Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Loss+binding+of+pax9+to+promoter+correlated+well+with+the+severity+of+the+tooth+agenesis+pattern+in+vivo. assertion.
- assertion asSentence Genetic+interactions+between+Pax9+and+Msx1+regulate+lip+development+and+several+stages+of+tooth+morphogenesis. assertion.
- assertion asSentence Mice+lacking+both+Osr2+and+Pax9+exhibited+early+tooth+developmental+arrest+with+significantly+reduced+Bmp4+and+Msx1+mRNA+expression+in+the+developing+tooth+mesenchyme. assertion.
- assertion asSentence Pbx1+is+an+essential+regulator+of+mesenchymal+function+during+renal+morphogenesis. assertion.
- assertion asSentence PBX1+plays+a+central+role+in+attenuating+the+activity+of+HOXA10+as+an+activator+of+osteoblast-related+genes. assertion.
- assertion asSentence During+pancreatic+islet+formation%2C+Pax6+expression+becomes+dependent+upon+Pbx1+and+Pbx2+function. assertion.
- assertion asSentence One+function+of+histone+acetyltransferase+p300+within+the+prefrontal+cortex+is+to+constrain+synaptic+plasticity%2C+since+it+is+required+for+the+formation+of+fear+extinction+memory. assertion.
- assertion asSentence Within+the+context+of+fear+extinction%2C+p300%2FCBP-associated+factor+functions+as+a+transcriptional+coactivator. assertion.
- assertion asSentence PEPCK+expression+is+coordinate+with+hepatic+energy+metabolism+to+control+gluconeogenesis. assertion.
- assertion asSentence High-dose+5-FU+treatment+can+significantly+increase+the+PCNA+index+in+severely+damaged+small+intestinal+mucosa. assertion.
- assertion asSentence Prosomatostatin+%28PC1%29+is+a+physiologic+substrate+of+proprotein+convertase+2+%28PC2%29+in+vivo+and+is+required+for+the+generation+of+brain+somatostatin-14+from+precursor. assertion.
- assertion asSentence Hormones+processed+by+PC2+affected+processes+that+regulate+islet+cell+differentiation+and+maturation+in+embryos+and+adults. assertion.
- assertion asSentence Sequences+with+a+Trp%2C+Tyr+and%2For+Pro+in+the+P1%27+or+P2%27+position%2C+or+a+basic+residue+in+the+P3+position%2C+are+preferentially+cleaved+by+PC2+and+not+by+other+enzymes+present+in+the+secretory+pathway. assertion.
- assertion asSentence Expression+of+PC1%2F3+rather+than+PC2+in+alpha-cells+induces+GLP-1+and+GLP-2+production+and+converts+the+alpha-cell+from+a+hyperglycemia-promoting+cell+to+one+that+lowers+blood+glucose+levels+and+promotes+islet+survival. assertion.
- assertion asSentence Expression+of+PCSK2+in+mouse+small+intestine. assertion.
- assertion asSentence PD-1%3APD-L+inhibitory+pathway+affects+both+CD4%28%2B%29+and+CD8%28%2B%29+T+cells+and+is+overcome+by+IL-2. assertion.
- assertion asSentence Role+for+PD-1-PD-L1+interaction+in+the+regulation+of+induction+and+progression+of+autoimmune+diabetes+in+the+NOD+mouse. assertion.
- assertion asSentence Essential+for+allograft+tolerance. assertion.
- assertion asSentence PD-1+and+its+ligands+regulate+both+the+induction+and+maintenance+of+CD8-positive+T+cell+tolerance. assertion.
- assertion asSentence Blockade+of+interactions+of+PD-1+with+its+ligand%2C+programmed+death+%28PD-L%29%2C+prevents+induction+of+invariant+natural+killer+%28NK%29T+cell+anergy%2C+preserving+the+therapeutic+activities+of+these+cells+against+B16+melanomas. assertion.
- assertion asSentence Interaction+between+PD-1+and+PD-L1+can+facilitate+regulatory+T+cells-induced+suppression+of+T-effector+cells+and+dampen+the+antitumor+immune+response. assertion.
- assertion asSentence Bacille+Calmette+Guerin+%28BCG%29+can+induce+Kawasaki+disease-like+features+in+programmed+death-1+%28PD-1%29+gene+knockout+mice. assertion.
- assertion asSentence The+number+and+frequencey+of+FoxP3%2C+TIM-3%2C+PD-1+expressing+Treg+cells%2C+present+during+allograft+response%2C+peaks+at+the+time+of+graft+rejection. assertion.
- assertion asSentence A+sub-population+of+Alix+localizes+extracellularly+and+regulates+integrin-mediated+cell+adhesions+and+fibronectin+matrix+assembly. assertion.
- assertion asSentence Alix+is+a+crucial+mediator+of+Ca%282%2B%29+induced+caspase+9+activation. assertion.
- assertion asSentence PKB+is+required+for+the+positive+effects+of+insulin+on+lipid+storage+and+regulation+of+PDE3B+and+AMPK+by+PKB+is+important+for+these+effects. assertion.
- assertion asSentence The+PDE4B+subfamily+is+involved+in+signaling+pathways+that+contribute+to+anxiogenic-like+effects+on+behavior. assertion.
- assertion asSentence PDE7A+is+involved+in+regulation+of+cell+proliferation+and+cytokine+production+of+NKT+cells. assertion.
- assertion asSentence PDE6gamma+is+a+major+component+of+the+photoresponse+and+is+required+to+support+rod+integrity. assertion.
- assertion asSentence During+kidney+development%2C+PDGFR+beta-mediated+reactive+oxygen+species+generation+and+Ca%282%2B%29+influx+suppress+PDGF+AA-induced+chemotaxis+in+metanephric+mesenchyme. assertion.
- assertion asSentence VEGF-null+cells+require+Pdgfra+signaling-mediated+stromal+fibroblast+recruitment+for+tumorigenesis. assertion.
- assertion asSentence Ciliary+PDGFR-alpha-alpha+%28homodimer+of+PDGFRa%29+signaling+is+linked+to+tissue+homeostasis+and+to+mitogenic+signaling+pathways. assertion.
- assertion asSentence MMP-13+induction+by+mechanical+strain+requires+the+transactivation+of+PDGFR-alpha+by+PKC-delta+and+the+cross-talk+between+PDGFR-alpha%2FPI3K%2FAkt+and+MEK%2FERK+pathways. assertion.
- assertion asSentence Activated+PDGFR-beta+increases+the+total+vessel+area+in+B16+melanoma. assertion.
- assertion asSentence The+anti-proliferative+effects+of+Klf4+on+neointimal+formation+depend+largely+on+PDGFR-mediated+PI3K+signaling+without+involvement+of+the+RAR+alpha-activated+signaling+pathways. assertion.
- assertion asSentence The+disruption+of+PPARgamma+signaling+in+endothelial+cells+is+sufficient+to+cause+mild+pulmonary+artery+hypertension+%28PAH%29+and+to+impair+recovery+from+chronic+hypoxia-induced+PAH. assertion.
- assertion asSentence Potentiation+of+platelet-derived+growth+factor+receptor-beta+signaling+is+mediated+by+integrin-associated+MFG-E8. assertion.
- assertion asSentence Specific+targeting+motif+in+the+NPP1+cytosolic+tail+that+delivers+PP%28i%29-generating+NPP+activity+to+osteoblast+matrix+vesicles+for+control+of+calcification. assertion.
- assertion asSentence RAGE+promotes+ectopic+chondrogenic+differentiation+and+arterial+calcification+in+Enpp1-%2F-+mice. assertion.
- assertion asSentence Facilitates+the+entry+of+lymphocytes+from+the+blood+into+secondary+lymphoid+organs. assertion.
- assertion asSentence Functional+ATX+is+selectively+expressed+in+high+endothelial+venules+%28HEVs%29+of+both+lymph+nodes+and+Peyer%27s+patches. assertion.
- assertion asSentence Reduction+of+functional+PDK-1+leads+to+impairment+of+electrogenic+intestinal+glucose+absorption+and+renal+glucose+reabsorption. assertion.
- assertion asSentence A+pathway+is+defined+that+links+the+kinases+PDK1+and+protein+kinase+A+%28PKA%29+in+the+induction+of+the+T+helper+%28Th%292+cell+cytokine+IL-4. assertion.
- assertion asSentence PI3K+signaling+in+the+PDK1+hypomorphic+mouse+reduces+concentrations+of+GABA+and+serotonin+in+anxiety+related+brain+regions. assertion.
- assertion asSentence PDK1+in+oocytes+is+required+to+maintain+the+survival+of+primordial+follicles. assertion.
- assertion asSentence The+hyperpolarizing+effect+of+epinephrine+in+pancreatic+islet+cells+is+sensitive+to+PI3K+and+PDK1. assertion.
- assertion asSentence PI3K+and+Pdk1+participate+in+the+regulation+of+intestinal+peptide+transport. assertion.
- assertion asSentence Regulation+of+3-phosphoinositide-dependent+protein+kinase+1+activity+by+homodimerization+in+live+cells. assertion.
- assertion asSentence An+important+role+for+MPK38-mediated+phosphorylation+of+PDK1+in+the+negative+regulation+of+PDK1+activity. assertion.
- assertion asSentence Hepatic+regeneration+and+enforced+PDX-1+expression+accelerate+transdifferentiation+in+liver. assertion.
- assertion asSentence Reduced+PDX-1+expression+impairs+islet+response+to+insulin+resistance+and+worsens+glucoe+homeostasis. assertion.
- assertion asSentence Utility+of+Pdx1+in+embryo+stem+cells+is+a+tool+for+monitoring+the+effects+of+factors+that+influence+pancreatic+differentiation+from+ES+cells. assertion.
- assertion asSentence Tgf-beta+potentiates+differentiation+of+embryonic+stem+cells+to+Pdx-1+expressing+endodermal+cells. assertion.
- assertion asSentence Interaction+of+endogenous+PDX-1+and+PCIF1+in+MIN6+insulinoma+cells%2C+is+demonstarted. assertion.
- assertion asSentence Pdx1+deficiency+leads+to+a+failure+of+beta+cell+compensation+for+insulin+resistance+at+least+in+part+by+impairing+critical+functions+of+the+endoplasmic+reticulum. assertion.
- assertion asSentence 14-3-3epsilon+interacts+directly+with+PDX-1+to+regulate+its+cellular+distribution+in+pancreatic+beta+cells. assertion.
- assertion asSentence Inter-strain+differences+in+PENK+and+PDYN+genes+expression+in+the+nucleus+accumbens+parallel+sensitivity+of+the+selected+mouse+strains+to+rewarding+effects+of+morphine. assertion.
- assertion asSentence Overexpression+of+PED%2FPEA-15+dysregulates+beta-cell+function+and+is+sufficient+to+impair+glucose+tolerance+in+mice. assertion.
- assertion asSentence PEA-15+can+integrate+signal+transduction+to+provide+a+specific+physiological+outcome+from+activation+of+the+multipotent+extracellular+signal-regulated+MAP+kinase+pathway. assertion.
- assertion asSentence Induction+of+Pea3+gene+expression+by+peripheral+signals+is+required+to+coordinate+the+central+position+and+terminal+arborization+of+specific+sets+of+spinal+motor+neurons. assertion.
- assertion asSentence PEA3+expression+in+developing+motor+neurons+is+regulated+by+GDNF+signals+from+the+limb+bud. assertion.
- assertion asSentence Reduced+tumorigenesis+in+mouse+mammary+cancer+cells+following+inhibition+of+Pea3-+or+Erm-dependent+transcription. assertion.
- assertion asSentence Immature+mast+cells+can+undergo+a+tightly+regulated+extravasation+cascade+consisting+of+rolling+on+and+adhesion+to+endothelium+and+followed+by+directed+diapedesis+and+reveal+E-selectin%2C+P-selectin%2C+VCAM-1+and+PECAM-1+as+required+adhesion+molecules. assertion.
- assertion asSentence PEMT+is+required+in+the+secretion+of+apoB100-containing+VLDLs. assertion.
- assertion asSentence Dietary+docosahexaenoic+acid+supplementation+modulates+hippocampal+development+in+the+Pemt-%2F-+mouse. assertion.
- assertion asSentence Morphine+dependence+is+examined+in+preproenkephalin+knockout+mice. assertion.
- assertion asSentence Preproenkephalin+deletion+in+Hyp+mice+%28Phex-deficient%29+partially+rescues+their+bone+mineralization+defect.A+role+for+Penk+in+osteoblast+differentiation. assertion.
- assertion asSentence No+difference+is+found+in+light-induced+mPer1+expression+in+the+suprachiasmatic+nuclei+of+two+mouse+lines+artificially+selected+for+nest-building+behavior. assertion.
- assertion asSentence CLOCK+is+a+real+signalling+molecule+that+mediates+the+serum-evoked+rapid+induction+of+Per1+in+fibroblasts+through+the+Ca2%2B-dependent+protein+kinase+C+%28PKC%29+pathway. assertion.
- assertion asSentence A+role+for+Period+1+in+the+regulation+of+the+renal+epithelial+sodium+channel+and+more+broadly+implicate+the+circadian+clock+in+control+of+sodium+balance. assertion.
- assertion asSentence In+mouse+lines+artificially+selected+for+nest-building+behavior%2C+light-induced+mPer2+expression+is+significantly+higher+in+the+suprachiasmatic+nuclei+of+big+compared+to+small+nest-builders. assertion.
- assertion asSentence mPER2+expression+in+the+shell+region+of+suprachiasmatic+nucleus+is+correlated+with+light+phase+delays. assertion.
- assertion asSentence SIRT1+binds+CLOCK-BMAL1+in+a+circadian+manner+and+promotes+the+deacetylation+and+degradation+of+PER2. assertion.
- assertion asSentence The+Per2+gene+functions+in+hepatocyte+protection+from+chemical+toxicants+via+the+regulation+of+hepatic+Ucp2+gene+expression+levels. assertion.
- assertion asSentence PER2+represses+PAI-1+gene+transcription+in+a+BMAL1%2F2-dependent+manner. assertion.
- assertion asSentence Whole-genome+microarray+profiling+demonstrates+that+PER2+dictates+the+specificity+of+PPARgamma+transcriptional+activity. assertion.
- assertion asSentence PER2+and+luciferase+peaks+in+suprachiasmatic+nucleus+and+peripheral+tissues+are+closely+linked+to+time+of+onset+of+bioluminescence+rhythms. assertion.
- assertion asSentence In+the+presence+of+PML+and+PER2%2C+BMAL1%2FCLOCK-mediated+transcription+is+enhanced. assertion.
- assertion asSentence The+circadian+regulation+of+mPer3+mRNA+stability+requires+the+cooperative+function+of+5%27-+and+3%27-untranslated+regions. assertion.
- assertion asSentence Profilin1+ablation+from+mouse+brains+leads+to+a+cerebellar+hypoplasia%2C+aberrant+organization+of+cerebellar+cortex+layers+and+ectopic+Cerebellar+granule+neurons+%28CGNs%29. assertion.
- assertion asSentence Hyper-phosphorylation+of+profilin2a+is+the+molecular+link+between+SMN+and+the+ROCK+pathway+repressing+neurite+outgrowth+in+neuronal+cells. assertion.
- assertion asSentence Besides+interferon-gamma+and+FasL%2C+perforin+is+required+for+liver+cell+destruction+by+self-reactive+cytotoxic+CD8+T+cells. assertion.
- assertion asSentence Semliki+Forest+virus+replication+in+perforin+and+FasL+deficient+mice+is+remarkably+restricted. assertion.
- assertion asSentence CD4+cells+expressing+gamma+interferon+and+perforin+mediate+protection+against+lethal+influenza+virus+infection. assertion.
- assertion asSentence Placental+growth+factor+plays+as+role+in+basal+adhesion+formation+and+in+carbon+dioxide+pneumoperitoneum-enhanced+adhesion+formation+after+laparoscopic+surgery+in+transgenic+mice. assertion.
- assertion asSentence Placental+growth+factor+finely+tunes+a+balanced+regulation+of+the+tissue+inhibitor+of+metalloproteinases-3%2Ftumor+necrosis+factor-alpha-converting+enzyme+axis+and+the+consequent+TNF-alpha+activation+in+response+to+transverse+aortic+constriction. assertion.
- assertion asSentence Progesterone+receptor+knockout+mice+have+an+improved+glucose+homeostasis+secondary+to+beta+-cell+proliferation. assertion.
- assertion asSentence PR+signaling+in+mice+is+not+essential+for+bone+growth+and+turnover. assertion.
- assertion asSentence The+HER4+intracellular+domain+is+a+physiologically+important+ERalpha+coactivator+and+cooperates+with+ERalpha+to+potentiate+PgR+expression+in+the+normal+and+malignant+breast. assertion.
- assertion asSentence Penetration+of+endogenous+steroid+hormones+corticosterone%2C+cortisol%2C+aldosterone+and+progesterone+into+the+brain+is+enhanced+in+mice+deficient+for+both+mdr1a+and+mdr1b+P-glycoproteins. assertion.
- assertion asSentence Mdr1b+triple+knock-out+mice+lacking+the+genes+for+Mrp1+and+Mdr1a%2F1b+are+more+susceptible+to+developing+features+of+chronic+obstructive+pulmonary+disease+%28COPD%29+than+their+wild-type+littermates. assertion.
- assertion asSentence Dysfunction+in+ABCB1A+has+only+a+weak+effect+on+susceptibility+to+dextran+sulfate+sodium-induced+colitis+in+SAM+strains. assertion.
- assertion asSentence Expression+of+P-glycoprotein+is+upregulated+by+Shiga-like+toxin+II. assertion.
- assertion asSentence Multidrug+resistance+of+L1210%2FVCR+cells+is+mediated+predominantly+by+the+drug+efflux+activity+of+Pgp. assertion.
- assertion asSentence Y397+and+Y1040+play+an+important+role+in+Abcb1a+catalysis. assertion.
- assertion asSentence Glucocorticoid+regulation+of+the+murine+PHEX+gene. assertion.
- assertion asSentence Preproenkephalin+deletion+in+Hyp+mice+%28Phex-deficient%29+partially+rescues+their+bone+mineralization+defect. assertion.
- assertion asSentence Cooperative+role+of+NF-%7Bkappa%7DB+and+poly%28ADP-ribose%29+polymerase+1+%28PARP-1%29+in+the+TNF-induced+inhibition+of+PHEX+expression+in+osteoblasts. assertion.
- assertion asSentence Piga+expression+is+required+to+properly+orient+hair+cells+in+the+inner+ear%2C+a+process+regulated+by+the+planar+cell+polarity+pathway. assertion.
- assertion asSentence The+poly+immunoglobulin+receptor+is+the+main+pathway+for+IgA+transport+into+the+male+reproductive+tract. assertion.