Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Elevated+plasma+levels+of+interferon-gamma+and+Cys-X-Cys+chemokine+receptor+3-binding+chemokine+CXCL10+are+present+in+patients+with+thoracic+aortic+aneurysms. assertion.
- assertion asSentence High+CXCL10+is+associated+with+B-cell+precursor+acute+lymphoblastic+leukemia. assertion.
- assertion asSentence Has+a+role+in+signaling+through+the+malic+enzyme+and+collagenase-1+AP-1+motifs. assertion.
- assertion asSentence The+insulin+gene+VNTR+polymorphism+in+Alzheimer%27s+disease. assertion.
- assertion asSentence Positive+independent+correlation+of+the+CAG+repeat+number+with+body+fat+content%2C+leptin+and+insulin. assertion.
- assertion asSentence Exercise+training-induced+increase+in+insulin+sensitivity+is+not+dependent+on+increase+in+adiponectinemia+in+healthy+men. assertion.
- assertion asSentence Cerebrospinal+fluid+levels+are+lower+in+motor+neuron+disease+than+in+normal+controls. assertion.
- assertion asSentence Genetic+variations+within+INS+are+associated+with+accelerated+fetal+growth. assertion.
- assertion asSentence Insulin+resistance+is+independently+associated+with+raised+fasting+plasma+glucagon+and+proinsulin+concentrations. assertion.
- assertion asSentence Palmitate+reduced+insulin-stimulated+glucose+transport+in+muscle+from+obese+individuals. assertion.
- assertion asSentence In+obese+humans+the+FAT%2FCD36+protein+content+in+skeletal+muscle+is+dynamically+regulated+by+insulin+in+vivo+on+the+short+term. assertion.
- assertion asSentence AS160+phosphorylation+is+essential+for+maintenance+of+insulin-stimulated+glucose+uptake+and+is+rapidly+reversed+after+insulin+removal. assertion.
- assertion asSentence IDE+forms+an+enclosed+catalytic+chamber+that+completely+engulfs+and+intimately+interacts+with+a+partially+unfolded+insulin+molecule. assertion.
- assertion asSentence Misfolded+proinsulin+exerts+dominant+effects+that+initially+inhibit+insulin+production%2C+progressing+to+beta+cell+demise+with+diabetes. assertion.
- assertion asSentence SHIP+has+a+negative+regulatory+role+in+TLR2-induced+neutrophil+activation+and+in+the+development+of+related+in+vivo+neutrophil-dependent+inflammatory+processes%2C+such+as+acute+lung+injury+in+transgenic+mice. assertion.
- assertion asSentence This+binding+mode+of+Ship+2+protein+is+identical+to+the+association+between+Ship2-Sam+and+the+Sam+domain+from+the+Ephrin+A2+receptor. assertion.
- assertion asSentence SHIP2+suppresses+ligand-induced+activation+of+EphA2+and+promotes+receptor+coordinated+chemotactic+cell+migration. assertion.
- assertion asSentence Polymorphism+in+exon+17+of+insulin+receptor+leads+to+increased+risk+of+insulin+resistance+in+women+with+polycystic+ovary+syndrome. assertion.
- assertion asSentence Insulin+interacts+in+trans+with+two+receptor+binding+sites+to+generate+high-affinity+interactions. assertion.
- assertion asSentence The+common+alleles+of+regulatory+variants+in+the+5%27+enhancer+and+promoter+regions+of+the+IPF1+gene+increase+susceptibility+to+type+2+diabetes+among+African+American+individuals. assertion.
- assertion asSentence Mutations+in+a+pedigree+reveals+in+a+point+mutation%2C+increasing+susceptibility+to+type+2+diabetes. assertion.
- assertion asSentence Presence+of+a+regulated%2C+alternative+splice+variant+of+IRAK1+that+functions+as+a+kinase-dead%2C+dominant-negative+protein+adds+further+complexity+to+the+variety+of+mechanisms+that+regulate+Toll%2FIL-1+receptor+signaling+and+subsequent+inflammatory+response. assertion.
- assertion asSentence ST2825+interfered+with+recruitment+of+IRAK1+and+IRAK4+by+MyD88%2C+causing+inhibition+of+IL-1beta-mediated+activation+of+NF-kappaB+transcriptional+activity. assertion.
- assertion asSentence Both+cytosolic+and+nuclear+actions+of+IRAK-1+participate+in+the+activation+of+NF-kappaB-dependent+transcriptional+events. assertion.
- assertion asSentence DSCR1-1S+isoform+positively+modulates+IL-1R-mediated+signaling+pathways+by+regulating+Tollip%2FIRAK-1%2FTRAF6+complex+formation. assertion.
- assertion asSentence Blockade+of+the+alpha6-integrin+enhanced+bone+marrow+%28BM%29+homing+of+human+and+nonhuman+primate+BM-derived+hematopoietic+stem%2Fprogenitor+cells. assertion.
- assertion asSentence Integrin+alpha6beta4+plays+an+essential+role+in+axonal+regeneration+and+subsequent+myelination. assertion.
- assertion asSentence Integrin+alpha6beta1+co-localizes+and+interacts+with+HAb18G%2FCD147+to+mediate+tumor+invasion+and+metastatic+processes. assertion.
- assertion asSentence TGF-beta-mediated+up-regulation+of+the+expression+of+the+integrin+subunits+alpha%282%29+and+alpha%286%29+is+mainly+mediated+in+MSC+by+Smad2. assertion.
- assertion asSentence Demonstrate+a+major+role+of+alpha6+integrin+in+the+proangiogenic+properties+of+endothelial+progenitor+cells. assertion.
- assertion asSentence The+alpha6beta1+integrin+is+a+netrin-4+receptor+in+endothelial+cells. assertion.
- assertion asSentence Reversible+phosphorylation+of+IRP2+during+G%282%29%2FM+has+a+role+in+modulating+the+iron-independent+expression+of+ferritin+and+other+IRE-containing+mRNAs+during+the+cell+cycle. assertion.
- assertion asSentence IRF1+is+one+of+the+transcription+factors+responsible+for+the+induced+coexpression+of+NF-kappa+B+activator+1+%28Act1%29+and+CD40+in+lung+epithelial+A549+cells+by+inflammatory+cytokines. assertion.
- assertion asSentence IFN+regulatory+factor+1+is+involved+in+TNF-alpha-induced+VCAM-1+expression+and+monocyte+adhesion+to+TNF-alpha-activated+endothelial+cells. assertion.
- assertion asSentence NKG2A+expression+on+gammadelta+lymphoproliferative+Disease+of+Large+Granular+Lymphocytes+correlates+with+asymptomatic+pathology%2C+even+in+the+presence+of+NKG2C+coexpression. assertion.
- assertion asSentence Common+occurrence+of+NKG2-C+gene+deletion+in+the+general+population. assertion.
- assertion asSentence Role+that+each+NKG2A+immunoreceptor+tyrosine-based+inhibitory+motif+plays+in+mediating+the+human+CD94%2FNKG2A+inhibitory+signal. assertion.
- assertion asSentence The+invariant+CD94+chain+plays+a+more+dominant+role+in+interacting+with+HLA-E+in+comparison+to+the+variable+NKG2+chain. assertion.
- assertion asSentence Single+Nucleotide+Polymorphisms+in+KNG1+is+associated+with+activated+partial+thromboplastin+time. assertion.
- assertion asSentence For+a+single+nucleotide+polymorphism+%28G58836C+in+intron+13%29+in+the+kinesin+light-chain+1+%28KNS2%29+gene%2C+the+association+between+Alzheimer%27s+disease+and+the+C+allele+is+found+to+be+significant. assertion.
- assertion asSentence Microtubule-Eg5+complex+binds+MgATP+tightly%2C+followed+by+rapid+ATP+hydrolysis+with+a+subsequent+slow+step+that+limits+steady-state+turnover. assertion.
- assertion asSentence A+critical+element+of+Eg5%2C+loop+5+%28L5%29%2C+accelerates+ADP+release+during+the+initial+microtubule-binding+event. assertion.
- assertion asSentence Importin+alpha5+and+alpha7+bind+to+Stat3+upon+cytokine+stimulation. assertion.
- assertion asSentence The+VP24+IFN+antagonist+function+of+ebolavirus+requires+the+ability+of+VP24+to+interact+with+KPNalpha. assertion.
- assertion asSentence Nucleoporin+Nup50+stabilizes+closed+conformation+of+armadillo+repeat+10+in+importin+alpha5. assertion.
- assertion asSentence Importin+alpha%2Fbeta-mediated+nuclear+import+machinery+is+regulated+in+a+cell+cycle-dependent+manner+through+the+modulation+of+interaction+modes+between+importins+alpha+and+beta. assertion.
- assertion asSentence %5Breview%5D+The+cellular+functions+of+Ran+are+mediated+by+RanGTP+interactions+with+nuclear+transport+receptors+related+to+importin+beta+and+depend+on+the+existence+of+chromosome-centered+RanGTP+gradient. assertion.
- assertion asSentence Ki-ras+mutations+and+HGF+signaling+cooperate+to+enhance+tumor+growth+by+increased+duration+of+MAPK+activation+and+decreased+apoptosis+in+human+carcinoma+cells. assertion.
- assertion asSentence K-ras+mutations+are+frequently+found+in+surgical+margins+in+non-small-cell+lung+carcinoma+patients. assertion.
- assertion asSentence Mutations+do+not+confer+a+growth+advantage+to+somatic+heterozygous+clusters+or+maintenance+turnover+units. assertion.
- assertion asSentence The+majority+of+colorectal+and+gastric+cancer+cells+with+KRAS+mutations+are+homogeneous+because+they+have+the+same+KRAS+mutation. assertion.
- assertion asSentence Wild+type+K-ras2+is+related+to+the+negative+regulation+of+cell+proliferation%2C+metabolism+and+transcriptional+control+in+colon+carcinoma+cells. assertion.
- assertion asSentence KRAS+WT+status+is+associated+to+survival+benefit+in+cetuximab+treated+metastatic+colorectal+cancer. assertion.
- assertion asSentence Mutational+activation+of+the+K-ras+gene%2C+HPV+infection+and+tobacco+or+alcohol+abuse%2C+can+be+considered+independently+or+in+combination+as+high+risk+factors+for+esophageal+squamous+cell+carcinoma+development. assertion.
- assertion asSentence KRAS+mutations+and+PI3KCA%2FPTEN+deregulation+significantly+correlate+with+resistance+to+cetuximab. assertion.
- assertion asSentence Mutations+in+the+KRAS+are+associated+with+Noonan+syndrome. assertion.
- assertion asSentence Mutation+in+KRAS+is+associated+with+adrenocortical+carcinomas. assertion.
- assertion asSentence Distinct+BRAF+%28V600E%29+and+KRAS+mutations+in+high+microsatellite+instability+sporadic+colorectal+cancer+in+African+Americans. assertion.
- assertion asSentence KRAS+mutations+are+associated+with+colorectal+neoplasms. assertion.
- assertion asSentence Matrix-assisted+laser+desorption+ionization+remains+a+potent+and+highly+clinically+significant+predictor+of+survival+after+first-line+treatment+with+erlotinib+in+non-smll-cell+lung+patients+with+wild-type+EGFR+and+independent+of+mutations+in+KRAS. assertion.
- assertion asSentence Mutations+in+KRAS+is+associated+with+lung+adenocarcinoma. assertion.
- assertion asSentence KRAS+mutations+are+very+infrequent+in+triple-negative+breast+tumors. assertion.
- assertion asSentence Frequently+downregulated+miR-217+can+regulate+KRAS+and+function+as+a+tumor+suppressor+in+pancreatic+ductal+adenocarcinoma+%28PDAC%29. assertion.
- assertion asSentence Wild-type+K-Ras.GTP+in+association+with+Gal-3+contributes+to+thyroid+carcinoma+malignancy. assertion.
- assertion asSentence In+KRAS+mutant+tumors%2C+PIK3CA+mutation+restores+cyclin+D1+expression+and+G%281%29-S+cell+cycle+progression+so+that+they+are+no+longer+dependent+on+KRAS+and+MEK%2FERK+signaling. assertion.
- assertion asSentence KRAS+mutation+is+associated+with+anti-EGFR+therapy+response+in+colorectal+cancer. assertion.
- assertion asSentence KRASG12D+is+associated+with+pancreatic+cancer. assertion.
- assertion asSentence The+KRAS+mutation+is+a+negative+predictive+factor+for+survival+in+patients+rectal+and+colon+cancer. assertion.
- assertion asSentence KRAS+signaling+pathway+alterations+in+microsatellite+unstable+gastrointestinal+cancers. assertion.
- assertion asSentence KRAS-mutated+non-small+cell+lung+cancer+cells+are+responsive+to+either+co-treatment+with+erlotinib+or+gefitinib+and+histone+deacetylase+inhibitors+or+single+treatment+with+lapatinib. assertion.
- assertion asSentence Amplification+of+the+driving+oncogene%2C+KRAS+or+BRAF%2C+underpins+acquired+resistance+to+MEK1%2F2+inhibitors+in+colorectal+cancer+cells. assertion.
- assertion asSentence Combined+KRAS+and+TP53+mutation+status+is+not+predictive+in+CAPOX-treated+metastatic+colorectal+cancer. assertion.
- assertion asSentence C-Raf+plays+a+unique+role+in+mediating+K-Ras+signaling+in+non-small+cell+lung+carcinoma+and+makes+it+a+suitable+target+for+therapeutic+intervention. assertion.
- assertion asSentence Combined+mutations+in+codons+12+and+13+of+KRAS+are+relatively+infrequent+and+most+commonly+occur+in+prostate+carcinomas. assertion.
- assertion asSentence Stromal+cells+in+colorectal+carcinoma+do+not+share+KRAS+mutations+that+the+epithelial+component+harbors. assertion.
- assertion asSentence Grossly+polypoid+colorectal+adenocarcinomas+with+a+persistent+pre-existing+adenomatous+polyp+with+villous+architecture+are+strongly+associated+with+KRAS+mutations. assertion.
- assertion asSentence Loss+of+heterozygosity+at+Kras+can+provide+cancer+cells+functional+growth+advantages+and+promote+metastasis. assertion.
- assertion asSentence Failure+to+phosphorylate+HsCyk-4+blocks+Ect2+recruitment+to+the+central+spindle+and+the+subsequent+induction+of+furrowing. assertion.
- assertion asSentence DeltaNp63+alone+can+restore+the+expression+of+the+basal+keratins+and+reinitiate+the+failed+epidermal+differentiation+program+in+the+skin+of+p63+null+animals. assertion.
- assertion asSentence Heterogeneity+of+cytokeratin+7+expression+in+pagetoid+Bowen%27s+disease. assertion.
- assertion asSentence A+20-residue+region+%28313-332%29+in+the+rod+domain+of+K8+specifically+recognized+by+A45-B%2FB3+monoclonal+antibody+undergoes+a+conformational+change+following+interaction+with+keratin+K18+and+plays+a+role+in+stabilization+of+the+keratin+cytoskeleton. assertion.
- assertion asSentence Cytokeratins+18+and+8+are+poor+prognostic+markers+in+patients+with+squamous+cell+carcinoma+of+the+oesophagus. assertion.
- assertion asSentence The+affected+members+of+all+five+families+possess+mutations+in+the+KRT9+gene+that+severely+affect+heterodimer+formation+with+the+type+II+keratin+partner. assertion.
- assertion asSentence Heterozygous+Ala137Pro+mutation+in+keratin+12+gene+found+in+Japanese+with+Meesmann%27s+corneal+dystrophy. assertion.
- assertion asSentence A+spontaneous+CD8+T+cell-dependent+autoimmune+disease+to+an+antigen+expressed+under+the+human+keratin+14+promoter. assertion.
- assertion asSentence Positive+expression+of+CK5%2F6+or+CK17+in+patients+with+triple-negative+breast+cancer+is+correlated+with+poor+prognosis%2C+high+grade+differentiation+and+axillary+lymph+node+metastasis. assertion.
- assertion asSentence The+KRT8%2FKRT18+heterodimeric+intermediary+filaments+of+the+cytoskeleton+apparently+are+an+essential+component+for+the+proper+targeting+of+CFTR+to+the+apical+membrane+in+epithelial+cells. assertion.
- assertion asSentence A+high+serum+CYFR21-1+concentration+is+associated+with+tumor+progression+and+poor+postoperative+outcomes+in+patients+with+intrahepatic+cholangiocarcinoma. assertion.
- assertion asSentence Transfected+p65+induces+transcriptional+activation+of+Hb1. assertion.
- assertion asSentence Transfected+p65+induces+transcriptional+activation+of+Hb5. assertion.
- assertion asSentence L1+expression+conferred+increased+cell+motility%2C+growth+in+low+serum%2C+transformation+and+tumorigenesis. assertion.
- assertion asSentence Nuclear+factor-kappaB+signaling+and+ezrin+are+essential+for+L1CAM+mediated+metastasis+of+colon+cancer+cells. assertion.
- assertion asSentence Overexpression+of+cell+adhesion+molecule+L1+is+asociated+with+gallbladder+carcinoma+progression. assertion.
- assertion asSentence L1CAM+promoted+cell+proliferation+by+mainly+activating+ERK+signaling. assertion.
- assertion asSentence LAG-3+activates+antigen-presenting+cells+through+MHC+class+II+signalling%2C+leading+to+increased+antigen-specific+T-cell+responses+in+vivo. assertion.
- assertion asSentence Tumor-infiltrating+NY-ESO-1-specific+CD8%2B+T+cells+are+negatively+regulated+by+LAG-3+and+PD-1+in+human+ovarian+cancer. assertion.
- assertion asSentence Mutation+of+a+single+residue%2C+arginine+65%2C+dramatically+decreases+the+binding+of+LAIR-1+to+collagens. assertion.
- assertion asSentence An+N-termninal+deletion+of+the+LAMA3+isoform+leads+to+the+chronic+ganulation+tissue+disorder+laryngo-onycho-cutaneous+syndrome. assertion.
- assertion asSentence Abnormal+distribution+of+laminin+alpha1+and+laminin+alpha5+in+glomerular+basement+membrane+is+correlated+with+GBM+thickening+and+splitting+in+human+Alport%27s+syndrome. assertion.
- assertion asSentence beta2+chain-containing+laminins+%28beta2-laminins%29+bound+more+avidly+to+alpha3beta1+and+alpha7X2beta1+integrins+than+beta1+chain-containing+laminins+%28beta1-laminins%29. assertion.