Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Diagnostic+utility+of+PAX8%2C+TTF-1+and+napsin+A+for+discriminating+metastatic+carcinoma+from+primary+adenocarcinoma+of+the+lung. assertion.
- assertion asSentence Chorionic+gonadotropin+down-regulates+the+expression+of+the+decoy+inhibitory+interleukin+1+receptor+type+II+in+human+endometrial+epithelial+cells. assertion.
- assertion asSentence Levels+of+interleukin-1beta+and+Il1R2in+the+peritoneal+fluid+of+normal+women+and+patients+with+endometriosis+suffering+from+pelvic+pain+and+infertility. assertion.
- assertion asSentence Use+of+the+stromal+cell-derived+factor-1%2FCXCR4+pathway+in+prostate+cancer+metastasis+to+bone. assertion.
- assertion asSentence Membrane+cholesterol+is+essential+for+CXCR4+conformation+and+binding+to+SDF-1+alpha+on+T+cells+and+is+required+by+HIV+on+target+cell+membranes+for+infection. assertion.
- assertion asSentence Follicular+dendritic+cell-mediated+up-regulation+of+CXCR4+expression+on+CD4+T+cells+in+coculture+correlates+with+augmented+HIV-1+binding+and+entry+into+these+cells+and+increases+susceptibility+of+germinal+center+CD4+T+cells+to+HIV+infection. assertion.
- assertion asSentence CCR5-binding+chemokines+modulate+CXCL12+%28SDF-1%29-induced+responses+of+progenitor+B+cells+in+human+bone+marrow+through+heterologous+desensitization+of+the+chemokine+receptor. assertion.
- assertion asSentence Engagement+of+both+CD4+and+CXCR4+is+required+for+HIV-induced+shedding+of+L-selectin+on+primary+resting+CD4%28%2B%29+T+cells. assertion.
- assertion asSentence Epithelial+CXCR4+can+transduce+functional+signals+in+human+intestinal+epithelial+cells+that+modulate+important+cAMP-mediated+cellular+functions. assertion.
- assertion asSentence Mechanisms+of+CXCR4%2FCXCL12-mediated+prostate+cancer+cell+migration+and+invasion. assertion.
- assertion asSentence HIV-1+activates+major+CXCR4-dependent+signal+transduction+pathways+and+acts+as+a+chemoattractant+for+unstimulated+primary+CXCR4%2BCD4%2B+T+cells. assertion.
- assertion asSentence The+SDF-1%2FCXCR4+axis+promotes+hematopoietic+stem%2Fprogenitor+cell+proliferation+in+contact+with+mesenchymal+stem+cells. assertion.
- assertion asSentence HIV-infected+cells+can+induce+autophagy+in+bystander+CD4%2B+T+lymphocytes+through+contact+of+Env+with+CXCR4. assertion.
- assertion asSentence Preferential+role+of+in+cytotoxic+T+lymphocyte+migration+toward+melanoma+cells. assertion.
- assertion asSentence By+activating+CXCR4%2C+macrophage+migration+inhibitory+factordisplays+chemokine-like+functions+and+acts+as+a+major+regulator+of+inflammatory+cell+recruitment+and+atherogenesis. assertion.
- assertion asSentence CXCR4+expression+is+an+important+prognostic+factor+in+ovarian+carcinoma. assertion.
- assertion asSentence G-CSF+induces+hematopoietic+stem+cell+mobilization+by+decreasing+bone+marrow+SDF-1+and+down-regulating+CXCR4+expression. assertion.
- assertion asSentence CXCR4+glycan+inhibits+CD4-independent+X4+virus+infection. assertion.
- assertion asSentence CHK+is+capable+of+inhibiting+the+CXCL12-CXCR4+pathway+in+neuroblastoma. assertion.
- assertion asSentence Breast+cancer+metastasis+suppressor+1+inhibits+SDF-1alpha-induced+migration+of+non-small+cell+lung+cancer+by+decreasing+CXCR4+expression. assertion.
- assertion asSentence Blocking+CXCR7+can+be+useful+for+therapeutic+interference+with+CXCR4-mediated+activation+of+integrins. assertion.
- assertion asSentence HIV+utilizes+the+Galphai-dependent+signaling+from+the+chemokine+coreceptor+CXCR4+to+activate+a+cellular+actin-depolymerizing+factor%2C+cofilin%2C+to+overcome+the+static+cortical+actin+restriction+in+resting+CD4+T+cells. assertion.
- assertion asSentence Slits+are+negative+regulators+of+Sdf1+and+Cxcr4+in+breast+cancer+cells. assertion.
- assertion asSentence IGF-1+transgene+expression+induces+massive+stem+cell+mobilization+via+SDF-1alpha+signaling+and+culminates+in+extensive+angiomyogenesis+in+the+infarcted+heart. assertion.
- assertion asSentence SDF-1alpha%2FCXCR4+axis+involves+in+cyclic+stretch+-mediated+cellular+functions+in+human+saphenous+vein+smooth+muscle+cells. assertion.
- assertion asSentence Arrest+of+CXCR4+can+inhibit+liver+metastasis+of+colon+cancer+through+blocking+cell+proliferation+and+migration+induced+by+SDF-1. assertion.
- assertion asSentence High+CXCR4+is+associated+with+liver+metastasis+of+colorectal+cancer. assertion.
- assertion asSentence BCR+signaling+promotes+decrease+of+CXCR4+and+CD62L+membrane+expression+in+progressive+cases+only. assertion.
- assertion asSentence The+receptor+for+CXCL12%2C+CXCR4%2C+is+strongly+expressed+on+human+brain+microvessel+endothelial+cells+under+standard+culture+conditions+and+is+downregulated+upon+binding+to+CXCL12%2C+after+incubation+of+the+monolayers+with+cytokines+and+lipopolysaccharide. assertion.
- assertion asSentence CXCR4-induced+T+cell+adhesion+and+migration+are+not+affected+by+loss+of+SH2+domain+containing+leukocyte+protein+of+76+kDa+%28SLP76%29+in+Jurkat+T+cells. assertion.
- assertion asSentence Chondrosarcoma+cell+invasion+is+increased+by+hypoxia+induced+expression+of+CXCR4+and+MMP1+and+is+mediated+by+HIF-1a+and+ERK. assertion.
- assertion asSentence Dedicator+of+cytokinesis+%28DOCK%29180+links+CXCR4+signaling+to+Rac+activation+in+order+to+control+endothelial+cell+migration+during+cardiovascular+development. assertion.
- assertion asSentence Regulation+of+bone+marrow+progenitor+cell+trafficking+by+SDF-1+and+CXCR4+is+dependent+on+Src-mediated+c-kit+phosphorylation. assertion.
- assertion asSentence The+autocrine%2Fparacrine+macrophage+migration+inhibitory+factor+%28MIF%29-CXCR4%2FCXCR7+axis+plays+an+important+pleiotropic+role+in+rhabdomyosarcoma+growth. assertion.
- assertion asSentence Up-regulation+of+CXCR4+is+associated+with+colorectal+cancer+progression. assertion.
- assertion asSentence USP8+promotes+trafficking+and+degradation+of+CXCR4+at+the+sorting+endosome. assertion.
- assertion asSentence Enoxaparin+%28LMWH%29+inhibits+the+formation+of+hepatic+metastasis+of+colon+cancer+by+disrupting+the+interaction+of+CXCR4+and+CXCL12. assertion.
- assertion asSentence No+significant+association+between+the+SDF-1+and+CXCR4+polymorphisms+and+endometrium+cancer+risk. assertion.
- assertion asSentence High+expression+of+CXCR4+is+associated+with+gallbladder+cancer. assertion.
- assertion asSentence High+CXCR4+expression+correlates+with+a+poor+response+to+sunitinib+in+metastatic+renal+cancer. assertion.
- assertion asSentence X4+HIV-1+gp120+is+pro-fibrogenic+through+its+interactions+with+CXCR4+on+activated+human+hepatic+stellate+cells. assertion.
- assertion asSentence UL33+and+UL78+heteromerize+with+host+CCR5+and+CXCR4+impairing+their+HIV+coreceptor+activity. assertion.
- assertion asSentence Plasmacytoid+dendritic+cells+%28pDCs%29+constitutively+migrate+into+the+splenic+white+pulp+in+a+manner+dependent+on+chemokine+receptors+CXCR4+and+CCR7. assertion.
- assertion asSentence Heterozygous+or+homozygous+variant+genotype+confers+a+%3E40%25+reduced+relative+risk+of+lung+cancer+in+Latino+Americans+controlling+for+other+lung+cancer+risk+factors. assertion.
- assertion asSentence SEMA3B+exerts+unexpected+functions+in+cancer+progression+by+fostering+a+prometastatic+environment+through+elevated+IL-8+secretion. assertion.
- assertion asSentence SEMA3B+plays+role+in+inhibiting+of+growth+of+renal%2C+ovarian+and+colorectal+cancer+cells. assertion.
- assertion asSentence Recruitment+of+USP7+to+LANA+plays+a+role+in+the+regulation+of+viral+latent+replication. assertion.
- assertion asSentence The+crystal+structure+of+Rab7-GTP+in+complex+with+the+Rab7+binding+domain+of+RILP+reveals+that+Rab7+interacts+with+RILP+specifically+via+two+distinct+areas. assertion.
- assertion asSentence The+oncogene+DEK+promotes+leukemic+cell+survival+and+is+downregulated+by+both+Nutlin-3+and+chlorambucil+in+B-chronic+lymphocytic+leukemic+cells. assertion.
- assertion asSentence DEK+can+contribute+directly+to+joint+inflammation+in+juvenile+idiopathic+arthritis+by+generating+ICs+through+high-affinity+interaction+between+DEK+and+DEK+autoantibodies. assertion.
- assertion asSentence TDP-43+proteinopathy+is+the+common+pathologic+substrate+linking+frontotemporal+lobar+degeneration+and+amyotrophic+lateral+sclerosis. assertion.
- assertion asSentence Cdk6+up-regulation+in+TDP-43-depleted+cells+is+accompanied+by+an+increase+in+phosphorylation+of+two+of+its+major+targets%2C+the+retinoblastoma+protein+pRb+and+pRb-related+protein+pRb2%2Fp130. assertion.
- assertion asSentence C-terminus+of+TDP-43+is+essential+for+solubility+and+cellular+localization. assertion.
- assertion asSentence VCP+mutations+causing+frontotemporal+lobar+degeneration+disrupt+localization+of+TDP-43+and+induce+cell+death. assertion.
- assertion asSentence Unrelated+families+with+familial+Amyotrophic+lateral+sclerosis+carrying+the+p.Ala382Thr+TARDBP+missense+mutation+developed+frontotemporal+lobar+dementia. assertion.
- assertion asSentence TDP-43+regulates+its+mRNA+levels+through+a+negative+feedback+loop. assertion.
- assertion asSentence TDP-43+requires+its+C-terminal+prion-like+domain+and+a+portion+of+RRM2+%28RNA+recognition+motif+2%29+to+aggregate+in+yeast+toxicity. assertion.
- assertion asSentence Fecal+fat+excretion+is+increased+in+patients+with+type+2+diabetes+with+fecal+elastase+deficiency. assertion.
- assertion asSentence Multiple+U2AF65+binding+sites+within+SF3b155+regulate+conformational+rearrangements+during+spliceosome+assembly. assertion.
- assertion asSentence ANGPTL-2+and+-3+have+enhancing+effect+on+human+hematopoietic+progenitor+cell+survival%2C+effects+requiring+the+CC+domain+of+the+ANGPTL+molecules. assertion.
- assertion asSentence Keratinocyte-derived+Angptl2+functions+in+dermatomyositis+pathogenesis+by+inducing+chronic+inflammation+in+skin+tissue. assertion.
- assertion asSentence Icmt+traverses+the+Eendoplasmic+reticulum+membrane+eight+times%2C+with+both+N+and+C+termini+disposed+toward+the+cytosol+and+with+a+helix-turn-helix+structure+comprising+transmembrane+%28TM%29+segments+7+and+8. assertion.
- assertion asSentence Role+of+TACI+coding+variants+in+common+variable+immunodeficiency+and+selective+IgA+deficiency. assertion.
- assertion asSentence Single+Nucleotide+Polymorphisms+in+TNFRSF13B+is+associated+with+common+variable+immunodeficiency. assertion.
- assertion asSentence Fucosyltransferases%2C+O-FucT-1+is+a+soluble+protein+that+localizes+to+the+endoplasmic+reticulum+and+recognizes+properly+folded+epidermal+growth+factor-like+repeats. assertion.
- assertion asSentence The+JAFZ1-JJAZ1+fusion+gene+is+present+in+the+endometrial+stromal+and+smooth+muscle+components+of+endometrial+stromal+tumors. assertion.
- assertion asSentence SUZ12%2C+a+component+of+the+polycomb+repressor+complex+2%2C+is+recruited+to+the+beta-globin+gene. assertion.
- assertion asSentence Genetic+defects+in+PRC2+components+other+than+EZH2+are+not+common+in+myeloid+malignancies. assertion.
- assertion asSentence E6AP+is+extensively+involved+in+the+ubiquitin-mediated+degradation+of+SCRIB+%28an+HPV+E6-dependent+substrate%29+as+a+cellular+E3+ubiquitin-protein+ligase. assertion.
- assertion asSentence Essential+role+for+mammalian+Scribble+in+the+regulation+of+the+polarity+specifically+involved+in+directed+epithelial+migration. assertion.
- assertion asSentence hScrib+is+involved+in+the+development+of+endometrial+cancer. assertion.
- assertion asSentence MORC3+colocalizes+with+PML+by+a+two-step+molecular+mechanism. assertion.
- assertion asSentence The+intensity+of+the+tetramer-staining+of+the+HA-1%2FHA-2-specific+cytotoxic+T+cells+strongly+correlates+with+their+capability+to+recognize+mHag+positive+target+cells. assertion.
- assertion asSentence ACAP2+has+robust%2C+constitutive+Arf6+GAP+activity+in+vivo%2C+with+little+activity+toward+Arf1. assertion.
- assertion asSentence PRAME+expression+is+not+associated+with+down-regulation+of+retinoic+acid+signaling+in+primary+acute+myeloid+leukemia. assertion.
- assertion asSentence Transportin+3+and+importin+alpha+act+as+receptors+and+are+required+for+effective+nuclear+import+of+HIV-1+integrase+in+virus-infected+cells. assertion.
- assertion asSentence A+role+of+the+SEZ6L+Met430Ile+polymorphic+variant+in+increasing+lung+cancer+risk. assertion.
- assertion asSentence Rhes+can+interfere+with+the+functional+activity+of+wt+and+mutated+TSHr+and+with+the+respective+hormone-stimulated+cAMP+production+of+FSHr+and+LHr. assertion.
- assertion asSentence The+largest+miRNA-146a-TSPAN12+response+to+stress+of+amyloidbeta+peptide+%2B+tumor+necrosis+factoralpha+is+found+in+human+neuronal+glial+cells+from+Alzheimer+brain. assertion.
- assertion asSentence Multiple+congenital+anomalies-hypotonia-seizures+syndrome+is+caused+by+a+mutation+in+PIGN. assertion.
- assertion asSentence The+WW1+and+WW2+domains+of+YAP2+recognize+various+PPXY+motifs+within+WBP2+and+WBP1+in+a+highly+promiscuous+and+subtle+manner. assertion.
- assertion asSentence The+ability+of+CLDN14+to+be+recruited+to+these+junctions+is+crucial+for+the+hearing+process. assertion.
- assertion asSentence DDAH2+mRNA+expression+is+inversely+associated+with+some+cardiovascular+risk-related+features. assertion.
- assertion asSentence A+haplotype+of+nonsynonymous+single-nucleotide+polymorphisms+in+PADI4+contributes+to+development+of+rheumatoid+arthritis+regardless+of+anti-cyclic+citrullinated+peptide+or+erosive+joint+status. assertion.
- assertion asSentence PADI4+expression+is+related+to+the+tumorigenic+process+of+esophageal+cancer+and+deoxycholate-induced+apoptosis. assertion.
- assertion asSentence Maintenance+of+normoglycemia+and+not+glycemia-independent+actions+of+insulin+maintained+dimethylarginine+tissue+levels+by+preserving+physiological+DDAH+activity. assertion.
- assertion asSentence Caspase+14+is+a+cysteine+protease+and+is+inhibited+by+full-length+LEKTI+and+5+recombinant+fragments+of+LEKTI+to+varied+extents. assertion.
- assertion asSentence Decreased+expression+of+GCIP+in+vivo+is+present+in+human+breast+carcinoma. assertion.
- assertion asSentence SMUG1+plays+little+natural+role+in+antibody+diversification. assertion.
- assertion asSentence RNA+helicase+cytoplasmic+sensor+RIG-I+mediates+innate+antiviral+signaling+that+is+not+inhibited+by+dihydroxyacetone+kinase. assertion.
- assertion asSentence A+RIG-I%2FIFNalphabeta+receptor+%28IFNAR%291-dependent+pathway+mediates+SOCS1+and+SOCS3+up-regulation+in+influenza+A+virus-infected+bronchial+epithelial+cells. assertion.
- assertion asSentence The+activation+of+RIG-I+occurs+through+an+RNA-+and+ATP-driven+structural+switch+in+the+SF2+domain. assertion.
- assertion asSentence HSV-1+US11+binds+to+RIG-I+and+MDA-5+and+inhibits+their+downstream+signaling+pathway. assertion.
- assertion asSentence The+absence+of+direct+binding+of+BAF+to+MAN1-C+eliminates+disruption+of+this+interaction+as+the+cause+of+the+premature+aging+phenotype. assertion.
- assertion asSentence Examine+P504S+expressing+circulating+prostate+cells+as+a+marker+for+prostate+cancer. assertion.
- assertion asSentence Coronin+1C+negatively+regulates+epithelial+cell+migration+via+FAK-mediated+inhibition+of+cell-matrix+adhesion. assertion.
- assertion asSentence PSTPIP1+acts+downstream+of+CD2%2FCD2AP+to+link+CD2+engagement+to+the+WASp-evoked+actin+polymerization+required+for+synapse+formation+and+T+cell+activation. assertion.
- assertion asSentence Focal+segmental+glomerulosclerosis+in+a+patient+homozygous+for+a+CD2AP+mutation. assertion.
- assertion asSentence Oxidative+stress+induces+increased+BACE+protein+levels+and+activity+in+NT2+neurons+accompanied+by+an+increase+in+amyloid+beta+protein+precursor. assertion.
- assertion asSentence An+isoenzyme+specifically+truncates+amyloid+beta-peptide+after+its+presenilin-dependent+generation. assertion.