Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _3 value "Modified assertion" provenance.
- _4 value "TNF-alpha induced a transient increase in secretion of sPLA2-IIA lasting 4 hours. After 24 hours incubation, the levels of TNF-alpha induced sPLA2-IIA was lower than in control cells." provenance.
- _3 value "The skeletal muscle sarco(endo)plasmic reticulum calcium ATPase (SERCA1) gene is transactivated as early as 2 days after the removal of weight-bearing (Peters, D. G., Mitchell-Felton, H., and Kandarian, S. C. (1999) Am. J. Physiol. 276, C1218-C1225), but the transcriptional mechanisms are elusive." provenance.
- _4 value "However, transfected cells that overexpress TIEG mRNA and protein (TIEG-6 and TIEG-7) display changes that mimic those of MG-63 cells treated with TGF-beta, i.e. increased alkaline phosphatase activity, decreased levels of osteocalcin mRNA and protein, and decreased cell proliferation" provenance.
- _5 value "Exogenous/ectopic expression studies with GRIP-1 sense and antisense vectors in myogenic C2C12 cells demonstrated that this SRC is necessary for (1) induction/activation of myogenin, MEF-2, and the crucial cell cycle regulator, p21, and (2) contractile protein expression and myotube formation. Furthermore, we demonstrate that the SRC GRIP-1 coactivates MEF-2C-mediated transcription. GRIP-1 also coactivates the synergistic transactivation of E box-dependent transcription by myogenin and MEF-2C." provenance.
- _5 value "title := \"The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C-dependent gene expression and skeletal muscle differentiation.\"" provenance.
- _6 value "Expression of active PTPH1 also reduced receptor-induced activation of Erk2 MAP kinase, its upstream activator, Mek, and the Jnk kinases." provenance.
- _6 value "Expression of active PTPH1 also reduced receptor-induced activation of Erk2 MAP kinase, its upstream activator, Mek, and the Jnk kinases." provenance.
- _4 value "SOCS3 inhibits insulin activation of Stat5B without modifying the insulin receptor tyrosine kinase activity" provenance.
- _4 value "Using transfection of COS-7 cells, we show that insulin induction of SOCS-3 is enhanced upon Stat5B expression. Moreover, Stat5B from insulin-stimulated cells binds directly to a Stat element present in the SOCS-3 promoter." provenance.
- _5 value "insulin induction of SOCS3 is enhanced upon Stat5B expression" provenance.
- _6 value "this negative regulation likely results from competition between SOCS3 and Stat5B binding to the same insulin receptor motif SOCS3 binds to the insulin receptor at phosphotyrosine 960, which is precisely where Stat5B binds" provenance.
- _5 value "the major tyrosine phosphorylation sites of Cbl by Abl are localized at tyrosine 700 and 774" provenance.
- _5 value "Taken together, these data suggest that the mechanism by which SOCS-3 inhibits the gp130 signaling pathway depends on recruitment to the phosphorylated gp130 receptor, " provenance.
- _2 value "Cells treated with hydrogen peroxide, EGTA or BAPTA-AM, to remove calcium did not stimulate conversion of p35 to p25 following hydrogen peroxide treatment." provenance.
- _3 value "accumulation of both LDL receptor and CLA-1 mRNAs was upregulated by ACTH in a dose- and time-dependent manner, with an earlier induction of LDL receptor than CLA-1 mRNA expression. (Bu)(2)cAMP also increased the levels of these two mRNAs." provenance.
- _3 value "accumulation of both LDL receptor and CLA-1 mRNAs was upregulated by ACTH in a dose- and time-dependent manner, with an earlier induction of LDL receptor than CLA-1 mRNA expression. (Bu)(2)cAMP also increased the levels of these two mRNAs." provenance.
- _5 value "Inhibition of MEK reduced the activated and basal expression of claudin-2 messenger RNA and protein expression" provenance.
- _3 value "Here we show that coincubation of SMC with macrophages or oxidized low density lipoproteins (LDL) from macrophage-conditioned medium activates these same regulatory pathways and stimulates SR-A expression" provenance.
- _5 value "Heterologous expression of PSD-95 enhanced NRG activation of ErbB4 and MAP kinase." provenance.
- _4 value "We report that SF2/ASF levels were substantially increased in the lower uterine region, and this was associated with a parallel decrease in levels of hnRNP A1/A1B during gestation." provenance.
- _4 value "Cyclin D2 and Cyclin D3 protein levels increased slightly in the first 24 hours after Erythropoietin (Epo)+/Stem cell factor (Scf)- stimulation but declined sharply after 48 hours." provenance.
- _4 value "CD40L induces FL expression." provenance.
- _5 value "HKa blocked the adhesion of Mac-1 transfected cells to fibrinogen and ICAM-1 in a dose-dependent manner." provenance.
- _4 value "Modified assertion" provenance.
- _5 value "# Ariadne: We have previously shown that BMK1 regulates c- jun gene expression through direct phosphorylation and activation of transcription factor MEF2C. [Regulation]" provenance.
- _5 value "Here, we demonstrate that, in addition to MEF2C, BMK1 phosphorylates and activates MEF2A and MEF2D but not MEF2B. The blocking of BMK1 signaling inhibits the epidermal growth factor-dependent activation of these three MEF2 transcription factors. The sites phosphorylated by activated BMK1 were mapped to Ser-355, Thr-312, and Thr-319 of MEF2A and Ser-179 of MEF2D both in vitro and in vivo." provenance.
- _5 value "We found that the NF1/X and NF1/Red1 isoforms strongly suppressed HGF promoter activity" provenance.
- _3 value "Here we demonstrate that galectin-8, a secreted mammalian (beta)-galactoside binding protein, inhibits adhesion of human carcinoma (1299) cells to plates coated with integrin ligands, and induces cell apoptosis" provenance.
- _5 value "Although found predominantly in the cytoplasm and, less abundantly, in the nucleus, VCP can be translocated from the nucleus after stimulation with epidermal growth factor." provenance.
- _5 value "In vitro, PKC directly phosphorylated platelet syntaxin 4 and recombinant syntaxin 4. PKC phosphorylation in vitro inhibited (71 +/- 8%) the binding of syntaxin 4 to SNAP-23." provenance.
- _6 value "(DN) mutant for Pyk2 (PKM) completely blocked JNK activation by Ang II" provenance.
- _6 value "DN mutants of Rac1 (DN-Rac1) and MEK kinase (DN-MEKK1) also abolished it" provenance.
- _5 value "This study provides evidence that cAMP and protein kinase A are important regulators of CD14 expression in macrophages." provenance.
- _4 value "Enforced expression of mSPP1 in NIH 3T3 fibroblasts not only decreased SPP and enhanced ceramide levels, it also markedly diminished survival and induced the characteristic traits of apoptosis." provenance.
- _3 value "RTP, also called Drg1/Cap43/rit42/TDD5/Ndr1, was originally identified as a homocysteine-responsive gene product," provenance.
- _3 value "native and oxidized LDL significantly increased IGF-1-binding protein-2 and IGF-1-binding protein-4 expression" provenance.
- _3 value "oxidized LDL significantly reduced IGF-1 and IGF-1R mRNA by 80 and 61%, respectively, and reduced IGF-1 and IGF-1R protein expression by 63 and 46%." provenance.
- _3 value "oxidized LDL significantly reduced IGF-1 and IGF-1R mRNA by 80 and 61%, respectively, and reduced IGF-1 and IGF-1R protein expression by 63 and 46%." provenance.
- _4 value "In cancer cells, stable transfection of RARbeta exhibited strong inhibition of AP-1 activity" provenance.
- _7 value "all three RAR subtypes, RARalpha, RARbeta, and RARgamma, could effectively inhibit phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity and the activity of oncogenes c-Jun and c-Fos on AP-1 containing reporter genes in the presence of retinoic acid (RA)" provenance.
- _4 value "The addition of all-trans retinoic acid (ATRA) in combination with basic fibroblast growth factor (bFGF) to human fibroblasts results in a synergistic induction of tissue inhibitor of metalloproteinases-1 (TIMP-1) protein production...An incubation of 10 min to 12 h with bFGF alone followed by ATRA gave a similar synergistic induction of TIMP-1 protein to that seen with both agents together. Treatment of cells with ATRA first followed by bFGF was ineffective." provenance.
- _4 value "TNF induces CCL11 in dermal fibroblasts " provenance.
- _3 value "jubilant" provenance.
- _6 value "One site, Ser(364), is conserved with c-Raf but two additional sites, Ser(428) and Thr(439), are unique to B-Raf." provenance.
- _5 value "One site, Ser(364), is conserved with c-Raf but two additional sites, Ser(428) and Thr(439), are unique to B-Raf." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "Using the appropriate 'kinase inactive' mutant receptors, we show that ligand-induced activation of Met results in transphosphorylation of Ron, and vice versa. Transphosphorylation is direct, as it occurs in Met or Ron receptors lacking the docking sites for signal transducers. Phosphate groups are transferred to the tyrosine phosphorylation sites responsible both for kinase up-regulation (Met: Y1234/Y1235 and Ron: Y1238/Y1239) and for generation of signal transducer docking sites (Met: Y1349/Y1356 and Ron Y1353/Y1360). " provenance.
- _5 value "Using the appropriate 'kinase inactive' mutant receptors, we show that ligand-induced activation of Met results in transphosphorylation of Ron, and vice versa. Transphosphorylation is direct, as it occurs in Met or Ron receptors lacking the docking sites for signal transducers. Phosphate groups are transferred to the tyrosine phosphorylation sites responsible both for kinase up-regulation (Met: Y1234/Y1235 and Ron: Y1238/Y1239) and for generation of signal transducer docking sites (Met: Y1349/Y1356 and Ron Y1353/Y1360). " provenance.
- _5 value "Using the appropriate 'kinase inactive' mutant receptors, we show that ligand-induced activation of Met results in transphosphorylation of Ron, and vice versa. Transphosphorylation is direct, as it occurs in Met or Ron receptors lacking the docking sites for signal transducers. Phosphate groups are transferred to the tyrosine phosphorylation sites responsible both for kinase up-regulation (Met: Y1234/Y1235 and Ron: Y1238/Y1239) and for generation of signal transducer docking sites (Met: Y1349/Y1356 and Ron Y1353/Y1360). " provenance.
- _5 value "Using the appropriate 'kinase inactive' mutant receptors, we show that ligand-induced activation of Met results in transphosphorylation of Ron, and vice versa. Transphosphorylation is direct, as it occurs in Met or Ron receptors lacking the docking sites for signal transducers. Phosphate groups are transferred to the tyrosine phosphorylation sites responsible both for kinase up-regulation (Met: Y1234/Y1235 and Ron: Y1238/Y1239) and for generation of signal transducer docking sites (Met: Y1349/Y1356 and Ron Y1353/Y1360). " provenance.
- _5 value "Using the appropriate 'kinase inactive' mutant receptors, we show that ligand-induced activation of Met results in transphosphorylation of Ron, and vice versa. Transphosphorylation is direct, as it occurs in Met or Ron receptors lacking the docking sites for signal transducers. Phosphate groups are transferred to the tyrosine phosphorylation sites responsible both for kinase up-regulation (Met: Y1234/Y1235 and Ron: Y1238/Y1239) and for generation of signal transducer docking sites (Met: Y1349/Y1356 and Ron Y1353/Y1360). " provenance.
- _5 value "Using the appropriate 'kinase inactive' mutant receptors, we show that ligand-induced activation of Met results in transphosphorylation of Ron, and vice versa. Transphosphorylation is direct, as it occurs in Met or Ron receptors lacking the docking sites for signal transducers. Phosphate groups are transferred to the tyrosine phosphorylation sites responsible both for kinase up-regulation (Met: Y1234/Y1235 and Ron: Y1238/Y1239) and for generation of signal transducer docking sites (Met: Y1349/Y1356 and Ron Y1353/Y1360). " provenance.
- _5 value "Using the appropriate 'kinase inactive' mutant receptors, we show that ligand-induced activation of Met results in transphosphorylation of Ron, and vice versa. Transphosphorylation is direct, as it occurs in Met or Ron receptors lacking the docking sites for signal transducers. Phosphate groups are transferred to the tyrosine phosphorylation sites responsible both for kinase up-regulation (Met: Y1234/Y1235 and Ron: Y1238/Y1239) and for generation of signal transducer docking sites (Met: Y1349/Y1356 and Ron Y1353/Y1360). " provenance.
- _5 value "Gadd45 family proteins interact with several nuclear hormone receptors including RXR alpha, RAR alpha, ER alpha, PPAR alpha, PPAR beta, and PPAR gamma2 in vitro. Interaction between Gadd45 family proteins and nuclear hormone receptors resulted in modest activation of transactivating function of nuclear hormone receptors in reporter systems." provenance.
- _5 value "Gadd45 family proteins interact with several nuclear hormone receptors including RXR alpha, RAR alpha, ER alpha, PPAR alpha, PPAR beta, and PPAR gamma2 in vitro. Interaction between Gadd45 family proteins and nuclear hormone receptors resulted in modest activation of transactivating function of nuclear hormone receptors in reporter systems." provenance.
- _4 value "TNF alpha, IFN gamma and IL1 beta induced the tyrosine and threonine phosphorylation of ERK MAP kinases. Treatment with PD98059, an inhibitor of MEK1 and MEK2 kinase inhibited ERK MAP kinase phosphorylation by IFN gamma, TNF alpha and IL1 beta." provenance.
- _3 value "# Ariadne: These facts indicate that the expression of hepatic CYP51 is maintained by serum insulin, and its lowest physiological level is sufficient for supporting the expression of CYP51. [Expression]" provenance.
- _5 value "Src, Lyn and Lck tyrosine kinases phosphorylate DAPP1 at Tyr(139) in vitro at similar rates in the presence or absence of PtdIns(3,4,5)P(3), and overexpression of these kinases in HEK-293 cells induces the phosphorylation of Tyr(139). co-expression of DAPP1 with Src, Lyn or Lck induced a very high level of phosphorylation of DAPP1 at Tyr139, even in unstimulated cells, which was not increased further by agonist stimulation of cells. As Src-family kinases activate the PI 3-kinase pathway in many cells [1], it is possible that the overexpression of Src, Lyn or Lck in HEK-293 cells induces the activation of PI 3-kinase, thereby promoting DAPP1 phosphorylation in unstimulated cells. As Src-family tyrosine kinases are located at the plasma membrane by virtue of myristoylation and palmitoylation of their N-termini [26], it is likely that the role of PtdIns(3,4,5)P3 is to recruit DAPP1 to the cell membrane, where it can be phosphorylated with Src-family tyrosine kinases." provenance.
- _6 value "Treatment of cells with phosphoinositide 3-kinase (PI 3-kinase) inhibitors or expression of a dominant-negative PI 3-kinase prevent phosphorylation of DAPP1 at Tyr(139), and a PH-domain mutant of DAPP1, which does not interact with PtdIns(3,4,5)P(3) or PtdIns(3,4)P(2), is not phosphorylated at Tyr(139) following agonist stimulation of cells." provenance.
- _5 value "Bacterial lipoproteins (BLPs), which are expressed by all bacteria, are potent activators of Toll-like receptor-2 (TLR2). Here we show that the adaptor molecule, myeloid differentiation factor 88 (MyD88), mediates both apoptosis and nuclear factor-kappaB (NF-kappaB) activation by BLP-stimulated TLR2." provenance.
- _5 value "Inhibition of the NF-kappaB pathway downstream of MyD88 potentiates apoptosis, indicating that these two pathways bifurcate at the level of MyD88. TLR2 signals for apoptosis through MyD88 via a pathway involving Fas-associated death domain protein (FADD) and caspase 8." provenance.
- _8 value "Interestingly, BLP also activates caspase 1 through TLR2, resulting in proteolysis and secretion of mature IL-1beta." provenance.
- _5 value "Modified assertion" provenance.
- _3 value "LPS exposure leads to an increase of MMP-2 and MMP-9 in bronchoalveolar lavage (BAL) from various animals (19,24,25). Similar results were obtained in rats after subacute hyperoxia (26) or after exposure to ozone (27)." provenance.
- _3 value "These observations strongly suggest an involvement of MMP-2 and MMP-9 in acute inflammatory processes. Moreover, we have shown in mice that LPS-induced acute inflammation could be reduced by corticosteroid treatment, as observed by inhibition of inflammatory cell infiltration (mainly neutrophils) and reduction of MMP-2 and MMP-9 activity" provenance.
- _4 value "As expected, mRNA levels for LPL were reduced in fld white adipose tissue, as were those of adipsin. We also found that uncoupling protein 1 mRNA in brown adipose tissue from fld mice was reduced." provenance.
- _3 value "However, in fld mice, a greater proportion of the cholesterol was present in the HDL fraction and less cholesterol was present in the LDL/VLDL fraction" provenance.
- _4 value "hormone-sensitive lipase activity was found to be reduced 50% in fld compared to wild type tissue" provenance.
- _4 value "Signaling via calmodulin, calcineurin, and Tcn1p induced Rcn1p expression, suggesting that Rcn1p operates as an endogenous feedback inhibitor of calcineurin." provenance.
- _3 value "These changes were accompanied by rapid and profound mitochondrial dysfunction characterized by opening of the mitochondrial PT pore, proton electrochemical gradient (Deltapsim) suppression, and increased reactive oxygen species production." provenance.
- _3 value "Osteosarcomas with NRP2 showed significantly poorer prognosis than those without NRP2. NRP acts as a VEGF-amplifier in a paracrine or autocrine manner in the osteosarcoma. NRP2 expression cooperatively promotes angiogenesis and growth in osteosarcomas with VEGF expression." provenance.
- _5 value "Electromobility shift assays show increased STAT1, STAT3, STAT5, and AP-1 DNA binding activity in RAW 264.7 cells after hyperoxia. Taken together, our data suggest that the 5' distal enhancer elements of the HO-1 gene in concert with the promoter regulate HO-1 gene induction and highlight the complexity of HO-1 gene transcription in response to hyperoxia." provenance.
- _6 value "Active c-Abl kinase leads to Cdk5 tyrosine phosphorylation, and this phosphorylation is enhanced by Cables. Phosphorylation of Cdk5 by c-Abl occurs on tyrosine 15 (Y15), which is stimulatory for p35/Cdk5 kinase activity." provenance.
- _5 value "The activity of phosphoinositide 3-kinase (PI3-K) is essential for the differentiation of skeletal muscle cells by largely unknown mechanisms. Here we show that inhibition of PI3-K activity by the pharmacological agent LY294002 affects early processes of myoblast differentiation including the transcriptional activation of myogenin." provenance.
- _4 value "Overexpression of p130(Cas), but not an AND-34-binding mutant of p130(Cas), inhibited the Ral GEF activity of co-transfected AND-34" provenance.
- _7 value "Overexpression of p130(Cas), but not an AND-34-binding mutant of p130(Cas), inhibited the Ral GEF activity of co-transfected AND-34" provenance.
- _4 value "Addition of FGF-2 to osteoclast cultures revealed an up-regulation in FGFR1 mRNA and protein levels. Osteoblasts when stimulated by FGF-2 also showed an up-regulation in the levels of FGFR1. FGF-2 induced the kinase activity of FGFR1 at 1 minute, which reached maximum at 2 minutes, and decreased considerably after 10 minutes." provenance.
- _4 value "IGFBP-3 mediates TGF-beta 1 proliferative response in colon cancer cells, which can be confirmed by antisense deoxyribonucleotides to IGFBP-3 that completely blocks the ability of TGF-beta 1 to elicit the proliferative response." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _7 value "CBP and p300 are highly related proteins that act as cofactors for many transcription factors, including the nuclear hormone receptors, Myb and CREB" provenance.
- _5 value "Kit and other RTKs will activate the MAP kinase signaling pathway and has been reported both to increase the transcriptional activity of Mitf as well as down-regulate Mitf protein levels." provenance.
- _6 value "Kit and other RTKs will activate the MAP kinase signaling pathway and has been reported both to increase the transcriptional activity of Mitf as well as down-regulate Mitf protein levels." provenance.
- _6 value "Kit and other RTKs will activate the MAP kinase signaling pathway and has been reported both to increase the transcriptional activity of Mitf as well as down-regulate Mitf protein levels." provenance.
- _6 value "Kit and other RTKs will activate the MAP kinase signaling pathway and has been reported both to increase the transcriptional activity of Mitf as well as down-regulate Mitf protein levels." provenance.
- _6 value "Kit and other RTKs will activate the MAP kinase signaling pathway and has been reported both to increase the transcriptional activity of Mitf as well as down-regulate Mitf protein levels." provenance.
- _6 value "Kit and other RTKs will activate the MAP kinase signaling pathway and has been reported both to increase the transcriptional activity of Mitf as well as down-regulate Mitf protein levels." provenance.
- _7 value "Wnt signaling is bypassed in many melanoma cell lines owing to mutations in beta catenin which result in its stabilization. Although deregulation of Wnt- and RTK-mediated signaling will affect a range of target genes, both pathways impact on Mitf expression or Mitf levels. Note also that while GSK3beta is regulated by both RTK signaling and the Wnt signaling pathway, it is likely that each pathway regulates a different pool of GSK3beta The presence of a Wnt ligand activates the receptor for Wnt, the seven transmembrane domain protein Frizzled, which in turn leads to activation of Dishevelled, and subsequently to the inhibition of GSK-3. Current models suggest that the action of GSK-3 results in phosphorylation of beta catenin leading to its destabilization and degradation (Cadigan and Nusse 1997) and as a consequence, the presence of a Wnt signal increases the level of beta catenin in the cell. Control of beta catenin degradation is also influenced by components of a complex containing the product of the adenomatous polyposis coli gene APC, which is a good substrate for GSK3beta in vitro and which can form a complex with GSK3beta and beta catenin, together with the axin homolog conductin (Rubinfeld et al. 1993, 1996; Behrens et al. 1998). Indeed, phosphorylation of APC by GSK3beta stimulates its ability to bind beta catenin and overexpression of APC following transfection substantially reduces beta catenin levels (Munemitsu et al. 1995). Similarly, overexpression of conductin also results in degradation of beta catenin and it has been suggested that conductin acts downstream from APC in directing the destabilization of beta catenin containing the product of the adenomatous polyposis coli gene APC, which is a good substrate for GSK3beta in vitro and which can form a complex with GSK3beta and beta catenin, together with the axin homolog conductin (Rubinfeld et al. 1993, 1996; Behrens et al. 1998). Indeed, phosphorylation of APC by GSK3beta stimulates its ability to bind beta catenin and overexpression of APC following transfection substantially reduces beta catenin levels (Munemitsu et al. 1995). Similarly, overexpression of conductin also results in degradation of beta catenin and it has been suggested that conductin acts downstream from APC in directing the destabilization of beta catenin Lef1 in the absence of a Wnt signal can repress transcription in association with Groucho-like factors. Similarly, under some circumstances Pax3 can repress transcription, perhaps through its interaction with HIRA (Magnaghi et al. 1998), amammalian homolog of a yeast transcriptional corepressor, and with the transcriptional repressor hDaxx which can suppress the ability of Pax3 to activate transcription" provenance.
- _3 value "Human tip49a and tip49b genes were mapped on 3q21 and 19q13.2, respectively. Consistent with the notion that tip49 family genes are essential for cell growth, Northern blot analysis demonstrated that both genes are expressed ubiquitously in human tissues. It is worthy of notice that the testes contained large amounts of the both transcripts." provenance.
- _4 value "cholesterol-dependent binding of annexin II to membranes." provenance.
- _5 value "Since CGRP and adrenomedullin can both signal through CRLR, which has been previously shown to require a chaperone protein for function, we now propose that a functional CGRP or adrenomedullin receptor consists of at least three proteins: the receptor (CRLR), the chaperone protein (RAMP), and RCP that couples the receptor to the cellular signal transduction pathway." provenance.
- _2 value "Thiazolidinediones (TZDs) reduce insulin resistance in type 2 diabetes by increasing peripheral uptake of glucose, and they bind to and activate the transcriptional factor peroxisome proliferator-activated receptor-gamma (PPAR-gamma)." provenance.
- _5 value "mounting evidence that an activating mutation may enhance kit signaling and also induce factor-independent activation of kit. For instance, this activation could occur through degradation of SHP-1, the protein tyrosine phosphatase that negatively regulates kit signaling." provenance.
- _4 value "Modified assertion" provenance.
- _6 value "We found that oncogenic Ras upregulates PML expression, and overexpression of PML induces senescence in a p53-dependent manner. p53 is acetylated at lysine 382 upon Ras expression, an event that is essential for its biological function. Ras induces re-localization of p53 and the CBP acetyltransferase within the PML nuclear bodies and induces the formation of a trimeric p53-PML-CBP complex. Lastly, Ras-induced p53 acetylation, p53-CBP complex stabilization and senescence are lost in PML-/- fibroblasts. " provenance.
- _4 value "These findings indicate that TNF-induced MT stabilization is mediated by hyperphosphorylation of Op18 and that this promotes cell death." provenance.
- _4 value "These findings indicate that TNF-induced MT stabilization is mediated by hyperphosphorylation of Op18 and that this promotes cell death." provenance.
- _4 value "These findings indicate that TNF-induced MT stabilization is mediated by hyperphosphorylation of Op18 and that this promotes cell death." provenance.