Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence The+LCA5+gene+on+chromosome+6q14+encodes+the+ciliary+protein+lebercilin+associated+with+Leber+congenital+amaurosis+type+5. assertion.
- assertion asSentence CAGE+promotes+motility+of+cancer+cells+through+activation+of+focal+adhesion+kinase+%28FAK%29. assertion.
- assertion asSentence Hypomethylated+CAGE+promoter+CpG+islands+are+frequently+involved+in+uterine+cervical+carcinogenesis. assertion.
- assertion asSentence BMPER+is+an+endothelial+cell+regulator+and+controls+bone+morphogenetic+protein-4-dependent+angiogenesis. assertion.
- assertion asSentence Of+European+non-diabetic+offspring+of+type+2+diabetes+patients%2C+46%25+are+homozygous+carriers+of+the+Arg325Trp+polymorphism+of+SLC30A8. assertion.
- assertion asSentence Children+who+carry+homozygous+SLC30A8+single-nucleoetide+polymorphism+progress+to+diabetes+faster+than+heterozygote+carriers. assertion.
- assertion asSentence ZnT8RWQA+is+a+necessary+complement+to+the+classification+and+prediction+of+childhood+type+1+diabetes. assertion.
- assertion asSentence The+associations+between+SNPs+of+TCF7L2%2C+CDKAL1%2C+SLC30A8+and+HHEX+and+the+development+of+DR+and+DN. assertion.
- assertion asSentence The+pro-apoptotic+activity+of+indoleamine+2%2C+3-dioxygenase+is+responsible+for+its+transcriptional+regulation+and+the+modulation+of+its+pro-apoptotic+activity+during+death+receptor+activation+in+melanoma+cells. assertion.
- assertion asSentence Individuals+with+mutations+in+KCNV2+manifest+a+wide+range+of+macular+and+autofluorescence+abnormalities. assertion.
- assertion asSentence Overexpression+of+FAM46D+is+associated+with+neoplasms. assertion.
- assertion asSentence Disruption+of+the+STK9+gene+causes+severe+X-linked+infantile+spasms+and+mental+retardation. assertion.
- assertion asSentence Engagement+of+BDCA-2+blocks+TRAIL-mediated+cytotoxic+activity+of+plasmacytoid+dendritic+cells. assertion.
- assertion asSentence RHAU+has+a+dual+function%2C+being+involved+in+both+the+synthesis+and+degradation+of+mRNA+in+different+subcellular+compartments. assertion.
- assertion asSentence Blood+pressure+is+associated+with+SNPs+of+ADAMTS16+in+human. assertion.
- assertion asSentence The+transcription+factor+gene+CIZ%2FNMP4+is+recurrently+involved+in+acute+leukemia+through+fusion+with+either+EWSR1+or+TAF15. assertion.
- assertion asSentence ASXL1+gene+mutation+is+associated+with+chronic+myeloid+leukemia. assertion.
- assertion asSentence ASXL1+mutation+is+asssociated+with+chronic+myelogenous+leukemia. assertion.
- assertion asSentence Nonsense+mutations+in+ASXL1+cause+Bohring-Opitz+syndrome. assertion.
- assertion asSentence Desiging+peptides+based+on+human+WNT8+as+potent+inhibitors+of+signaling+pathways. assertion.
- assertion asSentence Expression+of+anti-endothelial+cell+antibodies+%28AECA%29might+be+a+useful+marker+to+predict+the+course+of+sarcoidosis+%5BAECA%5D. assertion.
- assertion asSentence Nuclear+coactivator+p120alpha+is+essential+for+ligand-dependent+stimulation+of+thyroid+hormone+receptors+and+PPARgamma%2C+p120beta+acted+as+a+coactivating+protein+predominantly+for+androgen+receptors%5Bnuclear+coactivator+p120%5D. assertion.
- assertion asSentence Exposure+to+high+glucose+increases+miR-486-5p+expression+and+inhibits+SIRT1+expression+in+human+adipose+tissue-derived+mesenchymal+stem+cells. assertion.
- assertion asSentence %5BmiR-885-3p%5D+has+a+role+in+the+regulation+of+cell+viability%2C+apoptosis+and%2For+autophagy+in+squamous+cell+carcinoma+cells+upon+cisplatin+exposure. assertion.
- assertion asSentence miR-376b+controls+autophagy+by+directly+regulating+intracellular+levels+of+two+key+autophagy+proteins%2C+ATG4C+and+BECN1. assertion.
- assertion asSentence Haplotype+HLA-DR8+is+associated+with+oncychomycosis+in+Mexican+families. assertion.
- assertion asSentence EVI1+is+a+critical+player+in+tumor+growth+in+a+subset+of+MLL-rearranged+acute+myeloid+leukemia. assertion.
- assertion asSentence Mammalian+ACSF3+protein+is+a+malonyl-CoA+synthetase+that+supplies+the+chain+extender+units+for+mitochondrial+fatty+acid+synthesis. assertion.
- assertion asSentence NLRC5+is+a+critical+component+of+inflammasome-dependent+interleukin+%28IL%29-1beta+secretion+in+response+to+a+repertoire+of+stimuli+that+also+activate+NLRP3. assertion.
- assertion asSentence A+gain-of-function+cDNA+screen+reveals+that+Coco%2C+a+secreted+antagonist+of+TGF-beta+ligands%2C+induces+dormant+breast+cancer+cells+to+undergo+reactivation+in+the+lung. assertion.
- assertion asSentence Mutation+my+be+involed+in+the+inflammatory+and+apoptoic+pathways+in+hydatidiform+moles. assertion.
- assertion asSentence One+of+the+conservative+regions+is+responsible+for+the+enhancer+activity+and+is+able+to+interact+with+proteins+of+HeLa+cell+nuclear+extract. assertion.
- assertion asSentence TORC2+regulates+germinal+center+repression+of+the+TCL1+oncoprotein+to+promote+B+cell+development+and+inhibit+transformation. assertion.
- assertion asSentence mTORC2+is+crucial+for+Notch+signaling+to+regulate+Akt+and+NF-kappaB. assertion.
- assertion asSentence APOBEC3A+can+activate+the+DNA+damage+response+and+cause+cell-cycle+arrest. assertion.
- assertion asSentence When+recognition+loop+of+9-11+amino+acids+is+grafted+from+the+donor+APOBEC3F+or+3G+proteins+into+the+acceptor+scaffold+of+AID%2C+the+mutational+signature+of+AID+changes+toward+that+of+the+donor+proteins. assertion.
- assertion asSentence Alternative+splicing+of+A3F+mRNA+generates+truncated+antiviral+proteins+that+differ+sharply+in+their+sensitivity+to+Vif. assertion.
- assertion asSentence APLF+has+a+role+in+chromosomal+DNA+double-strand+break+repair. assertion.
- assertion asSentence PIKfyve-dependent+channel+degradation+is+essential+to+prevent+Ca2%2B-induced+toxicity+in+neurons. assertion.
- assertion asSentence Crucial+role+of+LIPH+gene+in+hair+growth. assertion.
- assertion asSentence A+phosphatidic+acid-phospholipase+A1alpha-lysophosphatidic+acid-P2Y5+axis+regulates+differentiation+of+hair+follicles+via+a+tumour+necrosis+factor+alpha+converting+enzyme-transforming+growth+factor+alpha-epidermal+growth+factor+receptor+pathway. assertion.
- assertion asSentence Reflux+laryngitis+is+associated+with+down-regulation+of+mucin+gene+expression. assertion.
- assertion asSentence The+FLCN-FNIP+complex+deregulated+in+Birt-Hogg-Dube+syndrome+is+absolutely+required+for+B-cell+differentiation. assertion.
- assertion asSentence Rab27a+or+Munc13-4+recruitment+to+lytic+granules+is+preferentially+regulated+by+different+receptor+signals%2C+demonstrating+that+individual+target+cell+ligands+regulate+discrete+molecular+events+for+lytic+granule+maturation. assertion.
- assertion asSentence Familial+hemophagocytic+lymphohistiocytosis+type+3+%28FHL3%29+caused+by+deep+intronic+mutation+and+inversion+in+UNC13D. assertion.
- assertion asSentence A+founder+mutation+in+Anoctamin+5+is+a+major+cause+of+limb-girdle+muscular+dystrophy. assertion.
- assertion asSentence The+ubiquitin-specific+protease+12+%28USP12%29+is+a+negative+regulator+of+notch+signaling+acting+on+notch+receptor+trafficking+toward+degradation. assertion.
- assertion asSentence The+risk+allele+%28Y153H%29+of+the+preeclampsia+susceptibility+gene+STOX1+negatively+regulates+trophoblast+invasion+by+upregulation+of+the+cell-cell+adhesion+protein+a-T-catenin+%28CTNNA3%29. assertion.
- assertion asSentence Mitotic+entry+is+enhanced+through+the+direct+upregulation+of+cyclin+B1+expression+effectuated+by+STOX1A. assertion.
- assertion asSentence URG11+mediates+hypoxia-induced+epithelial-to-mesenchymal+transition+through+the+suppression+of+E-cadherin+and+the+activation+of+the+beta-catenin%2FT-cell+factor+pathway. assertion.
- assertion asSentence ORAOV1+plays+pivotal+roles+in+the+growth+and+angiogenesis+of+oral+squamous+cell+carcinoma. assertion.
- assertion asSentence ORAOV1+has+an+important+role+in+regulating+cell+growth+of+cervical+cancer+HeLa+cells+through+regulating+the+cell+cycle+and+apoptosis. assertion.
- assertion asSentence The+full+Ska1+complex+forms+assemblies+on+microtubules+that+can+facilitate+the+processive+movement+of+microspheres+along+depolymerizing+microtubules. assertion.
- assertion asSentence Examination+of+the+zinc+transporter+gene%2C+SLC39A12. assertion.
- assertion asSentence A+relationship+between+the+presence+of+endothelial+colony-forming+cells+and+Arg%2FArg+genotype+in+KIF6+in+patients+with+acute+myocardial+infarction. assertion.
- assertion asSentence Translation+initiates+from+a+non-AUG+%28ACG%29+start+codon. assertion.
- assertion asSentence The+JAFZ1-JJAZ1+fusion+gene+is+present+in+the+endometrial+stromal+and+smooth+muscle+components+of+endometrial+stromal+tumors. assertion.
- assertion asSentence Thrombospondin+type+I+domain+containing+7A+%28THSD7A%29+mediates+endothelial+cell+migration+and+tube+formation. assertion.
- assertion asSentence THSD7A+is+a+membrane-associated+N-glycoprotein+with+a+soluble+form. assertion.
- assertion asSentence Similar+to+EIG121L+gene%2C+expressed+in+various+organs+of+Xenopus+during+development. assertion.
- assertion asSentence The+activity+of+ERK8+in+transfected+HEK-293+cells+depends+on+the+relative+rates+of+ERK8+autophosphorylation+and+dephosphorylation+by+one+or+more+members+of+the+PPP+family+of+protein+serine%2Fthreonine+phosphatases. assertion.
- assertion asSentence Common+variants+at+MS4A4%2FMS4A6E%2C+CD2AP%2C+CD33+and+EPHA1+are+associated+with+late-onset+Alzheimer%27s+disease. assertion.
- assertion asSentence The+native+disulfide+array+of+human+defensin+5+is+a+requirement+for+its+activity+against+Staphylococcus+aureus. assertion.
- assertion asSentence Saitohin+interacts+with+peroxiredoxin+6%2C+a+unique+member+of+that+family+that+is+bifunctional+and+the+levels+of+which+increase+in+Pick+disease. assertion.
- assertion asSentence IL-27+triggers+STAT+activation+and+gene+transcription+of+a+subset+of+inflammatory+cytokines+in+primary+human+mast+cells+and+in+human+monocytes. assertion.
- assertion asSentence IL-27+has+an+antiproliferative+activity+on+melanomas+through+WSX-1%2FSTAT1+signaling. assertion.
- assertion asSentence IL-27+induced+by+mycobacterium+tuberculosis+infection+in+human+macrophages+opposed+IFN-gamma+production+by+antagonizing+IL-18+activity. assertion.
- assertion asSentence Th1+and+Th2+responses+are+controlled+by+intracellular+glutathione+redox+status+in+DCs+through+IL-27+production. assertion.
- assertion asSentence Viral+dsRNA-activated+human+dendritic+cells+produce+IL-27+to+act+as+a+specialized+procytotoxic%2C+antiviral+cytokine+in+the+development+of+effector+CD8%28%2B%29+T+cells. assertion.
- assertion asSentence NEIL2+is+involved+in+global+genome+repair+mainly+for+removing+oxidative+products+of+cytosine. assertion.
- assertion asSentence The+damage+specificity+of+human+homologues+of+Endo+III+%28hNTHl%29+and+Endo+VIII+%28hNEIL1+and+hNEIL2%29+is+compared+to+elucidate+the+repair+role+in+cells. assertion.
- assertion asSentence The+critical+role+of+NEIL2+and+PNKP+in+maintenance+of+the+mammalian+mitochondrial+genome. assertion.
- assertion asSentence TORC2+inhibition+reduced+proliferation+and+anchorage-independent+growth+of+breast+cancer+and+prostate+cancer+cell+lines. assertion.
- assertion asSentence Rig-1+protein+is+up-regulated+in+a+tumor+cell+line+stimulated+with+interferon+type+II. assertion.
- assertion asSentence MMS22L+and+TONSL+are+required+for+the+maintenance+of+genome+stability. assertion.
- assertion asSentence RNF169+as+a+component+in+DNA+damage+signal+transduction+and+adds+to+the+complexity+of+regulatory+ubiquitylation+in+genome+stability+maintenance. assertion.
- assertion asSentence Endogenous+expression+of+hemokinin-1+is+demonstrated+in+bronchi+and+is+involved+in+contraction+of+airway+explants. assertion.
- assertion asSentence MCOLN2+traffics+through+the+ADP-ribosylation+factor+6+%28Arf6%29-associated+pathway%2C+colocalizing+with+major+histocompatibility+protein+class+I+and+CD59+in+long+recycling+endosomes. assertion.
- assertion asSentence PIR2%2FRNF144B%2FIBRDC2+regulates+the+stability+of+TAp73+and+DNp73. assertion.
- assertion asSentence The+cause+of+unusually+severe+dominant+hypercholesterolemia+is+due+to+the+effect+of+mutant+PCKS9+on+apolipoprotein+B+secretion. assertion.
- assertion asSentence Mutations+in+the+PCSK9+gene+are+associated+with+variable+phenotype+of+autosomal+dominant+hypercholesterolemia. assertion.
- assertion asSentence In+men%2C+variation+in+plasma+PCSK9+concentration+influences+the+catabolism+of+LDL+apolipoprotein+B-100. assertion.
- assertion asSentence CT+domain+interaction+with+the+LBD+of+the+LDLR+at+endosomal+pH+constitutes+a+second+step+in+the+PCSK9-mediated+LDLR+binding+that+leads+to+receptor+degradation. assertion.
- assertion asSentence Two+separable+genomic+regions+code+for+initiation+and+positive+feedback+of+Ptf1a+transgene+expression+in+the+developing+nervous+system. assertion.
- assertion asSentence Some+carcinomas+of+the+upper+aerodigestive+tract+have+a+rearrangement+of+the+nuclear+protein+of+the+testis+%28NUT%29+gene+%28NUT+midline+carcinomas%29. assertion.
- assertion asSentence HLTF+and+SHPRH+suppress+mutagenesis+in+a+damage-specific+manner%2C+preventing+mutations+induced+by+UV+rays+and+methyl+methanesulfonate. assertion.
- assertion asSentence U2B%27%27+has+a+relaxed+specificity+for+its+RNA+targets. assertion.
- assertion asSentence NK+cell-mediated+induction+of+dendritic+cell+maturation+is+dependent+on+NKp30. assertion.
- assertion asSentence NKp30+is+a+triggering+receptor+downstream+of+adhesion+and+plays+an+important+role+in+NK+cell+activation%2C+degranulation+and+cytotoxicity. assertion.
- assertion asSentence The+stalk+domain+and+the+glycosylation+status+of+the+activating+natural+killer+cell+receptor+NKp30+are+important+for+ligand+binding. assertion.
- assertion asSentence SMS1+regulates+subcellular+pools+of+diacylglycerol-binding+proteins+in+the+Golgi+apparatus. assertion.
- assertion asSentence SMS1-mediated+SM+synthesis+directs+Tf-TfR+to+undergo+clathrin-dependent+endocytosis+and+recycling%2C+promoting+the+proliferation+of+lymphoma+cells. assertion.
- assertion asSentence Circulating+prostate-derived+PSA+and+membrane+PSM+mRNA+pre-+and+post-radical+prostatectomy+improves+accuracy+of+a+nomogram+to+predict+biochemical+recurrence+of+prostate+cancer. assertion.
- assertion asSentence IL-29%2FIL-28A+suppress+herpes+simplex+virus+type+1+%28HSV-1%29+infection+of+human+NT2-N+neurons. assertion.
- assertion asSentence IL28B+gene+variations+independently+predict+sustained+virologic+response+in+human+immunodeficiency+virus%2Fhepatitis+C+virus-coinfected+patients+with+hepatitis+C+virus+genotype+1+and+non-genotype+1+hepatitis+C+virus+infection. assertion.
- assertion asSentence 28B+genotype+is+more+frequent+in+individuals+who+have+cleared+an+acute+hepatitis+C+infection. assertion.
- assertion asSentence IL28B+genotype+and+hepatic+expression+of+interferon+stimulated+genes+are+independent+predictors+of+response+to+treatment+with+pegIFN-alpha+and+ribavirin+in+patients+with+chronic+hepatitis+C. assertion.
- assertion asSentence The+individuals+with+CC+genotype+of+interleukin+28B+have+higher+probability+of+clearing+hepatitis+c+than+those+with+TC+or+TT+genotype. assertion.
- assertion asSentence The+HLA-DQB1+%2A+0301+allele+and+the+IL28B+rs12979860+genotype+are+significant+independent+predictors+of+response+to+pegIFN+%2F+RBV+treatment+in+patients+with+chronic+HCV+infection. assertion.
- assertion asSentence IL28B+SNPs+and+mutations+in+the+core+region+and+NS5A+region+of+hepatitis+C+virus+are+associated+with+peginterferon+responsiveness+in+chronic+hepatitis+C. assertion.