Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Bisecting+GlcNAc+residues+on+laminin-332+down-regulate+galectin-3-dependent+keratinocyte+motility. assertion.
- assertion asSentence STMN1+knockdown+in+AGS+and+MKN7+cell+lines+suppressed+proliferation+%28p%3C0.001%29%2C+reduced+monolayer+colony+formation+%28p%3C0.001%29%2C+inhibited+cell+invasion+and+migration+ability+%28p%3C0.001%29+and+induced+G1+phase+arrest. assertion.
- assertion asSentence Dual+role+of+LBP+and+CD14+in+initiation+of+proinflammatory+signaling+and+clearance+or+neutralization+of+LPS. assertion.
- assertion asSentence Mutations+in+the+gene+encoding+the+lamin+B+receptor+produce+an+altered+nuclear+morphology+in+granulocytes+%28Pelger-Huet+anomaly%29. assertion.
- assertion asSentence Familial+lecithin%3Acholesterol+acyltransferase+%28LCAT%29+deficiency%2C+arising+from+mutation%2C+is+associated+with+complete+absence+of+Lecithin%3Acholesterol+acyltransferase+%28LCAT%29+activity. assertion.
- assertion asSentence HbA1c+provides+an+easy-to-assess%2C+accurate+measure+of+LCAT+activity+in+type+2+diabetes. assertion.
- assertion asSentence Glucocorticoids+causes+dissociation+of+T-cell+receptor+associated+protein+complex+containing+LCK+and+FYN. assertion.
- assertion asSentence Suppressor+of+cytokine+signaling+1+interacts+with+oncogenic+lymphocyte-specific+protein+tyrosine+kinase. assertion.
- assertion asSentence Lipocalin+2+has+at+least+two+functions+related+to+tumorigenesis%2C+one+involving+apoptosis+induction+of+normal+hematopoietic+cells+and+the+other+being+tissue+invasion+by+leukemia+cells. assertion.
- assertion asSentence Neutrophil+gelatinase-associated+lipocalin+%28NGAL%29+represents+a+novel%2C+sensitive+marker+of+kidney+function+in+adult+patients+with+chronic+heart+failure+and+normal+serum+creatinine. assertion.
- assertion asSentence NGAL+is+a+potent+inducer+of+heme+oxygenase-1+and+somewhat+superoxide+dismutase-1+and+superoxide+dismutase-2. assertion.
- assertion asSentence Maternal+lipocalin-2+concentrations+are+significantly+increased+in+preeclampsia. assertion.
- assertion asSentence Both+IL-1beta+and+TNF-alpha+regulate+NGAL+expression+in+polymorphonuclear+granulocytes+of+chronic+hemodialysis+patients. assertion.
- assertion asSentence The+unfolded+protein+response+activates+Lcn2+production+in+human+prostate+cancer+cells+in+an+NF-kappaB-dependent+manner. assertion.
- assertion asSentence LAT+recruits+Src+homology+2+domain-containing+leukocyte+76+kDa+protein+%28SLP-76%29+following+T-cell+receptor+ligation+and+membrane+translocation+of+Akt+and+phosphatidylinositol+3-kinase+%28PI3K%29phosphorylation+in+Jurkat+cells%2C+activating+Akt+signaling. assertion.
- assertion asSentence Combining+regulated+deletion+of+endogenous+SLP-76+with+transgenic+expression+of+a+SLP-76+SH2+domain+mutant+demonstrates+that+the+SLP-76+SH2+domain+is+required+for+peripheral+T+cell+activation+and+positive+selection+of+thymocytes. assertion.
- assertion asSentence Complementary+phosphorylation+sites+in+the+adaptor+protein+SLP-76+promote+synergistic+activation+of+natural+killer+cells. assertion.
- assertion asSentence The+importance+of+allele+drop-out+in+LDLR+genotyping. assertion.
- assertion asSentence Overexpression+of+peroxisome+proliferator+activated+receptor+gamma+coactivator-1alpha+in+HepG2+cells+represses+the+gene+expression+of+LDL+receptor+and+does+not+affect+the+estrogen+receptor+alpha+-induced+LDL+receptor+expression. assertion.
- assertion asSentence Polymorphism+of+LDLR+changes+the+ratio+of+serum+lipids+in+people+on+a+high-carbohydrate%2Flow-fat+diet. assertion.
- assertion asSentence Strong+associations+between+cord+leptin+levels+and+other+measures+of+fetal+growth+in+both+groups+and+with+glycemic+control+in+diabetic+group. assertion.
- assertion asSentence Administrastion+of+leptin+drops+body+mass+index+from+51.2+%2B%2F-+2.5+%28mean+%2B%2F-+SEM%29+at+baseline+to+26.9+%2B%2F-+2.1+kg%2Fm2+after+18+months+in+obese+adults. assertion.
- assertion asSentence Interaction+between+the+LEP+A19G+and+LEPR+K109R+polymorphisms+on+the+change+in+fasting+insulin. assertion.
- assertion asSentence Ghrelin+and+leptin+control+immune+cell+activation+and+inflammation. assertion.
- assertion asSentence Gln223Arg+polymorphism+of+LEPR+in+Mexican+adolescents+is+associated+with+haemodynamic+and+metabolic+disturbances+related+to+obesity. assertion.
- assertion asSentence Gut+leptin+is+a+major+regulator+of+rapid+intestinal+glucose+transport. assertion.
- assertion asSentence Infliximab+increases+leptinemia+in+Crohn+disesase. assertion.
- assertion asSentence Circulating+leukocytes+contribute+to+the+development+and+progression+of+nephropathy%2C+partially+through+the+effects+of+leptin%2C+in+patients+with+type+2+diabetes. assertion.
- assertion asSentence Leptin+is+an+independent+factor+that+is+associated+with+C-reactive+protein+in+Japanese+type+2+diabetic+patients. assertion.
- assertion asSentence Anorexia+nervosa+is+associated+with+decreased+plasma+leptin+levels. assertion.
- assertion asSentence Allelic+variants+are+specifically+associated+with+distinctly+different+eating+patterns%2C+namely+extreme+snacking+behavior+or+excessive+portion+size. assertion.
- assertion asSentence Serum+leptin+and+adiponectin+are+positively+associated+with+bone+mineral+density+at+the+distal+radius+in+patients+with+type+2+diabetes+mellitus. assertion.
- assertion asSentence Leptin+repllacement+in+a+case+of+a+missense+mutation+is+able+to+alleviate+obesity+and+cognition+disorders. assertion.
- assertion asSentence Measured+serum+leptin+levels+in+prostate+cancer+patients. assertion.
- assertion asSentence Leptin+gene+polymorphism+is+associated+with+breast+cancer. assertion.
- assertion asSentence Leptin+acts+through+the+MAPK+pathway+to+downregulate+cAMP-induced+StAR+protein+expression+and+progesterone+production+in+immortalized+human+granulosa+cells. assertion.
- assertion asSentence In+hyperglycemic+leptin-deficient+Lep%28ob%2Fob%29+transgenic+mice%2C+leptin+acutely+and+potently+improves+glucose+metabolism%2C+before+any+change+of+body+fat+mass%2C+via+a+mechanism+involving+the+p110alpha+and+-beta+isoforms+of+phosphatidylinositol-3-kinase. assertion.
- assertion asSentence The+A19G+LEP+polymorphism+is+associated+with+colorectal+cancer+in+Mexican+patients. assertion.
- assertion asSentence Serum+leptin+levels+are+correlated+with+cardiovascular+disease+risk+and+metabolic+syndrome+in+Taiwanese+adults. assertion.
- assertion asSentence A+human+liver+cell+line+expresses+the+leptin+receptor+long+form+Ob-Rb+in+sufficient+quantity+to+respond+to+leptin+signalling+in+terms+of+STAT+activation. assertion.
- assertion asSentence LEPR+single+nucleotide+polymorphisms+contribute+to+variation+in+obesity+phenotypes. assertion.
- assertion asSentence The+leptin+receptor+with+the+conserved+Y985+and+Y1077+motifs+in+the+cytosolic+domain+is+binding+of+CIS+%28cytokine-inducible+SH2+protein%29. assertion.
- assertion asSentence Leptin+increases+the+expression+of+several+cytokines+in+normal+and+tumoral+colonocytes+by+targeting+leptin+receptor. assertion.
- assertion asSentence LEPR+SNP+polymorphisms+associated+with+the+development+of+HELLP+syndrome. assertion.
- assertion asSentence G3057A+LEPR+polymorphism+is+associated+with+obesity+in+Tunisian+women. assertion.
- assertion asSentence Leptin+receptor+with+genotype+Arg%2FArg+mostly+reduced+their+BMI+during+8+weeks+of+training+intervention%2C+compared+to+carriers+of+the+Gln+allele. assertion.
- assertion asSentence Human+septic+patients+have+increased+circulating+recombinant+soluble+leptin+receptor+concentrations+which+are+correlated+with+disease+severity+indices. assertion.
- assertion asSentence High+circulating+levels+of+leptin+receptor+occur+in+patients+with+advanced+stage+of+colon+cancer. assertion.
- assertion asSentence The+phenotype+of+individuals+with+OB-R+deficiency+and+postulates+the+effects+of+auxilin-1+deficiency+%28mental+retardation%2Fepilepsy%29+and+endospanin-1+deficiency+%28OB-R+specific+functions%29+in+humans. assertion.
- assertion asSentence LETM1+suppressed+lung+cancer+cell+growth+in+vitro+and+in+vivo. assertion.
- assertion asSentence Galectin-1-induced+cell+death+proceeds+via+a+caspase-independent+pathway+that+involves+a+unique+pattern+of+mitochondrial+events. assertion.
- assertion asSentence Internalization+of+Gal-1+depends+on+its+lectin+activity+and+follows+dual+pathways+involving+clathrin-coated+vesicles+and+raft-dependent+endocytosis. assertion.
- assertion asSentence Gal-1+induces+phosphatidylserine+exposure+and+subsequent+phagocytic+removal+of+living+cells. assertion.
- assertion asSentence Increased+expression+of+galectin-1+is+associated+with+human+oral+squamous+cell+carcinoma+development. assertion.
- assertion asSentence The+regulatory+effect+of+galectin-1+is+mediated+in+part+through+its+ability+to+induce%2C+in+an+inhibitor+of+DNA+binding+3+%28Id3%29-dependent+manner%2C+the+expression+of+IL-10+in+monocytes+and+monocyte-derived+dendritic+cells+of+lung+cancer+patients. assertion.
- assertion asSentence Lung+cancer-derived+galectin-1+enhances+tumorigenic+potentiation+of+tumor-associated+dendritic+cells+by+expressing+heparin-binding+EGF-like+growth+factor. assertion.
- assertion asSentence Finally%2C+exogenous+addition+of+galectin-3+into+HUVECs+induced+angiogenesis+in+an+APN-dependent+manner. assertion.
- assertion asSentence DX-52-1+and+HUK-921+inhibit+a+carbohydrate+binding-independent+function+of+galectin-3+that+is+involved+in+cell+migration. assertion.
- assertion asSentence HSV-1+infection+increased+galectin-3+binding+to+carbohydrate+residues+on+IgG. assertion.
- assertion asSentence Gal-3+promotes+epithelial+cell+migration+by+cross-linking+MGAT5-modified+complex+N-glycans+on+alpha3beta1+integrin. assertion.
- assertion asSentence High+expression+of+Galectin-3+is+closely+related+to+the+development+of+thyroid+papillary+carcinoma. assertion.
- assertion asSentence Wild-type+K-Ras.GTP+in+association+with+Gal-3+contributes+to+thyroid+carcinoma+malignancy. assertion.
- assertion asSentence The+diagnostic+power+of+galectin-3+in+distinguishing+between+benign+and+malignant+melanocytic+lesions+relies+on+the+pattern+and+the+intensity+of+its+expression. assertion.
- assertion asSentence Galectin-3+facilitates+cell+motility+in+gastric+cancer+by+up-regulating+protease-activated+receptor-1+%28PAR-1%29+and+matrix+metalloproteinase-1+%28MMP-1%29. assertion.
- assertion asSentence NGF+induces+Mac-2BP+expression+via+the+PI3K%2FAkt%2FNF-kappaB+pathway. assertion.
- assertion asSentence Galectin-8+up-regulation+is+associated+with+hypopharyngeal+and+laryngeal+tumor+progression. assertion.
- assertion asSentence Nasopharyngeal+carcinoma+cells+can+release+HLA+class-II+positive+exosomes+containing+galectin+9+and%2For+LMP1. assertion.
- assertion asSentence The+crystal+structure+of+the+human+galectin-9+N-terminal+carbohydrate+recognition+domain+in+complex+with+N-acetyllactosamine+dimers+and+trimers. assertion.
- assertion asSentence In+Ishikawa+cells+LH%2FhCG+does+not+utilize+its+conventional+receptor. assertion.
- assertion asSentence Cultured+human+early+pregnancy+placental+explants+also+released+LHCGR+via+microvesicles. assertion.
- assertion asSentence Role+for+LIF+in+loss+of+autocrine+prolactin+suppression+contributing+to+unrestrained+prolactinomas+prolactin+secretion. assertion.
- assertion asSentence hCG-mediated+LIF+expression+in+the+endometrium+is+dependent+on+prior+induction+of+PROK1. assertion.
- assertion asSentence LIF+protein+is+expressed+in+Alzheimer%27s+and+Parkinson+diseases. assertion.
- assertion asSentence The+cytokine+LIF+promotes+trafficking+of+T-type+calcium+channel+subunits+in+human+HEK293+cells+via+transient+activation+of+JAK-+and+ERK-kinase+signaling+pathways. assertion.
- assertion asSentence Down+regulation+of+Leukemia+inhibitory+factor+receptor+is+associated+with+hepatocellular+carcinoma. assertion.
- assertion asSentence LIG1-deficiency+reduces+recombinational+repair+of+DNA+double-strand+beaks. assertion.
- assertion asSentence In+response+to+DNA+damage%2C+DNA+ligase+IIIalpha+translocate+from+centrosomes+to+chromosomes. assertion.
- assertion asSentence The+alpha2+helix+in+the+Lig4+BRCT-1+domain+is+required+for+adenovirus-mediated+degradation+of+Lig4. assertion.
- assertion asSentence The+p57%28Kip2%29+control+of+LIMK-1+ultimately+affects+cell+mobility+negatively. assertion.
- assertion asSentence LIMK1+mediates+both+the+mesenchymal+and+amoeboid+modes+of+invasion+of+HT1080+cells. assertion.
- assertion asSentence The+LIPC+promoter+-514+C-T+polymorphism+is+associated+with+a+significantly+reduced+development+of+neointima+after+surgery. assertion.
- assertion asSentence Association+of+the+LIPC+polymorphism+with+CHD+risk+among+US+diabetic+men. assertion.
- assertion asSentence Glucose+increases+HL+expression+in+HepG2+cells+via+elevation+of+USF1+and+USF2. assertion.
- assertion asSentence SREBP-1+is+involved+in+the+early+regulation+of+delta5+desaturase+gene+by+simvastatin%2C+in+THP-1+cells. assertion.
- assertion asSentence ERGIC-53+bound+high-mannose-type+oligosaccharides+with+low+affinity+and+broad+specificity%2C+not+discriminating+between+monoglucosylated+and+deglucosylated+high-mannosetype+oligosaccharides. assertion.
- assertion asSentence A+population+of+cultured+skin+fibroblasts+from+lipodystrophic+patients+with+heterozygous+R482Q%2FW+mutations+in+the+lamin+A%2FC+gene+present+dysmorphic+nuclei+or+a+disorganization+of+the+nuclear+lamina%2C+or+both. assertion.
- assertion asSentence Mutations+in+LMNA+cause+a+severe+and+progressive+dilated+cardiomyopathy+in+a+relevant+proportion+of+patients. assertion.
- assertion asSentence Missense+mutation+in+peripheral+nerve+disease+in+an+individual. assertion.
- assertion asSentence The+most+frequently+encountered+mutations+associated+with+Dilated+Cardiomiopathy+are+found+in+LMNA%2C+coding+for+lamins+A+and+C%2C+intermediate+filament+proteins. assertion.
- assertion asSentence Founder+effect+and+estimation+of+the+age+of+the+c.892C%3ET+%28p.Arg298Cys%29+mutation+in+LMNA+associated+to+Charcot-Marie-Tooth+subtype+CMT2B1+in+families+from+North+Western+Africa. assertion.
- assertion asSentence Atypical+Werner%27s+syndrome+with+the+severe+metabolic+complications%2C+the+extent+of+the+lipodystrophy+is+associated+with+A133L+mutation+in+the+LMNA+gene+and+these+patients+present+with+phenotypically+heterogeneous+disorders. assertion.
- assertion asSentence Low+lamin+A%2FC+expression+in+SC+adipose+tissue+is+associated+with+significant+alterations+in+the+lipid+profile+and+increased+fat+cell+lipolysis%2C+independent+of+the+level+of+total+or+abdominal+adiposity. assertion.
- assertion asSentence R25G+mutation+in+exon+1+of+LMNA+gene+is+associated+with+dilated+cardiomyopathy+and+limb-girdle+muscular+dystrophy+1B. assertion.
- assertion asSentence Cardiac+involvement+represents+a+very+common+phenotypic+expression+of+LMNA+gene+mutation. assertion.
- assertion asSentence 60%25+of+transgenic+mice+that+overexpressed+both+OLIG2+and+LMO1+developed+pre-T+lymphoblastic+lymphoma%2Fleukemia+with+large+thymic+tumor+masses. assertion.
- assertion asSentence LMO2-C+can+bind+endogenous+GATA1+and+LDB1+protein+in+K562+cells+and+downregulate+the+expression+of+hematopoietic+specific+gene+glycoprotein. assertion.
- assertion asSentence LMO2+is+regulated+at+both+a+posttranscriptional+and+post-translational+level+in+erythroid+progenitors+during+erythropoiesis. assertion.
- assertion asSentence LMO2+protein+expression+is+correlated+with+improved+hematologic+remission+and+overall+survival+in+the+CML+patients+treated+with+IM. assertion.
- assertion asSentence Loss+or+reduction+of+LOX+function+during+tumor+development+is+a+direct+consequence+of+somatic+mutations+and+associated+with+colon+tumor+pathogenesis. assertion.
- assertion asSentence The+lysyl+oxidase+pro-peptide+attenuates+fibronectin-mediated+activation+of+focal+adhesion+kinase+and+p130Cas+in+breast+cancer+cells. assertion.