Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Mice+lacking+Hfe+or+producing+a+C282Y+mutant+Hfe+protein+develop+hyperferremia+and+have+high+hepatic+iron+levels. assertion.
- assertion asSentence Rag1+deficiency+in+Hfe+knock-out+mice+leads+to+heightened+iron+overload%2C+mainly+in+the+liver. assertion.
- assertion asSentence Modulates+stage-specific+markers+by+modulating+protein+kinase+C+activity%2C+providing+control+over+the+timing+of+steps+in+the+keratinocyte+differentiation+program. assertion.
- assertion asSentence Foxd3+is+upstream+of+several+pathways+critical+for+beta-cell+mass+expansion+in+vivo. assertion.
- assertion asSentence FoxJ1+playes+role+in+in+oro-facial+morphogenesis. assertion.
- assertion asSentence Foxj1-dependent+gene+expression+is+required+for+differentiation+of+radial+glia+into+ependymal+cells+and+a+subset+of+astrocytes+in+the+postnatal+brain. assertion.
- assertion asSentence Mechanisms+of+FOXC2-+and+FOXD1-mediated+regulation+of+the+RI+alpha+subunit+of+cAMP-dependent+protein+kinase+include+release+of+transcriptional+repression+and+activation+by+protein+kinase+B+alpha+and+cAMP. assertion.
- assertion asSentence Hepatocyte+growth+factor+is+essential+for+migration+of+myogenic+cells+and+promotes+their+proliferation+during+the+early+periods+of+tongue+morphogenesis+in+mouse+embryos. assertion.
- assertion asSentence Hepatocyte+growth+factor%2Fscatter+factor+induces+feedback+up-regulation+of+CD44v6+in+melanoma+cells+through+Egr-1. assertion.
- assertion asSentence Hgf+is+involved+in+branching+morphogenesis+of+salivary+glands. assertion.
- assertion asSentence Homozygous+p21%28cip%29+loss+releases+islets+from+growth+inhibition%2C+markedly+enhancing+proliferation+in+response+to+HGF+and+placental+lactogen. assertion.
- assertion asSentence Plasminogen+activation+can+protect+the+lung+against+fibrosis+by+increasing+the+availability+of+active+HGF. assertion.
- assertion asSentence Overexpression+of+NK2+acts+as+an+antagonist+of+HGF+and+promotes+liver+fibrosis+in+CCl4-induced+chronic+liver+injury. assertion.
- assertion asSentence uPA+promotes+muscle+regeneration+through+HGF+activation+and+subsequent+myoblast+proliferation. assertion.
- assertion asSentence HGF+from+local+smooth+muscle+cells+plays+an+important+role+for+the+differentiation+of+homing+bone+marrow+mesenchymal+stem+cells. assertion.
- assertion asSentence Inhibition+of+TLR4-induced+IkappaB+kinase+activity+by+the+RON+receptor+tyrosine+kinase+and+its+ligand%2C+macrophage-stimulating+protein. assertion.
- assertion asSentence The+restoration+of+Hrs+expression+increased+cell+proliferation+and+anchorage-independent+growth+in+a+mouse+embryonic+fibroblast+line+established+from+a+Hrs+knockout+mouse. assertion.
- assertion asSentence Loss+of+Hhex+is+associated+with+reduction+in+hematopoietic+maturation+accompanied+by+reduced+proliferation. assertion.
- assertion asSentence Mice+lacking+the+Hifa+gene+in+neural+cells+have+defective+brain+development. assertion.
- assertion asSentence Nickel+compounds+induce+HIF-1+transactivation+and+Cap43+protein+expression+through+a+PI-3K%2FAkt-dependent+and+p70%28S6k%29-+independent+pathway. assertion.
- assertion asSentence Increased+levels+of+SUMO-1+participate+in+the+modulation+of+HIF-1alpha+function+through+sumoylation+in+brain+and+heart. assertion.
- assertion asSentence The+pathological+changes+caused+by+pVHL+inactivation+in+skin+and+liver+are+due+largely+to+dysregulation+of+HIF+target+genes. assertion.
- assertion asSentence Growth+factor-deprived+hematopoietic+cells+do+not+engage+in+glucose-dependent+anabolic+synthesis+and+neither+express+Hif-1alpha+mRNA+nor+require+HIF-1alpha+protein+to+regulate+cell+survival+in+response+to+hypoxia. assertion.
- assertion asSentence Sphingosine-1-phosphate+acts+trogh+its+recept+and+HIf1alpha+receptor+to+regulate+T-cell+activation%2C+providing+a+therapeutic+target+for+prevention+of+diabetes+and+its+vascular+complications. assertion.
- assertion asSentence HIF-1+alpha+is+required+for+ischemic+preconditioning-induced+mitochondrial+reactive+oxygen+species+production+and+myocardial+protection+against+ischaemia-reperfusion+injury. assertion.
- assertion asSentence HIF-1alpha+promotes+glioblastoma+neovascularization+via+SDF1alpha+induction+and+recruitement+of+bone+marrow-derived+CD45+positive+myeloid+cells. assertion.
- assertion asSentence HIF-1alpha+functions+as+a+coactivator+of+the+metallothionein+gene+transcription+by+interacting+with+MTF-1+during+hypoxia. assertion.
- assertion asSentence Baicalein+induces+functional+Hif1a. assertion.
- assertion asSentence HIF-1alpha+siRNA+and+VEGF165+siRNA+can+inhibit+retinal+neovascularization. assertion.
- assertion asSentence Endotoxin+tolerance+impairs+HIF-1alpha+induction+which+reduces+the+ability+of+monocytic+cells+to+survive+and+function+under+hypoxic+conditions. assertion.
- assertion asSentence Hypoxia+stimulates+hepatocyte+epithelial+to+mesenchymal+transition+%28EMT%29+by+a+HIF+and+TGF-beta-dependent+mechanism. assertion.
- assertion asSentence Elevated+levels+of+TIMP-1+in+the+microenvironment+of+tumour+cells+can+promote+metastasis+by+inducing+HIF-1alpha-dependent+HGF-signaling. assertion.
- assertion asSentence Fh1-associated+cyst+formation+is+Hif+independent%2C+as+is+striking+upregulation+of+antioxidant+signaling+pathways+revealed+by+gene+expression+profiling. assertion.
- assertion asSentence High+HIF1alpha+is+associated+with+chronic+myeloid+leukemia. assertion.
- assertion asSentence HIF-1alpha+knockdown+decreased+and+HIF-1alpha+overexpression+increased+neuroglobin+levels%2C+consistent+with+a+connection+between+HIF-1+and+neuroglobin+induction. assertion.
- assertion asSentence MT1-MMP+in+niche+cells+regulates+postnatal+hematopoiesis%2C+by+modulating+hematopoietic+hypoxia-inducible+factor-1+-+dependent+niche+factors+that+are+critical+for+terminal+differentiation+and+migration. assertion.
- assertion asSentence The+tumor+suppressor+function+of+HINT1+is+caused+by%2C+at+least+in+part%2C+its+normal+role+in+enhancing+cellular+responses+to+DNA+damage+by+regulating+the+functions+of+both+gamma-H2AX+and+ATM. assertion.
- assertion asSentence Expression+of+Hipk2+in+the+mouse+nucleus+accumbens+is+modulated+by+a+sequence+variant+%28B2+SINE+indel%29+in+the+3%27+UTR+of+Comt+%28catechol-O-methyltransferase%29. assertion.
- assertion asSentence HIRA+interacts+with+H3.3%2FH4+in+the+absence+of+Daxx. assertion.
- assertion asSentence Heterochromatin+is+refractory+to+H2ax+modification+in+mice. assertion.
- assertion asSentence H2AX%2C+similar+to+PARP-1%2C+confers+cellular+protection+against+alkylation-induced+DNA+damage. assertion.
- assertion asSentence Changes+in+chromatin+structure+are+sufficient+to+elicit+extensive+gamma-H2AX+formation+in+the+relative+absence+of+DNA+strand+breaks. assertion.
- assertion asSentence Wild-type+p53-induced+phosphatase+1+dephosphorylates+histone+variant+gamma-H2AX+and+suppresses+DNA+double+strand+break+repair. assertion.
- assertion asSentence First+demonstration+of+a+cytotoxic+mechanism+based+on+direct+interaction+between+an+anticancer+agent+and+hexokinase. assertion.
- assertion asSentence HMGB1+release+from+macrophages+is+correlated+with+the+occurrence+of+apoptosis. assertion.
- assertion asSentence Global+ischemia-reperfusion+injury+initiated+by+resuscitated+hemorrhagic+shock+activates+neutrophil+NAD%28P%29H+oxidase+through+HMGB1%2FTLR4+signaling. assertion.
- assertion asSentence Src+family+kinases+are+necessary+for+cell+migration+induced+by+extracellular+HMGB1. assertion.
- assertion asSentence HMGB1+C-terminal+tail+is+responsible+for+the+inhibitory+effects+of+HMGB1+on+phagocytosis+of+apoptotic+neutrophils. assertion.
- assertion asSentence The+expression+of+HMGB1+is+obviously+increased+in+the+lung+and+BALF+of+asthmatic+mice+and+dexamethasone+produces+no+significant+effect+on+HMGB1+expression. assertion.
- assertion asSentence Myocyte-derived+HMGB1+and+TNF-alpha+work+in+concert+to+promote+ischemia%2Freperfusion-induced+myocardial+apoptosis+through+JNK+activation. assertion.
- assertion asSentence The+functional+receptor+for+HMGB1+consists+of+a+complex+of+RAGE+and+cell+surface+heparan+sulfate. assertion.
- assertion asSentence High+mobility+group+box+1+promotes+small+intestinal+damage+induced+by+nonsteroidal+anti-inflammatory+drugs+through+Toll-like+receptor+4. assertion.
- assertion asSentence HMGA1+proteins+are+involved+in+several+functions+by+regulating+miRNA+expression. assertion.
- assertion asSentence Involvement+of+tumor+necrosis+factor+alpha%2C+rather+than+interleukin-1alpha%2Fbeta+or+nitric+oxides+in+the+heme+oxygenase-1+gene+expression+by+lipopolysaccharide+in+the+mouse+liver. assertion.
- assertion asSentence Sodium+nitroprussside+contributes+to+HO-1+induction+via+the+cycl+AMP-protein+kinase+A-mitogen-activated+protein+kinase+pathway. assertion.
- assertion asSentence Insulin+induces+heme+oxygenase-1+mRNA+and+protein+expression+in+renal+cells+in+a+phosphatidylinositol+3-kinase%2FAkt+and+NF-E2-related+factor-2-dependent+manner. assertion.
- assertion asSentence HO-1+exerts+adaptive+cytoprotective+and+anti-inflammatory+functions+in+the+context+of+innate+toll-like+receptor+4+activation. assertion.
- assertion asSentence Isothiocyanates+activate+antioxidant+response+element%28ARE%29-mediated+HO-1+gene+transcription+through+Nrf2%2FARE+signaling+pathway. assertion.
- assertion asSentence Subway+particulate+matter+induced+an+increased+expression+of+MMP-12+and+HO-1+both+in+vitro+and+in+vivo. assertion.
- assertion asSentence Heme+oxygenase-1+deficiency+leads+to+disrupted+response+to+acute+stress+in+stem+cells+and+progenitors. assertion.
- assertion asSentence HO-1+plays+an+important+role+in+contact+hypersensitivity+%28CHS%29+and+is+an+important+pharmacological+target+for+the+treatment+of+CHS. assertion.
- assertion asSentence Heme+oxygenase-1+plays+a+critical+role+in+the+anti-inflammmatory+mechanism+of+ginsenoside+Rh1+in+activated+microglia. assertion.
- assertion asSentence Lipopolysaccharide+induced+autophagic+signaling+in+macrophages+via+a+TLR4%2C+HO-1+dependent+pathway+in+macrophages. assertion.
- assertion asSentence Heme+oxygenase-1-mediated+autophagy+protects+against+hepatocyte+cell+death+and+hepatic+injury+from+infection%2Fsepsis+in+mice. assertion.
- assertion asSentence Non-receptor+Bruton+tyrosine+kinase+%28Btk%29-dependent+induction+of+HO-1+by+lipopolysaccharide+is+mediated+by+Nrf2+in+macrophages%2C+via+a+transcriptional+mechanism. assertion.
- assertion asSentence Manganese+potentiates+lipopolysaccharide-induced+heme-oxygenase+1+in+microglia. assertion.
- assertion asSentence Lack+of+HO-1+renders+induced+pluripotent+stem+cells+more+prone+to+oxidative+stress-induced+cell+death+and+differentiation. assertion.
- assertion asSentence Bach1+regulates+osteoclastogenesis+under+inflammatory+conditions%2C+via+both+HO-1-dependent+and+HO-1-independent+mechanisms. assertion.
- assertion asSentence Maximal+seizures+induce+a+marked+%28approximately+12-fold%29+up-regulation+of+NGFI-B+in+the+dentate+gyrus. assertion.
- assertion asSentence Nur77+is+phosporylated+at+Ser354+by+ribosomal+S6+kinase+in+vitro+and+in+vivo. assertion.
- assertion asSentence Nur77+functions+as+a+master+regulator+of+the+differentiation+and+survivl+of+patrolling+Ly6-+monocytes. assertion.
- assertion asSentence Hn1+depletion+in+B16.F10+melanoma+cells+promotes+a+differentiated+phenotype+that+includes+increased+melanogenesis+and+cell+cycle+arrest. assertion.
- assertion asSentence HNF-6+inhibits+Foxa1+by+inhibiting+the+activity+of+the+TGF-beta+signaling+pathway. assertion.
- assertion asSentence Foxa1+plays+a+pivotal+role+in+controlling+prostate+morphogenesis+and+cell+differentiation. assertion.
- assertion asSentence Foxa1+and+Foxa2+regulate+multiple+phases+of+midbrain+dopaminergic+neuron+development+in+a+dosage-dependent+manner. assertion.
- assertion asSentence A+critical+involvement+of+FoxA1+in+stimulating+neural+differentiation+of+pluripotent+stem+cells+at+early+stages. assertion.
- assertion asSentence In+preadipocytes+Foxa-2+inhibits+adipocyte+differentiation+by+activating+transcription+of+the+Pref-1+gene. assertion.
- assertion asSentence Foxa2+regulates+multiple+pathways+of+insulin+secretion. assertion.
- assertion asSentence Foxa1+and+Foxa2+regulate+multiple+phases+of+midbrain+dopaminergic+neuron+development+in+a+dosage-dependent+manner. assertion.
- assertion asSentence Formation+of+midgut+and+hindgut+definitive+endoderm+is+unaffected+by+loss+of+Foxh1+or+Foxa2. assertion.
- assertion asSentence Foxa2+is+required+for+uterine+gland+development+and+pregnancy+in+mice. assertion.
- assertion asSentence Pyocyanin+induces+goblet+cell+hyperplasia+and+mucus+hypersecretion+by+inactivating+FoxA2. assertion.
- assertion asSentence Hepatocyte+nuclear+factor+4+response+to+injury+involves+a+rapid+decrease+in+DNA+binding+and+transactivation+via+a+JAK2+signal+transduction+pathway. assertion.
- assertion asSentence HNF-4+transcription+factor+influences+the+villus+metabolome+by+regulating+genes+that+are+involved+in+lipid+metabolism. assertion.
- assertion asSentence Mouse+Ntcp+is+regulated+by+HNF-4alpha+via+a+conserved+distal+cis-element+independently+of+HNF-1alpha. assertion.
- assertion asSentence FOLR1+is+a+target+for+regulation+by+HNF4-alpha+in+visceral+endoderm. assertion.
- assertion asSentence Hnf4alpha+plays+an+important+role+in+the+regulation+of+the+cell+survival+at+the+condensed+mesenchyme+stage+in+nephrogenesis. assertion.
- assertion asSentence HNF4a+positively+regulates+the+expression+of+miRs-200+and+-34a. assertion.
- assertion asSentence HNF-6+inhibits+Foxa1+by+inhibiting+the+activity+of+the+TGF-beta+signaling+pathway. assertion.
- assertion asSentence HNF-6+and+OC-2+play+partially+redundant+roles+in+developing+pancreas%2C+antero-posterior+patterning+of+the+gut+and+in+enteroendocrine+differentiation. assertion.
- assertion asSentence Onecut1+and+Onecut2+are+expressed+in+both+developing+and+mature+horizontal+cells+of+the+retina. assertion.
- assertion asSentence Plays+a+vital+role+in+the+generation+of+neural+crest+cells. assertion.
- assertion asSentence Hoxa1+acts+in+a+genetic+cascade+upstream+of+genes+controlling+specific+aspects+of+embryonic+development. assertion.
- assertion asSentence Cytokine-stimulated+pathways+regulate+HoxA10-mediated+repression+of+the+CYBB+and+NCF2+genes+in+differentiating+myeloid+cells+and+in+mature+phagocytes+during+the+inflammatory+response. assertion.
- assertion asSentence Autocrine+stimulation+of+myeloid+progenitors+by+Tgfbeta2+as+one+mechanism+by+which+HoxA10+expands+this+population. assertion.
- assertion asSentence Hoxa11+is+required+for+proper+cellular+proliferation+and+apoptotic+responses+in+the+developing+neonatal+uterus. assertion.
- assertion asSentence HOXA13+directly+regulates+EphA6+and+EphA7+in+the+developing+genital+tubercle. assertion.
- assertion asSentence Hoxa3+regulates+the+proliferation+and+differentiation+of+the+3rd+pharyngeal+arch+mesoderm. assertion.
- assertion asSentence HOXA3+can+facilitate+tissue+remodeling+via+coordinated+changes+in+both+epithelial+and+endothelial+cell+gene+expression+and+behavior+in+adult+tissues+during+wound+repair. assertion.
- assertion asSentence HOXA3+accelerates+wound+repair+by+mobilizing+endothelial+progenitor+cells+and+attenuating+the+excessive+inflammatory+response+of+chronic+wounds. assertion.