Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence The+presence+of+the+AUP1-Ube2g2+complex+at+LDs+provides+a+direct+molecular+link+between+LDs+and+the+cellular+ubiquitination+machinery. assertion.
- assertion asSentence Specific+interactions+of+SUMO-3+with+its+modifying+enzyme%2C+UBC9. assertion.
- assertion asSentence OZF+interacts+with+UBC9%2C+the+E2+enzyme+involved+in+the+covalent+conjugation+of+the+small+ubiquitin-like+modifier+1+%28SUMO-1%29. assertion.
- assertion asSentence Ubc9+is+an+important+C%2FEBPalphap30+target+through+which+C%2FEBPalphap30+enhances+the+sumoylation+of+C%2FEBPalphap42+to+inhibit+granulocytic+differentiation. assertion.
- assertion asSentence RSUME+increases+noncovalent+binding+of+SUMO-1+to+Ubc9+and+enhances+Ubc9+thioester+formation+and+SUMO+polymerization. assertion.
- assertion asSentence MEL-18+bound+to+HSF2+inhibits+its+sumoylation+by+binding+to+and+inhibiting+the+activity+of+UBC9+enzymes+in+the+vicinity+of+HSF2. assertion.
- assertion asSentence Ubc9+expression+correlates+positively+with+Dukes%27+stage+and+negatively+with+the+Gleason+score+in+a+variety+of+neoplasms. assertion.
- assertion asSentence UbcH7+charged+with+ubiquitin+has+an+affinity+for+E6-associated+protein+%28E6AP%29+similar+to+that+of+uncharged+UbcH7. assertion.
- assertion asSentence Activating+transcription+factor+3+activates+p53+by+preventing+E6-associated+protein+from+binding+to+E6. assertion.
- assertion asSentence Reduced+expression+of+the+maternally+inherited+ubiquitin+protein+ligase+3A+gene+is+associated+with+Angelman+syndrome. assertion.
- assertion asSentence In+interphase%2C+a+significant+fraction+of+vertebrate+SUMO1-modified+RanGAP1+forms+a+stable+complex+with+the+nucleoporin+RanBP2%2FNup358+at+nuclear+pore+complexes. assertion.
- assertion asSentence SUMO1+represses+transcriptional+activity+of+SOX3. assertion.
- assertion asSentence CTCF+protein+can+be+posttranslationally+modified+by+the+small+ubiquitin-like+protein+SUMO. assertion.
- assertion asSentence Adenosine+signaling+mediates+SUMO-1+modification+of+IkappaBalpha+during+hypoxia+and+reoxygenation. assertion.
- assertion asSentence Human+herpesvirus+5+IE2+bound+physically+to+SUMO-1+through+a+SUMO-interacting+motif+%28SIM%29. assertion.
- assertion asSentence SUMO1+gene+genetic+variation+do+not+play+a+significant+role+in+the+development+of+cleft+palate+and+cleft+lip+development+in+patients+from+Central+Europe. assertion.
- assertion asSentence Proteasomal+dysfunction+causes+accumulation+of+SUMOylated+alpha-synuclein+and+subsequently+its+aggregation%2C+pointing+to+the+contribution+of+this+posttranslational+modification+to+inclusion+bodies+in+alpha-synucleinopathies. assertion.
- assertion asSentence Loop+1+insertion+in+SENP6+and+SENP7+as+a+platform+to+discriminate+between+SUMO1+and+SUMO2%2F3+isoforms+in+this+subclass+of+the+SUMO+protease+family. assertion.
- assertion asSentence ERbeta+SUMO-1+modification+occurs+on+a+unique+nonconsensus+sumoylation+motif+which+becomes+fully+competent+upon+phosphorylation+of+its+contained+serine+residue. assertion.
- assertion asSentence SUMO1+modification+is+required+for+PTEN+tumour+suppressor+function+by+controlling+PTEN+membrane+association+and+regulation+of+the+phosphatidylinositol-3+kinase%2FAKT+pathway. assertion.
- assertion asSentence The+DNA+binding+affinity+of+UBF%27s+fifth+box+domain+%28HMG+box+5%29+is+found+to+be+much+weaker+than+that+of+the+first+HMG+box+domain+%28HMG+box+1%29. assertion.
- assertion asSentence Alterations+in+alpha-helical+content+and+hydrolase+activity+of+parkinsonism-associated+ubiquitin+carboxyl-terminal+hydrolase+L1+variants. assertion.
- assertion asSentence UCH-L1+levels+are+higher+in+patients+with+diffuse+traumatic+brain+injury+compared+to+those+with+mass+lesions. assertion.
- assertion asSentence Plasma+urocortin+1+is+elevated+in+heart+failure+%28in+proportion+to+the+degree+of+cardiac+dysfunction%29+in+concert+with+the+generalized+neurohormonal+activation+seen+in+this+condition. assertion.
- assertion asSentence The+polymorphism+-3826+A%2FG+of+the+UCP1+gene+is+associated+with+a+greater+degree+of+obesity+and+very+high+figures+of+arterial+tension. assertion.
- assertion asSentence UCP1+gene+is+associated+with+hearing+disorders+among+Japanese+elderly. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+in+UCP1+is+associated+with+insulin+resistance+in+morbid+obese+patients. assertion.
- assertion asSentence Glucose+induces+and+leptin+decreases+expression+of+uncoupling+protein-2+mRNA+in+human+islets. assertion.
- assertion asSentence No+association+between+the+different+polymorphisms+and+diabetic+nephropathy. assertion.
- assertion asSentence The+principal+mechanisms+regulating+UCP2+gene+expression+are+similar+in+rats+and+humans%2C+being+consistent+with+a+role+for+UCP2+as+a+modulator+of+insulin+secretion+in+humans. assertion.
- assertion asSentence G-866A+polymorphism+in+the+UCP2+gene+is+associated+with+a+reduced+risk+of+diabetic+neuropathy+in+type+1+diabetes. assertion.
- assertion asSentence UCP2+plays+an+important+protective+role+against+oxidative+stress+damage+to+human+sperm+by+diminishing+reactive+oxygen+species+production. assertion.
- assertion asSentence Mitochondrial+uncoupling+protein%2C+involved+in+thermogenesis.+mRNA+levels+elevated+in+weight+loss+associated+with+gastrointestinal+adenocarcioma. assertion.
- assertion asSentence Alteration+of+lysine+220+to+alanine%2C+histidine%2C+or+arginine+significantly+impaired+enzyme+function. assertion.
- assertion asSentence UGT2B7+and+UGT1A7+heterozygosity+predicted+increased+apparent+oral+clearance+of+mycophenolic+acid+%28MPA%29. assertion.
- assertion asSentence In+human+prostate%2C+UGT2B15+and+UGT2B17+genes+have+complementary+roles+and+are+expressed+in+cells+where+their+specific+substrates+are+synthesized. assertion.
- assertion asSentence The+UGT2B17+deletion+polymorphism+is+associated+with+prostate+cancer+risk. assertion.
- assertion asSentence Species+variations+of+the+glycomoiety+of+THP+can+lead+to+the+differential+binding+of+THP+to+type+1-fimbriated+E.+coli. assertion.
- assertion asSentence The+autosomal-dominant+gene+mutations+responsible+for+UMOD-associated+kidney+disease+cause+a+profound+reduction+of+THP+excretion. assertion.
- assertion asSentence Assessed+tubular+function+in+diabetic+children+by+measuring+Tamm-Horsfall+protein+and+glutathione+S-transferase+levels+in+urine. assertion.
- assertion asSentence Familial+juvenile+hyperuricaemic+nephropathy-causing+uromodulin+mutants+are+impaired+in+protein+maturation+and+trafficking. assertion.
- assertion asSentence Elevated+uromodulin+concentrations+precede+the+onset+of+chronic+kidney+disease+and+associate+with+a+common+polymorphism+in+the+UMOD+region. assertion.
- assertion asSentence Hyperuricemia+disproportionate+to+renal+function+represents+the+hallmark+of+renal+disease+caused+by+UMOD+mutation. assertion.
- assertion asSentence B4GALT3%2C+DAP3%2C+RGS16%2C+TMEM183A+and+UCK2--were+significantly+overexpressed+in+dup%281q%29-positive+ALLs+compared+with+high+hyperdiploid+ALLs+without+dup%281q%29. assertion.
- assertion asSentence Increased+orotate+phosphoribosyltransferase+expression+is+associated+with+bladder+cancers. assertion.
- assertion asSentence Mutations+at+Arg276+effectively+transform+UNG+into+a+single-stranded+DNA-specific+uracil-DNA+glycosylase. assertion.
- assertion asSentence UNG2+binds+to+the+carboxyl+terminus+of+latency-associated+nuclear+antigen+of+Kaposi%27s+sarcoma-associated+herpesvirus+and+retains+its+enzymatic+activity+in+the+complex. assertion.
- assertion asSentence XRCC1+complexes+performed+complete+repair+of+uracil+with+higher+efficacy+than+UNG2+complexes. assertion.
- assertion asSentence RXRalpha+and+LXR+activate+two+promoters+in+placenta-+and+tumor-specific+expression+of+PLAC1. assertion.
- assertion asSentence Pharmacological+activation+of+endothelial+LXRs+reduces+angiogenesis+by+restraining+cholesterol-dependent+vascular+endothelial+growth+factor+receptor-2+compartmentation+and+signaling. assertion.
- assertion asSentence Upstream+transcription+factor+1+%28USF1%29%2C+is+the+first+gene+associated+with+familial+combined+hyperlipidemia. assertion.
- assertion asSentence USF1+GC+haplotype+is+associated+with+BMI+in+premenopausal+Korean+females. assertion.
- assertion asSentence USF1+and+USF2+regulate+transcriptional+activity+of+the+FOXE1+promoter. assertion.
- assertion asSentence Defective+gene+induction+of+USF1+variant+by+insulin+contributes+to+the+risk+of+developing+dyslipidemia. assertion.
- assertion asSentence USF1+and+USF2+positively+regulate+the+core+of+P1+promoter+od+AAH. assertion.
- assertion asSentence USP1+and+UAF1+form+a+complex+in+the+cytoplasm+that+subsequently+translocates+to+the+nucleus+through+import+mediated+by+USP1+nuclear+localization+signals. assertion.
- assertion asSentence USH2C+and+USH2A+manifest+photoreceptor+disease+with+rod-+and+cone-mediated+visual+losses+and+thinning+of+the+outer+nuclear+layer. assertion.
- assertion asSentence On+average%2C+USH2A+patients+lose+visual+acuity+faster+than+rhodopsin+patients+and+slower+than+%28retinitis+pigmentosa+GTPase+regulator%29+RPGR+patients. assertion.
- assertion asSentence Mutations+in+the+USH3+gene+underlie+Usher+syndrome+type+3. assertion.
- assertion asSentence The+JmjC+domain-containing+protein+UTX+specifically+demethylates+mono-%2C+di-+and+trimethylated+K27+of+histone+H3+in+vitro. assertion.
- assertion asSentence There+is+an+association+of+UVRAG+polymorphisms+with+susceptibility+to+non-segmental+vitiligo+in+a+Korean+sample. assertion.
- assertion asSentence The+C-terminal+fragment+of+VASP+%28336-380%29+forms+a+tetramer+in+solution+via+a+coiled+coil+arrangement+and+is+solely+responsible+for+tetramerization+of+full-length+VASP. assertion.
- assertion asSentence VASP+phosphorylation+controls+remodeling+of+the+actin+cytoskeleton. assertion.
- assertion asSentence High+VASP+expression+is+associated+with+focal+adhesion+assembly+in+myofibroblasts+fostering+a+microenvironment+that+promotes+tumor+growth. assertion.
- assertion asSentence Prolonged+treatment+with+albuterol+prevents+the+agonist-induced+phosphorylation+of+VASP+at+Ser157. assertion.
- assertion asSentence Vav+associates+with+Grb2. assertion.
- assertion asSentence Vav+interacts+with+gp130. assertion.
- assertion asSentence Vav+plays+crucial+functions+in+the+maturation+process+of+myeloid+cells. assertion.
- assertion asSentence CD147%2C+via+the+selective+inhibition+of+specific+downstream+elements+of+the+Vav1%2FRac1+route%2C+contributes+to+the+negative+regulation+of+T-cell+responses. assertion.
- assertion asSentence EHD2+associates+in+the+plasma+membrane+with+Vav1%2C+a+Nek3-regulated+GEF+%28guanine-nucleotide-exchange+factor%29+for+Rho+GTPases. assertion.
- assertion asSentence Vav2+is+a+GDP%2FGTP+exchange+factor+%28GEF%29+for+Rac+in+vivo. assertion.
- assertion asSentence Vav2-mediated+nucleotide+exchange+of+Rho+GTPases+follows+the+Theorell-Chance+catalytic+mechanism+in+which+Vav2.Rho+GTPase+complex+is+the+major+species+during+the+exchange+process+and+Vav2.GDP-Mg2%2B.Rho+GTPase+ternary+complex+is+present+only+transiently. assertion.
- assertion asSentence The+EGFR%2FVav2%2FRac1+axis+is+a+crucial+pathway+for+the+acquisition+of+motile+and+invasive+properties+of+most+head+and+neck+squamous+cell+carcinoma+cells. assertion.
- assertion asSentence The+tumor+necrosis+factor-alpha-stimulated+redox-sensitive+vascular+cell+adhesion+molecule-1+selective+signaling+pathway+in+endothelial+cells+depends+upon+isoprenylcysteine+carboxyl+methyltransferase+as+a+critical+component. assertion.
- assertion asSentence Blood+levels+do+not+differ+in+normal+and+coronary+artery+disease+patients. assertion.
- assertion asSentence Anionic+peptide+factor%2Fphosphatidylcholine+particles+promote+the+inhibition+of+VCAM1+in+umbilical+vein+endothelial+cells. assertion.
- assertion asSentence Gliclazide+treatment+reduces+serum+ICAM-1+levels+in+poorly+controlled+type+2+diabetic+patients. assertion.
- assertion asSentence LDL+lipoprotein+subunit+L5+induces+human+umbilical+vein+endothelial+cells+%28HUVEC%29+to+express+VCAM1. assertion.
- assertion asSentence A+VCAM-1-mediated+mechanism+recruits+leukocytes+to+the+lymph+nodes+during+inflammation. assertion.
- assertion asSentence Vascular+cell+adhesion+molecule+1+expression+is+only+blocked+by+the+inhalational+anesthetics+and+not+by+morphine. assertion.
- assertion asSentence Key+players+involved+in+transmigration+and+invasion+of+MSCs+are+the+endothelial+phenotype%2C+VCAM-1%2FVLA-4%2C+beta1+integrins%2C+MMP-2+secretion+and+cytokines. assertion.
- assertion asSentence Gb3+induces+oxidative+stress+and+up-regulates+the+expression+of+ICAM1%2C+VACAM1+and+selectin+E+in+Fabry+disease+vascular+endothelial+cells. assertion.
- assertion asSentence Liraglutide+inhibits+TNF-+or+glucose-mediated+induction+of+PAI-1+and+vascular+adhesion+molecule+expression. assertion.
- assertion asSentence Gastrin+induces+interactions+between+human+mononuclear+leukocytes+and+endothelial+cells+through+the+activation+of+CCK-2+receptors+and+the+enhancement+of+endothelial+P-selectin+and+VCAM-1. assertion.
- assertion asSentence LPS-induced+VCAM-1+expression+and+adhesion+of+THP-1+cells+are+mediated+through+the+TLR4%2FERK%2FcPLA%282%29alpha+phosphorylation+and+COX-2+expression%2FPGE%282%29+synthesis+in+RASFs. assertion.
- assertion asSentence Suppressed+VCAM1+gene+expression+is+associated+with+cigarette+smoking. assertion.
- assertion asSentence VCAM1+plays+a+key+role+during+C.+pneumoniae+entry+into+human+cells. assertion.
- assertion asSentence Presence+of+elevated+VCAM-1+levels+in+patients+undergoing+coronary+artery+bypass+surgery+predicts+a+higher+risk+for+post-operative+atrial+fibrillation. assertion.
- assertion asSentence Protein+kinase+A-alpha+directly+phosphorylates+FoxO1+in+vascular+endothelial+cells+to+regulate+expression+of+vascular+cellular+adhesion+molecule-1+mRNA. assertion.
- assertion asSentence Cancer+cells+expressing+VCAM-1+can+thrive+in+leukocyte-rich+microenvironments+through+juxtacrine+activation+of+a+VCAM-1-Ezrin-PI3K%2FAkt+survival+pathway. assertion.
- assertion asSentence SVIP+is+an+endogenous+inhibitor+of+ERAD+that+acts+through+regulating+the+assembly+of+the+gp78-p97%2FVCP-Derlin1+complex. assertion.
- assertion asSentence VCP-containing+protein+mediates+the+endoplasmic+reticulum+degradation+of+V2+vasopressin+receptors. assertion.
- assertion asSentence ELF2+transactivates+VCP+promoter+through+binding+to+two+motifs%2C+with+a+predominant+contribution+of+the+upstream+one. assertion.
- assertion asSentence Expression+levels+of+VCP+mRNA+significantly+decreased+in+the+cell+lines+from+non-small+cell+lung+cancer+%28NSCLC%29. assertion.
- assertion asSentence Knockdown+of+erasin%2C+a+platform+for+p97%2FVCP+and+ubiquilin+binding%2C+or+knockdown+of+ubiquilin+in+human+cells+slowed+degradation+of+two+classical+endoplasmic+reticulum-associated+protein+degradation+substrates. assertion.
- assertion asSentence The+role+of+the+N-domain+in+the+ATPase+activity+of+the+mammalian+AAA+ATPase+p97%2FVCP. assertion.
- assertion asSentence Human+voltage-dependent+anion+selective+channel+1+is+a+target+antigen+for+anti-glomerular+endothelial+cell+antibody+in+mixed+connective+tissue+disease. assertion.
- assertion asSentence Approaching+the+structure+of+human+VDAC1%2C+a+key+molecule+in+mitochondrial+cross-talk. assertion.
- assertion asSentence FimA+strengthens+the+VDAC1-hexokinase+interaction+and+prevents+dissociation+of+hexokinase+from+VDAC1+triggered+by+apoptotic+stimuli. assertion.
- assertion asSentence VDAC+is+the+ATP+conduit+in+the+IP+receptor-mediated+signaling+pathway+in+human+erythrocytes. assertion.