Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Irgm1+is+essential+for+the+expansion+of+CD4%2B+T+lymphocyte+populations+after+TCR+stimulation. assertion.
- assertion asSentence Irgm3+functions+to+counter+the+effects+of+Irgm1. assertion.
- assertion asSentence Expression+of+Nsg1+in+the+mouse+nucleus+accumbens+is+modulated+by+a+sequence+variant+%28B2+SINE+indel%29+in+the+3%27+UTR+of+Comt+%28catechol-O-methyltransferase%29. assertion.
- assertion asSentence The+COOH-terminal+NES+and+Src+homology+2+target+motifs+play+key+roles+in+Dok-7%2FMuSK+signaling+for+neuromuscular+synaptogenesis. assertion.
- assertion asSentence Regulation+of+sympathetic+neuron+differentiation+by+endogenous+neurotrophin-3. assertion.
- assertion asSentence NT-3+and+BDNF+exert+a+profound+effect+on+the+types+of+neurotransmitter+receptors+expressed+on+postnatal+SGN. assertion.
- assertion asSentence NT-3+expression+in+the+GI+tract+is+largely+restricted+to+smooth+muscle+at+ages+when+vagal+axons+grow+into+the+GI+tract. assertion.
- assertion asSentence Knockdown+of+Dok6+decreased+neurite+outgrowth+in+cortical+neurons+upon+neurotrophin+3+stimulation. assertion.
- assertion asSentence SLIT2+acts+in+parallel+with+NTN1+to+generate+cell+boundaries+along+ducts+during+bi-layered+tube+formation. assertion.
- assertion asSentence Netrin-1+is+crucial+for+both+the+initial+dispersal+of+spinal+cord+oligodendrocyte+precursors+and+their+subsequent+development+in+the+presumptive+white+matter. assertion.
- assertion asSentence Netrin-1+binding+to+beta-Amyloid+Protein+Precursor+suppresses+Amyloid+beta-Protein+production+and+decreased+netrin-1+expression+is+associated+with+increased+Amyloid+beta-Protein+concentration. assertion.
- assertion asSentence Netrin-1-alpha3beta1+integrin+interactions+modulate+distinct+routes+of+interneuronal+migration+and+the+consequent+positioning+of+groups+of+cortical+interneurons+in+the+developing+cerebral+cortex. assertion.
- assertion asSentence During+development%2C+netrin-1+plays+a+critical+role+for+the+establishment+of+functional+balanced+locomotor+central+pattern+generators+circuitry. assertion.
- assertion asSentence Both+Slit+and+netrin-1+signalling+contribute+to+floor+plate-derived+chemorepulsion+of+cranial+motor+axons. assertion.
- assertion asSentence Netrin-1+expression+is+suppressed+at+the+translational+level+and+MAPK+activation+leads+to+rapid+translation+of+netrin-1+mRNA+in+the+kidney+tubular+epithelial+cells. assertion.
- assertion asSentence Both+NTRK1+and+NTRK2+receptors+are+necessary+for+the+timely+assembly+of+primordial+follicles+and+for+sustaining+early+follicular+development. assertion.
- assertion asSentence Binding+of+full-length+TrkB+receptor+to+BDNF+plays+a+role+in+the+development+of+neuropathic+pain-like+thermal+hyperalgesia+induced+by+nerve+injury. assertion.
- assertion asSentence Increased+expression+of+trkb+in+the+mechanically+compressed+spinal+cord+of+the+spinal+hyperostotic+mouse+%28twy%2Ftwy%29. assertion.
- assertion asSentence Signalling+through+TrkB+is+an+important+component+of+the+mechanism+that+regulates+the+early+survival+of+female+germ+cells. assertion.
- assertion asSentence Motoneuron+survival+after+facial+nerve+lesioning+is+significantly+enhanced+by+transactivation+of+Trk+receptor+tyrosine+kinases+by+adenosine+agonists. assertion.
- assertion asSentence Both+NTRK1+and+NTRK2+receptors+are+necessary+for+the+timely+assembly+of+primordial+follicles+and+for+sustaining+early+follicular+development. assertion.
- assertion asSentence TrkB-dependent+activation+of+PLCgamma1+signaling+is+an+important+molecular+mechanism+of+limbic+epileptogenesis. assertion.
- assertion asSentence Binding+of+the+receptor+tyrosine+kinase+TrkB+to+the+neural+cell+adhesion+molecule+%28NCAM%29+regulates+phosphorylation+of+NCAM+and+NCAM-dependent+neurite+outgrowth. assertion.
- assertion asSentence Preferential+expression+of+BETA2%2FNeuroD1+and+TrkC+in+posterior+lobes+explains+the+earlier+start+of+cell+apoptosis+and+preferential+loss+of+granule+cells+in+the+posterior+lobes. assertion.
- assertion asSentence Ntsr1+receptor+subtype+is+necessary+for+normal+dopaminergic+function. assertion.
- assertion asSentence An+essential+role+of+mNUDC+for+anterograde+transport+of+dynein+and+dynactin+by+kinesin-1. assertion.
- assertion asSentence Corticotropin-releasing+factor+Crf%2FCRH+promoter+contains+multiple+nuclear+factor+%28NF%29-kappaB+and+Nurr1+binding+sites. assertion.
- assertion asSentence Consequences+of+prenatal+viral-like+immune+activation+are+exacerbated+in+offspring+with+genetic+predisposition+to+dopaminergic+abnormalities+induced+by+mutations+in+Nurr1. assertion.
- assertion asSentence There+is+a+direct+interaction+between+Nurr1+and+the+Pitx3+gene+promoter. assertion.
- assertion asSentence Nurr1+is+critical+for+the+development+and+maintenance+of+midbrain+dopaminergic+%28DA%29+neurons+in+mouse. assertion.
- assertion asSentence OA1+interacts+with+MART-1+at+early+stages+of+melanogenesis+to+control+melanosome+identity+and+composition. assertion.
- assertion asSentence The+protein+product+is+generated+using+polyamine-regulated+programmed+ribosomal+frameshifting. assertion.
- assertion asSentence Loss+of+occludin+expression+is+at+least+partially+involved+in+the+senescence-escape+program+during+mammary+tumorigenesis. assertion.
- assertion asSentence Disruptions+of+occludin+and+claudin-5+in+brain+endothelial+cells+in+vitro+and+in+brains+of+mice+with+acute+liver+failure. assertion.
- assertion asSentence De+novo+suprabasal+induction+of+ODC+activity+in+adult+mouse+skin+activates+keratinocytes+and+stimulates+vascularization+in+the+dermal+layer+in+a+manner+similar+to+skin+undergoing+wound+healing. assertion.
- assertion asSentence Odc+is+a+critical+Myc+transcription+target+that+regulates+checkpoints+that+guard+against+tumorigenesis+and+is+an+effective+target+for+cancer+chemoprevention. assertion.
- assertion asSentence High+expression+of+osteoglycin+decreases+the+gelatinase+activity+of+hepatocarcinoma+Hca-F+cells+cultured+with+extract+of+lymph+node. assertion.
- assertion asSentence Expression+in+mice+with+collagen-induced+arthritis+treated+with+Kanzo-bushi-to%2C+a+Kampo+medicine. assertion.
- assertion asSentence Increased+bone+resorption+is+a+noncell+autonomous+defect%2C+caused+by+exuberant+stimulation+of+osteo-clastogenesis+by+Cx43-deficient+bone+marrow+stromal+cells%2C+via+decreased+Opg+production. assertion.
- assertion asSentence Omentin-1+ameliorates+arterial+calcification+and+bone+loss+in+vivo+through+the+regulation+of+the+RANK+signalling+pathway+in+osteoprotegerin-deficient+mice. assertion.
- assertion asSentence Coexistence+of+delta-opioid+receptors+and+mu-opioid+receptors+in+small+dorsal+root+ganglia+neurons+is+a+basis+for+direct+interaction+of+opioid+receptors+in+modulation+of+nociceptive+afferent+transmission+and+opioid+analgesia. assertion.
- assertion asSentence No+impairment+in+spatial+learning+in+kappa+opioid+receptor+mutants+or+in+mossy+fibers+in+CA3+hippocampal+region+long-term+potentiation. assertion.
- assertion asSentence Kappa+opioid+receptor+contributes+to+EGF-stimulated+neurite+extension+in+development. assertion.
- assertion asSentence The+ability+of+buprenorphine+to+interact+with+the+ORL1+receptor+modulates+its+acute+motor+stimulatory+and+rewarding+effects. assertion.
- assertion asSentence Homozygote+congenic+mu-receptor+knockout+mice+display+baseline+hyperalgesia%2C+no+morphine+place+preference%2C+no+morphine+analgesia+and+no+morphine+locomotion. assertion.
- assertion asSentence An+epigenetic+mechanism+consisting+of+DNA+methylation+and+chromatin+modification+underlies+the+cell+stage-specific+mechanism+of+MOR+gene+expression. assertion.
- assertion asSentence Morphine+activation+of+Mu+opioid+receptors+RGS14+prevents+G-protein-coupled+receptor+kinases+from+phosphorylating+those+residues+required+for+receptor+endocytosis. assertion.
- assertion asSentence PARP-1+can+function+as+a+repressor+of+mu+opioid+receptor+%28MOR%29+transcription+dependent+on+the+MOR+poly%28C%29+sequence. assertion.
- assertion asSentence The+mu+opioid+receptor+is+not+involved+in+ethanol-stimulated+dopamine+release+in+the+ventral+striatum+of+C57BL%2F6J+mice. assertion.
- assertion asSentence Expression+of+Sqstm1+in+the+mouse+striatum+is+modulated+by+a+sequence+variant+%28B2+SINE+indel%29+in+the+3%27+UTR+of+Comt+%28catechol-O-methyltransferase%29. assertion.
- assertion asSentence Mitochondria+are+aggregated+by+p62%2C+following+its+recruitment+by+Parkin+in+a+VDAC1-independent+manner. assertion.
- assertion asSentence p62+localizes+to+the+endoplasmic+reticulum+%28ER%29-associated+autophagosome+formation+site+independently+of+LC3+localization+to+membranes. assertion.
- assertion asSentence Loss+of+oncostatin+M+is+associated+with+chondrosarcoma. assertion.
- assertion asSentence Claudin+11+tight+junctions+improve+the+resistive+properties+of+myelin+sheaths+for+small+axons+in+the+central+nervous+system. assertion.
- assertion asSentence Coordination+of+signaling+molecules+that+specify+different+neuronal+cell+type+control+is+effective+for+conferring+proper+cell+identity+in+the+floor-plate+region+of+midbrain+and+does+not+require+Otx2+protein+expression. assertion.
- assertion asSentence In+vertebrates%2C+the+Otx2+promoter+acquires+multiple%2C+spatiotemporally+specific+cis-regulators+in+order+to+precisely+control+highly+coordinated+processes+in+head+development. assertion.
- assertion asSentence Otx2+is+involved+in+the+molecular+mechanism+by+which+identity+and+fate+of+glutamatergic+precursors+are+established+in+the+thalamus. assertion.
- assertion asSentence Wnt%2Fbeta-catenin+signaling+is+required+for+differentiation+of+the+retinal+pigment+epithelium+by+directly+regulating+the+expression+of+Mitf+and+Otx2. assertion.
- assertion asSentence Oxytocin+plays+a+role+in+the+regulation+of+blood+pressure+and+salt+appetite. assertion.
- assertion asSentence An+investigation+of+various+behaviours%2C+most+notably+social+recognition%2C+in+both+oxytocin+receptor+containing+and+oxytoxin+receptor+knockout+mice. assertion.
- assertion asSentence Inflammatory+cytokines+modulate+the+expression+of+functional+oxytocin+receptors+in+airway+smooth+muscle. assertion.
- assertion asSentence The+activity+of+P2X2%2F3+receptors+in+nodose+ganglion+neurons+is+involved+in+the+transmission+of+myocardial+ischemic+nociceptive+signal. assertion.
- assertion asSentence An+allelic+polymorphism+%28P451L%29+in+the+predicted+death+domain+of+P2X7R+confers+a+drastically+reduced+sensitivity+to+ATP-induced+pore+formation+in+cells+from+some+commonly+used+strains+of+mice%2C+i.e.%2C+C57BL%2F6+and+DBA%2F2. assertion.
- assertion asSentence P2X7+is+a+good+candidate+susceptibility+gene+for+diabetes+in+NOD+mice. assertion.
- assertion asSentence Microglia+from+P2X%287%29+receptor-deficient+mice+failed+to+exhibit+neuronal+cell+injury+in+the+presence+of+BzATP. assertion.
- assertion asSentence There+is+an+interaction+between+P2X7+protein+and+Caveolin-1+in+lipid+rafts. assertion.
- assertion asSentence ROS-mediated+activation+of+the+ASK1-p38+MAPK+pathway+downstream+of+P2X%287%29+receptor+is+required+for+ATP-induced+apoptosis+in+macrophages. assertion.
- assertion asSentence T+cells+from+one+gene-deficient+strain+unexpectedly+exhibit+higher+levels+of+P2X%287%29+activity+than+that+found+in+cells+from+control%2C+unmanipulated+C57BL%2F6+mice. assertion.
- assertion asSentence ATP+increases+chemokine+CXCL2+production+via+both+NFAT+transcription+factor+and+protein+kinase+C%2FMAP+kinase+signaling+pathways+by+purinergic+receptor+P2X7+stimulation+in+microglia. assertion.
- assertion asSentence ATP+released+from+BLM-injured+lung+cells+constitutes+a+major+endogenous+danger+signal+that+engages+the+P2X%287%29+receptor%2Fpannexin-1+axis%2C+leading+to+IL-1beta+maturation+and+lung+fibrosis. assertion.
- assertion asSentence Extracellular+NAD%2B+shapes+the+Foxp3%2B+regulatory+T+cell+compartment+through+the+ART2-P2X7+pathway. assertion.
- assertion asSentence Per1+mRNA+expression+in+a+manner+sensitive+to+P2X7+purinergic+receptor+antagonists+in+cultured+microglia+exposed+to+ATP. assertion.
- assertion asSentence A+key+role+for+the+P2X7+receptor+as+an+essential+pro-survival+signal+required+for+optimal+ES+cell+colony+growth+in+the+presence+of+leukemia+inhibitor+factor+%28LIF%29. assertion.
- assertion asSentence Co-expression+of+P2X4+receptor+with+P2X7+receptor+enhances+P2X7-mediated+inflammation+through+both+facilitation+of+release+of+cytokines+and+suppression+of+autophagy. assertion.
- assertion asSentence Induction+of+the+osmolyte+permeability+in+Plasmodium-infected+erythrocytes+involves+autocrine+purinoceptor+signaling. assertion.
- assertion asSentence P2Y+receptors+mediate+Ca2%2B+signaling+in+duodenocytes+and+contribute+to+duodenal+mucosal+bicarbonate+secretion. assertion.
- assertion asSentence Heterologous+down-regulation+of+angiotensin+type+1+receptors+by+purinergic+P2Y2+receptor+stimulation+through+S-nitrosylation+of+NF-kappaB. assertion.
- assertion asSentence Real-time+imaging+reveals+that+P2Y2+and+P2Y12+receptor+agonists+are+not+chemoattractants+and+macrophage+chemotaxis+to+complement+C5a+is+phosphatidylinositol+3-kinase+%28PI3K%29-+and+p38+mitogen-activated+protein+kinase+%28MAPK%29-independent. assertion.
- assertion asSentence Dynein+and+its+regulators+dynactin+and+LIS1+localize+to+the+leading+cell+cortex+during+wound+healing. assertion.
- assertion asSentence Lis1+is+essential+for+cortical+microtubule+organization+and+desmosome+stability+in+the+epidermis. assertion.
- assertion asSentence A+VAV1-Rac1-PAK1+signaling+axis+in+mononuclear+phagocytes+regulating+superoxide+production+in+a+stimulus-dependent+manner. assertion.
- assertion asSentence PAK3+regulates+dendritic+spines+morphogenesis. assertion.
- assertion asSentence PAPP-A+acts+as+a+potent+anabolic+factor+in+the+regulation+of+bone+formation. assertion.
- assertion asSentence PAPP-A-deficient+mice+are+resistant+to+neointimal+formation+after+injury. assertion.
- assertion asSentence PAPPA+modulates+ovarian+function+and+female+fertility+by+controlling+the+bioavailability+of+ovarian+insulin-like+growth+factors. assertion.
- assertion asSentence Major+contributors+to+extended+life+span+of+PAPP-A+knockout+mice+are+delayed+occurrence+of+fatal+neoplasias+and+decreased+incidence+of+age-related+degenerative+changes. assertion.
- assertion asSentence Pax-2%2FRB+binding+reverses+repression+of+Rig-1+protein. assertion.
- assertion asSentence Decreasing+the+levels+of+Pax3%2FPax7+RNA+leads+to+a+marked+and+selective+decrease+in+Myf5%2C+MyoD+and+Desmin+expression. assertion.
- assertion asSentence The+miRNA-mediated+down-regulation+of+Pax3+by+MyoD+regulates+terminal+differentiation+in+muscle+cells. assertion.
- assertion asSentence Pax3+promotes+the+activation+of+myogenesis+in+blood+vessel-derived+cells. assertion.
- assertion asSentence Melanocyte+migration+and+proliferation+are+controlled+both+through+the+regulation+of+Pax3+by+nonphosphorylated+Brn2+and+through+the+regulation+of+MITF-M+by+the+overall+BRN2+level. assertion.
- assertion asSentence APE%2FRef-1+mediated+CD40+activation+of+PAX5+and+EBF. assertion.
- assertion asSentence A+molecular+basis+for+the+hierarchical+dependence+of+Pax5+function+on+EBF+and+E2A+in+B+lymphocyte+development. assertion.
- assertion asSentence The+dramatic+early+loss+of+trabecular+bone%2C+coupled+with+the+marked+increase+in+functional+osteoclasts+seen+in+Pax5-deficient+mice%2C+demonstrates+a+key+role+for+Pax5+in+the+control+of+normal+osteoclast+development. assertion.
- assertion asSentence Pax6+regulates+delta-catenin+expression+during+central+nervous+system+development+in+mice. assertion.
- assertion asSentence Pax6+is+required+for+differentiation+and%2For+maintenance+of+external+plexiform+layer+interneurons+in+the+adult+mouse+olfactory+bulb. assertion.
- assertion asSentence Pax6+mutant+mice+have+reduced+numbers+of+basal+progenitor+cells+in+the+ventral+part+of+the+thalamus. assertion.
- assertion asSentence In+the+retinal+pigment+epithelium%28RPE%29+%2C+PAX6+cooperates+with+either+one+%28or+both%29+of+two+related+RPE+transcription+factors%2C+MITF+and+TFEC%2C+to+suppress+extracellular+signals+that+in+the+normal+retina+induce+a+signaling+cascade+promoting+retina+formation. assertion.
- assertion asSentence Direct+functional+role+played+by+Pax7+during+embryonic+development. assertion.
- assertion asSentence Pax1+and+Pax9+can+transactivate+regulatory+sequences+in+the+Bapx1+promoter+to+induce+chondrogenic+differentiation+in+the+sclerotome. assertion.