Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence The+absence+or+inhibition+of+PAI-1+in+adipocytes+protects+against+insulin+resistance+by+promoting+glucose+uptake+and+adipocyte+differentiation+via+increased+PPARgamma+expression. assertion.
- assertion asSentence PAI-1+deficiency+protects+mice+from+glomerular+injury+in+longer+term+diabetes+and+endogenous+PAI-1+maintains+normal+renal+interstitial+structure+in+ageing+not+associated+with+diabetes. assertion.
- assertion asSentence Induction+of+PAI-1+by+TGFbeta+is+critical+for+the+induction+of+proliferation+arrest. assertion.
- assertion asSentence PAI-1+influences+sensitivity+to+etoposide-induced+apoptosis+through+the+PI3K%2FAkt+cell+survival+pathway+by+acting+upstream+of+PI3K+and+Akt. assertion.
- assertion asSentence A+molecular+link+exists+between+the+circadian+clock+and+lipid+metabolism+system+in+the+regulation+of+PAI-1+gene+expression. assertion.
- assertion asSentence PAI-2+and+TG2+are+downstream+mediators+in+the+antiapoptotic+response+triggered+upon+TBK1+activation. assertion.
- assertion asSentence Absence+of+tissue+plasminogen+activator+gene+or+activity+impairs+cerebellar+motor+learning. assertion.
- assertion asSentence Proteolysis+of+dendritic+spines+in+layer+II%2FIII+of+the+visual+cortex+by+tissue-type+plasminogen+activator+declines+with+age+and+increases+with+monocular+deprivation+only+in+young+mice. assertion.
- assertion asSentence The+proteolytic+enzyme+tissue+plasminogen+activator+%28tPA%29+plays+a+major+function+in+%27conditioning-injury+induced%27+axon+regeneration. assertion.
- assertion asSentence uPA+promotes+muscle+regeneration+through+HGF+activation+and+subsequent+myoblast+proliferation. assertion.
- assertion asSentence Expesssed+by+ssensory+cells+in+the+olfactory+neuroepithelium. assertion.
- assertion asSentence The+beta2+isoform+mediates+close+to+one-half+the+chemokine-induced+calcium+signal+in+resting+and+anti-IgM-activated+B+cells. assertion.
- assertion asSentence Loss+of+PLCbeta2+and+PLCbeta3+significantly+impaired+T+cell+migration. assertion.
- assertion asSentence PLCgamma1+and+PLCgamma2+play+nonredundant+and+obligatory+roles+in+NK+cell+ontogeny+and+in+its+effector+functions. assertion.
- assertion asSentence Neuronal+surface+sialylation+and+fucosylation+are+regulated+via+PLCgamma+by+L1%2C+modulating+neurite+outgrowth%2C+cell+survival+and+migration. assertion.
- assertion asSentence Nephrin+Tyr-1204+phosphorylation+triggers+the+Ca%282%2B%29+response+in+a+PLC-gamma1-dependent+fashion. assertion.
- assertion asSentence PLD1+positively+regulates+mTOR+signaling+leading+to+the+production+of+IGF2%2C+an+autocrine+factor+instrumental+for+the+initiation+of+satellite+cell+differentiation. assertion.
- assertion asSentence ARF6+is+a+critical+regulator+of+C2C12+myoblast+fusion+and+participates+in+the+regulation+of+PLD+activities+that+trigger+both+phospholipids+production+and+actin+cytoskeleton+reorganization+at+fusion+sites. assertion.
- assertion asSentence Phospholipase+D2-dependent+inhibition+of+the+nuclear+hormone+receptor+PPARgamma+by+cyclic+phosphatidic+acid. assertion.
- assertion asSentence Mature+focal+adhesions+and+their+derivative+fibronectin+fibril-aligned+fibrillar+adhesions+%28FbAs%29+serve+as+docking+sites+for+vimentin+intermediate+filaments+%28IFs%29+in+a+plectin+isoform+1f+%28P1f%29-dependent+manner. assertion.
- assertion asSentence Plf-mRNA+is+differentially+expressed+in+murine+skin+in+response+to+mechanistically+distinct+tumor+promoters. assertion.
- assertion asSentence Plasmin-mediated+proteolysis+is+required+for+hepatocyte+growth+factor+activation+during+liver+repair. assertion.
- assertion asSentence Plasmin+plays+an+essential+role+in+amplification+of+psoriasiform+skin+inflammation. assertion.
- assertion asSentence A+phenotypic+overlap%2C+defined+as+an+additional+delay+in+wound+healing+in+the+double-deficient+mice+compared+to+the+individual+single-deficient+mice%2C+between+MMP-13+and+the+plasminogen+activation+system. assertion.
- assertion asSentence alpha2AP+is+associated+with+the+progression+of+fibrosis. assertion.
- assertion asSentence Plk1+colocalized+with+p-MEK1%2F2+at+various+meiotic+stages+after+GVBD+when+microtubule+began+to+organize. assertion.
- assertion asSentence Mitotic+progression+and+control+of+mitotic+reentry+after+DNA+damage+resides%2C+at+least+in+part%2C+on+the+dynamic+behavior+of+Plk1. assertion.
- assertion asSentence Plk1-mediated+phosphorylation+of+UAP56+regulates+the+stability+of+UAP56. assertion.
- assertion asSentence Cardiomyocyte+NOS1+signaling+modulates+phospholamban+serine16+phosphorylation%2C+in+part%2C+via+peroxynitrite. assertion.
- assertion asSentence The+developmental+increase+in+Plp1+gene+expression+that+occurs+during+the+active+myelination+period+is+governed+by+transcription+regulatory+elements+present+within+the+first+intron. assertion.
- assertion asSentence Mas+deficiency+in+FVB%2FN+mice+leads+to+dramatic+changes+in+glucose+and+lipid+metabolisms%2C+inducing+a+metabolic+syndrome-like+state. assertion.
- assertion asSentence GIOT-4+coactivated+ERbeta+in+ovarian+granulosa+cells. assertion.
- assertion asSentence The+presence+of+cis-acting+elements+confer+the+cell+type+specificity+of+Phgdh+transcription+in+the+distal+promoter+region. assertion.
- assertion asSentence The+cis-acting+elements+necessary+for+basal+transcription+of+Phgdh+are+contained+within+the+-196%2F%2B4+proximal+sequence+of+the+promoter%2C+in+which+the+conserved+Sp1+recognition+sites+play+an+important+role+for+basal+promoter+activity. assertion.
- assertion asSentence Human+and+mouse+nyctalopin+are+membrane-bound+extracellular+proteins+and+are+functionally+conserved. assertion.
- assertion asSentence Sodium-hydrogen+exchanger+6+depletion+leads+to+abnormal+accumulation+of+GM2+ganglioside+and+unesterified+cholesterol+within+late+endosomes+and+lysosomes+of+neurons+in+selective+brain+regions. assertion.
- assertion asSentence The+defect+in+Reactive+Oxygen+Species+production+and+killing+of+s+aureus+by+p40%28phox-%2F-%29+neutrophils+defines+p40%28phox%29+as+an+essential+component+in+bacterial+killing. assertion.
- assertion asSentence NADPH+oxidase-dependent+generation+of+lysophosphatidylserine+enhances+clearance+of+activated+and+dying+neutrophils+via+G2A. assertion.
- assertion asSentence Neutrophil+transendothelial+migration+induced+by+septic+alveolar+macrophages+is+dependent+on+the+generation+of+superoxide+in+endothelial+cells+via+the+c-Src+kinase%2FNADPH+oxidase+signaling+pathway. assertion.
- assertion asSentence PDGF+activates+SSH1L+in+VSMC+by+a+mechanism+that+involves+Nox1-mediated+oxidation+of+14-3-3+and+Ser-834+SSH1L+auto-dephosphorylation. assertion.
- assertion asSentence Kidney+specific+inactivation+of+Ofd1+leads+to+renal+cystic+disease. assertion.
- assertion asSentence The+ciliogenic+protein+Oral-Facial-Digital+1+regulates+the+neuronal+differentiation+of+embryonic+stem+cells. assertion.
- assertion asSentence Increasing+dietary+cholesterol+restores+diet-induced+weight+gain+in+mice+deficient+in+NPC1L1-dependent+cholesterol+absorption. assertion.
- assertion asSentence Molecular+cloning+and+transport+properties+of+NaCT. assertion.
- assertion asSentence The+transport+of+apolipoprotein+%28apo%29+B-100+in+nonobese%2C+nondiabetic%2C+nonnephrotic+CKD+subjects+and+healthy+controls+%28HC%29. assertion.
- assertion asSentence Constitutive+androstane+receptor+activation+decreases+plasma+apolipoprotein+B-containing+lipoproteins+and+atherosclerosis+in+low-density+lipoprotein+receptor-deficient+mice. assertion.
- assertion asSentence An+important+role+of+AKAP150+in+coordinating+signaling+events+regulating+the+frequency+of+intrinsic+pulsatile+GnRH+secretion. assertion.
- assertion asSentence Overexpression+of+murine+VASH1+inhibited+angiogenic+sprouting+and+supports+vascular+maturation+processes+in+vivo. assertion.
- assertion asSentence OGR1%27s+role+in+osteoclastogenesis+is+not+strong+enough+to+affect+overall+bone+development. assertion.
- assertion asSentence The+levels+of+ADAM4+and+ADAM6+are+dramatically+reduced+in+Adam2+and+Adam3+knockout+sperm+defective+in+various+fertilization+processes. assertion.
- assertion asSentence The+variable+regions+associated+with+IgA+of+peritoneal+B1b+cells+displayed+extensive+variation+due+to+somatic+hypermutation. assertion.
- assertion asSentence PDE4D+plays+a+critical+role+in+the+control+of+trachea+smooth+muscle+contraction. assertion.
- assertion asSentence PDE4D+functions+as+a+proliferation+promoting+factor+in+prostate+cancer. assertion.
- assertion asSentence Activation+of+phosphodiesterase+4D+constrains+myocardial+contractility+via+a+ss2+adrenergic+receptor-coupled+phosphoinositide+3-kinase+mechanism. assertion.
- assertion asSentence Mrp4+is+required+for+normal+Leydig+cell+testosterone+production. assertion.
- assertion asSentence Aard+is+specifically+up-regulated+in+Sertoli+cells+during+mouse+testis+differentiation. assertion.
- assertion asSentence Diabetes-linked+zinc+transporter+ZnT8+is+a+homodimeric+protein+expressed+by+distinct+rodent+endocrine+cell+types+in+the+pancreas+and+other+glands. assertion.
- assertion asSentence AGO2+downregulation+impaired+both+short-term+and+long-term+contextual+fear+memories. assertion.
- assertion asSentence Ago2+is+essential+for+normal+self-renewal+and+differentiation. assertion.
- assertion asSentence A+T-type+calcium+channel+required+for+normal+function+of+a+mammalian+mechanoreceptor. assertion.
- assertion asSentence MKL2+regulates+a+conserved+TGF-beta+signaling+pathway+that+is+required+for+angiogenesis+and+ultimately+embryonic+survival. assertion.
- assertion asSentence Expressed+in+developing+blood+vessels%2C+Rasgrp3+contributes+to+the+incidence+of+cardiovascular+defects+found+in+embryos+from+diabetic+mothers. assertion.
- assertion asSentence NZF-3+works+downstream+of+neurogenin+1+%28Neurog1%29+and+plays+a+crucial+role+together+with+Neurog1+in+neuronal+differentiation. assertion.
- assertion asSentence A+soluble+form+of+mouse+GITR+ligand+%28sGITR-L%29+induces+GITR-dependent+NF-kappa+B+activation+and+blocks+in+vitro+suppression+mediated+by+both+resting+and+preactivated+polyclonal+and+antigen-specific+regulatory+T+%28Treg%29+cells. assertion.
- assertion asSentence The+GITR-GITR+ligand+pathway%2C+mediated+by+interactions+with+epidermal+keratinocytes+and+Langerhans+cells%2C+promotes+cutaneous+dendritic+cell+migration+and+hapten-specific+T+cell+responses. assertion.
- assertion asSentence GITRL-dependent+expansion+of+Treg+within+the+cornea+is+one+mechanism+underlying+immune+privilege+in+corneal+allografts. assertion.
- assertion asSentence B+cell+expression+of+GITRL+induced+Treg+proliferation%2C+maintaining+their+numbers+above+a+threshold+required+for+the+prevention+of+autoimmunity. assertion.
- assertion asSentence Cloned+as+a+calcium-+and+neural-selective+transcriptional+activator+of+the+gene+for+Brain-Derived+Neurotrophic+Factor+%28BDNF%29. assertion.
- assertion asSentence NEU4+is+involved+in+regulation+of+neuronal+function+by+polySia+degradation+in+mammals. assertion.
- assertion asSentence Mice+mutant+for+alpha8-integrin+exhibit+a+specific+impairment+of+long-term+potentiation+at+synapses+of+Schaffer+collateral-CA1+field+of+the+hippocampus. assertion.
- assertion asSentence Low-affinity+transporter+SMCT2+initiates+lactate+absorption+in+the+early+parts+of+the+proximal+tubule+followed+by+the+participation+of+the+high-affinity+transporter+SMCT1+in+the+latter+parts+of+the+proximal+tubule. assertion.
- assertion asSentence Inhibition+by+sildenafil+ameliorates+right+ventricular+hypertrophy+and+pulmonary+fibrosis+caused+by+intratracheal+bleomycin. assertion.
- assertion asSentence PDE5+inhibition+enhances+ischemia-induced+angiogenesis+with+mobilization+of+endothelial+progenitor+cells+through+a+protein+kinase+G-dependent+HIF-1%2Fvascular+endothelial+growth+factor+pathway. assertion.
- assertion asSentence Activation+of+GABA%28B%29+receptor+by+either+GABA+or+the+selective+agonist+baclofen+induces+ERK%281%2F2%29+phosphorylation+in+cultured+cerebellar+granule+neurons. assertion.
- assertion asSentence E2F4+is+important+in+early+stages+of+commitment+to+the+lymphoid+lineage. assertion.
- assertion asSentence The+FBXL5-IRP2+axis+is+integral+to+control+of+iron+metabolism+in+vivo. assertion.
- assertion asSentence START-GAP2+is+localized+in+focal+adhesions+through+a+%22FAT+%28focal+adhesion+targeting%29%22+region+in+the+N-terminal+half. assertion.
- assertion asSentence Nomenclature+and+overview+of+the+mouse+%28Mus+musculus+and+Mus+sp.%29+immunoglobulin+kappa+%28IGK%29+genes. assertion.
- assertion asSentence The+Igkappa+gene+enhancers%2C+E3%27+and+Ed%2C+are+essential+for+triggering+transcription. assertion.
- assertion asSentence Acute+and+chronic+cholinergic+stimulation+provoke%2C+in+vivo%2C+depletion+of+the+membrane+store+of+somatodendritic+m2R+through+different+intracellular+mechanisms. assertion.
- assertion asSentence M%282%29+receptor+plays+a+critical+role+in+specific+components+of+cognitive+abilities+in+mice. assertion.
- assertion asSentence Lack+of+association+of+a+spontaneous+mutation+of+the+Chrm2+gene+with+behavioral+and+physiologic+phenotypic+differences+in+inbred+mice. assertion.
- assertion asSentence In+mice%2C+GPVI-mediated+platelet+adhesion+to+the+atherosclerotic+vascular+wall+is+involved+in+atheroprogression+in+vivo. assertion.
- assertion asSentence A+crucial+and+selective+role+of+PI3Kbeta+in+signaling+through+GPVI+and+integrin+alpha%28IIb%29beta%283%29. assertion.
- assertion asSentence Glycoprotein+6+cleavage+in+vitro+can+occur+independently+through+either+ADAM10+or+ADAM17+in+response+to+distinct+stimuli. assertion.
- assertion asSentence Chato+regulates+convergent+extension+in+the+mouse+embryo. assertion.
- assertion asSentence IkappaBNS+regulates+production+of+interleukin+%28IL%29-2+and+other+cytokines+induced+via+T-cell+receptor+ligation. assertion.
- assertion asSentence Mice+that+are+null+mutant+for+the+Teashirt3+%28Tshz3%29+gene+exhibit+congenital+pelvi-ureteric+junction+obstruction+with+defective+smooth+muscle+differentiation+and+absent+peristalsis+in+the+proximal+ureter. assertion.
- assertion asSentence Siglec-G+and+CD22+have+partly+compensatory+functions+and+together+are+crucial+in+maintaining+the+B+cell+tolerance. assertion.
- assertion asSentence The+critical+importance+of+pre-BCR+and+BCR+receptor+levels+for+the+normal+development+of+B-lymphocyte+subpopulations+in+the+context+of+intact+VDJ+recombination+and+a+diverse+antibody+repertoire. assertion.
- assertion asSentence Predominantly+expressed+in+developing+neuron. assertion.
- assertion asSentence Chd2+heterozygous+mutant+mice+exhibit+increased+extramedullary+hematopoiesis+and+susceptibility+to+lymphomas. assertion.
- assertion asSentence CYP2R1+is+a+strong+candidate+for+the+microsomal+vitamin+D+25-hydroxylase. assertion.
- assertion asSentence mSCART1+is+highly+related+to+the+WC1+family+of+the+SRCR+superfamily. assertion.
- assertion asSentence Zeta-sarcoglycan+is+an+integral+component+of+the+sarcoglycan+complex+and+is+important+in+the+pathogenesis+of+muscular+dystrophy. assertion.
- assertion asSentence The+Disc1+mutant+mice+displayed+abnormal+emotional+behavior+as+assessed+by+the+elevated+plus-maze+and+cliff-avoidance+tests. assertion.
- assertion asSentence DISC1+and+fasciculation+and+elongation+protein+%28Fez%29zeta-1+regulate+cell+positioning+and+morphogenesis+of+newborn+neurons+in+hippocampus. assertion.
- assertion asSentence Mouse+ortholog+of+human+PRSS35+is+an+ovary-selectively+expressed+gene. assertion.
- assertion asSentence An+important+role+for+the+DNA+damage+response+mediated+by+ATR-Chk2+in+p53+activation+and+renal+cell+apoptosis+during+cisplatin+nephrotoxicity. assertion.
- assertion asSentence G%282%29-M+and+G%281%29-S+cell-cycle+checkpoints+in+the+early+embryo+are+differentially+regulated+by+ATM+and+ATR+in+response+to+genotoxic+stress. assertion.