Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence No+differences+in+expression+of+NR2A%2C+NR2C+or+NR2D+are+found+in+any+brain+region+examined+during+ethanol+consumption+and+acute+ethanol+withdrawal. assertion.
- assertion asSentence Regulated+appearance+of+NMDA+receptor+subunits+and+channel+functions+during+in+vitro+neuronal+differentiation. assertion.
- assertion asSentence In+ectoderm-targeted+transgenic+mice+overexpressing+the+glucocorticoid+receptor+%28GR%29+%5Bkeratin+5+%28K5%29-GR+mice%5D%2C+the+NF-kappaB+activity+is+greatly+decreased+due+to+functional+antagonism+between+GR+and+NF-kappaB. assertion.
- assertion asSentence An+essential+role+of+the+forebrain+GR+in+coordinating+endocrine+responses+to+stimuli+of+a+psychological+origin. assertion.
- assertion asSentence Pituitary+glucocorticoid+receptors+are+centrally+involved+in+regulating+hypothalamic-pituitary-adrenal+axis+activity+in+neonates+and+mediate+negative+feedback+regulation+in+adult+animals. assertion.
- assertion asSentence ANGPTL4+is+a+direct+GR+target+that+participates+in+glucocorticoid-regulated+triglyceride+metabolism. assertion.
- assertion asSentence Absence+of+MED1+in+the+liver+diminishes+Dex-induced+hepatic+steatosis+by+altering+the+GR-+and+CAR-dependent+gene+functions. assertion.
- assertion asSentence The+expression+of+the+mPon2+gene+is+directly+regulated+by+glucocorticoid-glucocorticoid+receptor+complexes. assertion.
- assertion asSentence The+glucocorticoid+receptor+in+the+distal+nephron+is+not+necessary+for+the+development+or+maintenance+of+dexamethasone-induced+hypertension. assertion.
- assertion asSentence Both+overlapping+and+differential+GR+targets+are+regulated+in+developing+vs.+adult+skin. assertion.
- assertion asSentence Glucocorticoid+receptor+dimerization+is+required+for+survival+in+septic+shock+via+suppression+of+interleukin-1+in+macrophages. assertion.
- assertion asSentence Hyperhomocysteinemia+is+associated+with+increased+methylation+of+Nr3c1+in+aorta. assertion.
- assertion asSentence Ligand-activated+nuclear+receptors+FXR%2FNR1H4+and+GR%2FNR3C1+and+nuclear+receptor+interacting+partners+are+less+abundant+in+Atp7b%28-%2F-%29+hepatocyte+nuclei. assertion.
- assertion asSentence mGluR1+plays+an+essential+role+in+the+adaptation+of+horizontal+optokinetic+response+eye+movements. assertion.
- assertion asSentence Metabotropic+glutamate+receptor+subtype-1+is+essential+for+motor+coordination+in+the+adult+cerebellum. assertion.
- assertion asSentence S+demonstrate+that+ADAMTS-7%2C+a+direct+target+of+PTHrP+signaling%2C+negatively+regulates+endochondral+bone+formation+by+associating+with+and+inactivating+GEP+chondrogenic+growth+factor. assertion.
- assertion asSentence Progranulin+is+abundantly+expressed+in+motor+neurons+and+is+cytoprotective+over+prolonged+periods+when+over-expressed+in+a+neuronal+cell+line. assertion.
- assertion asSentence Progranulin+plays+an+indispensable+role+in+enhancing+hippocampal+neurogenesis+induced+by+voluntary+exercise. assertion.
- assertion asSentence The+PMN+transendothelial+migration+induced+by+the+activated+myocytes+is+dependent+on+the+production+and+secretion+of+the+chemokines+LIX+and+KC+by+the+activated+myocytes. assertion.
- assertion asSentence Overexpression+of+keratinocyte-derived+chemokine+%28KC%29+in+transgenic+mice+produced+hyperplastic+prostate+epithelial+acini+associated+with+a+periacinar+reactive+stroma+%5Bkeratinocyte-derived+chemokine%5D. assertion.
- assertion asSentence The+lack+of+CXCR2+in+hematopoietic+cells+is+sufficient+to+protect+from+adipose+and+skeletal+muscle+macrophage+recruitment+and+development+of+insulin+resistance+in+diet-induced+obese+mice. assertion.
- assertion asSentence CXCL1+and+its+receptor%2C+CXCR2%2C+mediate+sickle+cell+acute+vaso-occlusive+crisis+during+hemolytic+transfusion+reactions. assertion.
- assertion asSentence Knockout+of+the+Pdia3+protein+in+mice+eliminates+the+rapid+response+to+calcitriol+in+intestinal+epithial+cells. assertion.
- assertion asSentence Grp+78+is+essential+for+alpha%282%29macroglobulin-induced+signal+transduction. assertion.
- assertion asSentence Binds+to+fkbp23+in+endoplasmic+reticulu. assertion.
- assertion asSentence GRP78+inhibits+both+insulin-dependent+and+ER+stress-dependent+SREBP-1c+proteolytic+cleavage+and+explain+the+role+of+ER+stress+in+hepatic+steatosis+in+obese+rodents. assertion.
- assertion asSentence Liver-specific+loss+of+glucose-regulated+protein+78+perturbs+the+unfolded+protein+response+and+exacerbates+a+spectrum+of+liver+diseases+in+mice. assertion.
- assertion asSentence Regulatory+expression+of+Goosecoid+in+P19+embryonal+carcinoma+cells. assertion.
- assertion asSentence Act+on+the+mouse+kidney%2C+in+part%2C+through+a+cGMP-dependent%2C+GC-C-independent+mechanism%2C+causing+significant+natriuresis+by+renal+tubular+processes. assertion.
- assertion asSentence GCC+signaling+plays+a+protective+role+in+the+integrity+of+the+intestinal+mucosal+barrier+by+regulating+myosin+light+chain+kinase+activation+and+tight+junction+disassembly. assertion.
- assertion asSentence Glycophorin+A+has+an+essential+role+in+the+expression+of+O-linked+antigens+on+the+erythrocyte+membrane. assertion.
- assertion asSentence GzmA+accesses+the+mitochondrial+matrix+to+cleave+the+complex+I+protein+NDUFS3%2C+an+iron-sulfur+subunit+of+the+NADH%3Aubiquinone+oxidoreductase+complex+I. assertion.
- assertion asSentence Granzyme+B+expression+is+augmented+in+activated+T+cells+from+Bcl6-%2F-+knockout+mice. assertion.
- assertion asSentence There+is+a+role+for+Granzyme+B+in+age-related+skin+thinning+and+frailty. assertion.
- assertion asSentence Mutations+lead+to+loss+of+CTCF+binding+and+Igf2+imprinting+only+when+passaged+through+the+female+germline. assertion.
- assertion asSentence The+H19%2FIgf2+imprinting+control+region+%28ICR%29+is+a+DNA+methylation-dependent+chromatin+insulator+in+somatic+cells. assertion.
- assertion asSentence The+2.4-kb+H19+imprinting+control+region+insertion+is+sufficient+to+transmit+parent-of-origin-dependent+DNA+methylation+patterns+independent+of+its+methylation+status+in+sperm. assertion.
- assertion asSentence Histone+H1+poly%5BADP%5D-ribosylation+of+proteins+over+a+specific+time+course+is+required+for+the+changes+in+synaptic+plasticity+related+to+memory+stabilization+in+mice. assertion.
- assertion asSentence An+unsuspected+role+for+the+MHC-I-Ly49+interaction+in+the+development+and+function+of+the+brain. assertion.
- assertion asSentence Ethanol-elicited+reduction+in+proteasome+activity+contributes+to+the+suppression+of+SIINFEKL-H2Kb+presentation+on+the+surface+of+liver+cells. assertion.
- assertion asSentence L%28d%29-restricted+killing+of+Toxoplasma+gondii-infected+target+cells+is+demonstrated+for+the+first+time+and+is+critically+dependent+on+the+strain+of+T.+gondii+tested. assertion.
- assertion asSentence The+stronger+affinity+of+the+TL+Ag+for+CD8alphaalpha+is+largely+mediated+by+three+amino+acids+on+exposed+loops+of+the+conserved+alpha3+domain. assertion.
- assertion asSentence Stable+expression+of+Qa1+on+the+surface+of+mature+dendritic+cells+%28DC%29+contributes+to+the+protection+of+DC+from+natural+killer+cell-mediated+lysis. assertion.
- assertion asSentence Co-ordinated+post-translational+modifications+of+p65+and+histone+H3+involving+phosphorylation+and+acetylation+drive+COX-2-dependent+transcriptional+activation+of+the+MMP-9+gene+in+response+to+challenge+of+macrophages+with+M.+avium. assertion.
- assertion asSentence No+expression+after+kidney+reperfusion+injury. assertion.
- assertion asSentence Embryonic+stem+cell-derived+hematopoietic+progenitor+cells+%28HPCs%29+express+high+levels+of+H60%2C+rendering+HPCs+susceptible+to+natural+killer+%28NK%29+cell+killing+in+vitro+and+in+vivo. assertion.
- assertion asSentence Hand1+and+Stra13+promote+cell+cycle+exit+and+restrict+cells+towards+the+Trophoblast+Giant+cell+fate. assertion.
- assertion asSentence Hand1+is+expressed+in+apical+cells+lining+maternal+blood+spaces. assertion.
- assertion asSentence The+absence+of+Hand2+expression+in+the+interventricular+boundary+region+inhibits+expansion+and+trabeculation+in+this+area%2C+contributing+to+the+proper+formation+of+the+interventricular+septum+. assertion.
- assertion asSentence Hand2+is+necessafry+for+terminal+differentiation+of+enteric+neurons+from+crest-derived+precursors. assertion.
- assertion asSentence Twist1%2C+along+with+Hand2%2C+is+essential+for+the+proximodistal+patterning+and+development+of+the+mandible+and+ossification. assertion.
- assertion asSentence HAP1+facilitates+potentiation+of+InsP3+receptor-1+mediated+Ca2%2B+release. assertion.
- assertion asSentence Tbx2%2C+a+central+intermediary+of+Bmp-Smad+signaling%2C+has+a+central+part+in+directing+Has2+and+Tgfbeta2+expression%2C+facilitating+endocardial+cushions+formation. assertion.
- assertion asSentence The+acetylation+of+EKLF+plays+a+role+in+its+ability+to+alter+the+beta-like+globin+locus+chromatin+structure+and+activate+transcription+of+the+adult+beta-globin+gene. assertion.
- assertion asSentence The+development+of+atypical+hemolytic+uremic+syndrome+depends+on+complement+C5. assertion.
- assertion asSentence P2Y2+and+P2Y12+receptor+agonists+are+not+chemoattractants+and+macrophage+chemotaxis+to+complement+C5a+is+phosphatidylinositol+3-kinase+%28PI3K%29-+and+p38+mitogen-activated+protein+kinase+%28MAPK%29-independent. assertion.
- assertion asSentence Dysregulation+of+complement+C5+in+synovial+joints+has+a+key+role+in+the+pathogenesis+of+osteoarthritis. assertion.
- assertion asSentence C5+deficiency+leads+to+attenuated+inflammation+and+normalized+MMP-9+activity+concomitantly+with+a+significant+reduction+of+fibrosis. assertion.
- assertion asSentence A+closed-open+transition+that+is+inherently+voltage+independent+is+subject+to+dual+allosteric+regulation+by+voltage+sensor+movement+and+cAMP+binding. assertion.
- assertion asSentence HCN+channels+regulate+the+pyramidal+cell+dendritic+excitability+of+hippocamus. assertion.
- assertion asSentence Dendritic+HCN1+channels+play+a+critical+role+in+regulating+cortical+pyramidal+cell+excitability. assertion.
- assertion asSentence Shortening+and+shaping+of+light+responses+by+activation+of+HCN1+is+an+important+step+at+least+in+the+scotopic+pathways. assertion.
- assertion asSentence TRIP8b+isoforms+are+important+regulators+of+HCN1+trafficking+in+entorhinal+neurons. assertion.
- assertion asSentence Functional+myocardial+I%28f%29+channels+reflect+the+heteromeric+assembly+of+HCN2+and+HCN4+subunits+and+further+that+the+HCN4+subunit+underlies+the+cAMP-mediated+regulation+of+cardiac+I%28f%29+channels. assertion.
- assertion asSentence Absence+of+CD5+dramatically+reduces+progression+of+pulmonary+inflammatory+lesions+in+SHP-1+protein-tyrosine+phosphatase-deficient+%27viable+motheaten%27+mice. assertion.
- assertion asSentence SHP-1+plays+a+critical+role+in+regulating+the+IL-4%2FIL-13+signaling+pathway+and+in+maintaining+lung+homeostasis. assertion.
- assertion asSentence SHP-1+plays+an+important+role+in+airway+mucin+production+through+regulating+oxidative+stress. assertion.
- assertion asSentence The+activity+of+the+orexin+neuron+in+the+LHA+contributes+to+the+promotion+and+maintenance+of+food+anticipatory+activity+. assertion.
- assertion asSentence Orexin+plays+an+essential+role+in+mediating+reduced+depression-like+symptoms+induced+by+calorie+restriction. assertion.
- assertion asSentence Orexin+neurons+are+indispensable+for+stress-induced+thermogenesis+in+mice. assertion.
- assertion asSentence Hdac1+is+autoregulated. assertion.
- assertion asSentence Histone+deacetylase-2+is+a+key+regulator+of+diabetes-+and+transforming+growth+factor-beta1-induced+renal+injury. assertion.
- assertion asSentence HDAC1+and+HDAC2+form+a+developmental+switch+that+controls+synapse+maturation+and+function+acting+in+a+manner+dependent+on+the+maturational+states+of+neuronal+networks. assertion.
- assertion asSentence HDAC4+and+HDAC5+form+homo-+and+hetero-oligomers+via+a+conserved+coiled-coil+domain+near+their+amino+termini. assertion.
- assertion asSentence Suppression+of+HDAC6+expression+reduces+axonal+length. assertion.
- assertion asSentence Knock-out+of+the+histidine+decarboxylase+gene+causes+a+general+endocrine+imbalance+in+the+hormones+which+are+related+to+histamine%2C+namely+ACTH%2C+triiodothyronine+and+endorphin+inside+the+immune+cells. assertion.
- assertion asSentence Histidine-decarboxylase+%28a+histamine+synthesizing+enzyme%29+knock-out+mice+displayed+sleep+fragmentation+and+increased+paradoxical+sleep+compared+to+wild-type+mice. assertion.
- assertion asSentence Increased+HDGF+expression+is+correlated+with+disease+progression+of+hepatocellular+carcinoma+and+represent+a+specific+prognostic+factor+in+patient+with+liver+cancer. assertion.
- assertion asSentence HDGF+functions+as+a+transcriptional+repressor+of+the+SMYD1+gene+through+interaction+with+the+transcriptional+corepressor+CtBP. assertion.
- assertion asSentence Mutant+huntingtin+protein+effects+disease-related+transcription+in+the+brain. assertion.
- assertion asSentence Hdh+facilitates+dynein-mediated+vesicle+transport. assertion.
- assertion asSentence Huntington%27s+disease+protein+contributes+to+RNA-mediated+gene+silencing+through+association+with+Argonaute+and+P+bodies. assertion.
- assertion asSentence Inhibition+of+lipid+signaling+enzyme+diacylglycerol+kinase+epsilon+attenuates+mutant+huntingtin+toxicity. assertion.
- assertion asSentence The+heme-binding+properties+and+coordination+structure+of+mouse+liver+p22HBP+are+distinct+from+those+of+SOUL+protein%2C+despite+high+sequence+homology. assertion.
- assertion asSentence Heparin-binding+epidermal+growth+factor-like+growth+factor+%28HB-EGF%29+produced+by+contracting+muscle+acts+as+an+insulin+sensitizer+that+facilitates+peripheral+glucose+disposal. assertion.
- assertion asSentence HES-1+is+a+regulator+of+intracellular+signal+transduction+stimulated+by+cell+adhesion+molecules+involved+in+neurite+outgrowth. assertion.
- assertion asSentence Hes1+transcription+repression+activity+is+inhibited+by+Hes6. assertion.
- assertion asSentence Hairy%2Fenhancer+of+split+protein+%28Hes1%29%2C+a+bHLH+transcriptional+repressor+functioning+in+neuronal+differentiation%2C+is+a+target+of+mouse+miRNA-23b+%28miR-23b%29. assertion.
- assertion asSentence GATA-2+regulates+myeloid+progenitor+function+through+HES-1. assertion.
- assertion asSentence Shh+stimulation+of+progenitor+proliferation+and+cell+diversification+requires+Gli2+and+Hes1+activity. assertion.
- assertion asSentence Notch1%2FNICD+levels+are+significantly+regulated+by+GSK-3beta+and+by+GSK-3alpha. assertion.
- assertion asSentence Hes1+expression+is+reduced+in+Tbx1+null+cells+and+is+required+for+the+development+of+structures+affected+in+22q11+deletion+syndrome. assertion.
- assertion asSentence FRS2alpha+fine-tunes+the+FGF2-signaling+to+control+self-renewal+and+proliferation+of+neural+stem+cells+through+Hes1. assertion.
- assertion asSentence Methylation+of+Hes1+and+Neurog2+promoter+is+associated+with+caudal+neural+tube+development. assertion.
- assertion asSentence Hes1+expression+and+CYLD+repression+are+essential+events+downstream+of+Notch1+in+T-cell+leukemia. assertion.
- assertion asSentence Hes1+regulates+the+number+and+anterior-posterior+patterning+of+mesencephalic+dopaminergic+neurons+at+the+mid%2Fhindbrain+boundary+%28isthmus%29. assertion.
- assertion asSentence The+domains+of+Hes-1+needed+to+block+adipogenesis+coincide+with+those+necessary+for+transcriptional+repression. assertion.
- assertion asSentence Neu4+is+not+the+only+sialidase+contributing+to+the+metabolic+bypass+in+Hexa%28-%2F-%29+mice. assertion.
- assertion asSentence CHF1+plays+an+important+role+in+regulation+of+ventricular+septation+in+mammalian+heart+development+and+is+important+for+normal+myocardial+contractility. assertion.
- assertion asSentence Iron+uptake+from+plasma+transferrin+by+the+duodenum+is+impaired+in+the+Hfe+knockout+mouse. assertion.