Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _6 value "ATF1 and CREB can be phosphorylated by Rsk2 which is a protein kinase directly activated by Erk MAP kinase. These results suggest a signaling pathway in which Erk MAP kinase activates the c-fos enhancer by direct phosphorylation of p62TCF and by activation of Rsk related kinases that phosphorylate ATF1 and CREB." provenance.
- _6 value "ATF1 and CREB can be phosphorylated by Rsk2 which is a protein kinase directly activated by Erk MAP kinase. These results suggest a signaling pathway in which Erk MAP kinase activates the c-fos enhancer by direct phosphorylation of p62TCF and by activation of Rsk related kinases that phosphorylate ATF1 and CREB." provenance.
- _6 value "ATF1 and CREB can be phosphorylated by Rsk2 which is a protein kinase directly activated by Erk MAP kinase. These results suggest a signaling pathway in which Erk MAP kinase activates the c-fos enhancer by direct phosphorylation of p62TCF and by activation of Rsk related kinases that phosphorylate ATF1 and CREB." provenance.
- _5 value "Modified assertion" provenance.
- _4 value "Modified assertion" provenance.
- _5 value "PKC-theta activation of NF-kappaB is mediated through the selective induction of IKKbeta, while the Cot- and NIK-dependent pathway involves induction of both IKKalpha and IKKbeta." provenance.
- _5 value "PKC-theta activation of NF-kappaB is mediated through the selective induction of IKKbeta, while the Cot- and NIK-dependent pathway involves induction of both IKKalpha and IKKbeta." provenance.
- _5 value "PKC-theta acts directly or indirectly to stimulate phosphorylation of IKKbeta, leading to activation of this enzyme" provenance.
- _4 value "C2-ceramide-induced membrane association of p21Ras was reduced by 30-50% in PPT1-overexpressing cells compared with control." provenance.
- _6 value "Consistent with increased resistance to apoptosis, we found increased phosphorylation of the antiapoptotic protein Akt (protein kinase B) in PPT1-overexpressing cells." provenance.
- _4 value "Overexpression of PPT1 inhibited this C2-ceramide- or LY294002-mediated activation of caspase-3 by 50%." provenance.
- _7 value "Stra13 expression is transcriptionally repressed and maintained at a low level in cells through a negative autoregulatory mechanism that is brought about by its interaction with the corepressor histone deacetylase (HDAC1)." provenance.
- _5 value "Stra13 expression is transcriptionally repressed and maintained at a low level in cells through a negative autoregulatory mechanism that is brought about by its interaction with the corepressor histone deacetylase (HDAC1)." provenance.
- _4 value "These data indicate that endogenous reactive oxygen species are necessary for the activation of p56(Hck), p72(Syk), and p77(Btk) by spores; they also indicate that some species of spores are capable of activating tyrosine kinases independent of superoxide anion." provenance.
- _5 value "Substitution of threonine 68 by alanine in the full-length kinase-dead Chk2 dramatically reduced but did not abolish the ATM phosphorylation of Chk2/Cds1 in vitro (Fig. 4B; threonine 68 accounts for approximately 70% of the total phosphorylation)." provenance.
- _3 value "By using this process we have identified five genes (POMC, PC2, prolactin, HSGP25L2G, and one novel) that are both abnormally expressed in the pituitaries of obese mice and are sensitive to the effects of leptin POMC, PC2 and HSGP25L2G expressions were decreased in response to leptin and prolactin expression was increased" provenance.
- _6 value "However, Wy14,643 and PPARalpha/RXRalpha significantly reduced HNF-4 expression in HepG2 cells.These results suggest that PPARalpha and agonist repress cholesterol 7alpha-hydroxylase activity by reducing the availability of HNF-4 for binding to the DR-1 sequence and therefore attenuates the transactivation of CYP7A1 by HNF-4" provenance.
- _3 value "trichostatin A (TSA), an inhibitor of histone deacetylases Complex hybridization of cDNA arrays revealed repression of Bcl-xL, CRAB2 and TFIID/TAFII31 as well as induction of p21waf1/cip1, GATA-2, hsp86, ID1, ID2 and ID3 mRNA expression, which could be verified by Northern blotting." provenance.
- _3 value "trichostatin A (TSA), an inhibitor of histone deacetylases Complex hybridization of cDNA arrays revealed repression of Bcl-xL, CRAB2 and TFIID/TAFII31 as well as induction of p21waf1/cip1, GATA-2, hsp86, ID1, ID2 and ID3 mRNA expression, which could be verified by Northern blotting." provenance.
- _3 value "trichostatin A (TSA), an inhibitor of histone deacetylases Complex hybridization of cDNA arrays revealed repression of Bcl-xL, CRAB2 and TFIID/TAFII31 as well as induction of p21waf1/cip1, GATA-2, hsp86, ID1, ID2 and ID3 mRNA expression, which could be verified by Northern blotting." provenance.
- _3 value "trichostatin A (TSA), an inhibitor of histone deacetylases Complex hybridization of cDNA arrays revealed repression of Bcl-xL, CRAB2 and TFIID/TAFII31 as well as induction of p21waf1/cip1, GATA-2, hsp86, ID1, ID2 and ID3 mRNA expression, which could be verified by Northern blotting." provenance.
- _3 value "trichostatin A (TSA), an inhibitor of histone deacetylases Complex hybridization of cDNA arrays revealed repression of Bcl-xL, CRAB2 and TFIID/TAFII31 as well as induction of p21waf1/cip1, GATA-2, hsp86, ID1, ID2 and ID3 mRNA expression, which could be verified by Northern blotting." provenance.
- _4 value "demonstrate that the inhibition of the aPKCs or the down-regulation of p62 severely abrogates NF-kappaB activation by IL-1 and TRAF6, suggesting that both proteins are critical intermediaries in this pathway" provenance.
- _6 value "demonstrate that the inhibition of the aPKCs or the down-regulation of p62 severely abrogates NF-kappaB activation by IL-1 and TRAF6, suggesting that both proteins are critical intermediaries in this pathway" provenance.
- _4 value "Inhibition of STAT3 activation by SOCS could be overcome by overexpression of native JAK1 and JAK2." provenance.
- _4 value "Modified assertion" provenance.
- _7 value "Interestingly, this ectopic expression of Smad6 blocks BMP2-induced TAK1 activation and p38 phosphorylation." provenance.
- _4 value "FGF-1 and FGF-2 competed efficiently with (125)I-FGF-2 for binding to FGFR-1 and FGFR-1L, whereas FGF-4 was less efficient. FGF-1, FGF-2, and FGF-4 enhanced mitogen-activated protein kinase (MAPK) activity, increased steady-state c-fos mRNA levels, and stimulated proliferation through either receptor" provenance.
- _5 value "DNA binding assays and cell transfection experiments revealed that the bipartite core sequence of FPB (5'-ATCAATCA-3') binds the PBX1/2, PREP1, and HOXB1 proteins, and this in turn leads to promoter transactivation." provenance.
- _5 value "Additional fragments derived from the promoters of phospholipid transfer protein and hepatic nuclear factor-4 (HNF4) and the apoCIII enhancer that had been shown to bind GST.ZF3-8 in vitro were also used in reporter assays. Transcriptional repression in the presence of ZNF202 was similar to the one observed for the apoE and apoAIV promoters (Table I)" provenance.
- _5 value "IL-17 activates the transcription factor nuclear factor (NF)-kappaB and c-Jun NH(2)-terminal kinase (JNK)" provenance.
- _5 value "In embryonic fibroblasts (EFs) derived from TRAF6 knockout mice, IL-17 failed to activate the IkappaB kinases (IKKs) and JNK. Consequently, IL-17-induced IL-6 and intercellular adhesion molecule 1 expression in the TRAF6-deficient cells was abolished." provenance.
- _5 value "Insulin receptor substrates (IRS-1 and -2) are essential for intracellular signaling by insulin and IGF-I, anabolic regulators of bone metabolism." provenance.
- _3 value "The direct role of glucocorticoids in regulating the expression of the murine gene encoding the major BCKAD subunit E2, upon which the other BCKAD subunits assemble, was therefore examined" provenance.
- _4 value "Both RGS3 and RGS3T bound to endogenous Galpha(q/11) and inhibited endothelin-1-stimulated calcium mobilization and mitogen-activated protein kinase activity to a similar extent." provenance.
- _3 value "# Ariadne: In vitro , bacterially expressed glutathione S -transferase-PASS1 fusion protein bound to hsp27, and hsp27 was co-immunoprecipitated with c-Myc-tagged PASS1 overexpressed in several cell lines. [Binding]" provenance.
- _4 value "The sequences of the other cDNA fragments were identical to those of contrapsin, transketolase, and vanin-3. The latter two were up-regulated, whereas contrapsin was down-regulated in neonatal MT-null mice." provenance.
- _7 value "Using a series of specific small molecule inhibitors, both protein kinase C (PKC) and phosphoinositide-3 kinase (PI-3K) appeared to be required for SDF-1alpha-mediated phosphorylation of focal adhesion proteins and the migration of both CTS and primary marrow CD34(+) cells, whereas the mitogen-activated protein kinases ERK-1 and -2 were not." provenance.
- _8 value "Using a series of specific small molecule inhibitors, both protein kinase C (PKC) and phosphoinositide-3 kinase (PI-3K) appeared to be required for SDF-1alpha-mediated phosphorylation of focal adhesion proteins and the migration of both CTS and primary marrow CD34(+) cells, whereas the mitogen-activated protein kinases ERK-1 and -2 were not." provenance.
- _9 value "Using a series of specific small molecule inhibitors, both protein kinase C (PKC) and phosphoinositide-3 kinase (PI-3K) appeared to be required for SDF-1alpha-mediated phosphorylation of focal adhesion proteins and the migration of both CTS and primary marrow CD34(+) cells, whereas the mitogen-activated protein kinases ERK-1 and -2 were not." provenance.
- _5 value "Using a series of specific small molecule inhibitors, both protein kinase C (PKC) and phosphoinositide-3 kinase (PI-3K) appeared to be required for SDF-1alpha-mediated phosphorylation of focal adhesion proteins and the migration of both CTS and primary marrow CD34(+) cells, whereas the mitogen-activated protein kinases ERK-1 and -2 were not." provenance.
- _6 value "Using a series of specific small molecule inhibitors, both protein kinase C (PKC) and phosphoinositide-3 kinase (PI-3K) appeared to be required for SDF-1alpha-mediated phosphorylation of focal adhesion proteins and the migration of both CTS and primary marrow CD34(+) cells, whereas the mitogen-activated protein kinases ERK-1 and -2 were not." provenance.
- _7 value "We observed that several other focal adhesion components, including focal adhesion kinase (FAK) and the adaptor molecules Crk and Crk-L, are phosphorylated on SDF-1alpha stimulation." provenance.
- _5 value "We observed that several other focal adhesion components, including focal adhesion kinase (FAK) and the adaptor molecules Crk and Crk-L, are phosphorylated on SDF-1alpha stimulation." provenance.
- _6 value "Upon activation, the HGF-receptor c-Met binds and phosphorylates the multisite docking protein Gab1. Besides binding motifs for phosphatidylinositol 3-kinase and Grb2, Gab 1 contains multiple Tyr-X-X-Pro (YXXP) motifs which, when phosphorylated, are potential binding sites for the adapter proteins c-Crk and Crk-like (CRKL)." provenance.
- _2 value "Overexpression experiments in REF52 rat fibroblasts showed that BFL-1 conferred increased resistance to apoptosis induced by serum deprivation" provenance.
- _4 value "Activation of the human GM-CSF promoter in T cells appears to be tightly regulated by induction and binding of multiple transcription factors including NF-kappaB/Rel, AP-1, and NFAT proteins ( 25 , 26 , 27 )." provenance.
- _5 value "Furthermore, macrophages lacking IRAK exhibit impaired LPS-stimulated TNF-alpha production" provenance.
- _3 value "The three sequences corresponded to a human gene homologous to the yeast translation initiation factor Sui-1, a cAMP-regulated phosphoprotein, ARPP-16/19, and a novel gene designated O48. ARPP only responded to OA" provenance.
- _4 value "Modified assertion" provenance.
- _4 value "Modified assertion" provenance.
- _3 value "Similar responses are observed for the serum and glucocorticoid-regulated kinase and channel-inducing factor genes. All four genes show clear and rapid up-regulation of their mRNA levels by aldosterone, which is paralleled by GR-mediated up-regulation of expression." provenance.
- _3 value "Similar responses are observed for the serum and glucocorticoid-regulated kinase and channel-inducing factor genes. All four genes show clear and rapid up-regulation of their mRNA levels by aldosterone, which is paralleled by GR-mediated up-regulation of expression." provenance.
- _4 value "Ras GTPase was activated by EGF, NGF, insulin and phorbolester in PC12 cells" provenance.
- _3 value ". The expression of this gene was down regulated by androgens in androgen sensitive prostate cells, but not in the hormone resistant cell lines." provenance.
- _5 value "# Jubilant: It was proved that Reactive oxygen species generation was dependent on P22-PHOX subunit of NADPHoxidase. Transfection with antisense P22-PHOX oligonucleotides reduced the Angiotensin induced Reactive oxygen species induction" provenance.
- _6 value "Modified assertion" provenance.
- _4 value "Recruitment of NADE to p75 NTR increased dose dependently by NGF." provenance.
- _5 value "In the present study, we show that the cyclin-dependent kinase inhibitor p21(WAF1/CIP1/SDI1) inhibits STAT3 transcriptional activation" provenance.
- _5 value "Modified assertion" provenance.
- _5 value "We show that exposure of NIH-3T3 and SV-40 transformed green monkey kidney (COS) cells to stress stimuli such as osmotic shock or UVC irradiation, but not to mitogenic activators such as PDGF or EGF, results in a marked cytoplasmic accumulation of hnRNP A1, concomitant with an increase in its phosphorylation. These effects are mediated by the MKK(3/6)-p38 pathway, and moreover, p38 activation is necessary and sufficient for the induction of hnRNP A1 cytoplasmic accumulation." provenance.
- _6 value "# Ariadne: In contrast, in Panc-1 cells overexpressing RhoB-F, RhoB-GG, and RhoB-WT, the ability of IGF-1 to stimulate AKT phosphorylation/activation was inhibited by 50% (.. 16%), 50% (.. 18%), and 65% (.. 15%), respectively. [Regulation]" provenance.
- _3 value "It is thought that neutrophils are attracted to the skin by an array of chemotactic factors (Camp 1989;Camp et al. 1990). These include a number of neutrophil-activating polypeptide species such as interleukin-8 (IL-8), gro/MGSA (growth-related gene/melanoma growth stimulatory activity), or the complement split product C5ades arg (Schröder et al. 1987,1988a,1998b,van Damme et al. 1988;Baggiolini et al. 1989;Gillitzer et al. 1996). " provenance.
- _6 value "transactivation activity of Nur77 was significantly inhibited by cotransfection of RARalpha or RXRalpha" provenance.
- _6 value "transactivation activity of Nur77 was significantly inhibited by cotransfection of RARalpha or RXRalpha" provenance.
- _5 value "Treatment with TNFalpha at concentrations of 0.1-10 ng/ml resulted in a dose dependent increase in 11beta-HSD1 reductase activity from 1.5 to 10-fold. Insulin (0.1-100 nM) had no effect under basal conditions, but inhibited the stimulatory effects of TNFalpha (5 ng/ml) on 11beta-HSD1 reductase activity in a dose dependent fashion (8-66%) inhibition)." provenance.
- _4 value "The expression of GLUT1 mRNA increased after 4 h of stimulation with IGF-I and decreased after 24 h. Blocking PI3K activity by inhibitor wortmannin abolished the effect of IGF-I on Glut1 mRNA expression in NIH-IGFR cells suggesting the involvement PI3K." provenance.
- _7 value "Moreover, IKKalpha either directly or indirectly enhances IKKbeta kinase activity for IkappaBalpha" provenance.
- _5 value "Two related kinases, IkappaB kinase alpha (IKKalpha) and IKKbeta, phosphorylate the IkappaB proteins, leading to their degradation and the subsequent activation of gene expression by NF-kappaB" provenance.
- _4 value "Using a transient transfection approach in a mature B cell line, 2PK3, we demonstrate that RGS1 and RGS3s are effective inhibitors of chemotaxis toward the lymphoid tissue chemokines stromal cell-derived factor-1, B lymphocyte chemoattractant, and EBV-induced molecule 1 ligand chemokine, whereas RGS2 has a minimal effect on migration to these chemokines." provenance.
- _3 value "ADAMTS-1 and cathepsin L are transcriptional targets of PR action. ADAMTS-1 is induced after LH stimulation in granulosa cells of preovulatory follicles and depends on PR." provenance.
- _4 value "Our results indicate that MEF2C can directly or indirectly activate the expression of MASH-1, leading to neurogenesis." provenance.
- _4 value "GM-CSF was detectable in the supernatant only 6 h after stimulation and accumulated over the subsequent time points (Figure 2A); intracellular levels reached a maximum 2 to 6 h after stimulation (Figure 2B)" provenance.
- _3 value "Figure 2 in the actual paper." provenance.
- _3 value "Figure 2 in the actual paper." provenance.
- _3 value "Figure 2 in the actual paper." provenance.
- _3 value "Figure 2 in the actual paper." provenance.
- _3 value "Figure 2 in the actual paper." provenance.
- _3 value "Figure 2 in the actual paper." provenance.
- _5 value "SUMO-1 negatively regulates c-Jun activity" provenance.
- _5 value "We report here that the serine proteinase inhibitor (serpin) PI-9 accounts for the endogenous caspase-1 inhibitory activity in human SMCs and prevents processing of the enzyme's natural substrates, IL-1beta and IL-18 precursor." provenance.
- _4 value "Treatment of U937 cells with TNF-alpha for 5 min increased the intracellular concentration of ceramide, however it was prevented by incubation with D609 (which inhibits acidic Sphingomyelinase activity). Further showed that D609 also inhibited the TNF-alpha induced apoptosis. This suggests that TNF-alpha induced ceramide generation and apoptosis were mediated by sphingomyelinase." provenance.
- _4 value "elastase is the principal factor that propagates pancreatic inflammation into a systemic illness through direct activation of systemic inflammatory cells." provenance.
- _4 value "Preincubation with quinacrine (inhibitor of PLA(2)) before stress also suppressed the expression of Hsp68 only after oxidative stress." provenance.
- _2 value "Fig. 3" provenance.
- _6 value "Activated hPRP4 phosphorylates residue Thr-417 on Elk-1 resulting in Elk-1 activation." provenance.
- _4 value "# Ariadne: On the other hand, previous studies have shown that acetaldehyde induces the levels of c-Jun through a PKC-dependent mechanism and enhances murine alpha2(I) collagen promoter mediated by PKC activation ( 46 , 47 ). [Expression]" provenance.
- _4 value "# Ariadne: Therefore, the present study demonstrates that PGE 2 has the ability to stimulate AP-1-mediated expression of CD14 in mouse macrophages via cAMP-dependent protein kinase A. [Expression] # Ariadne: PGE 2 -stimulated expression of CD14 was inhibited by antisense c- fos and c- jun oligonucleotides, but not by their sense oligonucleotides. [Expression]" provenance.
- _6 value "# Ariadne: Therefore, the present study demonstrates that PGE 2 has the ability to stimulate AP-1-mediated expression of CD14 in mouse macrophages via cAMP-dependent protein kinase A. [Expression] # Ariadne: PGE 2 -stimulated expression of CD14 was inhibited by antisense c- fos and c- jun oligonucleotides, but not by their sense oligonucleotides. [Expression]" provenance.
- _4 value "PGE2 stimulated the CD14 gene expression at the transcriptional level via protein kinase A." provenance.
- _5 value "PGE2-stimulated expression of CD14 was inhibited by antisense c-fos and c-jun oligonucleotides" provenance.
- _5 value "The biological activity of u-PA, t-PA, as well as that of limiting concentration of FCS (1%), was mediated by PTK and PKC." provenance.
- _5 value "The biological activity of u-PA, t-PA, as well as that of limiting concentration of FCS (1%), was mediated by PTK and PKC." provenance.
- _9 value "MBIP interacts with one of the two leucine-zipper-like motifs of MUK/DLK/ZPK and inhibits the activity of MUK/DLK/ZPK to induce JNK/SAPK activation." provenance.
- _5 value "PACAP induced expression of GLAST via activation of PKA-dependent signaling pathways only, but it affected the expression of GLT-1 via both PKA and PKC-dependent signaling pathways." provenance.
- _5 value "PACAP induced expression of GLAST via activation of PKA-dependent signaling pathways only, but it affected the expression of GLT-1 via both PKA and PKC-dependent signaling pathways." provenance.
- _5 value "CEACAM1 undergoes ligand-stimulated phosphorylation by the insulin receptor" provenance.
- _6 value "# Ariadne: Collectively, these results support the concept that p38 kinase targets MEF2C at a unique site (Thr293), whose phosphorylation is required to stimulate MEF2- dependent transcription during muscle differentiation. [MolTransport]" provenance.
- _5 value "Activation of p38 also enhances the transcriptional activities of myocyte enhancer binding factor 2A (MEF2A) and MEF2C by direct phosphorylation" provenance.
- _5 value "Activation of p38 also enhances the transcriptional activities of myocyte enhancer binding factor 2A (MEF2A) and MEF2C by direct phosphorylation" provenance.