Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence WWOX+induces+apoptosis+and+inhibits+human+hepatocellular+carcinoma+cell+growth+through+a+mechanism+enhanced+by+JNK+inhibition. assertion.
- assertion asSentence WWOX+gene+can+suppress+adhesion+to+fibronectin+in+ovarian+cancer+cells. assertion.
- assertion asSentence CGP+samples+demonstrated+significant+associations+after+Bonferroni+correction+between+Isnp1%2C+both+tumour+grade+%28p%28corr%29%3D0.033%29+and+histology+%28p%28corr%29%3D0.046%29%2C+Isnp8%2C+tumour+grade+%28p%28corr%29%3D0.032%29+and+T1497G+and+progression-free+survival+%28p%28corr%29%3D0.037%29. assertion.
- assertion asSentence Reversing+effect+of+exogenous+WWOX+gene+expression+on+malignant+phenotype+of+primary+cultured+lung+carcinoma+cells. assertion.
- assertion asSentence Aberrant+WWOX+transcription+and+decreased+expression+are+frequent+in+salivary+neoplasms+and+WWOX+transcription+is+associated+with+p53+staining. assertion.
- assertion asSentence 2B4-mediated+activation+of+natural+killer+cells+involves+the+complex+interactions+of+LAT%2C+Ras%2C+Raf%2C+ERK+and+p38+kinase+in+the+regulation+of+lytic+function+and+cytokine+production. assertion.
- assertion asSentence Single+nucleotide+polymorphism+in+CD244+gene+is+associated+with+rheumatoid+arthritis. assertion.
- assertion asSentence CD244+is+not+associated+with+susceptibility+to+rheumatoid+arthritis+and+systemic+lupus+erythematosus+in+a+Korean+population. assertion.
- assertion asSentence Altered+expression+of+splice+variants+of+CS1+and+2B4+that+mediate+differential+signalling+in+PBMC+from+patients+with+SLE. assertion.
- assertion asSentence S1+specificity+pocket+of+the+aminopeptidases+that+generate+antigenic+peptides. assertion.
- assertion asSentence The+ERAP1+gene+is+associated+with+genetic+predisposition+to+ankylosing+spondylitis+and+influences+the+functional+severity+of+the+disease+in+a+Spanish+population. assertion.
- assertion asSentence A+functional+variant+in+ERAP1+predisposes+to+multiple+sclerosis. assertion.
- assertion asSentence CRK7+modifies+MAP+kinases+regulation+and+resistance+to+estrogen+signaling+inhibitors+in+breast+cancers. assertion.
- assertion asSentence Rsf-1+is+the+major+gene+within+the+11q13.5+amplicon+that+contributes+to+paclitaxel+resistance+in+ovarian+cancers. assertion.
- assertion asSentence A+higher+expression+level+of+Rsf-1+is+associated+with+advanced+clinical+stage+and+lymph+node+metastasis+in+ovarian+clear-cell+carcinoma. assertion.
- assertion asSentence Mixed+lineage+kinase+7+%28MLK7%29%2C+a+splice+variant+of+the+ZAK+gene%2C+encodes+an+isoform+which+is+the+MAPKKK+required+for+modulation+of+the+stress-activated+MAPKs+downstream+of+anisomycin+and+UV+stimulation. assertion.
- assertion asSentence BCL11A+binds+a+core+motif+in+the+gamma-globin+proximal+promoter%2C+recruits+and+interacts+with+partners+to+form+a+repression+complex%2C+leading+to+deacetylation+of+histones+and+down-regulation+of+gamma-globin+transcription. assertion.
- assertion asSentence The+LRP1B+gene+is+a+candidate+tumor+suppressor+gene+in+urothelial+cancer. assertion.
- assertion asSentence Tyrosine+phosphorylation+of+the+beta-amyloid+precursor+protein+cytoplasmic+tail+promotes+interaction+with+Shc. assertion.
- assertion asSentence CLIC5A+colocalizes+with+ezrin+and+podocalyxin+in+podocytes+and+is+required+for+the+development%2Fmaintenance+of+the+proper+glomerular+endothelial+cell+and+podocyte+architecture. assertion.
- assertion asSentence FTY720+induces+time-dependent+modulation+of+S1P+receptors+on+human+OPCs+with+consequent+functional+responses+that+are+directly+relevant+for+the+remyelination+process. assertion.
- assertion asSentence Found+in+trophoblasts+in+both+normal+and+abnormal+pregnancies. assertion.
- assertion asSentence FGFRL1+is+capable+of+inducing+syncytium+formation+of+heterologous+cells+in+vitro. assertion.
- assertion asSentence Duox1+plays+a+critical+role+in+mucin+expression+by+airway+epithelial+cells+through+PKCdelta%2FPKC-Duox1-ROS-TACE-pro-ligand-EGF+receptor+cascade. assertion.
- assertion asSentence Heterodimerization+controls+localization+of+Duox-DuoxA+NADPH+oxidases+in+airway+cells. assertion.
- assertion asSentence Protein+is+highly+expressed+in+the+intestine%2C+kidney%2C+cholangiocytes+and+the+blood-brain+barrier. assertion.
- assertion asSentence Human+peptidyl-prolyl+isomerase-like+3+%28Ppil3%29+is+one+of+the+Apoptin-associated+proteins. assertion.
- assertion asSentence A+1756+bp+cDNA+encoded+human+protein+kinase+CK1+%28438+AA%2C+mol+wt+50.272+Da%2C+isoelectric+point+of+9.37%29+mapping+to+chromosome+15q22. assertion.
- assertion asSentence The+P+blood+group+phenotype+is+due+to+several+disctint+nonfunctional+alleles+of+A4GALT+without+any+predominant+allele. assertion.
- assertion asSentence Localized+to+the+islets+of+Langerhans. assertion.
- assertion asSentence Toll-like+receptor+9+functions+in+the+activation+of+RF+expressing+B-cells. assertion.
- assertion asSentence Toll-like+receptor+9+binds+single-stranded+CpG-DNA+in+a+sequence-+and+pH-dependent+manner. assertion.
- assertion asSentence Plays+a+role+of+in+the+recognition+of+M.+bovis+BCG+by+dendritic+cells. assertion.
- assertion asSentence The+widespread+expression+of+TLR9+in+the+nasal+mucosa+along+with+its+rich+representation+in+leukocytes+in+different+compartments. assertion.
- assertion asSentence Divergent+TLR7+and+TLR9+signaling+and+type+I+interferon+production+distinguish+pathogenic+and+nonpathogenic+AIDS+virus+infections. assertion.
- assertion asSentence TLR9+expression+is+increased+in+breast+cancer+and+CpG+oligonucleotide-induced+cellular+invasion+is+mediated+via+TLR9+and+TRAF6%2C+independent+of+MyD88. assertion.
- assertion asSentence Cultured+human+melanocytes+express+functional+toll-like+receptors+2-4%2C+7+and+9. assertion.
- assertion asSentence The+polymorphism+of+rs187084+and+rs352139+in+TLR-9+is+not+associated+with+SLE+in+Han+Chinese. assertion.
- assertion asSentence Monocyte-mediated+inhibition+of+TLR9-dependent+IFN-alpha+induction+in+plasmacytoid+dendritic+cells+questions+bacterial+DNA+as+the+active+ingredient+of+bacterial+lysates. assertion.
- assertion asSentence Plasmacytoid+dendritic+cells+play+an+important+role+in+IFN-alpha+production+during+varicella-zoster+virus+infection+through+TLR9-dependent+and+-independent+pathways. assertion.
- assertion asSentence Lactobacillus+johnsonii+N6.2+probiotic+stimulates+the+innate+immune+response+through+Toll-like+receptor+9+in+Caco-2+cells. assertion.
- assertion asSentence Loss+of+TLR9+is+associated+with+renal+cell+carcinoma. assertion.
- assertion asSentence HCV-positive+serum+causes+enhanced+TLR9+expression. assertion.
- assertion asSentence In+mononuclear+cells+carrying+the+TC+genotype+of+rs5743836%2C+IL-6+up-regulates+TLR9+expression. assertion.
- assertion asSentence TLR9+polymorphisms+are+not+candidates+for+susceptibility+to+systemic+lupus+erythematosus%2C+at+least%2C+in+eastern+Asian+population. assertion.
- assertion asSentence Dual+or+triple+activation+of+TLR7%2C+TLR8%2C+and%2For+TLR9+by+single-stranded+oligoribonucleotides. assertion.
- assertion asSentence SCCRO+regulates+Gli1--a+key+regulator+of+the+hedgehog+%28HH%29+pathway. assertion.
- assertion asSentence The+GG+genotype+of+the+DCUN1D1+rs4859147+Single+Nucleotide+Polymorphism+represents+a+risk+factor+for+the+development+of+frontotemporal+lobar+degeneration+%2C+increasing+the+risk+of+about+fourfold. assertion.
- assertion asSentence Both+neurons+and+cancer+cells+strictly+inhibit+cytochrome+c-mediated+apoptosis+by+a+mechanism+dependent+on+glucose+metabolism. assertion.
- assertion asSentence Mitochondrial+import+and+direct+electron+transfer+from+cytochrome+c+to+Rac1+modulates+mitochondrial+H%282%29O%282%29+production+in+alveolar+macrophages+pulmonary+fibrosis. assertion.
- assertion asSentence C-terminal+region+of+the+Gene33+protein+%28ERBB+receptor+feedback+inhibitor+1%29+regulates+MEK-ERK+pathway-directed+Elk-dependent+transcription. assertion.
- assertion asSentence The+human+TREM+gene+cluster+at+6p21.1+encodes+both+activating+and+inhibitory+single+IgV+domain+receptors+and+includes+TREM2. assertion.
- assertion asSentence Signaling+pathway+by+which+G%28i%29-coupled+receptor+specifically+induces+Rac+and+Cdc42+activation+through+direct+interaction+of+Gbetagamma+with+FLJ00018. assertion.
- assertion asSentence WNT-4+protein+is+expressed+in+the+developing+nephron+during+morphogenetic+period+of+the+kidney. assertion.
- assertion asSentence Wnt4+is+specifically+involved+in+joint+development. assertion.
- assertion asSentence N-terminal+myr-tagged+SKAP1+for+membrane+binding+facilitated+constitutive+RapL+membrane+and+Rap1+binding+and+effectively+substituted+for+PI3K+and+TCR+ligation+in+the+activation+of+LFA-1+in+T+cells. assertion.
- assertion asSentence Up-regulation+of+SNAT2+is+essential+for+the+rapid+restoration+of+cell+volume+after+hypertonic+stress. assertion.
- assertion asSentence Functionally+defective+germline+variant+of+sialic+acid+acetylesterase+%28Met89Val%29+is+not+associated+with+type+1+diabetes+mellitus+and+Graves%27+disease. assertion.
- assertion asSentence CIT-K+is+capable+of+physically+and+functionally+interacting+with+the+actin-binding+protein+anillin. assertion.
- assertion asSentence DSCR1-1S+isoform+positively+modulates+IL-1R-mediated+signaling+pathways+by+regulating+Tollip%2FIRAK-1%2FTRAF6+complex+formation. assertion.
- assertion asSentence The+combined+expression+of+CK7+and+CK20+has+a+low+specificity+in+the+distinction+between+esophageal+and+cardiac+%28stomach%29+adenocarcinomas. assertion.
- assertion asSentence Positive+CK20+RT-PCR%2C+depth+of+tumor+invasion%2C+lymph+node+status%2C+metastasis+and+microvessel+density+are+significantly+correlated+with+vascular+invasion. assertion.
- assertion asSentence Loss+of+CDX2+and+CK20+is+more+frequently+encountered+in+mismatch+repair-deficient+colorectal+cancer. assertion.
- assertion asSentence CK20+and+CEA+are+expressed+in+non-macroscopically+involved+lymph+nodes+of+colorectal+cancer. assertion.
- assertion asSentence It+can+be+helpful+in+cases+with+metastatic+rectal+carcinoma%2C+especially+those+with+CK7%2B%2FCK20%2B+or+CK20-%2FCK7-+immunophenotype. assertion.
- assertion asSentence CK20+and+CEA+are+significantly+more+frequently+detected+in+colon+cancer+patients+than+in+healthy+controls+and+can+serve+as+markers. assertion.
- assertion asSentence CK20+expression+is+associated+with+the+progression+of+breast+cancer. assertion.
- assertion asSentence Both+the+CK7-%2FCK20%2B+phenotype+and+expression+of+the+antibody+CDX2+are+highly+specific+and+sensitive+markers+of+colorectal+origin. assertion.
- assertion asSentence Tissues+from+patients+with+prostate+cancer+and+prostatic+intraepithelial+neoplasia+exhibit+increased+spermine+oxidase+expression. assertion.
- assertion asSentence Fully+protonated+forms+of+the+inhibitors+and+the+unprotonated+form+of+an+amino+acid+residue+with+a+pK%28a%29+of+approximately+7.4+in+the+active+site+are+preferred+for+binding. assertion.
- assertion asSentence Rif+GTPase+is+an+alternative+trigger+of+stress-fiber+formation+in+epithelial+cells. assertion.
- assertion asSentence Psoriasis+is+associated+with+genetic+polymorphism+in+the+CCHCR1+gene+and+in+a+genomic+segment+flanking+the+HLA-C+region+in+the+North+Indian+population. assertion.
- assertion asSentence 3-kb+upstream+promoter+of+human+Robo4+contains+information+for+cell+type-specific+expression+in+the+intact+endothelium. assertion.
- assertion asSentence Levels+of+Tom22+in+mitochondria+accelerate+the+rate+of+Tom7+assembly+into+the+mature+TOM+complex. assertion.
- assertion asSentence Notch1+ligand%2C+Delta-like+ligand-4%2C+stimulates+R-Ras-dependent+alpha+5+beta+1+integrin-mediated+adhesion%2C+demonstrating+the+physiological+relevance+of+this+pathway. assertion.
- assertion asSentence The+Ang1%2FTie2+signal+potentiates+basal+Notch+signal+controlling+vascular+quiescence+by+up-regulating+Dll4+through+AKT-mediated+activation+of+beta-catenin. assertion.
- assertion asSentence The+UGT1A7+haplotype+is+a+suitable+susceptibility+marker+for+the+development+of+hepatocellular+carcinoma+in+hepatitis+B+carriers. assertion.
- assertion asSentence Paracetamol+disposition+can+be+used+as+a+probe+to+assess+UGT1A6+ontogeny+in+the+first+months+of+life. assertion.
- assertion asSentence Single-nucleotide+polymorphisms%2C+T181A+of+the+UGT1A6+gene+is+found+to+be+significantly+associated+with+the+risk+of+asthma. assertion.
- assertion asSentence Genetic+polymorphisms+in+UDP-glucuronosyltransferase+1A6+are+not+associated+with+NSAIDs-related+peptic+ulcer+haemorrhage. assertion.
- assertion asSentence PHD2+does+not+mediate+the+TCDD-mediated+HIF-1+alpha+destabilization+nor+control+the+interference+of+AhR+and+HIF-1+alpha+pathways. assertion.
- assertion asSentence HNF1alpha+and+HNF4alpha+are+the+factors+involved+in+the+interindividual+variability+of+liver+UGT1A6+and+UGT1A9+mRNA+expression. assertion.
- assertion asSentence DDX26+maps+to7p12%2C+a+region+of+frequent+chromosome+amplifications+in+glioblastoma+involving+the+EGFR+gene. assertion.
- assertion asSentence Nonviral+gene+transfer+of+UGT1A1+into+Gunn+rat+liver+and+muscle+corrected+hyperbilirubinemia. assertion.
- assertion asSentence It+is+the+enzyme+responsible+for+glucuronidation+of+SN-38+to+form+less+toxic%2C+inactive+metabolite+SN38G. assertion.
- assertion asSentence In+human+hepatic+cells+and+human+UGT1A+transgenic+mice%2C+LXRalpha+activators+induce+UGT1A3+mRNA+levels+and+the+formation+of+CDCA-24glucuronide+%2824G%29+and+LCA-24G. assertion.
- assertion asSentence Genetic+polymorphisms+of+UGT1A+as+a+prognostic+factor+in+advanced+colorectal+cancer+patients+treated+with+5-fluorouracil+plus+oxaliplatin+or+irinotecan. assertion.
- assertion asSentence Polymorphisms+within+the+gene+are+markers+for+personalized+irinotecan+therapy+in+Japanese+cancer+patients. assertion.
- assertion asSentence Genetic+Polymorphisms+in+UDP+glucuronosyltransferase+1A1+is+associated+with+toxicities+of+combination+chemotherapy+with+irinotecan+and+cisplatin+in+gynecologic+cancers. assertion.
- assertion asSentence Examine+role+of+UGT1A1+polymorphisms+in+patient+response+to+gastric+cancers+treated+with+FOLFOX+or+FOLFIRI. assertion.
- assertion asSentence Homozygous+variant+of+nucleotide+211+G--A+mutation+of+UGT1A1+gene+is+a+significant+risk+factor+associated+with+severe+hyperbilirubinemia+among+Malayasian+Chinese+newborns. assertion.
- assertion asSentence The+MDR1+G2677T%2FA+variation+and+UGT1A1%2A28+are+independent+risk+factors+for+severe+atazanavir-associated+hyperbilirubinemia+in+Korean+human+immunodeficiency+virus-infected+patients. assertion.
- assertion asSentence Neonates+who+carry+the+nucleotide+211+GA+or+AA+variation+within+coding+region+in+UGT1A1+gene+are+more+susceptible+to+develop+early-onset+neonatal+breastfeeding+jaundice. assertion.
- assertion asSentence Repeat+polymorphism+in+UGT1A1+is+associated+with+Prostate+Cancer. assertion.
- assertion asSentence HLA-positive+breast+cancer+patients+have+higher+alanine+aminotransferase+elevation+and+a+higher+incidence+of+Gilbert%27s+syndrome. assertion.
- assertion asSentence ERK-dependent+phosphorylation+of+the+transcription+initiation+factor+TIF-IA+is+required+for+RNA+polymerase+I+transcription+and+cell+growth. assertion.
- assertion asSentence Down-regulation+of+CNGA3+contributes+to+the+pathogenic+mechanism+by+which+CNGB3+mutations+lead+to+human+cone+disease. assertion.
- assertion asSentence Subretinal+administration+of+rAAV5-hCNGB3+with+a+long+version+of+the+red+cone+opsin+promoter+in+younger+animals+led+to+a+stable+therapeutic+effect+for+at+least+33+months. assertion.
- assertion asSentence Gene+expression+incresed+in+multiple+sclerosis+patients+treated+with+interferon-beta. assertion.
- assertion asSentence The+high+expression+of+HSF1+in+gastro-intestinal+cancer+is+associated+with+suppressed+expression+of+XAF1. assertion.