Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence UV-induced+activation+of+p53R2+transcription+and+binding+of+p53R2+to+hRRM1+to+form+RR+holoenzyme+are+impaired+in+the+p53-mutant+cell+line+PC3. assertion.
- assertion asSentence A+heterozygous+truncating+mutation+in+RRM2B+causes+autosomal-dominant+progressive+external+ophthalmoplegia+with+multiple+mtDNA+deletions. assertion.
- assertion asSentence Reduced+mRNA+and+protein+content+of+Plin+and+G0S2+and+borderline+increased+ATGL+protein+in+sc+adipose+tissue+from+poorly+controlled+type+2+diabetic+subjects. assertion.
- assertion asSentence Secreted+PLA2+III+induces+apoptosis+of+primary+cortical+neurons+in+culture+by+suppressing+production+of+Bcl-xl%2C+promoting+Bax%2C+augmenting+caspase+3+and+cleaving+alpha-fodrin. assertion.
- assertion asSentence Expression+of+dual+oxidase+2+in+human+colon+and+Caco-2+cells. assertion.
- assertion asSentence Thyroid+peroxidase+consumes+hydrogen+peroxide+produced+by+DUOX2%2C+decreasing+the+availability+of+this+substance+at+the+apical+membrane+of+thyrocytes. assertion.
- assertion asSentence Direct+interaction+of+NADPH+oxidase+4+with+toll-like+receptor+4+is+involved+in+lipopolysaccharide-mediated+generation+of+reactive+oxygen+species+and+NF-kappa+B+activation+in+HEK293T+cells. assertion.
- assertion asSentence NOX4+mediates+7-ketocholesterol-induced+endoplasmic+reticulum+stress+and+apoptosis+in+aortic+smooth+muscle+cells. assertion.
- assertion asSentence Nox4+type+NADPH+oxidase+promotes+endothelial+angiogenic+responses+in+human+microvascular+endothelial+cells+in+vitro. assertion.
- assertion asSentence Nox4-generated+ROS+are+required+for+transformation+phenotype+of+melanoma+cells+and+contribute+to+melanoma+growth+through+regulation+of+G%282%29-M+cell+cycle+progression. assertion.
- assertion asSentence NOX-4+is+upregulated+in+idiopathic+pulmonary+fibrosis+and+has+a+role+in+tissue+repair+functions+of+myofibroblasts+and+fibrogenesis. assertion.
- assertion asSentence NADPH+oxidase+NOX4+is+a+critical+mediator+in+oncogenic+H-RasV12-induced+DNA-damage+response+and+subsequent+senescence. assertion.
- assertion asSentence A+polymorphism+within+IL21R+confers+risk+for+systemic+lupus+erythematosus. assertion.
- assertion asSentence IL-21+contributes+to+the+ongoing+Th1+mucosal+response+in+Crohn%27s+disease. assertion.
- assertion asSentence Mutations+in+ATP6V0A4+present+enlarged+vestibular+aqueduct+and+early+onset+sensorial+hearing+loss. assertion.
- assertion asSentence Overexpression+of+the+Interferon+regulatory+factor+4-binding+protein+is+associated+with+Colorectal+Carcinoma. assertion.
- assertion asSentence CaMKII+is+a+key+effector+in+the+Ca2%2B+and+microtubule-dependent+delivery+of+calcyon+to+the+cell+surface. assertion.
- assertion asSentence Increased+expression+of+PCA3+is+associated+with+prostate+cancer. assertion.
- assertion asSentence High+PCA3+expression+is+associated+with+prostate+cancer+progression. assertion.
- assertion asSentence Lethality+of+Nsdhl+deficient+mouse+embryos+is+rescued+by+transgenic+mice+expressing+human+Nsdhl. assertion.
- assertion asSentence The+missense+mutation+of+the+NSDHL+gene+is+detected+in+CHILD+syndrome. assertion.
- assertion asSentence A+functionally+compromised+TAS2R+receptor+negatively+impacts+glucose+homeostasis%2C+providing+an+important+link+between+alimentary+chemosensation+and+metabolic+disease. assertion.
- assertion asSentence Examine+JAM-1+expression+in+normal%2Finflammed+lymphatic+endothelium. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+%28SNPs%29+in+the+F11+receptor+gene+%28F11R%29+are+associated+with+hypertension+and+obesity+in+Hong+Kong+Chinese. assertion.
- assertion asSentence Partitioning-defective+protein+6+associated+constitutively+with+endogenous+aPKCs. assertion.
- assertion asSentence DCIR+as+an+antigen+presenting+cell+receptor+that+is+endocytosed+efficiently+in+a+clathrin-dependent+manner+and+negatively+affects+TLR8-mediated+cytokine+production. assertion.
- assertion asSentence F2L+is+a+chemoattractant+peptide+promoting+calcium+mobilization+and+chemotaxis+in+dendritic+cells+and+monocytes. assertion.
- assertion asSentence CDO+and+BOC+forms+complexes+with+specific+cadherins+that+mediate+some+of+the+promyogenic+effects+of+cell-cell+contact. assertion.
- assertion asSentence Allelic+variation+in+or+near+the+coding+regions+of+the+FOXP3+gene+does+not+have+a+major+role+in+the+inherited+susceptibility+to+the+common+form+of+type+1+diabetes. assertion.
- assertion asSentence Increase+of+functional+FOXP3+in+T+cells+in+cancer+patients+is+a+response+to+the+process+of+malignant+transformation. assertion.
- assertion asSentence Fox3p+expression+is+inherent+feature+of+the+function+of+type+1+regulatory+T+cells+specific+for+desmoglein-3%2C+the+autoantigen+of+pemphigus+vulgaris. assertion.
- assertion asSentence Expression+of+FOXP3+is+a+normal+consequence+of+CD4%28%2B%29+T+cell+activation+and+can+no+longer+be+used+as+an+exclusive+marker+of+T+regulatory+cells. assertion.
- assertion asSentence In+Dermatophagoides+farinae-stimulated+PBMCs+from+patients+with+asthma%2C+expression+of+GATA-3+and+T-bet+and+FOPX3+expression+is+decreased. assertion.
- assertion asSentence Foxp3+can+regulate+pim+2+expression. assertion.
- assertion asSentence Preservation+of+FoxP3%2B+regulatory+T+cells+in+the+peripheral+blood+of+HIV-1-infected+elite+suppressors+correlates+with+low+CD4%2B+T-cell+activation. assertion.
- assertion asSentence CD4%28%2B%29CD25%28%2B%29+regulatory+T+cells+and+Foxp3+mRNA+together+with+IgE+participated+in+the+pathogenesis+of+RSV+bronchiolitis. assertion.
- assertion asSentence Foxp3+and+apolipoprotein+A1+are+over-abundant+in+carotid+artery+plaques+from+symptomatic+subjects. assertion.
- assertion asSentence Antibody-mediated+FOXP3+protein+therapy+induces+apoptosis+in+cancer+cells+in+vitro+and+inhibits+metastasis+in+vivo. assertion.
- assertion asSentence Relationship+between+level+of+pre-+and+post-kidney+transplantation+level+of+CD4%28%2B%29CD25%28%2B%29Foxp3%28%2B%29+T-regulatory+lymphocytes+and+treatment+outcome. assertion.
- assertion asSentence Intraepithelial+effector+%28CD3%2B%29%2Fregulatory+%28FoxP3%2B%29+T-cell+ratio+predicts+a+clinical+outcome+of+human+colon+carcinoma. assertion.
- assertion asSentence TGF-beta+induced+Foxp3%2B+regulatory+T+cells. assertion.
- assertion asSentence Platelets+and+activated+Tregs+co-express+latent+TGF-beta+and+GARP+on+their+membranes. assertion.
- assertion asSentence Microbiota+is+required+for+the+generation+of+both+IL-17-positive+and+Foxp3-positive%2C+retinoic+acid-related+orphan+receptor+gamma-positive+transgenic+T+cells+in+the+intestinal+lamina+propria. assertion.
- assertion asSentence FoxP3+interacts+with+H1.5+to+alter+its+binding+to+target+genes+to+modulate+their+expression+and+to+program+Treg+function. assertion.
- assertion asSentence Autoantibodies+to+villin+occur+frequently+in+IPEX%2C+a+severe+immune+dysregulation%2C+syndrome+caused+by+mutation+of+FOXP3. assertion.
- assertion asSentence Foxp3+modulates+HIV1+gene+expression+in+human+T+cells+by+inhibiting+HDAC1+activity. assertion.
- assertion asSentence Absolute+of+CD4%28%2B%29CD25%28%2B%29FOXP3%28%2B%29+regulatory+T-cell+count+rather+than+its+ratio+in+peripheral+blood+is+related+to+long-term+survival+of+renal+allografts. assertion.
- assertion asSentence FOXP3+is+not+mutated+in+human+melanoma. assertion.
- assertion asSentence A+higher+concentration+of+tumor-infiltrating+Foxp3+Tregs+in+hepatocellular+carcinoma+is+associated+with+higher+grade+and+poorly+differentiated+tumors+and+signifies+an+unfavorable+prognosis. assertion.
- assertion asSentence High+Sclerostin+in+blood+is+associated+with+bone+mineral+density+and+microarchitecture+in+haemodialysis. assertion.
- assertion asSentence Gastrin+activates+paracrine+networks+leading+to+induction+of+PAI-2+via+MAZ+and+ASC-1. assertion.
- assertion asSentence Protein-protein+interactions+between+human+exosome+components+support+the+assembly+of+RNase+PH-type+subunits+into+a+six-membered+PNPase-like+ring. assertion.
- assertion asSentence Defective+mitochondrial+translation+caused+by+a+ribosomal+protein+%28MRPS16%29+mutation. assertion.
- assertion asSentence The+mitochondrial+fission+protein+Fission+1+homologue+%28Fis1%29+conveys+an+apoptosis+signal+from+the+mitochondria+to+the+ER+by+interacting+with+Bap31+at+the+ER+and+facilitating+its+cleavage+into+the+pro-apoptotic+p20Bap31. assertion.
- assertion asSentence Surfactant+protein+B+intron+4+variations+enhance+susceptibility+to+squamous+cell+lung+cancer+in+German+patients. assertion.
- assertion asSentence Inactivation+of+Geminin%2C+an+inhibitor+of+origin+licensing%2C+leads+to+rereplication+in+human+normal+and+tumor+cells+within+the+same+cell+cycle. assertion.
- assertion asSentence Geminin+is+cleaved+in+primary+cells+and+cancer+cell+lines+induced+to+undergo+apoptosis+by+a+variety+of+stimuli. assertion.
- assertion asSentence Spastin+and+atlastin%2C+two+proteins+mutated+in+autosomal-dominant+hereditary+spastic+paraplegia%2C+are+binding+partners. assertion.
- assertion asSentence Mutations+in+SPG3A+represent+an+important+cause+of+patients+in+the+overall+hereditary+spastic+paraplegia+population. assertion.
- assertion asSentence Cloning%2C+expression+and+subcellular+localization+of+CutC. assertion.
- assertion asSentence The+IFN-beta-+and+tretinoin-induced+GRIM-19+is+upregulated+during+focal+cerebral+ischemia. assertion.
- assertion asSentence Human+galanin+expresses+amphipathic+properties+in+the+presence+of+phospholipids+which+in+turn+amplifies+its+vasoactive+effects+in+the+intact+peripheral+microcirculation. assertion.
- assertion asSentence Association+between+functionally+relevant+variants+of+the+adiponectin+pathway+and+breast+cancer+risk. assertion.
- assertion asSentence AdipoR1+has+a+role+in+cell+survival. assertion.
- assertion asSentence Adiponectin+decreases+the+receptor+dimerization+in+a+concentration-dependent+manner. assertion.
- assertion asSentence Globular+adiponectin+possesses+both+AdipoR1-dependent+ability+to+stimulate+COX-2+expression+and+AdipoR1-independent+effects+related+to+expression+of+VCAM-1+and+adhesion+of+monocytes+to+endothelium. assertion.
- assertion asSentence Variants+of+the+adiponectin+and+adiponectin+receptor-1+genes+and+posttransplantation+diabetes+mellitus+in+renal+allograft+recipients. assertion.
- assertion asSentence Increased+mRNA+and+protein+expression+of+adiponectin+receptors+is+related+with+increased+aortic+stiffness%2C+coronary+and+peripheral+atherosclerosis+in+patients+with+coronary+artery+disease. assertion.
- assertion asSentence The+loss+of+Bif-1+expression+in+a+subset+of+prostate+cancer+samples+is+in+agreement+with+the+proapoptotic+function+of+Bif-1. assertion.
- assertion asSentence NDUFAF1+is+an+important+protein+for+the+assembly%2Fstability+of+complex+I+%28NADH%3Aubiquinone+oxidoreductase%29. assertion.
- assertion asSentence TFB1M+is+a+nuclear-encoded+modifier+gene+for+phenotypic+expression+of+the+deafness-associated+homoplasmic+A1555G+mutation+in+the+mitochondrial+12S+rRNA+gene. assertion.
- assertion asSentence DHHC9+is+a+gastrointestinal-related+protein+highly+expressed+in+microsatellite+stable+colorectal+cancers. assertion.
- assertion asSentence SBDS+is+found+in+complexes+containing+the+human+Nip7+ortholog. assertion.
- assertion asSentence Mutations+of+the+Shwachman-Bodian-Diamond+syndrome+gene+is+not+associated+with+refractory+cytopenia. assertion.
- assertion asSentence Sara2+is+an+important+gene+in+processes+involving+erythroid+cell+proliferation+and+differentiation. assertion.
- assertion asSentence Five+mutations+in+the+SAR1B+gene+causing+Anderson+disease. assertion.
- assertion asSentence ANGPTL4+is+produced+by+human+myotubes+in+response+to+long+chain+fatty+acids+via+PPAR-delta. assertion.
- assertion asSentence Serum+Angptl4+levels+are+significantly+increased+in+end-stage+renal+disease. assertion.
- assertion asSentence Serum+angiopoietin-like+4+protein+levels+and+expression+in+adipose+tissue+are+inversely+correlated+with+obesity+in+monozygotic+twins. assertion.
- assertion asSentence ASB3+is+a+negative+regulator+of+TNF-R2-mediated+cellular+responses+to+TNF-alpha+by+direct+targeting+of+TNF-R2+for+ubiquitination+and+proteasome-mediated+degradation. assertion.
- assertion asSentence Single+nucleotide+polymorphism+in+INSIG2+is+associated+with+asthma+susceptibility+through+gene-gene+interactions. assertion.
- assertion asSentence SREBP-1+represents+one+of+the+transcriptional+regulators+of+human+17beta-HSD12. assertion.
- assertion asSentence Mutations+in+ING4+is+associated+with+cancer. assertion.
- assertion asSentence Mechanism+of+ING4+mediated+inhibition+of+the+proliferation+and+migration+of+human+glioma+cell+line+U251. assertion.
- assertion asSentence HN1+maintains+a+balance+between+the+androgen-regulated+nuclear+translocation+of+androgen+receptor+and+steady-state+Akt+phosphorylation%2C+predominantly+in+the+absence+of+androgens. assertion.
- assertion asSentence ZNF580+is+a+binding+partner+of+Smad2+and+is+involved+in+the+signal+transduction+of+the+transforming+growth+factor-beta+signalling+pathway. assertion.
- assertion asSentence Recognize+ubiquitin+and+act+in+the+removal+of+endosomal+protein-ubiquitin+conjugates. assertion.
- assertion asSentence miR-126+can+downregulate+EGFL7+expression+at+the+protein+level+in+ECV-304+cells. assertion.
- assertion asSentence Estimation+of+the+prevalence+of+homozygous+MYO15A+mutations+in+autosomal+recessive+nonsyndromic+deafness+in+Turkey+as+0.062+%2895%25+confidence+interval+is+0.020-0.105%29. assertion.
- assertion asSentence Role+for+17-beta-HSDXI+in+androgen+metabolism+during+steroidogenesis. assertion.
- assertion asSentence Increased+Pan1b+is+associated+with+prostate+cancer+of+seminal+vesicle+invasion. assertion.
- assertion asSentence The+mannose+6-phosphate+uncovering+enzyme+participates+in+the+uncovering+of+the+mannose+6-phosphate+recognition+tag+on+lysosomal+enzymes%2C+a+process+that+facilitates+recognition+of+those+enzymes+by+mannose+6-phosphate+receptors+to+delivery+to+lysosomes. assertion.
- assertion asSentence Microphthalmia-associated+transcription+factor+interacts+with+LEF-1%2C+a+mediator+of+Wnt+signaling. assertion.
- assertion asSentence Additional+prolactin+%28PRL%29+regulatory+elements+corresponding+to+LEF-l+and+AP-1+transcription+factor+binding+sites+appear+important+for+PRL+expression. assertion.
- assertion asSentence Dpr1+negatively+modulates+the+basal+activity+of+Wnt1%2Fbeta-catenin+signaling+in+the+nucleus+by+keeping+LEF1+in+the+repressive+state. assertion.
- assertion asSentence GnRH+regulation+of+Jun+transcription+requires+a+functional+interaction+between+TCF%2FLEF+and+beta-catenin. assertion.
- assertion asSentence A+strong+promoter+activity+of+pre-B+cell+stage-specific+Crlz1+gene+is+caused+by+one+distal+LEF-1+and+multiple+proximal+Ets+sites. assertion.
- assertion asSentence Human+neutral+sphingomyelinases+%28SMases%29%2C+are+capable+of+hydrolyzing+sphingosylphosphocholine. assertion.
- assertion asSentence The+expression+of+CKLF1+is+up-regulated+in+atherosclerotic+plaques. assertion.
- assertion asSentence A+chromosome+9p21.3+variant+predicts+the+risk+of+myocardial+infarction+among+white+men. assertion.