Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence WDR11%2C+a+WD+protein+that+interacts+with+transcription+factor+EMX1%2C+is+mutated+in+idiopathic+hypogonadotropic+hypogonadism+and+Kallmann+syndrome%2C+causing+impaired+pubertal+development. assertion.
- assertion asSentence The+acidic+stretch+of+the+SIM+of+MCAF1+plays+an+important+role+in+the+binding+to+SUMO-3. assertion.
- assertion asSentence Knockdown+of+retromer+protein+VPS35+activity+produces+no+change+in+the+quantity+or+cellular+distribution+of+total+cellular+amyloid+precursor+protein+%28APP%29+and+has+no+affect+on+internalization+of+cell-surface+APP. assertion.
- assertion asSentence The+interaction+between+CHFR+and+PARP-1+plays+an+important+role+in+cell+cycle+regulation+and+cancer+therapeutic+strategies. assertion.
- assertion asSentence CCAR1+regulates+expression+of+key+proliferation-inducing+genes. assertion.
- assertion asSentence The+loss+of+AGK+led+to+a+decrease+of+the+adenine+nucleotide+translocator+in+the+inner+mitochondrial+membrane+in+muscle. assertion.
- assertion asSentence This+is+the+first+mutation+in+AGK+gene+to+be+implicated+in+the+development+of+isolated+cataract. assertion.
- assertion asSentence CDK5RAP2+is+required+for+spindle+checkpoint+function. assertion.
- assertion asSentence The+specific+heterodimeric+interaction+between+IntS9+and+IntS11+is+mediated+by+a+discrete+domain+present+at+the+extreme+C+terminus+of+IntS9+and+within+the+C+terminus+of+IntS11%2C+adjacent+to+the+predicted+active+site+of+this+endonuclease. assertion.
- assertion asSentence Sec3+associates+with+a+subset+of+Exocyst+complexes+that+are+enriched+at+desmosomes. assertion.
- assertion asSentence As+the+generation+of+the+bulk+of+fOS+is+unaffected+by+co-down+regulation+of+Ngly1p+and+Engase1p%2C+alternative+quantitatively+important+mechanisms+must+underlie+the+liberation+of+these+fOS+from+either+LLO+or+glycoproteins+during+protein+N-glycosylation. assertion.
- assertion asSentence A+role+for+hTdp1+in+repair+of+free+radical-mediated+DNA+double+strand+breaks+bearing+terminally+blocked+3%27+overhangs. assertion.
- assertion asSentence The+role+of+TDP1+in+3%27-phosphoglycolate+processing+during+in+vitro+end+joining+of+DNA+double-strand+breaks. assertion.
- assertion asSentence Hr+and+VDR+interact+via+multiple+protein-protein+interfaces%2C+catalyzing+histone+demethylation+to+effect+chromatin+remodeling+and+repress+the+transcription+of+VDR+target+genes+that+control+the+hair+cycle. assertion.
- assertion asSentence TReP-132+is+a+basal+cell+cycle+regulatory+protein+interacting+with+Sp1+to+activate+the+p21+and+p27+gene+promoters. assertion.
- assertion asSentence A+modest+association+between+an+ADCY10+polymorphism+and+the+spinal+areal+BMD+in+premenopausal+white+women. assertion.
- assertion asSentence Human+BDP1+protein+represents+essential+components+of+TFIIIC1+and+TFIIIC1-like+activities. assertion.
- assertion asSentence Cbp+down-regulation+is+primarily+mediated+by+epigenetic+histone+modifications+via+oncogenic+MAPK%2FPI3K+pathways+in+a+subset+of+cancer+cells. assertion.
- assertion asSentence Human+trans-2-enoyl-CoA+reductase+%28TER%29+is+responsible+for+the+reduction+of+phytenoyl-CoA+to+phytanoyl-CoA+in+peroxisomes. assertion.
- assertion asSentence NRIP+plays+a+feed-forward+role+enhancing+androgen+receptor+%28AR%29-driven+NRIP+promoter+activity+via+NRIP+forming+a+complex+with+AR+to+protect+AR+protein+from+proteasome+degradation. assertion.
- assertion asSentence A+role+for+SELS+in+the+development+of+metabolic+disease%2C+especially+in+the+context+of+insulin+resistance. assertion.
- assertion asSentence miR-148a+is+an+androgen-responsive+microRNA+that+promotes+LNCaP+prostate+cell+growth+by+repressing+its+target+CAND1+expression. assertion.
- assertion asSentence The+PN2-3+fragment+of+CPAP+as+a+protein+with+an+unprecedented+tubulin+sequestering+mechanism+distinct+from+that+of+stathmin+family+proteins. assertion.
- assertion asSentence STIL+and+CPAP+are+essential+for+centriole+formation+and+for+proper+spindle+position. assertion.
- assertion asSentence ELL-associated+factors+1+and+2+are+positive+regulators+of+RNA+polymerase+II+elongation+factor+ELL. assertion.
- assertion asSentence Secretase+subunits+restrict+the+arrangement+of+the+transmembrane+domains+of+presenilin+during+the+formation+of+the+functional+structure+of+the+catalytic+pore. assertion.
- assertion asSentence The+physiological+role+of+hTHEM2+involves+catalysis+of+the+hydrolysis+of+cytosolic+medium-to-long-chain+acyl-CoA+thioesters. assertion.
- assertion asSentence Genetic+variants+of+human+organic+anion+transporter+4+demonstrate+altered+transport+of+endogenous+substrates. assertion.
- assertion asSentence Histone+deacetylase+8+is+required+for+centrosome+cohesion+and+influenza+A+virus+entry. assertion.
- assertion asSentence PBK%2FTOPK+is+upregulated+in+Burkitt%27s+lymphoma+and+other+highly+proliferative+malignant+cells+and+during+normal+fetal+development. assertion.
- assertion asSentence PBK%2FTOPK+plays+an+important+role+in+transiently+amplifying+neural+progenitors+in+the+adult+subependymal+zone+of+transgenically+targeted+mice. assertion.
- assertion asSentence Beta-defensin+3+%28HBD-3%29+is+a+multifunctional+antimicrobial+peptide+with+the+ability+to+link+host+defense+mechanisms+and+inflammation+with+tissue-remodeling+processes+in+articular+cartilage. assertion.
- assertion asSentence Both+palmitoylation+and+leucine-rich+repeats+are+required+for+the+plasma+membrane+localization+of+ERBIN. assertion.
- assertion asSentence Induction+of+NRF+in+human+airway+smooth+muscle+cells+by+neutrophil+elastase+mediates+the+suppression+of+interleukin+%28IL%29-8%2FCXCL8+expression. assertion.
- assertion asSentence Mechanism+mediating+the+oncogenic+function+of+SULF2+in+human+hepatoma+that+includes+GPC3-mediated+activation+of+Wnt+signaling. assertion.
- assertion asSentence PDGF-C+is+constitutively+expressed+in+the+human+kidney+and+is+upregulated+in+podocytes+and+interstitial+cells+after+injury%2Factivation+of+these+cells. assertion.
- assertion asSentence Plays+a+role+in+tissue+remodeling. assertion.
- assertion asSentence TEX14+prevents+the+completion+of+cytokinesis+by+altering+the+destiny+of+CEP55+from+a+nidus+for+abscission+to+an+integral+component+of+the+intercellular+bridge. assertion.
- assertion asSentence Tex14+is+an+important+mediator+of+kinetochore+structure+and+function+and+the+fidelity+of+chromosome+separation. assertion.
- assertion asSentence ANKH+is+not+significantly+involved+in+susceptibility+to+or+clinical+manifestations+of+ankylosing+spondylitis. assertion.
- assertion asSentence Cuff+tear+arthropathy+is+associated+with+variants+in+ANKH+and+TNAP+that+alter+extracellular+inorganic+pyrophosphate+concentrations+causing+calcium+crystal+deposition. assertion.
- assertion asSentence TNF-activated+NF-kappaB+promotes+inflammation-accelerated+vascular+calcification+by+inhibiting+ankylosis+protein+homolog+expression+and+consequent+pyrophosphate+secretion. assertion.
- assertion asSentence SKT+is+involved+in+the+etiology+of+intervertebral+disc+degeneration+among+young+adults. assertion.
- assertion asSentence Single-nucleotide+polymorphism+in+the+BTNL2+gene+is+associated+with+ulcerative+colitis. assertion.
- assertion asSentence ACTH+binding+to+MC2R+stimulates+PKA-dependent+p44%2Fp42%28mapk%29+phosphorylation. assertion.
- assertion asSentence Knockdown+of+either+beta-catenin+or+TCF-4+induced+LTR+activity+in+astrocytes. assertion.
- assertion asSentence Expression+of+CCL28+by+epithelial+cells+from+chronically+inflamed+liver+in+response+to+microbial+products+or+interleukin-1+provides+a+signal+to+localize+CCR10-expressing+regulatory+T+cells+at+mucosal+surfaces. assertion.
- assertion asSentence Overexpression+of+eIF4E-T+triggers+the+movement+of+eIF4E+into+the+processing+bodies. assertion.
- assertion asSentence MMP-26+plays+an+important+role+in+local+invasion+at+least+in+part+through+coordination+with+MMP-9. assertion.
- assertion asSentence Non-synonymous+SNP+rs3733591+variant+within+the+SLC2A9+gene+from+two+geographically+diverse+populations%28Han+Chinese+subjects+and+Solomon+Islanders%29+served+as+an+important+genetic+checkpoint+for+tophaceous+gout+and+increased+uric+acid+levels. assertion.
- assertion asSentence Homozygous+loss-of-function+mutations+of+SLC2A9+cause+a+total+defect+of+uric+acid+absorption%2C+leading+to+severe+renal+hypouricemia+complicated+by+nephrolithiasis+and+exercise-induced+acute+renal+failure. assertion.
- assertion asSentence Cellular+inhibitors+of+apoptosis+1+and+2+are+ubiquitin+ligases+for+the+apoptosis+inducer+Smac%2FDIABLO. assertion.
- assertion asSentence Second+mitochondria-derived+activator+of+caspase+%28SMAC%29%2FDiablo+participates+in+a+feedback+amplification+loop+to+promote+cytochrome+c+release+and+other+mitochondrial+events+in+apoptosis. assertion.
- assertion asSentence Extremely+high+stability+of+the+dimeric+form+of+Smac%2FDIABLO+also+implies+that+once+expressed+in+the+cell+the+protein+has+a+low+probability+of+dissociation+and%2C+consequently%2C+loss+of+function. assertion.
- assertion asSentence The+dimerization+of+Smac+is+critical+for+the+XIAP-mediated+retention+of+Smac+at+or+inside+the+mitochondria. assertion.
- assertion asSentence INPP5E+mutations+cause+primary+cilium+signaling+defects%2C+ciliary+instability+and+ciliopathies+in+humans. assertion.
- assertion asSentence Mutations+in+INPP5E%2C+encoding+inositol+polyphosphate-5-phosphatase+E%2C+link+phosphatidyl+inositol+signaling+to+the+ciliopathies. assertion.
- assertion asSentence Multimeric+unicircular+mtDNA+molecules+are+seen+in+cells+expressing+Twinkle. assertion.
- assertion asSentence THIK-1+and+THIK-2+are+abundantly+expressed+in+the+proximal+and+distal+nephron+of+the+mammalian+kidney. assertion.
- assertion asSentence Association+sith+resristin+concentrstion+and+body+composition+in+glucose+intolerance+and+type+2+diabetes. assertion.
- assertion asSentence Genetic+variants+at+the+RETN+locus+are+associated+with+the+plasma+RETN+concentration+and+cardiovascular+risk+factors. assertion.
- assertion asSentence Plasma+resistin+levels+are+associated+with+myocardium+injury+in+patients+with+acute+coronary+syndrome. assertion.
- assertion asSentence In+elderly+patients+with+aortic+stenosis%2C+higher+plasma+resistin+levels+are+associated+with+increased+valvular+calcium+content+and+inflammation. assertion.
- assertion asSentence Hypertensive+subjects+with+augmented+resistin+levels+exhibit+higher+albuminuria%2C+independently+of+established+risk+factors. assertion.
- assertion asSentence Admission+resistin+concentration+serves+as+an+early+predictive+marker+of+peripancreatic+necrosis+and+clinical+severity+in+acute+pancreatitis. assertion.
- assertion asSentence Glucose+fluctuation+induced+monocytes%2Fmacrophages+to+secrete+resistin. assertion.
- assertion asSentence Following+traumatic+brain+injury%2C+increased+plasma+resistin+levels+are+associated+with+Glasgow+Coma+Scale+score+and+mortality. assertion.
- assertion asSentence Elevated+serum+resistin+levels+are+associated+with+higher+rates+of+mortality+and+hospitalization+in+heart+failure. assertion.
- assertion asSentence Ser409%2C+located+within+the+pol-eta+binding+domain+of+Rad18%2C+is+phosphorylated+by+c-jun+kinase+in+response+to+dna+damage%2C+promoting+the+interaction+between+Rad18+and+pol-eta. assertion.
- assertion asSentence The+Rad6-Rad18+enzyme+plays+an+essential+role+in+promoting+replication+through+DNA+lesions+by+translesion+synthesis+in+mammalian+cells. assertion.
- assertion asSentence Not+associated+with+age-related+retinal+degeneration. assertion.
- assertion asSentence CRMP-5-IgG+defines+a+paraneoplastic+ophthalmological+entity+of+combined+optic+neuritis+and+retinitis+with+vitreous+inflammatory+cells. assertion.
- assertion asSentence Amyloid+beta-protein+precursor+expression+and+secretion+are+regulated+via+activation+of+ERK1%2F2+by+HGF+in+cells+transfected+with+APP751. assertion.
- assertion asSentence It+is+clear+that+some+single-nucleotide+polymorphisms+and+haplotypes+of+the+EB-1+gene+are+associated+with+genetic+difference+between+diabetic+patients+with+and+without+nephropathy. assertion.
- assertion asSentence Protein-protein+interactions+between+human+exosome+components+support+the+assembly+of+RNase+PH-type+subunits+into+a+six-membered+PNPase-like+ring. assertion.
- assertion asSentence The+existence+of+a+short+isoform+of+SMARCAD1+exclusively+expressed+in+the+skin%2C+is+demonstrated. assertion.
- assertion asSentence A+mutation+in+the+MRPS22+gene+led+to+reduction+of+12sRNA+in+fibroblasts+and+fatal+neonatal+hypertrophic+cardiomyopathy+%26+kidney+tubulopathy. assertion.
- assertion asSentence MEPE+is+expressed+in+salivary+gland+ducts. assertion.
- assertion asSentence MEPE+is+expressed+on+the+luminal+surface+of+kidney+proximal+tubules. assertion.
- assertion asSentence DJ-1+enhances+cell+survival+through+the+binding+of+Cezanne%2C+a+negative+regulator+of+NF-kappaB. assertion.
- assertion asSentence Furthermore%2C+the+activity+of+CPT+in+forming+PC+is+increased+in+the+breast+cancer+cell+lines+cultured+for+24+h. assertion.
- assertion asSentence TSR-1+domain-bearing+truncated+ADAMTS-9+demonstrates+positive+GAG-binding+ability+%26+displayed+low+aggrecanase+activity. assertion.
- assertion asSentence CXCR7+has+key+functions+in+promoting+breast+and+lung+tumor+development+and+progression. assertion.
- assertion asSentence The+C-terminus+of+EBNA-2+accounts+for+the+greater+ability+of+type+1+EBV+to+promote+B+cell+proliferation%2C+through+mechanisms+that+include+higher+induction+of+genes+%28LMP-1+and+CXCR7%29+required+for+proliferation+and+survival+of+EBV-LCLs. assertion.
- assertion asSentence There+is+a+homozygous+stop+mutation+affecting+a+highly+conserved+residue+of+COQ9%2C+leading+to+the+truncation+of+75+amino+acids. assertion.
- assertion asSentence HYMAI+gene+encodes+a+non-coding+transcript+that+is+expressed++only+from+the+paternal+allele. assertion.
- assertion asSentence Expression+levels+of+D40+mRNA+and+proteins+decrease+according+to+the+degree+of+spermatogenesis+impairment+in+male+infertile+patients. assertion.
- assertion asSentence VGluT2+is+the+only+vesicular+glutamate+transporter+expressed+in+transgenic+ventral+tegmental+area%2Fsubstantia+nigra+dopamine+neurons+in+vivo. assertion.
- assertion asSentence Small+interfering+RNA+significantly+attenuates+angiotensin+II+type+1+receptor-stimulated+inositol+phosphate+formation. assertion.
- assertion asSentence Thrombin+activation+of+osteopontin+%28OPN%29+%28resulting+in+OPN-R%29+and+its+subsequent+inactivation+by+thrombin-activatable+carboxypeptidase+B+%28generating+OPN-L%29+occurs+locally+within+inflamed+joints+in+rheumatoid+arthritis. assertion.
- assertion asSentence C12orf3%2C+FLJ10261+%28ORAOV2%29%2C+C11orf25+and+FLJ34272+constitute+a+family+of+eight-transmembrane+proteins+with+N-+and+C-terminal+tails+facing+the+cytoplasm. assertion.
- assertion asSentence ATGL+expression+in+skeletal+muscle+fibers%2C+slow-twitch%2C+is+demonstrated. assertion.
- assertion asSentence CysLT1R+and+CysLT2R+expression+in+monocytes+can+be+regulated+by+CysLT+itself+and+T%28H%292+cytokines+at+the+transcriptional+level. assertion.
- assertion asSentence Cysteinyl+leukotriene+receptor+2+gene+polymorphism+-1220+A%2FC+is+not+associated+with+atopic+dermatitis+or+psoriasis+vulgaris+in+Japanese+patients. assertion.
- assertion asSentence A+major+function+of+the+Nup107+complex+in+mitosis+is+to+ensure+the+proper+localization+of+the+chromosome+passenger+complex+at+the+centromere. assertion.
- assertion asSentence TEM7+expression+level+closely+parallels+histology-based+prognostication+of+OGS+metastasis+and%2C+therefore%2C+it+is+a+therapeutic+target. assertion.
- assertion asSentence ISD11+is+important+in+the+biogenesis+of+Fe-S+clusters+in+mammalian+cells. assertion.
- assertion asSentence Phosphorylation+of+Nogo+receptors+by+casein+kinase+II+%28CK2%29+inhibits+binding+of+the+myelin-associated+proteins. assertion.
- assertion asSentence Biological+role+of+SLURP-1+in+the+epidermis+is+to+provide+fine+tuning+of+the+physiologic+regulation+of+keratinocyt+functions+through+the+cholinergic+pathways. assertion.
- assertion asSentence CRM1-dependent+nuclear+export+of+Smurf1+is+essential+for+the+negative+regulation+of+TGF-beta+signaling+by+Smad7. assertion.