Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence MSI2+has+a+crucial+role+in+both+normal+and+malignant+hematopoiesis. assertion.
- assertion asSentence Both+WFIKKN1+and+WFIKKN2+have+high+affinity+for+growth+and+differentiation+factors+8+and+11. assertion.
- assertion asSentence BirA+ligase+biotinylates+K4%2C+K9%2C+K18+and+K23+in+histone+H3. assertion.
- assertion asSentence Reveal+myomasp%2FLRRC39+as+a+previously+unrecognized+component+of+an+M-band-associated+signaling+pathway+that+regulates+cardiomyocyte+gene+expression+in+response+to+biomechanical+stress. assertion.
- assertion asSentence Not+all+clinically+diagnosed+individuals+with+erythrokeratoderma+variabilis+harbor+Cx30.3+disease-associated+mutations. assertion.
- assertion asSentence NOR1+protein+is+predominantly+expressed+in+human+nasopharynx+and+tracheal+tissues+and+is+frequently+down-expressed+in+NPC. assertion.
- assertion asSentence USP7+can+stimulate+EBNA1-DNA+interactions+and+EBNA1+can+alter+histone+modification+at+oriP+through+recruitment+of+USP7. assertion.
- assertion asSentence Mutations+in+TSHZ2+and+TSHZ3+are+not+a+major+cause+of+pelvi-ureteric+junction+obstruction%2C+at+least+in+Albanian+and+Macedonian+populations. assertion.
- assertion asSentence The+NS5A+interaction+with+TBC1D20+and+Rab1+is+essential+for+the+viral+life+cycle. assertion.
- assertion asSentence The+CHMP4b-+and+Src-docking+sites+in+the+Bro1+domain+are+autoinhibited+in+the+native+state+of+Alix. assertion.
- assertion asSentence CC2D1A+interaction+with+CHMP4B%2F4A+blocks+HIV-1+budding. assertion.
- assertion asSentence Overexpression+of+NEU4+is+associated+with+neuroblastoma. assertion.
- assertion asSentence After+passage+across+the+translocase+of+the+mitochondrial+outer+membrane+Erv1+interacts+via+disulfide+bonds+with+Mia40. assertion.
- assertion asSentence Defects+in+GRK1+or+GRK7+cause+patients+to+suffer+from+an+inability+to+properly+deactivate+rhodopsin+leading+to+problems+with+recovery+and+dark+adaptation. assertion.
- assertion asSentence RTP+and+REEP+gene+expression+in+human+circumvallate+papillae+and+testis%2C+both+of+which+are+sites+of+taste+receptor+gene+expression. assertion.
- assertion asSentence PP2Ceta-2+inhibits+the+IL-1-NF-kappaB+signalling+pathway+by+selectively+dephosphorylating+IKKbeta. assertion.
- assertion asSentence The+KIAA1109-TENR-IL2-IL21+gene+cluster%2C+that+encodes+an+interleukin+%28IL-21%29+that+plays+an+important+role+in+Th17+cell+biology%2C+is+the+20th+locus+for+which+there+is+a+genome-wide+level+of+support+for+association+with+rheumatoid+arthritis. assertion.
- assertion asSentence EVC+and+LBN+play+roles+in+cardiovascular+development+and+disease. assertion.
- assertion asSentence Acute+elevation+of+plasma+non-esterified+fatty+acd+levels+downregulates+PPARGC1A%2C+PPARGC1B+and+PPARA+expression. assertion.
- assertion asSentence PGC-1alpha+and+PGC-1beta+expression+improved+mitochondrial+respiration+in+cells+from+patients+with+mitochondrial+disorders. assertion.
- assertion asSentence The+PPARGC1B+gene+Ala203Pro+polymorphism+is+associated+with+physical+performance+of+athletes. assertion.
- assertion asSentence An+asparagine+%28Asn-391%29+in+the+UGT+signature+sequence+of+UGT3A1+is+necessary+for+utilization+of+UDP-GlcNAc. assertion.
- assertion asSentence The+WDR36+D658G+is+a+neutral+variant+in+the+Australian+population. assertion.
- assertion asSentence Processing+of+CD109+into+180+kDa+and+25+kDa+proteins+by+furin%2C+followed+by+complex+formation+with+the+type+I+TGF-beta+receptor+is+required+for+the+regulation+of+TGF-beta+signaling+in+cancer+cells+and+keratinocytes. assertion.
- assertion asSentence CD109+is+an+important+regulator+of+SMAD7%2FSmurf2-mediated+degradation+of+TGFBR1. assertion.
- assertion asSentence Myotrophin%2FV-1+is+a+regulatory+protein+for+modulating+the+levels+of+activated+NFkappaB+dimers. assertion.
- assertion asSentence Genetic+polymorphism+of+CCDC26+is+associated+with+myeloid+malignancies+with+mutant+IDH1+and+IDH2+differentially. assertion.
- assertion asSentence Neither+human+hexokinase-1+nor+human+inorganic+pyrophosphatase+expression+segregated+concordantly+with+human+cytoplasmic+glutamic-oxaloacetic+transaminase+expression. assertion.
- assertion asSentence STARS+activates+serum+response+factor+by+inducing+the+nuclear+translocation+of+myocardin-related+transcription+factors+. assertion.
- assertion asSentence Intralysosomal+oligomerization+and+proteolytic+cleavage+as+two+steps+crucial+for+functional+activation+of+HGSNAT. assertion.
- assertion asSentence Amer1+exerts+its+negative+regulatory+role+in+Wnt+signaling+by+acting+as+a+scaffold+protein+for+the+beta-catenin+destruction+complex+and+promoting+stabilization+of+Axin+at+the+plasma+membrane. assertion.
- assertion asSentence The+carboxy-terminal+SH3+domain+of+the+adapter+protein+Mona+interacts+with+the+atypical+proline-rich+domain+of+Gab3+to+mediate+late+signaling+of+the+macrophage+colony-stimulating+factor+receptor. assertion.
- assertion asSentence Both+native+and+exogenous+MUC17+play+a+role+in+attachment+and+invasion+of+enteroinvasive+E.+coli+in+colonic+cell+lines+and+in+maintaining+epithelial+barrier+function. assertion.
- assertion asSentence NEK7+is+essential+for+PCM+accumulation+in+a+cell+cycle+stage-specific+manner. assertion.
- assertion asSentence Epigenetic+inactivation+of+GATA-5+by+methylation+of+CpG+islands+is+an+early+frequent+event+during+gastric+carcinogenesis+and+is+significantly+correlated+with+H.+pylori+infection. assertion.
- assertion asSentence A+19+amino+acid+peptide+%28pCM19%29+at+positions+42-60+of+hGlyrichin+is+crucial+for+its+antibacterial+activity. assertion.
- assertion asSentence Isthmin+unexpectedly+has+both+a+pro-survival+and+death-promoting+effect+on+endothelial+cells+depending+on+its+physical+state. assertion.
- assertion asSentence Forced+expression+of+either+SIRPalpha1+or+SIRPalpha2+displayed+distinct+suppressive+effect+on+the+anchorage-independent+growth+of+Hs578T+breast+carcinoma+cells. assertion.
- assertion asSentence The+role+of+cis+dimerization+of+signal+regulatory+protein+alpha+%28SIRPalpha%29+in+binding+to+CD47. assertion.
- assertion asSentence SIRPalpha1+in+hepatic+sinusoid+Kupffer+cells+is+associated+with+the+extent+of+autoimmune+hepatitis. assertion.
- assertion asSentence Constitutive+overexpression+of+STK35+proteins+enhances+caspase-independent+cell+death+under+oxidative+stress+conditions. assertion.
- assertion asSentence HECTD2+haplotypes+are+associated+with+the+susceptibility+to+human+prion+diseases. assertion.
- assertion asSentence LRAD3+that+modulates+amyloid+precursor+protein+trafficking. assertion.
- assertion asSentence Reflux+laryngitis+is+associated+with+down-regulation+of+mucin+gene+expression. assertion.
- assertion asSentence Ritonavir+%28at+100+mg+once+daily+and+100+mg+twice+daily+significantly+down-regulated+Kelch+domain+containing+3+in+20+healthy+individuals. assertion.
- assertion asSentence PLEKHA7+binds+with+p120catenin+and+non-centrosomal+minus+end+protein+Nezha+and+plays+a+linker+role+between+adherens+junction+and+non-centrosomal+microtubules. assertion.
- assertion asSentence A+homozygous+mutation+in+PRICKLE1+causes+an+autosomal-recessive+progressive+myoclonus+epilepsy-ataxia+syndrome. assertion.
- assertion asSentence E2F7-dependent+mechanism+contributes+to+p53-dependent+cell+cycle+arrest+in+response+to+DNA+damage. assertion.
- assertion asSentence Vertebral+defects+in+a+patient+with+Peters+plus+syndrome+and+mutations+in+B3GALTL. assertion.
- assertion asSentence The+retina+RDH12+reduces+4-HNE+to+a+nontoxic+alcohol%2C+protecting+cellular+macromolecules+against+oxidative+modification+and+protecting+photoreceptors+from+light-induced+apoptosis. assertion.
- assertion asSentence GSC+represses+EVX1+expression+and+is+required+for+development+of+anterior+primitive-streak-like+cell+progeny+in+response+to+activin. assertion.
- assertion asSentence Vaspin+is+expressed+in+the+human+placenta+and+is+regulated+by+nutrtional+status. assertion.
- assertion asSentence Expression+of+SALM+family+proteins+SALM3+and+SALM5+in+nonneural+and+neural+cells+induces+both+excitatory+and+inhibitory+presynaptic+differentiation+in+contacting+axons. assertion.
- assertion asSentence Mus81-Eme1+can+ensure+coordinate%2C+bilateral+cleavage+of+Holliday+junction-like+structures. assertion.
- assertion asSentence The+DSG4+protein+is+expressed+in+the+more+highly+differentiated+layers+of+the+epidermis. assertion.
- assertion asSentence Transcription+factor+SIX5+is+mutated+in+patients+with+branchio-oto-renal+syndrome. assertion.
- assertion asSentence LPS-TLR4+signaling+to+IRF-3%2F7+and+NF-kappaB+involves+the+toll+adapters+TRAM+and+TRIF. assertion.
- assertion asSentence The+spatiotemporal+mobilization+of+TICAM-1+in+response+to+dsRNA+and+the+formation+of+the+TICAM-1+speckles+containing+RIP1+and+NAP1+are+important+for+the+activation+of+the+TLR3-TICAM-1+pathway. assertion.
- assertion asSentence Inactivation+of+Trif+and+Cardif+can+also+occur+through+cellular+caspases+activated+by+various+pro-apoptotic+signals. assertion.
- assertion asSentence Hemojuvelin+missense+mutation+is+associated+with+hemochromatosis. assertion.
- assertion asSentence Excessive+interferon+%28IFN%29-gamma+signaling+promotes+accumulation+of+Roquin-mutated%2C+short-lived+effector-like+CD8%2B+T+cells+in+autoimmune-prone+transgenic+mice. assertion.
- assertion asSentence IL12B+and+IL23R+genes+play+a+fundamental+role+in+psoriasis+pathogenesis. assertion.
- assertion asSentence Sequence+variants+in+the+genes+for+the+interleukin-23+receptor+%28IL23R%29+and+its+ligand+%28IL12B%29+confer+protection+against+psoriasis. assertion.
- assertion asSentence IL23R+gene+is+one+of+the+genetic+factors+implicated+in+the+genetics+of+IBD+in+the+general+population. assertion.
- assertion asSentence Single+nucleotide+polymorphism+in+IL23R+is+associated+with+inflammatory+bowel+disease. assertion.
- assertion asSentence Common+variants+in+NOD2+and+IL23R+are+not+associated+with+inflammatory+bowel+disease+in+Indians. assertion.
- assertion asSentence IL23R%2C+NOD2%2FCARD15%2C+ATG16L1+and+PHOX2B+polymorphisms+in+a+group+of+patients+with+Crohn%27s+disease+and+correlation+with+sub-phenotypes. assertion.
- assertion asSentence Genetic+susceptibility+for+ankylosing+spondylitis+is+associated+with+the+IL-23R+gene+polymorphisms. assertion.
- assertion asSentence In+a+patient+with+consanguineous+parents%2C+history+of+disturbed+organization+and+development+of+the+retina%2C+a+diagnosis+of+Familial+hypomagnesemia+with+hypercalciuria+and+nephrocalcinosis+caused+by+claudin-19+mutation+should+be+considered. assertion.
- assertion asSentence SIK+is+a+negative+regulator+that+controls+TGFbeta+receptor+turnover+and+physiological+signaling. assertion.
- assertion asSentence TGR5+signaling+pathway+is+critical+in+regulating+intestinal+glucagon-like+peptide-1+secretion+in+CHO+cells+transiently+transfected+hTGR5+gene. assertion.
- assertion asSentence Stimulates+expression+of+both+chondrogenic+and+osteoblstic+markers+in+pluripotent+mesenchymal+C3H10T1%2F2+cells. assertion.
- assertion asSentence BAL1+and+BBAP+are+located+on+chromosome+3q21+in+a+head-to-head+orientation+and+are+regulated+by+a+IFN-gamma-responsive+bidirectional+promoter. assertion.
- assertion asSentence POP2+inhibits+both+the+interaction+of+ASC+with+various+NLR+pyrin+domains+and+inhibits+NF-kappaB+p65+%28RelA%29. assertion.
- assertion asSentence SPICE+is+required+for+centriole+duplication+and+mitotic+chromosome+congression. assertion.
- assertion asSentence Cell+proliferation+and+expression+of+EGFR+of+tumor+cells+can+be+inhibited+by+transfection+of+CKLFSF8. assertion.
- assertion asSentence KLB+and+FGFR1+form+a+1%3A1+heterocomplex+independent+of+the+galectin+lattice+that+transitions+to+a+1%3A2+complex+upon+the+addition+of+FGF21. assertion.
- assertion asSentence CNK3+and+IPCEF1+produce+a+single+protein+that+is+required+for+HGF+dependent+Arf6+activation+and+migration. assertion.
- assertion asSentence Three+L%2FP-PXY+motifs+of+AMOT%2Fp130+and+the+WW+domains+of+Nedd4+mediate+the+interaction+of+Nedd4%2C+Nedd4-2+and+Itch. assertion.
- assertion asSentence hPEBP4+inhibits+proteasome-dependent+ERalpha+degradation+through+the+Src+pathway. assertion.
- assertion asSentence COH1+as+a+Golgi-associated+matrix+protein+required+for+Golgi+integrity. assertion.
- assertion asSentence The+CKK+domain+binds+microtubules+and+represents+a+domain+that+evolved+with+the+metazoa. assertion.
- assertion asSentence OBSCN+and+C9orf65+comprise+a+highly+accurate+two-gene+classifier+for+differentiating+gastrointestinal+stromal+tumors+and+leiomyosarcomas. assertion.
- assertion asSentence A+decrease+in+Nkx2-3+gene+expression+level+can+profoundly+alter+the+expression+of+genes+and+cellular+functions+relevant+to+the+pathogenesis+and+progression+of+inflammatory+bowel+disease%2C+such+as+EDN1. assertion.
- assertion asSentence DCAL-1%2C+highly+expressed+on+dendritic+cells+and+B+lymphocytes%2C+acts+as+a+T+cell+costimulatory+molecule+which+skews+CD4%2B+T+cells+toward+a+Th2+response+by+enhancing+their+secretion+of+IL-4. assertion.
- assertion asSentence The+structural+basis+of+the+phosphoinhibition+of+GRASP-mediated+membrane+tethering+and+provide+a+mechanism+for+its+allosteric+regulation. assertion.
- assertion asSentence Low-affinity+transporter+SMCT2+initiates+lactate+absorption+in+the+early+parts+of+the+proximal+tubule+followed+by+the+participation+of+the+high-affinity+transporter+SMCT1+in+the+latter+parts+of+the+proximal+tubule. assertion.
- assertion asSentence Diacylglycerol+kinase+eta+%28DGKH%29+is+association+in+the+etiology+of+bipolar+disorder. assertion.
- assertion asSentence Increased+gene+expression+of+diacylglycerol+kinase+eta+is+found+in+brain+tissue+from+patients+with+bipolar+disorder. assertion.
- assertion asSentence Mutations+in+cilia+co-expressed+DCDC2%2C+DYX1C1+and+KIAA0319+genes+are+associated+with+a+cognitive+neurological+disorder%2C+dyslexia. assertion.
- assertion asSentence SPRED1+mutations+occurred+with+a+prevalence+of+0.5%25+in+NF1+patients+and+in+5%25+of+NF1+patients+displaying+an+NF1-like+phenotype. assertion.
- assertion asSentence 3+mutations+in+2+families+with+NAGS+deficiency+revealed+deleterious+effects+on+NAGS+affinity+for+substrates+%26+the+rate+of+catalysis. assertion.
- assertion asSentence IFN-lambdaR1+consists+of+two+distinct+domains+having+fibronectin+type+III+topology. assertion.
- assertion asSentence CITED4+is+epigenetically+silenced+in+the+vast+majority+of+oligodendroglial+tumours+with+1p+and+19q+deletions. assertion.
- assertion asSentence STIL+cooperates+with+SAS-6+and+PLK4+in+the+control+of+centriole+number+and+represents+a+key+centriole+duplication+factor+in+human+cells. assertion.
- assertion asSentence Consortin+is+a+trans-Golgi+network+cargo+receptor+for+the+plasma+membrane+targeting+and+recycling+of+connexins. assertion.
- assertion asSentence TMPRSS6+mutations+are+associated+with+iron-refractory+iron+deficiency+anemia. assertion.
- assertion asSentence MINK1+interacts+with+and+phosphorylates+PRICKLE1+and+PRICKLE2. assertion.
- assertion asSentence MMAA+acts+as+a+chaperone+of+human+MCM+protein. assertion.
- assertion asSentence Human+CPE-binding+protein+1+and+hGLD-2+are+antagonizing+factors+regulating+p53+mRNA+stability. assertion.