Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Promoter+hypermethylation+and+down+regulation+of+XAF1+is+associated+with+liver+tumor+recurrence+after+liver+transplantation. assertion.
- assertion asSentence CUG+codon+functions+as+a+major+translation+initiation+site+in+the+alternatively+spliced+transcript+variant+hSef-b. assertion.
- assertion asSentence JB12+cooperates+with+cytosolic+Hsc70+and+the+ubiquitin+ligase+RMA1+to+target+CFTR+and+CFTRDeltaF508+for+degradation. assertion.
- assertion asSentence Somatic+mutations+in+TET2+occur+in+about+15%25+of+patients+with+various+myeloid+cancers. assertion.
- assertion asSentence Mutated+in+myeloid+cancers+and+other+myeloproliferative+disorders. assertion.
- assertion asSentence TET2+mutations+are+not+associated+with+transformed+myeloproliferative+neoplasms. assertion.
- assertion asSentence Mutations+in+TET2+occurred+with+similar+frequency+in+myelodysplastic+syndromes+and+acute+myeloid+leukemias+and+associated+equally+with+either+ASXL1+or+NPM1+mutations. assertion.
- assertion asSentence Mutations+in+the+TET2+gene+is+associated+with+chronic+myelomonocytic+leukemia. assertion.
- assertion asSentence TET2+mutation+is+asssociated+with+chronic+myelogenous+leukemia. assertion.
- assertion asSentence Tet2+haploinsufficiency+contributes+to+hematopoietic+transformation+in+vivo. assertion.
- assertion asSentence Decreased+TET2+gene+expression+is+associated+with+chronic+myeloid+leukemia+progression. assertion.
- assertion asSentence In+both+mouse+and+human+cells%2C+TET2+inactivation+leads+to+a+dramatic+deregulation+of+hematopoiesis+that+ultimately+triggers+blood+malignancies. assertion.
- assertion asSentence PIP2+is+a+strong+positive+modulator+of+TRPM4+and+implicate+the+C-terminal+PH+domain+in+PIP2+action. assertion.
- assertion asSentence The+CNNM2+locus+is+associated+with+serum+Mg%282%2B%29+concentrations. assertion.
- assertion asSentence Mutually+exclusive+cytoplasmic+dynein+regulation+by+NudE-Lis1+and+dynactin. assertion.
- assertion asSentence PICH+phosphorylation+and+its+ATPase+activity+are+required+for+mitotic+chromosome+compaction+through+the+targeting+of+Plk1+to+chromosome+arms. assertion.
- assertion asSentence TRPM7+is+a+functionally+important+regulator+of+Mg2%2B+homeostasis+and+growth+in+vascular+smooth+muscle+cells. assertion.
- assertion asSentence TRPM7%27s+structural+duality+ensures+ideal+positioning+of+its+kinase+in+close+proximity+to+channel-mediated+Mg%282%2B%29+uptake%2C+allowing+for+the+adjustment+of+protein+translational+rates+to+the+availability+of+Mg%282%2B%29. assertion.
- assertion asSentence Association+of+the+D14+allele+with+knee+osteoarthritis+susceptibility+in+Han+Chinese. assertion.
- assertion asSentence Asporin+has+a+role+in+osteoblast-driven+collagen+biomineralization+activity. assertion.
- assertion asSentence ASPN+plays+positive+roles+in+the+mineralization+of+dental+pulp+stem+cells+and+predentin+to+dentin. assertion.
- assertion asSentence Aprataxin+is+critical+for+the+processing+of+obstructive+DNA+termini. assertion.
- assertion asSentence Protein+kinase+C+gamma%2C+a+causative+for+spinocerebellar+ataxia%2C+negatively+regulates+nuclear+import+of+aprataxin. assertion.
- assertion asSentence High+aprataxin+levels+are+associated+with+low+irinotecan+response+in+colorectal+cancer. assertion.
- assertion asSentence Aprataxin+is+required+for+the+normal+repair+rate+of+DNA+single-strand+breaks+induced+by+genotoxic+agents. assertion.
- assertion asSentence RNA+interference+of+CDX1+and+CDX2+and+chromatin+immunoprecipitation+in+colon+cancer+cells+revealed+that+MS4A12+transcript+and+protein+expression+is+essentially+dependent+on+the+presence+of+endogenous+CDX2. assertion.
- assertion asSentence CHMP4B+interacts+directly+with+CC2D1A+and+CC2D1B+with+nanomolar+affinity+by+forming+a+1%3A1+complex. assertion.
- assertion asSentence The+forkhead+transcription+factor+AFX+activates+apoptosis+by+induction+of+the+BCL-6+transcriptional+repressor. assertion.
- assertion asSentence A+deficiency+in+NSUN2+function+causes+intellectual+disability+in+individuals+homozygous+for+these+mutations. assertion.
- assertion asSentence The+associations+between+SNPs+of+TCF7L2%2C+CDKAL1%2C+SLC30A8+and+HHEX+and+the+development+of+DR+and+DN. assertion.
- assertion asSentence Overexpression+of+WHSC1L1+gene+is+associated+with+breast+cancer. assertion.
- assertion asSentence hDUS2+interacts+with+protein+kinase+PKR+through+its+dsRNA+binding%2Fdimerization+domain+and+inhibits+its+kinase+activity. assertion.
- assertion asSentence Substrate+specificity+of+RHBDL2+intramembrane+protease+is+governed+by+helix-breaking+residues+in+the+transmembrane+domain. assertion.
- assertion asSentence ADP-ribosylhydrolase+3+%28ARH3%29%2C+not+poly%28ADP-ribose%29+glycohydrolase+%28PARG%29+isoforms%2C+is+responsible+for+degradation+of+mitochondrial+matrix-associated+poly%28ADP-ribose%29. assertion.
- assertion asSentence Late-onset+mitochondrial+myopathy+with+dystrophic+changes+due+to+a+G7497A+mutation+in+the+mitochondrial+tRNA%28Ser%28UCN%29%29+gene. assertion.
- assertion asSentence TMEM70+is+involved+in+mitochondrial+ATP+synthase+biogenesis+in+higher+eukaryotes. assertion.
- assertion asSentence Knockdown+of+SEL1L+%5Bsel-1+suppressor+of+lin-12-like+%28Caenorhabditis+elegans%29%5D%2C+a+member+of+an+E3+ubiquitin+ligase+complex+involved+in+ER+protein+extraction%2C+rescued+significant+amounts+of+Cln6%28G123D%29+and+Cln6%28M241T%29+polypeptides. assertion.
- assertion asSentence CHP3+binds+directly+to+the+proximal+juxtamembrane+C-terminal+region+%28amino+acids+505-571%29+of+rat+NHE1+in+the+same+region+that+binds+CHP1+and+CHP2. assertion.
- assertion asSentence GSK-3beta+modulates+the+early+mitotic+Aurora-A+level+through+binding+and+phosphorylating+AIP. assertion.
- assertion asSentence A+p27%28kip1%29-binding+protein%2C+p27RF-Rho%2C+promotes+cancer+metastasis+via+activation+of+RhoA+and+RhoC. assertion.
- assertion asSentence PARI+suppresses+inappropriate+recombination+events+at+mammalian+replication+forks. assertion.
- assertion asSentence This+meta-analysis+demonstrates+a+significant+association+between+BANK1+and+TNFAIP3+gene+polymorphism+and+systemic+lupus+erythematosus+in+multiple+ethnic+populations. assertion.
- assertion asSentence Isolation+of+the+mouse+ortholog+and+comparison+to+the+human+protein. assertion.
- assertion asSentence ATG16L1+gene+is+asscociated+with+Crohn+disease+susceptibility+in+Hungarian+patients. assertion.
- assertion asSentence One+role+for+the+autophagy+pathway+in+Crohn+disease+pathogenesis+is+through+selective+effects+on+the+biology+and+specialized+properties+of+Paneth+cells. assertion.
- assertion asSentence Genetic+variants+in+IL-23R+and+ATG16L1+independently+predispose+to+increased+susceptibility+to+Crohn%27s+disease+in+a+Canadian+population. assertion.
- assertion asSentence Freeze-fracture+replica+immunolabelling+reveals+WD-repeat+protein+interacting+with+phosphoinositides+1+and+2+%28WIPI-1+and+WIPI-2%29+as+membrane+components+of+autophagosomes+and+the+plasma+membrane+%28PM%29. assertion.
- assertion asSentence ZNF312+and+other+brain-layer+biomarkers+have+area+dependent+expressions+in+the+human+fetal+cortex. assertion.
- assertion asSentence TMEM16A+inhibitors+reveal+TMEM16A+as+a+minor+component+of+calcium-activated+chloride+channel+conductance+in+airway+and+intestinal+epithelial+cells. assertion.
- assertion asSentence Upon+the+occurrence+of+DNA+damage%2C+FANCI+becomes+monoubiquitinated+on+Lys-523+by+the+UBE2T-FANCL+pair. assertion.
- assertion asSentence Knockdown+of+the+WRAP53+protein+triggers+massive+apoptosis+through+the+mitochondrial+pathway. assertion.
- assertion asSentence THAP+domain+of+THAP1+tend+to+manifest+at+an+earlier+age+and+exhibit+more+extensive+anatomical+distributions+than+mutations+localized+to+other+regions+of+THAP1. assertion.
- assertion asSentence Cloning+of+a+human+nuclear-encoded+mitochondrial+poly%28A%29+polymerase+%28hmtPAP%29that+has+a+role+in+mitochondrial+RNA+processing. assertion.
- assertion asSentence PUM2+and+DAZL%2C+are+capable+of+binding+the+same+mRNA+sequences+in+the+3%27UTR+of+human+SDAD1+mRNA. assertion.
- assertion asSentence In+intact+cells%2C+GrinchGEF+induced+specifically+Rho+activation+and+enhanced+RhoA-C-specific+downstream+effects. assertion.
- assertion asSentence High+RIF1+expression+is+associated+with+breast+tumors. assertion.
- assertion asSentence BAF180+suppresses+tumorigenesis%2C+at+least+in+part%2C+through+its+ability+to+regulate+p21. assertion.
- assertion asSentence MyoGEF+cooperates+with+nonmuscle+myosin+IIA+to+regulate+the+polarity+and+invasion+activity+of+breast+cancer+cells+through+activation+of+RhoA+and+RhoC. assertion.
- assertion asSentence C19ORF5+distributed+broadly+across+the+mitotic+spindle+and+reversibly+accumulated+during+reversible+mitotic+arrest. assertion.
- assertion asSentence High+myopia+is+caused+by+a+mutation+in+LEPREL1%2C+encoding+prolyl+3-hydroxylase+2. assertion.
- assertion asSentence FANCI%2C+a+member+of+the+Fanconi+anemia+pathway%2C+is+monoubiquitinated+in+a+site-specific+and+DNA+damage+dependent+manner. assertion.
- assertion asSentence OGFOD1+plays+an+important+role+in+ischemic+cell+survival+and+an+OGFOD1+iron+binding+residue+is+required+for+ATPAF1+gene+expression. assertion.
- assertion asSentence TSAP6+is+a+target+of+rhomboid+protease+RHBDD1-induced+proteolysis. assertion.
- assertion asSentence Nucleo-cytoplasmic+transport+of+hADI1+is+regulated+by+a+non-canonical+nuclear+export+signal+%28NES%29+located+in+the+N-terminal+region+of+hADI1. assertion.
- assertion asSentence Golgi-associated+retrograde+protein+orchestrates+retrograde+transport+from+endosomes+to+the+trans-Golgi+network+by+promoting+vesicle+tethering+and+assembly+of+SNARE+complexes+in+consecutive%2C+independent+steps. assertion.
- assertion asSentence Miro1%2C2+proteins+serve+as+a+%5BCa%282%2B%29%5D%28c%29-sensitive+switch+and+bifunctional+regulator+for+both+the+motility+and+fusion-fission+dynamics+of+the+mitochondria. assertion.
- assertion asSentence FBXW7+is+inactivated+by+mutation+in+diverse+human+cancer+types+with+an+overall+mutation+frequency+of+approximately+6%25. assertion.
- assertion asSentence p18-Cyclin+E+by+the+Skp1-Cul1-Fbw7+%28SCF%29+complex+and+its+interaction+with+the+Fbw7+protein+isoforms+can+take+place+independently+of+phosphorylation+of+p18-Cyclin+E+at+a+C-terminal+phosphodegron. assertion.
- assertion asSentence Polymorphism+of+hCDC4+is+a+risk+factor+for+breast+cancer+development+by+interacting+with+either+cyclin+E+or+full+term+pregnancy. assertion.
- assertion asSentence SGK1+inhibits+the+Notch1+signaling+pathway+via+phosphorylation+of+Fbw7. assertion.
- assertion asSentence Glomulin+binds+Rbx1+and+regulates+cullin-1+RING+ligase-mediated+turnover+of+Fbw7. assertion.
- assertion asSentence LB-PI4K2B-1S-specific+CD4%28%2B%29+T+cells+contributed+to+the+antitumor+response+by+both+directly+eliminating+malignant+cells+as+effector+cells+and+stimulating+CD8%28%2B%29+T+cell+immunity+as+helper+cells. assertion.
- assertion asSentence Acheron+regulates+vascular+endothelial+proliferation+and+angiogenesis+together+with+Id1+during+wound+healing. assertion.
- assertion asSentence Notch+signalling+protects+T-ALL+cells+from+apoptosis+by+upregulating+the+expression+of+GIMAP5. assertion.
- assertion asSentence Association+of+T+cell+antigen+CD7+with+type+II+phosphatidylinositol-4+kinase%2C+a+key+component+in+pathways+of+inositol+phosphate+turnover. assertion.
- assertion asSentence Changes+in+membrane+environment+can+regulate+PI4KIIalpha+activity. assertion.
- assertion asSentence LGR4+and+LGR5+bind+the+R-spondins+with+high+affinity+and+mediate+the+potentiation+of+Wnt%2Fbeta-catenin+signaling+by+enhancing+Wnt-induced+LRP6+phosphorylation. assertion.
- assertion asSentence Hsp90+has+a+major+role+in+controlling+PIDD+functional+activity. assertion.
- assertion asSentence MCM10+is+essential+for+the+efficient+elongation+step+of+chromosome+replication. assertion.
- assertion asSentence CaT1+is+the+channel+protein+that+contributes+to+T-lymphocyte+stores-operated+Ca%282%2B%29+channels+either+alone+or+as+a+subunit+in+a+heterogeneous+channel+complex. assertion.
- assertion asSentence The+ancestral+gain-of-function+haplotype+in+TRPV6+plays+a+role+in+calcium+stone+formation+in+certain+forms+of+absorptive+hypercalciuria. assertion.
- assertion asSentence p38+MAPK+is+an+upstream+regulator+of+nSMase2+and+there+is+a+role+for+nSMase2+in+pro-inflammatory+responses+induced+by+TNF-alpha+as+a+regulator+of+adhesion+proteins. assertion.
- assertion asSentence MMP2+and+neutral+sphingomyelinase-2+play+a+role+in+vasculopathy+triggered+by+a+humoral+immune+response+in+transplants. assertion.
- assertion asSentence PGE%282%29-EP4+signaling+augments+NF-kappaB1+p105+protein+stability+through+EPRAP+after+proinflammatory+stimulation%2C+limiting+macrophage+activation. assertion.
- assertion asSentence Reduction+in+R1+repressor+protein+correlates+significantly+with+an+increase+%28approximately+40%25%29+in+monoamine+oxidase+A+protein+levels+within+the+major+depressive+disorder+groups+compared+with+controls. assertion.
- assertion asSentence CDC42BPG+expression+is+regulated+by+promoter+methylation+and+Sp1+binding. assertion.
- assertion asSentence Thymosin+beta4+is+a+downstream+molecule+of+stabilin-2+that+plays+a+role+in+stabilin-2-mediated+cell+corpse+clearance. assertion.
- assertion asSentence miR-43c+directly+targets+adherens+junctions%27+transmembrane+protein+%28VEZT%29+and+suppresses+VEZT+protein+expression. assertion.
- assertion asSentence Blood+levels+are+not+changed+after+a+glucose+tolerance+test+in+normal+adults. assertion.
- assertion asSentence CARF+exerts+a+vital+control+on+the+p53-HDM2-p21WAF1+pathway+that+is+frequently+altered+in+cancer+cells. assertion.
- assertion asSentence The+inhibition+of+Akt+and+S6K1+phosphorylation+by+PRR5+knock+down+correlates+with+reduction+in+the+expression+level+of+platelet-derived+growth+factor+receptor+beta+%28PDGFRbeta%29. assertion.
- assertion asSentence Substrate+length+has+a+much+greater+influence+on+FIH-1-dependent+hydroxylation+of+Notch+than+of+HIF-1alpha%2C+predominantly+through+binding+affinity+rather+than+maximal+reaction+velocity. assertion.
- assertion asSentence URG4+plays+an+important+role+in+the+development+of+human+gastric+cancer+by+regulating+the+expression+of+cyclin+D1. assertion.
- assertion asSentence MFN1+is+required+for+both+the+virus-induced+redistribution+of+IPS-1+and+IFN+production. assertion.
- assertion asSentence Patterned+Purkinje+cell+degeneration+is+dependent+on+caspase+activation%2C+leading+to+the+marked+decrease+of+mitofusion+1+in+the+transgenic+Harlequin+cerebellum. assertion.
- assertion asSentence MTU1+is+not+required+for+mitochondrial+translation. assertion.
- assertion asSentence Cwc2%2FRBM22-RNA+contacts+are+functionally+important. assertion.
- assertion asSentence SHP-1+antagonizes+the+action+of+receptor+and+non-receptor-tyrosine+kinases+on+GIV+and+down-regulates+the+phospho-GIV-PI3K-Akt+axis+of+signaling. assertion.
- assertion asSentence High+Girdin+expression+is+associated+with+glioblastoma. assertion.
- assertion asSentence Epigenetic+regulation+of+DOK4+expression+is+associated+with+non-small-cell+lung+cancer. assertion.