+binding+site+are+associated+with+craniosynostosis. assertion.
- assertion asSentence Twist+proteins+promote+malignant+conversion+and+metastatic+dissemination. assertion.
- assertion asSentence Twist1+represents+one+of+the+factors+that+promotes+pathogenic+accumulation+of+fibroblasts+in+fibrotic+lung+disease. assertion.
- assertion asSentence ILK+regulates+the+expression+of+Her2%2Fneu+through+TWIST+and+YB-1%2C+lending+support+to+the+use+of+ILK+inhibitors+in+the+treatment+of+aggressive+Her2%2Fneu-positive+tumors. assertion.
- assertion asSentence Twist+is+an+upstream+regulator+of+the+E-cadherin-mediated+terminal+differentiation+and+fusion+in+a+human+trophoblastic+cell+line+in+vitro. assertion.
- assertion asSentence %2Auggest+that+Twist1-mediated+modulation+of+MDR1%2FP-gp+expression+plays+an+important+role+in+sensitization+of+cervical+cancer+cells+to+cisplatin. assertion.
- assertion asSentence Expression+of+CD134+and+CD134+ligand+in+lesional+and+nonlesional+psoriatic+skin. assertion.
- assertion asSentence Activated+human+natural+killer+%28NK%29+cells+are+able+to+help+T-cell+receptor-stimulated+autologous+CD4%2B+T+cells+by+a+process+that+involves+both+OX40+ligand+and+B7+antigen+costimulation. assertion.
- assertion asSentence Thymic+stromal+lymphopoietin+%28TSLP%29+and+human+DCs+plays+an+essential+role+in+evoking+inflammatory+Th2+responses+in+allergy+through+OX40+ligand+expression+on+DCs. assertion.
- assertion asSentence Expression+of+CD134+and+CD134+ligand+in+lesional+and+nonlesional+psoriatic+skin. assertion.
- assertion asSentence CD3%2B+T+lymphocytes+co-expressing+CD134+and+CD137+antigens+on+peripheral+blood+revealed+an+increased+percentages+of+OX-40%2FCD137+positive+cells+in+patients+with+Graves%27+disease+%28p%3C0.025%29+compared+to+the+controls. assertion.
- assertion asSentence Thioredoxin+is+a+regulator+of+gene+expression. assertion.
- assertion asSentence AlphaAR-stimulated+hypertrophic+signaling+in+adult+rat+ventricular+myocytes+is+mediated+via+a+TRX1-sensitive+posttranslational+oxidative+modification+of+thiols+on+Ras. assertion.
- assertion asSentence Thioredoxin-1+nitration+plays+a+causative+role+in+postischemic+cardiomyocyte+apoptosis. assertion.
- assertion asSentence FMRP+negatively+regulates+TXNRD1+translation. assertion.
- assertion asSentence TR-1+acts+as+a+negative+regulator+of+Tat-dependent+transcription. assertion.
- assertion asSentence Caveolin+1+expression+inhibits+TrxR1-mediated+cell+transformation. assertion.
- assertion asSentence High+expression+of+TXNRD1+is+associated+with+breast+cancer. assertion.
- assertion asSentence Catalytically+active+Tyk2+is+necessary+for+Janus+kinase+2+phosphorylation+and+association+with+the+platelet-activating+factor+receptor. assertion.
- assertion asSentence TYMS+and+MTHFR+compete+for+limiting+supplies+of+folate+required+for+the+remethylation+of+homocysteine. assertion.
- assertion asSentence Gene+expression+is+a+predictor+for+the+efficacy+of+fluoropyrimidine-based+chemotherapy+for+metastatic+colorectal+cancer. assertion.
- assertion asSentence Polymorphism+of+TYMS+partially+modifies+the+risk+of+esophageal+and+stomach+cancer+in+patients+with+smoking+habit. assertion.
- assertion asSentence Polymorphisms+of+reduced+folate+carrier%2Caminoimidazole+carboxamide+ribonucleotide+transformylase%2Cand+thymidylate+synthase+genes+contribute+to+the+therapeutic+response+in+rheumatoid+arthritis+patients+to+methotrexate. assertion.
- assertion asSentence No+association+between+either+green+tea+intake+or+gene+polymorphisms+of+MTHFR+%28C677T+and+A1298C%29+and+TYMS+%281494+ins%2Fdel%29+and+breast+cancer+risk. assertion.
- assertion asSentence Genetic+variations+in+thymidylate+Synthase+leads+to+hand-foot+syndrome+in+metastatic+colorectal+treated+with+5-fluorouracil+based+therapy. assertion.
- assertion asSentence The+proportion+of+individuals+who+are+homozygous+for+the+2R+allele+of+the+5%27UTR+TYMS+polymorphism+is+less+in+individuals+who+are+homozygous+for+the+T+allele+of+MTHFR+677+than+in+individuals+homozygous+for+the+C+allele+of+MTHFR+677. assertion.
- assertion asSentence miR-192+and+miR-215+target+thymidylate+synthase+expression+in+colorectal+cancer+cell+lines. assertion.
- assertion asSentence In-situ+TS1+protein+expression+in+Ewing%2Fprimitive+neuroectodermal+tumor+is+a+prognostic+marker. assertion.
- assertion asSentence An+important+role+of+polymorphisms+and+gene-gene+interactions+within+the+folate+pathway+in+high+dose+methotrexate-related+toxicity+in+childhood+acute+lymphoblastic+leukemia. assertion.
- assertion asSentence Thymidylate+synthase%28TS%29+protein+expression+tends+to+be+related+TS+mRNA+expression+and+is+an+independent+prognostic+factor+in+advanced+colorectal+cancer. assertion.
- assertion asSentence Human+Placental+protein%2Fpeptide+fraction+mediated+increase+in+tyrosinase+expression+occurred+through+transcriptional+upregulation+to+stimulate+melanogenesis+in+primary+melanocyte. assertion.
- assertion asSentence Most+patients+with+AROA+%28autosomal+recessive+ocular+albinism%29+represent+phenotypically+mild+variants+of+oculocutaneous+albinism+%2C+well+over+half+of+which+is+OCA1. assertion.
- assertion asSentence The+R402Q+tyrosinase+variant+does+not+cause+autosomal+recessive+ocular+albinism. assertion.
- assertion asSentence Association+of+TYR+p.R402Q+with+skin+cancer+risk+in+the+French+population. assertion.
- assertion asSentence DNA+sequence+variants+in+the+human+TYRP1+gene+are+not+associated+with+inherited+pigmentary+glaucoma+in+humans. assertion.
- assertion asSentence TYRP1+rs1408799+is+associated+with+melanoma. assertion.
- assertion asSentence The+expression+a+mutant+human+UBB+analogous+%28UB14%29+in+yeast+markedly+enhanced+cellular+susceptibility+to+toxic+protein+aggregates. assertion.
- assertion asSentence Ubiquitin+targeting+of+tau+protein+occurs+at+neurofibrillary+tangles+in+the+early+and+intermediate+maturation+stages. assertion.
- assertion asSentence The+cellular+effects+of+progerin+expression+in+Hutchinson-Gilford+progeria+syndrome+are+transduced%2C+at+least+in+part%2C+through+reduced+function+of+the+Ran+GTPase+and+E2+SUMOylation+pathways. assertion.
- assertion asSentence RAD6+can+form+a+ternary+complex+with+MDM2+and+p53+that+contributes+to+the+degradation+of+p53. assertion.
- assertion asSentence MCF10A+cells+stably+transfected+with+antisense+RAD6B+display+hypersensitivity+to+damage-inducing+drugs. assertion.
- assertion asSentence UBE2D2+is+required+for+GCMa+ubiquitination+and+for+association+with+the+SCF%28FBXW2%29+complex. assertion.
- assertion asSentence Knocking+down+UBE2D3+by+RNA+interference+leads+to+blockage+oof+retinoic+acid+induced+chclin+D1+degradation+and+cell+cycle+arrest. assertion.