Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence HoxA5+increases+Akt1+mRNA%2C+protein+expression+and+further+enhances+Akt+activity+via+a+coordinate+down+regulation+of+PTEN. assertion.
- assertion asSentence The+long%2C+noncoding+RNA+%28lncRNA%29+Mistral+%28Mira%29+activates+transcription+of+the+homeotic+genes+Hoxa6+and+Hoxa7+in+mouse+embryonic+stem+cells+%28mESC%29+by+recruiting+MLL1+to+chromatin. assertion.
- assertion asSentence The+long%2C+noncoding+RNA+%28lncRNA%29+Mistral+%28Mira%29+activates+transcription+of+the+homeotic+genes+Hoxa6+and+Hoxa7+in+mouse+embryonic+stem+cells+%28mESC%29+by+recruiting+MLL1+to+chromatin. assertion.
- assertion asSentence Specific+recruitment+of+MLL1+requires+multiple+interactions+and+is+a+precondition+for+stable+recruitment+of+MLL1+fusion+proteins+to+HoxA9+in+leukemogenesis. assertion.
- assertion asSentence Setbp1+promotes+the+self-renewal+of+murine+myeloid+progenitors+via+activation+of+Hoxa9+and+Hoxa10. assertion.
- assertion asSentence Hoxb1+contains+the+cis-acting+elements+sufficient+to+initiate+ectopic+local+nuclear+reorganisation+and+chromatin+decondensation+and+to+break+Hoxd+colinearity+in+the+primitive+streak+region+of+the+early+embryo. assertion.
- assertion asSentence Hoxb1+is+required+for+the+anterior-posterior+identity+of+precursors+that+contribute+to+the+lateral+vestibular+nucleus. assertion.
- assertion asSentence The+Hoxb3+gene+plays+an+essential+role+in+regulating+B+lymphopoiesis+in+the+BM+of+adult+mice. assertion.
- assertion asSentence Primitive+hematopoietic+stem+cells+%28HSCs%29+are+poised+to+become+definitive+adult+HSCs+and+this+transition+can+be+promoted+by+HoxB4+expression. assertion.
- assertion asSentence HOXB4+enforces+equivalent+fates+of+embryonic+stem-cell-derived+and+adult+hematopoietic+cells. assertion.
- assertion asSentence Hoxc8+downregulates+Mgl1+tumor+suppressor+gene+expression+and+reduces+its+concomitant+function+on+cell+adhesion. assertion.
- assertion asSentence Hox1b+contains+the+cis-acting+elements+sufficient+to+initiate+ectopic+local+nuclear+reorganisation+and+chromatin+decondensation+and+to+break+Hoxd+colinearity+in+the+primitive+streak+region+of+the+early+embryo. assertion.
- assertion asSentence Replacement+of+the+wild-type+Hoxd-13+gene+with+one+lacking+the+15-residue+polyalanine+tract+affected+sesamoid+bone+formation+in+knock-in+mice. assertion.
- assertion asSentence Heparanase+is+actively+involved+in+embryo+implantation. assertion.
- assertion asSentence Hepatic+lipase+expression+in+macrophages+contributes+to+atherosclerosis+in+apoE-deficient+and+LCAT-transgenic+mice. assertion.
- assertion asSentence Not+essential+for+diet-induced+gallstone+formation+in+mice. assertion.
- assertion asSentence HR+regulates+the+precise+timing+of+Wnt+signaling+required+for+hair+follicle+regeneration. assertion.
- assertion asSentence Hr+evokes+an+anti-apoptotic+response+by+disrupting+a+p53+dependent+pathway+involving+Bcl2+family+members. assertion.
- assertion asSentence A+critical+role+for+ras-mediated%2C+epidermal+growth+factor+receptor-dependent+angiogenesis+in+mouse+skin+carcinogenesis. assertion.
- assertion asSentence PI3K-Ras+pathway+is+a+major+mediator+of+Axl+actions+upstream+of+Rac+to+induce+GnRH+neuronal+cell+migration. assertion.
- assertion asSentence Pak1+regulates+multiple+c-Kit+mediated+Ras-MAPK+gain-in-function+phenotypes+in+Nf1%2B%2F-+mast+cells. assertion.
- assertion asSentence ILEI+requires+cooperation+with+oncogenic+Ras+to+govern+hepatocellular+EMT+through+mechanisms+involving+PDGF-R%2Fbeta-catenin+and+PDGF-R%2FStat3+signaling. assertion.
- assertion asSentence RGS14+assembles+a+multiprotein+complex+with+components+of+the+ERK+MAPK+pathway+in+a+manner+dependent+on+activated+H-Ras. assertion.
- assertion asSentence Histaminergic+neurons+protect+the+developing+hippocampus+from+KA-induced+neuronal+damage%2C+with+regulation+of+neuronal+survival+being+at+least+partly+mediated+through+H1+receptors. assertion.
- assertion asSentence Central+histamine+contributes+via+the+H1+receptor+to+changes+in+metabolic+rate+during+hypoxia+to+increasehypoxic+ventilatory+decline+in+conscious+mice. assertion.
- assertion asSentence Histamine+H1+receptors+are+upregulated+during+bone+marrow+regeneration+in+mice. assertion.
- assertion asSentence Bone+marrow-derived+mast+cell-elaborated+histamine+inhibits+CD4positiveCD25positive+regulatory+T+cell+suppressor+function+by+signaling+through+the+histamine+H1+receptor. assertion.
- assertion asSentence Eukaryotic+initiation+factor+2alpha+kinase+is+a+protagonist+of+heme-mediated+translational+control+of+CYP2B+enzymes+and+a+modulator+of+basal+endoplasmic+reticulum+stress+tone. assertion.
- assertion asSentence Prmt2+inhibits+NF-kappa+B+function+and+promotes+apoptosis. assertion.
- assertion asSentence Brucella+abortus+infection+of+trophoblast+giant+cells+in+placenta+is+mediated+by+Hsc70. assertion.
- assertion asSentence Heat+shock+protein+70+%28Hsc70%29+plays+a+significant+role+in+vascular+endothelial+cells+via+the+phosphatidylinositol+3-kinase%2FAkt+pathway. assertion.
- assertion asSentence Insulin+and+dexamethasone+augmented+11beta-HSD1+activity+and+expression+in+rat+white+adipose+tissue+in+vivo. assertion.
- assertion asSentence Role+of+11beta-hydroxysteroid+dehydrogenase+type+2+in+aortic+responses+to+glucocorticoids. assertion.
- assertion asSentence Hedgehog+signaling+has+a+protective+effect+in+glucocorticoid-induced+mouse+neonatal+brain+injury+through+an+11betaHSD2-dependent+mechanism. assertion.
- assertion asSentence Enzyme+activities+of+3-betaHSDH+increase+as+the+sound+pressure+levels+increase+in+adrenal+cortex+zona+fasciculate+polygonal+cells. assertion.
- assertion asSentence HSF-1+plays+an+important+role+in+conferring+resistance+to+hyperoxia+in+vitro. assertion.
- assertion asSentence Absence+of+caveolin-1+alters+heat+shock+protein+expression+in+spontaneous+mammary+tumors+driven+by+Her-2%2Fneu+expression. assertion.
- assertion asSentence Hsp110+over-expression+increases+the+immunogenicity+of+the+murine+CT26+colon+tumor. assertion.
- assertion asSentence The+constitutive+overexpression+of+HSP105+in+cancer+cells+is+involved+in+malignant+transformation+by+protecting+tumor+cells+from+apoptosis. assertion.
- assertion asSentence The+absolute+amounts+of+HSP25+in+extensor+digitorum+longus+and+soleus+muscles+are+similar+in+both+mouse+and+rat. assertion.
- assertion asSentence Hsp70+plays+a+vital+role+in+the+protective+effects+of+carbon+monoxide+against+cytokine-induced+endothelial+cell+apoptosis+and+against+the+lethal+effects+of+endotoxin+shock. assertion.
- assertion asSentence Vimentin+mutant+upregulates+Hsp70+and+the+activity+of+the+ubiquitin-proteasome+system. assertion.
- assertion asSentence Extracellular+HSP70+acting+via+TLR2+and+its+obligate+downstream+adaptor+molecule%2C+MyD88%2C+activate+NFkappaB%2C+causing+cardiomyocyte+inflammation+and+decreased+contractility. assertion.
- assertion asSentence The+Hsp70+inhibits+H%282%29O%282%29-induced+nucleolar+fragmentation+through+the+translocation+of+Hsp70+into+nucleolar+and+its+protection+against+impairment+of+nucleolin. assertion.
- assertion asSentence Melusin+directly+binds+to+Hsp90%2C+a+ubiquitous+chaperone+involved+in+regulating+several+signaling+pathways. assertion.
- assertion asSentence Extracellular+matrix+histone+H1+binds+to+perlecan%2C+is+present+in+regenerating+skeletal+muscle+and+stimulates+myoblast+proliferation. assertion.
- assertion asSentence NDST1+competes+with+EXT1+for+binding+to+EXT2. assertion.
- assertion asSentence Activation+of+the+5-HT1A+receptor+leads+to+a+number+of+neurotropic+events+by+activating+a+series+of+signal+transduction+molecules+leading+to+long-term+changes+required+for+neurogenesis. assertion.
- assertion asSentence Depression+of+preclinical+Huntington%27s+disease+corresponded+with+specific+increases+in+hippocampal+htr1A+and+htr1B+expression+and+cortical+htr2C+expression. assertion.
- assertion asSentence Htr1aKO+mice+exhibit+increased+social+anxiety-like+behavior+both+during+early+life+and+adulthood+and+this+phenotype+can+be+reversed+by+exposing+the+pups+to+daily+maternal+separation+during+the+neonatal+period. assertion.
- assertion asSentence Serotonin+1B+receptor+gene+deletion+selectively+enhances+learning+performance+when+the+cognitive+requirement+of+the+task+is+elevated. assertion.
- assertion asSentence Lack+of+serotonin1B+receptor+expression+leads+to+age-related+motor+dysfunction%2C+early+onset+of+brain+molecular+aging+and+reduced+longevity. assertion.
- assertion asSentence A+bifurcation+of+the+5-HT2A+receptor+signaling+pathway+is+neurotransmitter-+and+beta-arrestin2-dependent. assertion.
- assertion asSentence The+5-HT2AR-metabotropic+glutamate+mGluR2+receptor+%28mGluR2%29+complex+is+necessary+for+the+neuropsychological+responses+induced+by+hallucinogens. assertion.
- assertion asSentence Modulation+of+serotonin+2C+receptor+RNA+editing+by+sustained+changes+in+serotonergic+neurotransmission. assertion.
- assertion asSentence The+mechanisms+underlying+feeding+disorders+in+5-HT4+receptor+knockout+mice+are+related+to+a+lesser+efficacy+of+5-HT+%28hypothalamus%2C+nucleus+accumbens%29%2C+leptin+and+the+cocaine-amphetamine+related+transcript+to+reduce+food+intake+following+stress. assertion.
- assertion asSentence Binding+sites+consistent+with+mRNA+distribution+with+highest+densities+found+in+anterior+thalamic+nuclei. assertion.
- assertion asSentence 5-HT%287%29+receptor+deletion+augments+the+effect+of+various+SSRIs+on+REM+sleep+suppression+and+this+effect+is+distinct+from+those+mediated+via+5-HT%281A%29+receptors. assertion.
- assertion asSentence Apoptotic+cells+visualized+at+postnatal+day-1+significantly+reduced+in+the+striatum%2C+thalamus%2Fhypothalamus%2C+cerebral+cortex+and+hippocampus+of+5-HTT+knockout+mice. assertion.
- assertion asSentence Loss+of+intestinal+SERT+is+a+critical+factor+in+fructose-induced+impairment+of+intestinal+barrier+function+and+subsequently+the+development+of+liver+steatosis. assertion.
- assertion asSentence SERT+is+the+sole+protein+responsible+for+selective+5-HT+%285-hydroxytryptamine%29+reuptake+inhibitor-mediated+alterations+in+5-HT+clearance. assertion.
- assertion asSentence Expression+of+serotonin+transporter+%28SERT%29+is+comparable+in+brain+and+platelets+of+obese+ob%2Fob+and+wild-type+mice. assertion.
- assertion asSentence Extinction+learning+and+memory+of+conditioned+fear+can+be+modulated+by+both+the+5-HTT+gene+activity+and+social+experiences+in+adulthood. assertion.
- assertion asSentence Chemical+inhibitors+destabilize+HuR+binding+to+the+AU-rich+element+of+TNF-alpha+mRNA. assertion.
- assertion asSentence HuD+plays+a+role+in+synaptic+plasticity+mechanisms+stabilizing+mRNAs+associated+with+ribosomes+both+in+the+soma+and+dendrites+of+hippocampal+neurons. assertion.
- assertion asSentence Notch3+and+the+Notch3-upregulated+RNA-binding+protein+HuD+regulate+Ikaros+alternative+splicing. assertion.
- assertion asSentence Hus1+is+required+specifically+for+one+of+two+separable+mammalian+checkpoint+pathways+that+respond+to+distinct+forms+of+genome+damage+during+S+phase. assertion.
- assertion asSentence Role+of+carboxypeptidase+E+in+processing+of+pro-islet+amyloid+polypeptide+in+%7Bbeta%7D-cells. assertion.
- assertion asSentence BSP+gene+transcription+is+autoregulated+in+part+by+a+positive+feedback+on+its+own+promoter. assertion.
- assertion asSentence Lack+of+BSP+affects+both+osteoclast+formation+and+activity. assertion.
- assertion asSentence ICAM-1+facilitates+alveolar+macrophage+phagocytic+activity+through+effects+on+migration+over+the+AEC+surface. assertion.
- assertion asSentence Initiation+of+lacrimal+gland+and+ocular+surface+inflammation+and+role+of+ICAM-1+in+pathophysiology+of+dry+eye. assertion.
- assertion asSentence ICAM-1+cooperatively+with+L-selectin+regulates+induction+of+the+immediate-type+hypersensitivity+response+by+mediating+mast+cell+accumulation+into+inflammatory+sites. assertion.
- assertion asSentence ICAM-1+is+unique+in+supporting+migration+of+lymphocytes+into+inflamed+sites+and+trapping+them+within+the+lung. assertion.
- assertion asSentence Delayed+up-regulation+of+ICAM-1+adhesion+molecules+in+response+to+Pneumocystis+carinii+infection+is+involved+in+the+sluggish+recruitment+of+inflammatory+cells+into+neonatal+lungs+compared+with+adults. assertion.
- assertion asSentence Cytokine-induced+endothelial+intercellular+adhesion+molecule-1+and+vascular+cell+adhesion+molecule-1+expressionwas+inhibited+by+tecastemazole+in+a+manner+independent+of+H1+receptor+antagonism. assertion.
- assertion asSentence Predominant+mechanism+of+soluble+ICAM-1+production+differs+in+the+two+cell+types+from+opposite+sides+of+the+alveolar+wall. assertion.
- assertion asSentence An+important+role+of+PKC-delta+and+PI3K%2FAkt1%2C2+pathways+in+activating+mTOR+as+an+endogenous+modulator+to+ensure+a+tight+regulation+of+NF-kappaB+signaling+of+ICAM-1+expression+in+endothelial+cells. assertion.
- assertion asSentence Immobilization+of+ICAM-1%2C+rather+than+polarization+to+one+end+of+the+cell+or+clustering%2C+is+required+for+functional+interaction+of+ICAM-1+with+alpha+L+beta+2+integrin+%28LFA-1%29. assertion.
- assertion asSentence ICSBP+plays+a+critical+role+in+myeloid+cell+development+by+controlling+lineage+selection+and+is+indispensable+for+IFN-gamma-dependent+modulation+of+progenitor+cell+maturation. assertion.
- assertion asSentence IRF-8+interacts+with+autoantigen+Ro52+in+murine+macrophages+upon+interferon-gamma+and+Toll-like+receptor+stimulation. assertion.
- assertion asSentence Interferon-gamma+treatment+of+murine+macrophage+cell+line+RAW+264.7+induces+tumor+necrosis+factor-alpha+expression+at+transcriptional+level+requiring+the+coordinate+action+of+IRF-1+and+IRF-8. assertion.
- assertion asSentence Expression+of+Id1+is+found+in+adult%2C+regenerating+and+developing+pancreas+of+the+mouse. assertion.
- assertion asSentence Overexpression+of+ID1+alone+is+not+sufficient+to+drive+neoplastic+change+in+mouse+prostate. assertion.
- assertion asSentence Cell-nonautonomous+function+of+Id1+in+the+hematopoietic+progenitor+cell+niche. assertion.
- assertion asSentence Transcriptional+activation+of+the+Id2+gene+is+mediated+by+direct+binding+of+CCAAT%2Fenhancer+binding+protein+beta+to+promotor+regions. assertion.
- assertion asSentence Inhibitor+of+helix-loop-helix+protein%2C+Id2%2C+is+critical+to+control+the+proliferation+of+mammary+epithelial+cells+in+response+to+RANKL+stimulation. assertion.
- assertion asSentence Proper+expression+of+Id2+is+important+to+achieving+a+fine+balance+between+growth+and+differentiation+during+chondrogenesis. assertion.
- assertion asSentence Id2+plays+a+role+in+skin+tumorigenesis+by+suppressing+tumor+development+through+the+establishment+of+epidermal+gammadelta+T+cell-mediated+skin+immunosurveillance+and+by+promoting+tumor+cell+proliferation+via+the+control+of+the+cyclin+D1+protein+level. assertion.
- assertion asSentence E4BP4+acted+in+a+cell-intrinsic+manner+%27downstream%27+of+the+interleukin+15+receptor+%28IL-15R%29+and+through+the+transcription+factor+Id2. assertion.
- assertion asSentence Id2+expression+delineates+differential+checkpoints+in+the+genetic+program+of+CD8alpha%2B+and+CD103%2B+dendritic+cell+lineages. assertion.
- assertion asSentence BMP+signaling+is+primarily+responsible+for+the+serum-induced+Id2+expression. assertion.
- assertion asSentence Id3+is+expressed+within+the+cochlear+duct+in+a+pattern+that+is+consistent+with+a+role+in+regulation+of+hair+cell+development. assertion.
- assertion asSentence Expression+of+inhibitor+of+differentiation+gene+3+%28Id3%29+controls+the+frequency+of+promyelocytic+leukemia+zinc+finger+%28PLZF%29-expressing+gamma+delta+T+cells. assertion.
- assertion asSentence Id3+represses+p57%28Kip2%29+expression+in+human+beta-cells. assertion.
- assertion asSentence Consistent+and+selective+association+of+the+IDO-competent+phenotype+with+down-modulation+of+the+Tyrobp+gene. assertion.
- assertion asSentence Indoleamine+2%2C3+dioxygenase+is+a+key+immunosuppressive+factor+that+facilitates+tumor+progression+in+this+setting+of+chronic+inflammation+driven+by+repeated+topical+phorbol+myristate+acetate+exposure. assertion.
- assertion asSentence IDO1+is+a+lung-specific+innate+immune+mechanism+that+controls+pulmonary+Francisella+infections. assertion.
- assertion asSentence Mucopolysaccharidosis+type+I%2C+unique+structure+of+accumulated+heparan+sulfate+and+increased+N-sulfotransferase+activity+in+mice+lacking+alpha-l-iduronidase. assertion.
- assertion asSentence In+lipopolysaccharide-stimulated+murine+macrophages+LRG47+is+induced+by+IFN-beta+and+negatively+regulates+Toll-like+receptor+4+signaling+to+prevent+excess+proinflammatory+cytokine+production+and+shock. assertion.