Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence High+serum+vitronectin+is+associated+with+breast+cancer. assertion.
- assertion asSentence Ser968Thr+mutation+in+the+A3+domain+leads+to+defective+binding+to+collagen+and+bleeding+tendency. assertion.
- assertion asSentence Mutations+in+particular+domains+of+VWF+correlate+with+specific+subtypes+of+type+2+von+Willebrand+disease+depending+on+how+they+affect+its+post-translational+processing%2C+multimerization%2C+secretion%2C+or+binding. assertion.
- assertion asSentence Impaired+thrombus+generation+in+type+2B+VWD+ascribed+to+the+critical+function+of+larger+VWF+multimers+in+the+proper+spatial+growth+of+mural+thrombi+under+high+shear+rate+conditions. assertion.
- assertion asSentence VWF+stimulates+the+platelet+adhesion+onto+the+collagen+surface+by+enhancing+platelet+aggregation+in+the+platelet-reduced+condition. assertion.
- assertion asSentence A+marker+of+endothelial+damage%2Finjury+in+the+activation+of+vascular+and+coagulation+abnormalities+in+acute+coronary+syndromes. assertion.
- assertion asSentence No+association+between+plasma+vWF+levels+in+primary+graft+dysfunction+following+lung+transplantation. assertion.
- assertion asSentence The+N1421K+substitution+in+the+VWF+affects+the+GPIb+binding+site+or+a+recognition+element+by+a+conformational+change+of+the+A1+domain. assertion.
- assertion asSentence The+rapid+expulsion+and+unfolding+of+long+VWF+strings+that+remain+anchored+to+endothelial+cells+after+secretion+from+Weibel-Palade+bodies+can+alter+the+structure+or+exposure+of+some+VWF+monomeric+A2+domains+to+create+an+ADAMTS-13-cleavable+form. assertion.
- assertion asSentence The+structure+of+a+complex+between+GpIbalpha+and+the+cyclic+peptide+inhibitor+Callosteric+TERMALHNLC+defines+a+previously+unrecognized+VWF+binding+site+within+GpIbalpha. assertion.
- assertion asSentence VWF+protects+fibrinogen+against+degradation+by+plasmin%2C+preserving+its+clottability+in+plasma+and+its+adhesive+role+in+platelet-rich+thrombi. assertion.
- assertion asSentence NFIB%2FX+and+NFY+repressors+contribute+differentially+to+organ-specific+regulation+of+the+VWF+promoter+in+transgenic+mice. assertion.
- assertion asSentence mRNA+levels+of+CD31%2C+CD144%2C+CD146+and+vWf+in+whole+blood+as+detected+by+real+time+RT-PCR+cannot+be+used+as+biomarkers+for+end-stage+endothelial+cells+such+as+circulating+endothelial+cells. assertion.
- assertion asSentence Collagen+VI+microfibril+formation+is+abolished+by+an+%7Balpha%7D2%28VI%29+von+Willebrand+factor+type+A+domain+mutation+in+a+patient+with+Ullrich+congenital+muscular+dystrophy. assertion.
- assertion asSentence Preeclampsia+is+associated+with+decreased+levels+of+ADAMTS13%2C+independently+of+von+Willebrand+factor. assertion.
- assertion asSentence ARC15105+is+a+potent+antagonist+of+von+Willebrand+factor+mediated+platelet+activation+and+adhesion. assertion.
- assertion asSentence Von+Willebrand+factor+%28VWF%29+propeptide+binding+to+VWF+D%27D3+domain+attenuates+platelet+activation+and+adhesion. assertion.
- assertion asSentence Relationship+between+ABO+blood+groups+and+von+Willebrand+factor%2C+ADAMTS13+and+factor+VIII+in+patients+undergoing+hemodialysis. assertion.
- assertion asSentence Baseline+vWF+factor+predicts+the+development+of+elevated+pulmonary+artery+pressure+in+systemic+sclerosis. assertion.
- assertion asSentence Activation+of+Wiskott-Aldrich+syndrome+protein+and+its+association+with+other+proteins+by+stromal+cell-derived+factor-1alpha+is+associated+with+cell+migration+in+Jurkat+cells%2C+a+T-lymphocyte+line. assertion.
- assertion asSentence The+NTAL%2FLAB+is+expressed+in+a+variety+of+immune+cells. assertion.
- assertion asSentence LAB+has+the+ability+to+modulate+signaling+in+virtually+every+type+of+leukocyte. assertion.
- assertion asSentence WEE1+is+directly+transactivated+by+and+increased+in+association+with+c-Fos%2FAP-1. assertion.
- assertion asSentence WEE1+can+be+introduced+to+rescue+cells+from+the+damage+caused+by+certain+antineoplastic+agents. assertion.
- assertion asSentence Five+different+heterozygous+missense+mutations+%28T699M%2C+A716T%2C+V779M%2C+L829P%2C+G831D%29+in+the+WFS1+gene+found+in+six+low+frequency+sensorineural+hearing+loss+%28LFSNHL%29+families. assertion.
- assertion asSentence WFS1+is+not+a+major+susceptibility+gene+for+the+development+of+psychiatric+disorders+in+subjects+with+Wolfram+syndrome. assertion.
- assertion asSentence WFS1+mutations+lead+to+drastically+reduced+steady-state+levels+of+wolframin. assertion.
- assertion asSentence The+WFS1+gene+is+located+on+the+short+arm+of+chromosome+4+in+Wolfram+syndrome. assertion.
- assertion asSentence WFS1+gene+is+associated+with+autistic+traits%2C+empathy+and+Asperger+syndrome. assertion.
- assertion asSentence A+role+for+WFS1+in+the+negative+regulation+of+ER+stress+signaling+and+in+the+pathogenesis+of+diseases+involving+chronic%2C+unresolvable+ER+stress%2C+such+as+pancreatic+beta+cell+death+in+diabetes. assertion.
- assertion asSentence WHSC1+expression+increases+with+ascending+tumor+proliferation+activity. assertion.
- assertion asSentence WHSC1+regulates+the+methylation+status+of+the+histone+H4+K20+residue+and+is+required+for+the+recruitment+of+53BP1+to+sites+of+DNA+damage. assertion.
- assertion asSentence Oncogenic+activation+of+the+WNT%2Fbeta-catenin+signaling+pathway+is+common+in+hepatocellular+carcinoma. assertion.
- assertion asSentence Wnt1+signaling+inhibits+interfollicular+progenitor+cell+growth+and+promotes+terminal+differentiation+of+keratinocytes. assertion.
- assertion asSentence Silencing+of+WNT1+by+siRNA+induces+apoptosis+of+MCF-7+human+breast+cancer+cells. assertion.
- assertion asSentence Wnt1+and+Wnt+signaling+have+an+important+role+in+human+mesenchymal+stem+cell+osteogenesis. assertion.
- assertion asSentence HMGA1+is+involved+in+proliferation+and+gastric+tumor+formation+via+the+Wnt%2Fbeta-catenin+pathway. assertion.
- assertion asSentence High+Wnt1+is+associated+with+non-small+cell+lung+cancer+after+surgery. assertion.
- assertion asSentence Activating+mutations+of+the+WNT2+gene+are+not+a+major+contributor+to+the+development+of+autistic+disorder. assertion.
- assertion asSentence Inhibition+of+Wnt2+by+monoclonal+antibodies+is+of+therapeutic+interest+in+the+development+of+more+effective+treatments+for+malignnt+pleueral+mesothelioma. assertion.
- assertion asSentence The+increased+Wnt2+expression+in+gastric+cancers+is+paralleled+with+reduction+of+membranous+E-cadherin. assertion.
- assertion asSentence DNA+methylation+within+the+WNT2+promoter+in+human+placenta+is+associated+with+low+birthweight. assertion.
- assertion asSentence WNT3+regulates+distinct+internalization+pathways+of+LRP6+to+tune+the+activation+of+beta+catenin+signaling. assertion.
- assertion asSentence Altered+mRNA+expression+is+associated+with+prostate+cancer+recurrence. assertion.
- assertion asSentence The+Embryonic+Lethal+Abnormal+Vision-like+protein+HuR%2C+inhibited+translation+of+Wnt-5a+when+bound+to+highly+conserved+AU-rich+sequences+in+the+3%27-untranslated+region+of+the+Wnt-5a+mRNA. assertion.
- assertion asSentence WNT5A+is+an+important+target+of+CUTL1+and+mediator+of+invasiveness+and+tumor+progression+in+pancreatic+cancer. assertion.
- assertion asSentence The+genesis+of+myelocytic+leukemia+is+related+to+the+down-regulated+expression+of+Wnt5a. assertion.
- assertion asSentence Both+Wnt5a+and+Wnt3a+bound+Ror2%2C+only+Wnt5a+induced+Ror2+homo-dimerization+and+tyrosine+phosphorylation+in+U2OS+human+osteoblastic+cells. assertion.
- assertion asSentence Laminin+gamma2+mediates+Wnt5a-induced+invasion+of+gastric+cancer+cells. assertion.
- assertion asSentence WNT5A+signaling+is+important+in+modulating+tumorigenic+behaviors+of+enamel+epithelium+cells+in+ameloblastomas. assertion.
- assertion asSentence In+melanoma+cells%2C+expressions+of+Wnt5A+and+Klotho+are+inversely+correlated. assertion.
- assertion asSentence Hypermethylation+of+WNT5a+is+associated+with+colon+cancer. assertion.
- assertion asSentence Wnt5a+plays+an+important+role+in+human+hindgut+and+anorectal+morphogenesis. assertion.
- assertion asSentence Wnt5a+promotes+breast+cancer+cell+migration+via+Dvl2%2FDaam1%2FRhoA. assertion.
- assertion asSentence Wnt6+plays+an+important+role+in+tooth+development+by+promoting+human+dental+papilla+cell+differentiation%2C+without+significant+effects+on+cell+proliferation. assertion.
- assertion asSentence The+activity+of+the+Sprouty4+promoter+is+increased+by+Wnt7A%2FFrizzled+9+homolog+%28Fzd9%29+signaling+through+peroxisome+proliferator-activated+receptor+gamma+in+lung+cancer+cells. assertion.
- assertion asSentence Reexpression+of+WNT7A+during+malignant+transformation+of+ovarian+epithelial+cells+plays+a+critical+role+in+ovarian+cancer+progression+mediated+by+WNT%2Fbeta-catenin+signaling+pathway. assertion.
- assertion asSentence WNT8b+and+SHH+mutations+and+abnormal+expressions+are+present+in+the+peripheral+blood+of+children+with+sporadic+Hirschsprung+disease. assertion.
- assertion asSentence Homozygous+nonsense+mutation+in+WNT10B+is+associated+with+sporadic+split-hand%2Ffoot+malformation+with+autosomal+recessive+inheritance. assertion.
- assertion asSentence Wnt11+gene+is+expressed+during+early+embryonic+development+and+has+a+critical+role+in+regulation+of+gastrulation+movements. assertion.
- assertion asSentence Heplipin+induced+KG-1+cell+apoptosis+is+related+with+Wntl3+and+ATPase3. assertion.
- assertion asSentence The+coiled-coil+domain+of+WRB+is+the+binding+site+for+TRC40%2FAsna1. assertion.
- assertion asSentence WRN+effectively+stimulates+FEN-1+cleavage+of+branch-migrating+double-flap+structures+that+are+the+physiological+substrates+of+FEN-1+during+replication. assertion.
- assertion asSentence WRN+and+TP53+perform+different+functions+in+a+shared+DNA+damage+response+pathway. assertion.
- assertion asSentence Physical+interaction+between+RPA+and+WRN+or+BLM+helicases+plays+an+important+role+in+the+mechanism+for+RPA+stimulation+of+helicase-catalyzed+DNA+unwinding. assertion.
- assertion asSentence MutSalpha+and+MutSbeta+can+strongly+stimulate+the+helicase+activity+of+WRN+specifically+on+forked+DNA+structures+with+a+3%27-single-stranded+arm. assertion.
- assertion asSentence WRN+Cys1367Arg+SNP+is+not+associated+with+risk+and+prognosis+of+human+gliomas. assertion.
- assertion asSentence WRN+helicase+operates+in+an+EXO1-dependent+pathway+to+help+cells+survive+replicational+stress. assertion.
- assertion asSentence WRN+protein+participates+in+the+DNA+translesion+synthesis+pathway+to+prevent+genomic+instability+in+an+ATM%2FNBS1-dependent+manner. assertion.
- assertion asSentence WRN+stimulates+%28CTG%29%28n%29+HPR+on+the+template+DNA+strand+by+resolving+the+hairpin+so+that+it+can+be+efficiently+used+as+a+template+for+repair+or+replicative+synthesis. assertion.
- assertion asSentence WT1+gene+is+expressed+from+the+paternal+allele+in+fibroblasts+and+lymphocytes. assertion.
- assertion asSentence WT1+is+expressed+in+appreciable+numbers+of+endometrial+cancers. assertion.
- assertion asSentence Th1-biased+cellular+immune+responses+against+WT1+protein+should+be+elicited+in+patients+with+hematopoietic+malignancies. assertion.
- assertion asSentence Isoforms+of+WT1+play+antiapoptotic+roles+at+some+points+upstream+of+the+mitochondria+in+the+intrinsic+apoptosis+pathway. assertion.
- assertion asSentence WT1+expression+in+normal+bone+marrow+decreases+gradually+with+cell+differentiation. assertion.
- assertion asSentence Transcriptional+activation+of+ETS-1+by+the+Wilms%27+tumour+suppressor+WT1+is+a+crucial+step+in+tumour+vascularization+via+regulation+of+endothelial+cell+proliferation+and+migration. assertion.
- assertion asSentence WT1-shRNA+targeting+exon+5+should+serve+as+a+potent+anti-cancer+agent+for+various+types+of+solid+tumors. assertion.
- assertion asSentence Gynaecologic+epithelial+histologic+type+is+regulated+by+WT1+expression+through+its+selective+repression+of+HOX+genes. assertion.
- assertion asSentence The+high+frequency+of+loss+of+allelic+integrity+at+Wilms%27+tumor+suppressor+gene-1+locus+in+high-graded+breast+tumors+is+associated+with+aggressiveness+of+the+tumor. assertion.
- assertion asSentence Wilms+tumor+1+gene+mutations+are+associated+with+pediatric+T-cell+malignancies. assertion.
- assertion asSentence Single+nucleotide+polymorphism+in+the+mutational+hotspot+of+WT1+predicts+a+favorable+outcome+in+patients+with+cytogenetically+normal+acute+myeloid+leukemia. assertion.
- assertion asSentence Proteolysis+of+WT1+by+HtrA2+causes+the+removal+of+WT1+from+its+binding+sites+at+gene+promoters%2C+leading+to+alterations+in+gene+regulation+that+enhance+apoptosis. assertion.
- assertion asSentence The+high+Wt1+expression+correlated+with+the+presence+of+FLT3-ITD+%28P+%3D+0.014%29+and+lower+rate+of+complete+remission+%28P+%3D+0.023%29. assertion.
- assertion asSentence WT1+expression+is+a+marker+of+poor+prognosis+in+colorectal+cancers%2C+independent+of+AJCC+staging. assertion.
- assertion asSentence WT1+expression+is+down-regulated+in+the+ovulatory+polycystic+ovary+syndrome+endometrium+during+the+window+of+implantation. assertion.
- assertion asSentence XBP-1s+binds+to+and+activates+the+KSHV+immediate-early+gene+ORF50. assertion.
- assertion asSentence XBP-1+significantly+correlates+with+Epstein-Barr+virus+LMP1+expression+in+nasopharyngeal+tumor+biopsies. assertion.
- assertion asSentence The+molybdenum+center+of+XOR+is+posttranslationally+inactivated+by+oxygen+metabolites+in+%22normal%22+%2821%25+O2%29+cell+culture+atmosphere+and+this+inactivation+is+reversed+in+hypoxia+and+accounts+for+the+apparent+induction. assertion.
- assertion asSentence Non-diabetic%2C+non-smokers%2C+non-hypertensive+and+untreated+patients+with+familial+combined+hyperlipidemia+present+with+increased+levels+of+XO+and+NFKB+activity. assertion.
- assertion asSentence Lower+PON1+and+high+xanthine+oxidase+enzyme+activities+cause+an+imbalance+of+the+free+radical+system. assertion.
- assertion asSentence Decreased+XOR+is+associated+with+poorer+prognosis+in+patients+with+serous+ovarian+cancer. assertion.
- assertion asSentence SIRT1+regulates+NER+pathway+through+modulation+of+XPA+acetylation+status. assertion.
- assertion asSentence The+XPA+A23G+G+allele+is+a+low-penetrant+risk+factor+for+cancer+development. assertion.
- assertion asSentence XPC+Ala499Val+%28C%3ET%29+polymorphism+is+correlated+with+high+risk+of+idiopathic+azoospermia+in+the+Han-Chinese+population. assertion.
- assertion asSentence A+meta-analysis+of+association+between+XPC+polymorphisms+and+cancer+risk. assertion.
- assertion asSentence The+5%27-GTG-3%27+sequence%2C+containing+5R+thymine+glycol%2C+paired+with+adenine%2C+is+a+good+binding+substrate+for+XPA+and+XPC%2FHR23B. assertion.
- assertion asSentence XPC+exonic+variants+contributed+to+the+risk+of+gallbladder+cancer+%28GBC%29+in+this+Chinese+population. assertion.
- assertion asSentence XPC-PolyAT+polymorphisms+are+associated+with+a+higher+risk+of+developing+prostate+cancer. assertion.
- assertion asSentence Heme+regulates+gene+expression+by+triggering+CRM1-dependent+nuclear+export+of+BACH1. assertion.
- assertion asSentence Ihe+subcellular+localization+of+MSH4+is+regulated+by+an+active+nuclear+export+pathway+dependent+on+the+exportin+CRM1%3BCRM1+is+also+involved+in+MSH5+nuclear+export. assertion.