Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Gamma-secretase+cleavage+of+CT99+is+a+prerequisite+for+BACE-mediated+processing+at+Abeta-34+site+and+therefore%2C+BACE+and+gamma-secretase+activity+can+be+mutually+dependent. assertion.
- assertion asSentence Platelet+membrane+beta-secretase+activity+%28expressed+as+initial+rate%29+varied+over+fourfold+between+individuals. assertion.
- assertion asSentence Loss+of+specific+miRNAs+can+contribute+to+increased+BACE1+and+Abeta+levels+in+sporadic+Alzheimer%27s+disease. assertion.
- assertion asSentence Over-expression+of+BACE1+in+beta-amyloid+precursor+protein+%28APP%29-transfected+cells+is+decreased+by+simultaneous+low+density+lipoprotein+receptor-related+protein+1+%28LRP1%29+over-expression. assertion.
- assertion asSentence Nerve+growth+factor+shifts+amyloid-beta+protein+precursor+%28AbetaPP%29+processing+towards+the+alpha-secretase+%28non-amyloidogenic%29+pathway+in+rat+PC12+cells. assertion.
- assertion asSentence The+BACE1+has+an+ancient+role+in+response+to+low+oxygen%2Foxidative+stress. assertion.
- assertion asSentence In+HEK293+cells%2C+miR-195+regulates+the+BACE1+mRNA+translation+or+decay+process%2C+through+the+3%27-UTR+binding+site+1+without+affecting+transcription. assertion.
- assertion asSentence C-Cbl+is+a+negative+regulator+of+hepatocyte+growth+factor%2Freceptor+tyrosine+kinase+Met+signaling+in+B+cells%2C+mediating+ubiquitination+and%2C+consequently%2C+proteosomal+degradation+of+Met%2C+with+a+role+in+Met-mediated+tumorigenesis. assertion.
- assertion asSentence The+cellular+Nup62+is+specifically+recruited+by+HIV-1+IN+and+contribute+to+an+efficient+viral+DNA+integration. assertion.
- assertion asSentence The+cochaperone+HspBP1+binds+to+and+inhibits+Hsp70+activity. assertion.
- assertion asSentence The+extracellular+toll-like+receptor+4+%28TLR4%29domain-MD-2+complex+is+capable+of+binding+lipopolysaccharide+%28LPS%29+and+attenuating+LPS-induced+NF-kappa+B+activation+and+IL-8+secretion+in+wild-type+TLR4-expressing+cells. assertion.
- assertion asSentence The+structural+pattern+recognized+by+MD-2+is+defined+by+the+hydrophobic+patch+and+a+pair+of+separated+negative+charges. assertion.
- assertion asSentence Human+conjunctival+epithelial+cells+lack+LPS+responsiveness+due+to+deficient+expression+of+MD2. assertion.
- assertion asSentence The+MD-2%2F-1625+polymorphism+is+an+important+functional+variant. assertion.
- assertion asSentence The+leucine+at+position+815+is+required+for+the+normal+maturation+of+TLR4+and+for+formation+of+the+TLR4.MD-2+complex. assertion.
- assertion asSentence Polymorphisms+of+the+promoter+region+of+MD-2+gene+at+position+-+1625+C%2FG+is+correlated+with+MODS+and+sepsis+after+severe+trauma+in+Chinese+Han+population. assertion.
- assertion asSentence Cytokines+can+enhance+TLR4+and+MD-2+expressions+and+promote+the+reaction+with+LPS+in+intestinal+epithelial+cells. assertion.
- assertion asSentence GADD34-PP1c+recruited+by+Smad7+inhibits+TGFbeta-induced+cell+cycle+arrest. assertion.
- assertion asSentence TRIM29+is+upregulated+after+radical+prostatectomy+for+prostatic+neoplasms. assertion.
- assertion asSentence ATDC+increases+cell+proliferation+via+inhibition+of+p53+nuclear+activities. assertion.
- assertion asSentence Hypermethylation+of+HPP1+is+associated+with+hMLH1+hypermethylation+in+gastric+adenocarcinomas. assertion.
- assertion asSentence SH3BP4+is+a+negative+regulator+of+the+Rag+GTPase+complex+and+amino+acid-dependent+mTORC1+signaling. assertion.
- assertion asSentence The+TSLC1+promoter+region+has+many+methylated+cytosines+in+the+CpG+islands+in+chromosome+11q+LOH+in+breast+cancer. assertion.
- assertion asSentence Loss+of+TSLC1+is+associated+with+lower+patient+survival%2C+supporting+its+role+as+a+tumor+suppressor+in+lung+adenocarcinoma. assertion.
- assertion asSentence IGSF4+silencing+by+CpG+methylation+provides+an+anti-apoptotic+signal+to+Hodgkin%2FReed-Sternberg+cells+important+in+Hodgkin+lymphoma+pathogenesis. assertion.
- assertion asSentence Low+expression+and+high+alterations+%28methylation%2Fdeletion%29+%2855-59%25%29+of+ATM+and+CADM1+genes+along+with+poor+patient+outcome. assertion.
- assertion asSentence The+inherited+blindness+associated+protein+AIPL1+interacts+with+the+cell+cycle+regulator+protein+NUB1+in+the+retina. assertion.
- assertion asSentence Interacts+with+and+aids+in+processing+of+farnesylated+proteins+in+the+retina. assertion.
- assertion asSentence The+phenotype+of+LCA+%28Leber+congenital+amaurosis%29+in+patients+with+AIPL1+mutations+is+relatively+severe%2C+with+a+maculopathy+in+most+patients+and+keratoconus+and+cataract+in+a+large+subset. assertion.
- assertion asSentence Common+genetic+variation+in+the+BACE1-interacting+proteins%2C+RTN3+an+PPIL2%2C+does+not+influence+platelet+b-secretase+activity+or+susceptibility+to+Alzheimer%27s+disease+in+this+population. assertion.
- assertion asSentence IL-17RA+plays+a+functional+role+in+the+human+IL-25+receptor+complex+in+vitro+that+is+independent+of+IL-17A. assertion.
- assertion asSentence Zip1+and+CR+motifs+are+important+for+Kif4A+chromatin-binding+and+its+mitotic+function. assertion.
- assertion asSentence Loss+of+KIF4+expression+is+associated+with+gastric+carcinoma. assertion.
- assertion asSentence The+208delG+mutation+in+FSCN2+is+not+associated+with+hereditary+retinal+degeneration+in+the+Chinese+individuals+examined. assertion.
- assertion asSentence Despite+common+essential+features+that+are+shared+among+Ets+members%2C+the+crystal+structure+of+PDEF+Ets+domain+demonstrates+distinct+patterns+of+interactions+at+different+positions+of+DNA+in+achieving+sequence+specific+recognition. assertion.
- assertion asSentence Ataxin+10+and+eukaryotic+initiation+factors+interacts+with+M2+protein+of+influenza+A+virus. assertion.
- assertion asSentence Dada+shoe+that+the+His96-99-57+triad+is+responsible+for+the+Zn2%2B-mediated+inhibition+of+hK5+catalysis. assertion.
- assertion asSentence Ets+regulates+PRDX5+expression+through+their+interaction+with+HGMB1+protein. assertion.
- assertion asSentence Gamma-secretase+cleavage+of+CT99+is+a+prerequisite+for+BACE-mediated+processing+at+Abeta-34+site+and+therefore%2C+BACE+and+gamma-secretase+activity+can+be+mutually+dependent. assertion.
- assertion asSentence Both+thioredoxin+2+and+glutaredoxin+2+contribute+to+the+reduction+of+the+mitochondrial+2-Cys+peroxiredoxin+Prx3. assertion.
- assertion asSentence ASF1A+and+ASF1B+play+a+role+in+the+efficiency+of+nucleosome+assembly+in+vivo+in+human+cells. assertion.
- assertion asSentence Low+ASF1A+is+associated+with+familial+longevity. assertion.
- assertion asSentence YIPF3+is+synthesized+in+the+ER+as+a+N-glycosylated+form+%2840+kDa%29%2C+is+then+O-glycosylated+in+the+Golgi+apparatus+to+become+a+lower+mobility+form+%2846+kDa%29+and+finally+becomes+a+higher+mobility+form+cleaved+at+its+C-terminal+luminal+domain+%2836+kDa%29. assertion.
- assertion asSentence Patients+with+high+levels+of+expression+of+BRMS1+mRNA+have+a+better+prognosis+than+those+with+low+expression. assertion.
- assertion asSentence Breast+cancer+metastasis+suppressor+1+inhibits+SDF-1alpha-induced+migration+of+non-small+cell+lung+cancer+by+decreasing+CXCR4+expression. assertion.
- assertion asSentence Expression+of+BRMS1+mRNA+in+supraglottic+cancer+is+lower+than+that+in+adjacent+normal+mucosa. assertion.
- assertion asSentence PKD2+is+involved+in+the+production+of+IL-8%2C+a+potent+proinflammatory+chemokine%2C+by+epithelial+cells. assertion.
- assertion asSentence pFGE+is+retained+in+the+ER+through+its+C-terminal+tetrapeptide+PGEL%2C+a+noncanonical+variant+of+the+classic+KDEL+ER-retention+signal. assertion.
- assertion asSentence TCF+and+beta-catenin+binding+plays+important+roles+in+HCCR-1+oncogene+expression. assertion.
- assertion asSentence ZFP100+is+the+limiting+factor+for+histone+pre-mRNA+processing+in+vivo. assertion.
- assertion asSentence Rac1+activation+specifically+in+membrane+ruffles+by+the+guanine-nucleotide-exchange+factor+FLJ00068+is+sufficient+for+insulin+induction+of+glucose+uptake+into+skeletal-muscle+cells. assertion.
- assertion asSentence A+more+than+2-fold+higher+level+of+RNF19A+mRNA+in+the+blood+of+patients+with+prostate+cancer+than+in+healthy+controls+makes+it+an+early+diagnosis+marker+for+this+disease. assertion.
- assertion asSentence PRL-3%2C+like+PRL-1%2C+can+negatively+regulate+p53+via+the+activation+of+PIRH2+and+MDM2+in+cancer+cells. assertion.
- assertion asSentence Two+of+the+three+alleles+of+rs3832406+are+functionally+different+and+influence+the+splicing+efficiency+of+the+alternate+MTHFD1L+mRNA+transcripts. assertion.
- assertion asSentence Prevalence+of+minor+allele+A+%28adenosine%29+in+rs11754661+single+nucleotide+polymorphism+of+MTHFD1L+contributes+to+the+risk+of+Alzheimer%27s+disease+in+a+Han+population+of+mainland+China. assertion.
- assertion asSentence PTOP+heterodimerizes+with+POT1+and+regulates+POT1+telomeric+recruitment+and+telomere+length. assertion.
- assertion asSentence Mutations+in+NDUFAF3+%28C3ORF60%29%2C+encoding+an+NDUFAF4+%28C6ORF66%29-interacting+complex+I+assembly+protein%2C+cause+fatal+neonatal+mitochondrial+disease. assertion.
- assertion asSentence Rab27a+and+MyRIP+regulate+the+amount+and+multimeric+state+of+VWF+released+from+endothelial+cells. assertion.
- assertion asSentence ZNF521+modulates+erythroid+cell+differentiation+through+direct+binding+with+GATA-1. assertion.
- assertion asSentence SOSTDC1+is+expressed+in+normal+breast+tissue+and+this+expression+is+reduced+in+breast+cancer. assertion.
- assertion asSentence Hippo+pathway+negatively+regulates+TAZ+function+by+both+limiting+its+nuclear+accumulation+and+promoting+its+degradation. assertion.
- assertion asSentence WWTR1+is+an+oncogene+and+has+an+important+role+in+the+proliferation+of+colorectal+cancer+cells+and+in+tumor+growth+in+vivo. assertion.
- assertion asSentence Arthropathy+with+progressive+contractures+should+now+be+considered+part+of+the+spectrum+of+Aicardi-Goutieres+syndrome+because+of+SAMHD1+mutations. assertion.
- assertion asSentence Autosomal+dominant+inheritance+of+a+heterozygous+mutation+in+SAMHD1+causing+familial+chilblain+lupus. assertion.
- assertion asSentence mSin3A+interacts+with+HDAC2+via+the+HDAC-interacting+domain+%28HID%29+of+mSin3A. assertion.
- assertion asSentence Repression+of+p53-mediated+transcription+by+adenovirus+E1B+55-kDa+does+not+require+corepressor+mSin3A+and+histone+deacetylases. assertion.
- assertion asSentence Thrombin-induced+shedding+of+tumour+endothelial+marker+5+and+exposure+of+its+RGD+motif+are+regulated+by+cell-surface+protein+disulfide-isomerase. assertion.
- assertion asSentence Single+nucleotide+polymorphism+in+TIPARP+is+associated+with+ovarian+cancer. assertion.
- assertion asSentence CHMP2B+can+be+used+as+a+reliable+marker+for+GVD+in+neurons+of+the+AD+hippocampus. assertion.
- assertion asSentence Play+an+important+role+in+membrane-microtubule+interactions. assertion.
- assertion asSentence Suppression+of+the+negative+regulator+LRIG1+contributes+to+ErbB2+overexpression+in+breast+cancer. assertion.
- assertion asSentence UPF2+and+UPF3b+cooperatively+stimulate+both+ATPase+and+RNA+helicase+activities+of+UPF1. assertion.
- assertion asSentence Loss+of+D-glucuronyl+C-5+epimerase+is+associated+with+small-cell+lung+cancer. assertion.
- assertion asSentence SENP1+localization+is+influenced+by+expression+and+localization+of+SUMO-1-conjugated+target+proteins+within+the+cell. assertion.
- assertion asSentence Loop+1+insertion+in+SENP6+and+SENP7+as+a+platform+to+discriminate+between+SUMO1+and+SUMO2%2F3+isoforms+in+this+subclass+of+the+SUMO+protease+family. assertion.
- assertion asSentence Rip11%2FFIP5-kinesin-II+complex+plays+a+key+role+in+the+routing+of+internalized+receptors+through+the+perinuclear+recycling+endosomes. assertion.
- assertion asSentence The+GIGYF2+Asn56Ser+mutation+is+rare+in+Chinese+PD+patients. assertion.
- assertion asSentence APPL1+interacts+with+adiponectin+receptors+in+mammalian+cells+and+the+interaction+is+stimulated+by+adiponectin. assertion.
- assertion asSentence The+promyogenic+function+of+Cdo+involves+a+coordinated+activation+of+p38MAPK+and+Akt+via+association+with+scaffold+proteins%2C+JLP+and+Bnip-2+for+p38MAPK+and+APPL1+for+Akt. assertion.
- assertion asSentence APPL1+plays+a+key+role+in+coordinating+the+vasodilator+and+vasoconstrictor+effects+of+insulin+by+modulating+Akt-dependent+NO+production+and+ERK1%2F2-mediated+ET-1+secretion+in+the+endothelium. assertion.
- assertion asSentence LSm14A+is+a+processing+body-associated+sensor+of+viral+nucleic+acids+that+initiates+cellular+antiviral+response+in+the+early+phase+of+viral+infection. assertion.
- assertion asSentence GGA+proteins+funstion+with+the+phosphorylated+ACDL+in+the+memasin+2-recycling+pathway+from+endosomes+to+trans+Golgi+on+the+way+back+to+the+cell+surface. assertion.
- assertion asSentence WSB-1+is+part+of+an+E3+ubiquitin+ligase+for+the+thyroid-hormone-activating+type+2+iodothyronine+deiodinase+%28D2%29. assertion.
- assertion asSentence TCTN3+mutations+cause+Mohr-Majewski+syndrome. assertion.
- assertion asSentence The+RG-rich+and+RGG+box+of+SERBP1+is+asymmetrically+dimethylated+by+PRMT1+and+the+modification+affects+protein+interaction+and+intracellular+localization+of+the+protein. assertion.
- assertion asSentence Mutations+in+the+transporter+ABCA12+are+associated+with+lamellar+ichthyosis+type+2. assertion.
- assertion asSentence A+transcriptional+repressor+NIR+functions+in+the+rRNA+biogenesis+of+both+the+40S+and+60S+subunits. assertion.
- assertion asSentence The+shift+of+HIF-1+transactivation+by+reactive+oxidative+species+is+correlated+with+and+dependent+on+the+biphasic+redox+sensing+of+SENP3+that+leads+to+the+differential+SENP3%2Fp300+interaction+and+the+consequent+fluctuation+in+the+p300+SUMOylation+status. assertion.
- assertion asSentence The+R620W+C%2FT+polymorphism+of+PTPN22+is+associated+with+SLE+independently+of+the+association+of+PDCD1. assertion.
- assertion asSentence PTPN22+is+associated+with+an+earlier+age+of+onset+of+rheumatoid+arthritis+and+has+a+stronger+effect+in+males+than+in+females. assertion.
- assertion asSentence Variant+R620W+of+PTPN22+play+a+role+in+susceptibility+to+psoriatic+arthritis+in+men. assertion.
- assertion asSentence Moderate+association+of+the+R620W+variant+of+PTPN22+with+psoriatic+arthritis+in+the+Toronto+population+only. assertion.
- assertion asSentence The+autoimmune+disease+risk+allele+of+PTPN22+is+associated+with+skewing+of+serum+cytokine+profiles+toward+higher+IFNalpha+activity+and+lower+TNFalpha+levels+in+vivo+in+patients+with+systemic+lupus+erythematosus. assertion.
- assertion asSentence R263Q+missense+substitution+within+the+catalytic+domain+of+LYP+leads+to+reduced+phosphatase+activity. assertion.
- assertion asSentence There+is+no+interaction+between+tobacco+exposure+and+PTPN22+1858T+for+the+development+of+anti-CCP-positive+or+anti-CCP-negative+rheumatoid+arthritis. assertion.
- assertion asSentence Differential+PTPN22+gene+polymorphism+is+associated+with+ulcerative+colitis+and+Crohn%27s+disease. assertion.
- assertion asSentence Altered+B+cell+homeostasis+is+associated+with+type+I+diabetes+and+carriers+of+the+PTPN22+allelic+variant. assertion.
- assertion asSentence Several+functional+states+mediating+the+interaction+of+Mincle+and+yeast+at+the+surface+of+the+macrophage. assertion.
- assertion asSentence Beta-actin%2C+physically+interacts+through+its+N-terminus+with+FBXO25+and+is+enriched+in+the+FBXO25+nuclear+compartments. assertion.
- assertion asSentence ICK+and+FBX9+are+divergently+transcribed+from+a+bidirectional+promoter+that+is+GC-rich+and+contains+a+CpG+island. assertion.