Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Phagocytosis+and+fluid-phase+pinocytosis+of+larger+molecules+are+dependent+on+the+lipid+kinase+activity+of+p110alpha. assertion.
- assertion asSentence Deletion+of+the+p110alpha+catalytic+subunit+of+PI3K+led+to+increased+weight+gain+and+adipose+tissue+along+with+reduced+energy+expenditure. assertion.
- assertion asSentence The+p110alpha+isoform+of+PI3K+plays+a+fundamental+role+in+insulin+signaling+and+control+of+hepatic+glucose+and+lipid+metabolism. assertion.
- assertion asSentence PI3K%28p110alpha%29+is+essential+for+exercise-induced+cardioprotection+and+delivery+of+caPI3K+vector+can+improve+function+of+the+failing+heart. assertion.
- assertion asSentence The+action+of+PI3Kdelta+in+the+NK+compartment+is+as+relevant+to+survival+of+the+mice+as+the+delayed+tumor+progression. assertion.
- assertion asSentence Genetic+or+pharmaceutical+blockade+of+p110delta+phosphoinositide+3-kinase+enhances+IgE+production. assertion.
- assertion asSentence The+expression+of+the+PI%283%29K+regulatory+subunits+p55alpha+and+p50alpha+is+induced+by+Stat3+during+involution. assertion.
- assertion asSentence PI3K%2FAkt+activation+plays+a+critical+role+in+the+regeneration+of+pancreatic+acini+after+resection. assertion.
- assertion asSentence Direct+interactions+between+native+Syk+and+PI3K+proteins+are+differentially+regulated+during+FcgammaR+phagocytosis+and+endocytosis. assertion.
- assertion asSentence Pertuissis+toxin+promotes+macrophage+survival+through+inhibition+of+Smpd1+and+activation+of+the+PI3K%2FPKB+pathway. assertion.
- assertion asSentence Kringle+domain+of+uPA+induces+smooth+muscle+cell+migration+through+a+G-protein-coupled+PI3-K-dependent+process+involving+both+ERK+1%2F2+and+p38%28MAPK%29+and+is+mediated+in+part+through+EGFR. assertion.
- assertion asSentence The+unavailability+of+residue+Y179+on+PLD2+to+become+phosphorylated+leads+to+an+augmentation+of+DNA+synthesis+concomitantly+with+MEK+and+AKT+phosphorylation%2C+in+a+process+that+is+dependent+on+PI3K+and+independent+of+any+extracellular+stimuli. assertion.
- assertion asSentence PI3K%2FAkt+activation+plays+a+critical+role+for+both+PDX-1+expression+and+pancreatic+duct+cell+differentiation+into+insulin-producing+cells+during+pancreatic+regeneration. assertion.
- assertion asSentence Sustained+interaction+of+MyD88%2FPI3K+with+the+TLR4+intracellular+%22signaling+platform%22+negatively+regulates+signaling. assertion.
- assertion asSentence Deleting+p85alpha+alone+induced+resistance+to+diet-induced+obesity. assertion.
- assertion asSentence Heat+shock+protein+70+%28Hsc70%29+plays+a+significant+role+in+vascular+endothelial+cells+via+the+phosphatidylinositol+3-kinase%2FAkt+pathway. assertion.
- assertion asSentence PI3Kgamma+regulates+bone+homeostasis+by+modulating+osteoclastogenesis. assertion.
- assertion asSentence p85alpha+plays+an+essential+role+in+osteoblast+differentiation+from+MSCs+by+repressing+the+activation+of+MAPK+pathway. assertion.
- assertion asSentence Antimycin+A+induces+cytotoxicity+via+inhibition+of+PI3K%2FAkt%2FCREB+signaling. assertion.
- assertion asSentence The+PI3K+pathway+plays+a+central+role+in+the+regulation+of+activity-dependent+neuronal+survival+in+the+developing+cerebral+cortex. assertion.
- assertion asSentence PI3K+signaling+inhibits+Ig+gene+rearrangement+by+suppressing+the+expression+of+the+transcription+factor+Ikaros. assertion.
- assertion asSentence Prolactin+and+epidermal+growth+factor+stimulate+adipophilin+synthesis+in+HC11+mouse+mammary+epithelial+cells+via+the+PI3-kinase%2FAkt%2FmTOR+pathway. assertion.
- assertion asSentence Cockroach+allergen+per+a+7+down-regulates+expression+of+TLR-9+and+IL-12+release+from+mast+cells+via+activation+of+ERK+and+PI3K+signaling+pathways. assertion.
- assertion asSentence Functional+cooperativity+between+c-MYC+and+PIM1+in+prostate+tumorigenesis+in+vivo. assertion.
- assertion asSentence Signals+from+IL-7+and+RAG+DSBs+activate+distinct+Pim+kinase+family+members+that+have+context-dependent+activities+in+regulating+pre-B+cell+proliferation+and+survival. assertion.
- assertion asSentence PIP5Kgamma661+is+activated+by+AP-2+complex+and+generates+PI%284%2C5%29P2+in+hippocampal+neuron+synaptic+vesicle+endocytosis. assertion.
- assertion asSentence The+beta-+and+gamma-isoforms+of+type+I+PIP5K+regulate+distinct+stages+of+Ca2%2B+signaling+in+mast+cells. assertion.
- assertion asSentence PIR-B+on+relatively+primitive+B+cells%2C+B-1+cells%2C+suppresses+TLR9+signaling+via+Bruton%27s+tyrosine+kinase+%28Btk%29+dephosphorylation%2C+blocking+the+production+of+natural+IgM+antibodies. assertion.
- assertion asSentence PIR-B+negatively+regulates+macrophage+functions+in+response+to+pathogenic+bacteria+and+chronic+intestinal+inflammatory+responses. assertion.
- assertion asSentence PIR-B+knock-out+is+not+sufficient+to+induce+extensive+axonal+regeneration+after+spinal+cord+injury. assertion.
- assertion asSentence TSHbeta+gene+is+maximally+activated+by+a+combination+of+TRAP220%2C+Pit-1%2C+GATA-2+that+act+via+both+protein-DNA+and+protein-protein+interactions. assertion.
- assertion asSentence Deletion+of+the+Pitx1+genomic+locus+affects+mandibular+morphogenesis+and+expression+of+the+Barx1+and+Tbx1+genes. assertion.
- assertion asSentence Migration+of+subthalamic+nucleus+and+hypothalamic+neurons+is+severely+arrested+in+Pitx2+null+embryos. assertion.
- assertion asSentence Pitx2+is+an+upstream+activator+of+extraocular+myogenesis+and+survival. assertion.
- assertion asSentence Pitx2+regulates+myosin+heavy+chain+isoform+expression+and+multi-innervation+in+extraocular+muscle. assertion.
- assertion asSentence Pitx2+plays+a+crucial+functional+role+by+negatively+modulating+a+nodal-type+programme+in+the+left+sinus+venosus+myocardium. assertion.
- assertion asSentence TGFbeta-FGF9-PITX2+signaling+cascade+regulates+cranial+neural+crest+cell+proliferation+during+palate+formation. assertion.
- assertion asSentence A+homeodomain+protein+that+is+required+for+development+of+substantia+nigra+dopaminergic+neurons. assertion.
- assertion asSentence Motor+deficits+and+altered+striatal+gene+expression+in+aphakia+%28ak%29+mice. assertion.
- assertion asSentence The+frame-shift+mutation+%28Pitx+eyl+%29+affects+the+C-terminal+part+of+the+transcription+factor+Pitx3+and+causes+alterations+in+the+eye+and+brain. assertion.
- assertion asSentence PKA+anchoring+by+AKAP150+is+essential+for+the+enhancement+of+TRPV1+function+by+activation+of+the+PGE%282%29%2FPKA+signaling+pathway. assertion.
- assertion asSentence PKA+signaling+synergizes+with+SOX9+at+the+nuclear+and+cytoplasmic+levels+to+promote+BMP-2-induced+osteochondrogenic+differentiation. assertion.
- assertion asSentence Occlusion+of+PKA-dependent+processes+is+one+of+the+molecular+mechanisms+underlying+cognitive+decline+in+Huntington+disease. assertion.
- assertion asSentence EGF+reguires+cPKCalpha+for+the+activation+of+the+Na%2B%2FH%2B+exchanger+NHE1. assertion.
- assertion asSentence Prkca+participates+in+growth-factor-induced+signaling+in+C3H10T1%2F2+fibroblasts. assertion.
- assertion asSentence Adenovirus-delivered+short+hairpin+RNA+targeting+Pkca+improves+contractile+function+in+reconstituted+heart+tissue. assertion.
- assertion asSentence The+acute+effects+of+cigarette+smoke+on+eNOS+phosphorylation%2C+focusing+on+protein+kinases+%28PKs%29%2C+is+investigated. assertion.
- assertion asSentence An+investigation+of+the+marine+compound+spongistatin+1+links+the+inhibition+of+Pkca+translocation+to+nonmitotic+effects+of+tubulin+antagonism+in+angiogenesis. assertion.
- assertion asSentence PKC+alpha+mediates+beta-arrestin2-dependent+nephrin+endocytosis+in+hyperglycemia. assertion.
- assertion asSentence Protein+kinase+Calpha+signaling+regulates+inhibitor+of+DNA+binding+1+in+the+intestinal+epithelium. assertion.
- assertion asSentence In+the+molecular+pathway+to+secretion%2C+PKD2+is+a+key+component+of+the+PKC-mediated+pathway+to+platelet+activation+and+thrombus+formation+through+its+selective+regulation+of+dense+granule+secretion. assertion.
- assertion asSentence Membrane+residence+time+of+PKCalpha+after+depolarization-induced+translocation+is+significantly+decreased+when+it+is+present+with+the+mutant+PKCgamma+construct+of+spinocerebellar+ataxia+type+14. assertion.
- assertion asSentence VCAM-1+activation+of+endothelial+cell+NADPH+oxidase%2FPKCalpha%2FPTP1B+induces+transient+ERK1%2F2+activation+that+is+necessary+for+VCAM-1-dependent+leukocyte+transendothelial+migration. assertion.
- assertion asSentence Reveal+a+central+role+for+PKCalpha+in+cutaneous+wound+repair+via+changes+in+desmosomal+adhesiveness. assertion.
- assertion asSentence Activation+of+a+classical+PKC+in+skeletal+muscle+is+sufficient+to+cause+disturbances+in+whole-body+glucose+and+lipid+metabolism+followed+by+profound+alterations+in+oxidative+capacity%2C+ectopic+fat+deposition+and+physical+activity. assertion.
- assertion asSentence Inhibition+of+protein+kinase+C+beta+ameliorates+impaired+angiogenesis+in+type+I+diabetic+mice+complicating+myocardial+infarction. assertion.
- assertion asSentence Congo+red+inhibits+the+aggregation+of+mutant+PKCgamma+that+causes+SCA14+by+inhibiting+oligomerization. assertion.
- assertion asSentence PKCdelta+is+crucial+in+regulating+glucose+and+lipid+metabolism+and+controlling+the+cellular+redox+state+in+vascular+smooth+muscle+cells. assertion.
- assertion asSentence Activation-induced+Class+II+MHC+surface+expression+in+dendritic+cells+is+dependent+on+activation+of+PKCdelta. assertion.
- assertion asSentence PKC-delta+is+an+important+proinflammatory+signal+transducer+for+substance+P-NK1R-induced+chemokine+production+in+pancreatic+acinar+cells. assertion.
- assertion asSentence Curcumin+suppressed+STAT1+activation+by+directly+inhibiting+Janus-activated+kinase+1%2F2+and+protein+kinase+Cdelta+phosphorylation+in+bone+marrow-derived+DCs%2C+suppressing+translocation+and+binding+of+STAT1+to+the+GAS+element+of+the+IRF-1+promoter. assertion.
- assertion asSentence Protein+kinase+C+delta+mediates+arterial+injury+responses+through+regulation+of+vascular+smooth+muscle+cell+apoptosis. assertion.
- assertion asSentence PKCbetaII+and+PKCdelta+counter-regulate+BBB+permeability+during+aglycemic+hypoxia. assertion.
- assertion asSentence Expression+of+the+PKC-delta+in+coronary+vessels+is+under+control+of+the+g-protein+Galpha11. assertion.
- assertion asSentence PKCdelta+signaling+is+required+for+myoblast+fusion+by+regulating+the+expression+of+caveolin-3+and+beta1D+integrin+upstream+focal+adhesion+kinase. assertion.
- assertion asSentence Regulated+binding+of+importin-alpha+to+protein+kinase+Cdelta+in+response+to+apoptotic+signals+facilitates+nuclear+import. assertion.
- assertion asSentence PRR5L+degradation+promotes+mTORC2-mediated+PKC-delta+phosphorylation+and+cell+migration+downstream+of+Galpha12+in+fibroblasts+and+pulmonary+fibrosis. assertion.
- assertion asSentence Expression+of+activated+PKC+epsilon+%28PKC+epsilon%29+protects+the+ischemic+heart%2C+without+attenuating+ischemic+H%28%2B%29+production. assertion.
- assertion asSentence Involved+in+phytic+acid-induced+exocytosis+in+mouse+pancreatic+beta-cells. assertion.
- assertion asSentence PKCepsilon-Akt-eNOS+signaling+modules+as+critical+signaling+elements+during+PKCepsilon-induced+cardiac+protection. assertion.
- assertion asSentence The+susceptibility+of+PKC-epsilon+transgenic+mice+to+the+induction+of+sqquampous+cell+carcinoma+and+the+spontaneous+development+of+myeloproliferative+diseases+are+unrelated. assertion.
- assertion asSentence Deletion+of+genes+encoding+isoforms+of+protein+kinase+C+such+as+PKC+epsilon+can+improve+glucose+intolerance+in+fat+fed+mice. assertion.
- assertion asSentence Enhanced+PKCepsilon+mediated+phosphorylation+of+connexin43+at+serine+368+by+a+carboxyl-terminal+mimetic+peptide+is+dependent+on+injury. assertion.
- assertion asSentence PKC+lambda%2Fiota+emerges+as+a+critical+regulator+of+Th+2+activation. assertion.
- assertion asSentence Basal+or+elevated+aPKC+activity+is+required+for+the+ability+of+Src-transformed+cells+to+degrade+and+invade+the+extracellular+matrix. assertion.
- assertion asSentence Postprandial+activation+of+PKCmicro+plays+a+role+in+disordered+postprandial+adipocytokine+expression+through+AP-2beta. assertion.
- assertion asSentence Loss+of+PKCtheta+reduces+energy+expenditure+and+increases+the+risk+of+dietary+obesity+and+insulin+resistance+in+mice. assertion.
- assertion asSentence PKCtheta+is+a+critical+effector+molecule+in+the+PAR4-linked+signaling+pathways+and+in+the+regulation+of+normal+hemostasis+in+mice. assertion.
- assertion asSentence PKC-theta+is+a+critical+component+of+signaling+lymphocytic+activation+molecule+%28SLAM%29%2FSAP-mediated+pathways+that+influence+T+cell+receptor+%28TCR%29-driven+IL-4+production. assertion.
- assertion asSentence PKCzeta+is+critical+for+IL-4+signaling+and+Th2+differentiation+in+allergic+airway+inflammation. assertion.
- assertion asSentence CaBP4+is+phosphorylated+by+protein+kinase+C+zeta+%28PKCzeta%29+at+serine+37+both+in+vitro+and+in+the+retina+and+colocalizes+with+PKCzeta+in+photoreceptors. assertion.
- assertion asSentence Demonstrate+a+posttranscriptional+modulation+of+ileal+ASBT+function+and+membrane+expression+by+phorbol+ester+via+a+PKCzeta-dependent+pathway. assertion.
- assertion asSentence Coronary+artery+PKC-zeta+is+reduced+in+diabetic+G-alpha+11+knockout+mice. assertion.
- assertion asSentence Hydrogen+sulfide+and+L-cysteine+increase+phosphatidylinositol+3%2C4%2C5-trisphosphate+and+glucose+utilization+by+inhibiting+PTEN+protein+and+activating+PI3K%2CAKT%2C+PKCzeta%2Flambda+in+3T3l1+adipocytes. assertion.
- assertion asSentence pkd1+promotes+alphavbeta3+integrin+recycling+and+delivery+to+nascent+focal+adhesions. assertion.
- assertion asSentence Mechanical+stimuli+induce+cleavage+and+nuclear+translation+of+the+Pkd1+C+terminus. assertion.
- assertion asSentence Pkd1+and+Pkd2+are+required+for+normal+placental+development. assertion.
- assertion asSentence Lysophospholipids+produced+by+Pla2g1b+hydrolysis+suppress+hepatic+fat+utilization+and+down-regulate+energy+expenditure%2C+preventing+metabolically+beneficial+adaptation+to+a+high-fat+diet+exposure+in+promoting+diet-induced+obesity+and+type+2+diabetes. assertion.
- assertion asSentence Critical+role+of+cPLA2alpha+in+the+pathogenesis+of+CIA. assertion.
- assertion asSentence cPLA2alpha+plays+a+key+role+in+PGE+production+by+osteoblasts+and+in+osteoclastic+bone+resorption. assertion.
- assertion asSentence Group+X+secretory+phospholipase+A2+induces+potent+arachidonic+acid+release+without+activation+of+cPLA2a. assertion.
- assertion asSentence cPLA%282%29+is+required+to+secrete+sufficient+Monocyte+chemotactic+protein-1+to+induce+an+inflammatory+monocytic+response. assertion.
- assertion asSentence cPLA%282%29alpha+is+not+essential+to+activate+the+proton+conductance+or+for+a+normal+respiratory+burst. assertion.
- assertion asSentence Toll-like+receptor+9-stimulated+monocyte+chemoattractant+protein-1+is+mediated+via+JNK-cytosolic+phospholipase+A2-ROS+signaling. assertion.
- assertion asSentence Cytosolic+phospholipase+A2-alpha+is+an+early+apoptotic+activator+in+PEDF-induced+endothelial+cell+apoptosis. assertion.
- assertion asSentence The+involvement+of+phosphatidic+acid+phosphohydrolase+1+%28PAP-1%29+and+protein+kinase+C+%28PKC%29+in+the+Toll-like+receptor-4+%28TLR-4%29+activation+of+GIVA+PLA%282%29%2C+is+demonstrated. assertion.
- assertion asSentence CFTR+knockout+mice+develop+enhanced+airway+constriction+through+a+cPLA2alpha-dependent+mechanism. assertion.
- assertion asSentence Hepatocyte+cPLA%282%29alpha+protects+against+Fas-induced+liver+injury+and+this+effect+is+mediated+at+least+in+part+through+the+upregulation+of+EGFR. assertion.
- assertion asSentence Arachidonic+acid+can+induce+cPLA%282alpha%29%2FCOX-2+pathway+activation+in+mouse+endometrial+stromal+cells. assertion.
- assertion asSentence The+capacity+of+group+V+sPLA2+to+increase+atherogenicity+of+ApoE-%2F-+and+LDLR-%2F-+mouse+LDL+in+vitro+predicts+its+atherogenic+role+in+vivo. assertion.