Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Mutations+in+Fbx4+inhibit+dimerization+of+the+SCF%28Fbx4%29+ligase+and+contribute+to+cyclin+D1+overexpression+in+human+cancer. assertion.
- assertion asSentence Co-localises+with+the+interstitial+TTAGGG+repeats+in+interstitial+telomeres. assertion.
- assertion asSentence Down-regulation+of+TRF1%2C+TRF2+and+TIN2+genes+is+important+to+maintain+telomeric+DNA+for+gastric+cancers. assertion.
- assertion asSentence TIN2+mutants+defective+in+binding+of+TRF1+or+TRF2+induce+a+DNA+damage+response+and+destabilize+TRF1+and+TRF2+at+telomeres+in+human+cells. assertion.
- assertion asSentence TINF2%2C+a+component+of+the+shelterin+telomere+protection+complex%2C+is+mutated+in+dyskeratosis+congenita. assertion.
- assertion asSentence Both+point+mutation+and+deletion+associated+with+autosomal+recessive+spastic+ataxia+of+Charlevoix-Saguenay. assertion.
- assertion asSentence FGF20+is+associated+with+Parkinson%27s+disease+synergistically+with+SNCA. assertion.
- assertion asSentence CLDN17%2C+clustered+with+CLDN8+at+human+chromosome+21q22.11%2C+is+a+four-transmembrane+protein+with+WWCC+motif%2C+defined+by+W-X%2817-22%29-W-X%282%29-C-X%288-10%29-C. assertion.
- assertion asSentence %5Breview%5D+FGF21+mediates+biological+responses+by+activating+FGF+receptors+with+betaKlotho+in+cultured+cells. assertion.
- assertion asSentence Suppression+of+telomerase+activity+mediated+by+PinX1+is+involved+in+the+Mad1%2Fc-Myc+pathway. assertion.
- assertion asSentence DelGEF+binds+to+the+human+homologue+of+Sec5+and+modulates+secretion. assertion.
- assertion asSentence ESE-3+plays+a+role+in+the+induction+of+cellular+senescence+as+a+downstream+molecule+of+stress-induced+mitogen-activated+protein+kinase+p38. assertion.
- assertion asSentence Drosophila+HSP67Bc+is+the+functional+ortholog+of+human+HSPB8+and+Dm-HSP67Bc+induces+autophagy+via+the+eIF2alpha+pathway. assertion.
- assertion asSentence Transgenic+overexpression+of+nucleostemin+increases+the+population+doubling+and+decreases+the+senescence+of+mouse+embryonic+fibroblasts. assertion.
- assertion asSentence Nucleoplasmic+relocation+of+nucleostemin+during+nucleolar+disassembly+safeguards+the+G2-M+transit+and+survival+of+continuously+dividing+cells+by+MDM2+stabilization+and+p53+inhibition. assertion.
- assertion asSentence Apoptosis+of+HL-60+leukemia+cells+can+be+induced+by+silencing+NS+gene+expression. assertion.
- assertion asSentence Telomere+length+in+Sjogren+syndrome+is+shorter+and+associated+with+lower+levels+of+expression+of+p63+and+nucleostemin+than+in+non-Sjogren+syndrome. assertion.
- assertion asSentence Antiapoptotic+response+of+cells+requires+expression+of+both+p8+and+ProTalpha. assertion.
- assertion asSentence A+role+for+the+transcriptional+regulator+p8+in+autophagy%2C+is+demonstrated. assertion.
- assertion asSentence p8+expression+controls+pancreatic+cancer+cell+migration%2C+invasion+and+adhesion%2C+three+processes+required+for+metastasis%2C+at+least+in+part%2C+through+CDC42%2C+a+major+regulator+of+cytoskeleton+organization. assertion.
- assertion asSentence A+NUPR1%2FRELB%2FIER3+stress-related+pathway+that+is+required+for+oncogenic+Kras%28G12D%29-dependent+transformation+of+the+pancreas. assertion.
- assertion asSentence RNA+editing+enables+exonization+of+a+nuclear+prelamin+A+recognition+factor+Alu-exon. assertion.
- assertion asSentence Mutations+in+the+SLC17A5+gene+must+be+considered+in+two+siblings+with+hypomyelination%2C+even+in+the+absence+of+sialuria. assertion.
- assertion asSentence Che-1+interacts+with+NRAGE+and+NRAGE+overexpression+downregulates+endogenous+Che-1+by+targeting+it+for+proteasome-dependent+degradation. assertion.
- assertion asSentence Transgenic+mice+overexpressing+gremlin+in+the+bone+microenvironment+have+decreased+osteoblast+number+and+function+leading+to+osteopenia+and+spontaneous+fractures. assertion.
- assertion asSentence Variant+rs1129456+associates+with+diabetic+nephropathy. assertion.
- assertion asSentence Genetic+variation+in+GREM1+is+associated+with+fibrosis+in+pulmonary+sarcoidosis. assertion.
- assertion asSentence Gremlin+1+%28a+bone+morphogenetic+protein-7+antagonist%29+plays+a+critical+role+in+the+modulation+of+reno-protective+action+of+BMP-7+in+epithelial-to-mesenchymal+transition. assertion.
- assertion asSentence Polymorphisms+in+hHAVcr-1+are+not+associated+with+atopic+asthma+in+the+Japanese+population. assertion.
- assertion asSentence Involved+in+the+pathogenesis+of+systemic+lupus+erythematosus. assertion.
- assertion asSentence Dipsticks+can+provide+a+sensitive+and+accurate+detection+of+HAVCR1. assertion.
- assertion asSentence EWS-FLI1+mediated+overexpression+of+STEAP1+increases+the+invasiveness+and+oxidative+stress+levels+of+Ewing+tumor+cells. assertion.
- assertion asSentence HBP1+targets+P16%28INK4A%29%2C+upregulating+its+expression+and+consequently+is+involved+in+Ras-induced+premature+senescence. assertion.
- assertion asSentence The+200+kDa+crystal+structure+of+Sec22+bound+to+Sec23%2F24+reveals+that+the+transport+signal+is+a+folded+epitope+rather+than+a+conventional+short+peptide+sequence. assertion.
- assertion asSentence Paip1+interacts+with+poly%28A%29+binding+protein+through+two+independent+binding+motifs. assertion.
- assertion asSentence Poly%28A%29-binding+protein+modulates+mRNA+susceptibility+to+cap-dependent+miRNA-mediated+repression. assertion.
- assertion asSentence The+side+chain+of+the+invariant+MLLE+residue+K580+of+poly%28A%29-binding+protein+forms+hydrogen+bonds+with+the+backbone+of+PAM2+residues+5+and+7. assertion.
- assertion asSentence Cytoplasmic+PABP+accumulation+is+translationally+controlled+in+human+cytomegalovirus-infected+cells. assertion.
- assertion asSentence The+worldwide+involvement+of+DNAI1+mutations+in+PCD+pathogenesis+in+families+not+preselected+for+ODA+defects+ranges+from+7+to+10%25. assertion.
- assertion asSentence Mlh3+nullizygosity+significantly+increased+Apc+frameshift+mutations+and+tumor+multiplicity. assertion.
- assertion asSentence NPHP3+mutations+can+cause+a+broad+clinical+spectrum+of+early+embryonic+patterning+defects. assertion.
- assertion asSentence Failed+to+yield+any+clear+correlation+between+the+nature+of+the+mutation+and+clinical+features+of+Hailey-Hailey+disease. assertion.
- assertion asSentence The+abnormal+Ca2%2B+signaling+seen+in+Hailey-Hailey+disease+keratinocytes+correlates+with+decreased+protein+levels+of+ATP2C1. assertion.
- assertion asSentence A+spectrum+of+ATP2C1+gene+mutations+is+present+in+Japanese+HHD+patients. assertion.
- assertion asSentence p22phox+directly+interacts+with+Nox1+and+Nox4%2C+to+form+an+superoxide-generating+NADPH+oxidase. assertion.
- assertion asSentence Co-treatment+with+HGF+and+TGF-beta1+enhances+keratinocyte+migration%2C+accompanied+with+reactive+oxygen+species+generation+through+NADPH+oxidase%2C+involving+Nox-1+and+Nox-4+isozymes. assertion.
- assertion asSentence High+NOX1+expression+is+associated+with+colon+cancers. assertion.
- assertion asSentence Hyperglycemia+is+the+main+factor+which+induces+oxidative+stress+mainly+by+activation+of+NADPH+oxidase+in+monocytes+of+diabetic+patients. assertion.
- assertion asSentence Rac1+and+NOX1+are+required+for+Rhinovirus-induced+disruption+of+barrier+function+in+polarized+airway+epithelial+cells. assertion.
- assertion asSentence Siglec-7+can+inhibit+Fc+epsilon+receptor+I-mediated+serotonin+release+from+rat+basophilic+leukemia+cells+and+recruit+the+tyrosine+phosphatases+SHP-1+and+SHP-2. assertion.
- assertion asSentence The+decreased+expression+of+Siglec-7+represents+an+early+marker+of+dysfunctional+natural+killer-cell+subsets+associated+with+high+levels+of+HIV-1+viremia. assertion.
- assertion asSentence LAT+is+required+for+T+cell+activation. assertion.
- assertion asSentence SND%21+represents+promising+prostate+cancer+biomarker+and+therapeutic+target. assertion.
- assertion asSentence NEEP21+profoundly+affects+the+processing+of+beta-amyloid+precursor+proteins+and+Abeta+peptide+production. assertion.
- assertion asSentence TSPAN13+is+overexpressed+in+prostate+cancer+and+its+expression+correlates+with+factors+of+favourable+outcome. assertion.
- assertion asSentence Expression+of+the+forkhead+transcription+factor+FOXP1+is+associated+with+that+of+estrogen+receptor-beta+in+primary+invasive+breast+carcinomas. assertion.
- assertion asSentence Myc-mediated+repression+of+microRNA-34a+promotes+high-grade+transformation+of+B-cell+lymphoma+by+dysregulation+of+FoxP1. assertion.
- assertion asSentence Decreased+electron+Transport+Complex+III+activity+is+associated+with+ulcerative+colitis. assertion.
- assertion asSentence PUMA+makes+a+key+contribution+to+the+process+whereby+kaempferol+induces+ATM+protein+phosphorylation. assertion.
- assertion asSentence Autophagic+cell+death+is+induced+as+an+alternative+form+of+cell+death+by+5-fluorouracil+in+Bax+or+PUMA+deficient+HCT116+cells+which+are+apoptosis+defective. assertion.
- assertion asSentence On+mild+DNA+damage%2C+SMAR1+selectively+represses+BAX+and+PUMA+through+binding+to+the+MAR+independently+of+inducing+p53+deacetylation+through+HDAC1. assertion.
- assertion asSentence Slug+gene+facilitates+apoptosis+of+fibroblast-like+synoviocytes+by+increasing+Puma+transactivation. assertion.
- assertion asSentence Akt+requires+glucose+metabolism+to+suppress+puma+expression+and+prevent+apoptosis+of+leukemic+T+cells. assertion.
- assertion asSentence High+PDE7B+is+associated+with+chronic+lymphocytic+leukemia. assertion.
- assertion asSentence AFF4+is+required+for+super+elongation+complex+stability+and+proper+transcription+by+poised+RNA+polymerase+II. assertion.
- assertion asSentence INVS+mutation+can+cause+juvenile+nephronophthisis+with+abnormal+reactivity+of+the+Wnt%2Fbeta-catenin+pathway. assertion.
- assertion asSentence Lung+epithelial+cells+secrete+AMCase+via+an+EGFR-dependent+pathway+that+is+activated+by+ADAM17+and+mediates+its+effects+via+Ras. assertion.
- assertion asSentence Mutant+Ago2+protein+containing+6+point+mutations+%28G32W%2C+F128L%2C+R196Q%2C+P458S%2C+T741A%2C+S752G%29+failed+to+accumulate+in+P-bodies. assertion.
- assertion asSentence Hsp90+is+a+critical+modulator+of+Argonaute+function. assertion.
- assertion asSentence Many+mRNAs+derived+from+genes+containing+long+interspersed+nuclear+element+-1+are+elevated+in+Argonaute+2+%28AGO2+or+EIF2C2%29-depleted+cells. assertion.
- assertion asSentence C3PO+endonuclease+is+an+asymmetric+octamer+barrel+consisting+of+six+translin+and+two+TRAX+subunits+which+activates+RISC+by+degrading+the+Ago2-nicked+passenger+strand+of+siRNA. assertion.
- assertion asSentence Gene+expression+regulation+of+ZIPs+after+zinc+supplementation. assertion.
- assertion asSentence The+Siglec-9+peptide+binding+to+the+enzymatic+groove+of+VAP-1+can+be+used+for+imaging+conditions%2C+such+as+inflammation+and+cancer. assertion.
- assertion asSentence Siglec-8-induced+apoptosis+in+eosinophils+occurs+through+the+sequential+production+of+reactive+oxygen+species%2C+followed+by+induction+of+mitochondrial+injury+and+caspase+cleavage. assertion.
- assertion asSentence Variation+at+the+DISC1+locus+predisposes+individuals+to+a+variety+of+psychiatric+disorders. assertion.
- assertion asSentence DISC1+inhibits+NUDEL-oligopeptidase+activity+in+a+competitive+fashion. assertion.
- assertion asSentence DISC1+affects+the+maturation+of+front-temporal+cortical+systems. assertion.
- assertion asSentence DISC1+together+with+Hzf+interacts+with+a+specific+mRNAs+such+as+IP3R1+mRNA+and+regulates+their+dendritic+transport+via+Kinesin-1+and+translation+as+a+component+of+RNA+granules. assertion.
- assertion asSentence IL-17C+is+an+essential+autocrine+cytokine+that+regulates+innate+epithelial+immune+responses. assertion.
- assertion asSentence GNMT+is+destabilized+by+a+mutation. assertion.
- assertion asSentence BCA2+accelerates+the+internalization+and+degradation+of+viral+particles+following+their+tethering+to+the+cell+surface+and+is+a+co-factor+or+enhancer+for+the+tetherin-dependent+restriction+of+HIV-1+release+from+infected+cells. assertion.
- assertion asSentence Programmed+Cell+Death+4+%28PDCD4%29+is+regulated+by+microrna+miR-21+and+demonstrate+that+PDCD4+is+a+functionally+important+target+for+miR-21+in+breast+cancer+cells. assertion.
- assertion asSentence Inhibitors+of+miR-21+increased+levels+of+PDCD4+in+cholangiocarcinoma. assertion.
- assertion asSentence PDCD4+inhibits+the+malignant+phenotype+of+ovarian+cancer+cells. assertion.
- assertion asSentence PDCD4+plays+an+important+role+in+mediating+the+sensitivity+of+gastric+cancer+cells+to+TRAIL-induced+apoptosis+through+FLIP+suppression. assertion.
- assertion asSentence microRNA-21+expression+is+up-regulated+in+human+cholangiocarcinoma+and+PTEN%2C+PDCD4+are+direct+effectors+of+microRNA-21. assertion.
- assertion asSentence Increased+mRNA+expression+CGRP-RCP+in+gravid+myometrium+supports+the+possibility+of+involvement+of+CGRP+in+the+control+of+myometrial+contractility. assertion.
- assertion asSentence The+UBA4-URM1+system+represents+the+evolutionary+link+between+protein+conjugation+and+protein+modification+by+sulfur+carrier+proteins. assertion.
- assertion asSentence Downregulation+of+RPS6KA6+is+associated+with+colon+carcinoma. assertion.
- assertion asSentence SNEV%2C+the+human+orthologue+of+yeast+PRP19%2C+functions+in+splicing+and+homo-oligomerization+of+SNEV+in+HeLa+nuclear+extract+is+essential+for+spliceosome+assembly. assertion.
- assertion asSentence Purified+hPrp19%2FCDC5L+complexes+exhibit+an+elongated%2C+asymmetric+shape+with+a+maximum+dimension+of+approximately+20+nm. assertion.
- assertion asSentence RAGE+is+under+genetic+selection+in+the+non-African+populations. assertion.
- assertion asSentence Serine%2Fthreonine+kinase+39+is+a+candidate+gene+for+primary+hypertension+especially+in+women. assertion.
- assertion asSentence Lower+expression+of+both+MAT2A+and+MAT2beta+and+interfere+with+leptin+signaling+in+liver+cancer+cells. assertion.
- assertion asSentence Overexpression+of+DNA+polymerase+mu+in+a+Burkitt%27s+lymphoma+cell+line+induced+an+increase+in+somatic+mutations+specifically+targeted+to+G%2FC+residues+in+immunoglobulin+variable+genes. assertion.
- assertion asSentence OATP-D+plays+an+important+role+in+translocating+prostaglandins+in+specialized+tissues+and+cells. assertion.
- assertion asSentence The+common+SLCO1B3+GG%2FAA+haplotype+is+associated+with+impaired+testosterone+transport+and+improved+survival+in+patients+with+prostatic+cancer. assertion.
- assertion asSentence SLCO1B3+polymorphism+significantly+influences+plasma+mycophenolic+acid+glucuronide+pharmacokinetics+in+Japanese+renal+transplant+recipients. assertion.
- assertion asSentence DNA+methylation-dependent+gene+silencing+is+at+least+partly+involved+in+the+regulation+of+OATP1B3+expression+in+cancer%2Fimmortalized+cell+lines. assertion.
- assertion asSentence OATP1B3+is+one+of+the+transporters+contributing+to+the+supply+of+the+estrogen+precursor+estrone-3-sulfate+to+estrogen-dependent+breast+cancer+cells. assertion.