Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence LOX+473+GA+genotype+is+independently+associated+with+increased+risk+of+breast+cancer+in+Chinese+female+population. assertion.
- assertion asSentence LOXL1+is+not+found+to+be+a+gene+with+major+risk+for+Alzheimer%27s+disease. assertion.
- assertion asSentence Lp%28a%29+is+an+independent+risk+factor+for+the+progression+of+diabetic+nephropathy+in+type+2+diabetic+patients+with+overt+proteinuria. assertion.
- assertion asSentence Human+apolipoprotein%28a%29+carboxyl-terminal+kringle+IV-10-kringle+V+fusion+protein+is+an+effective+inhibitor+of+angiogenesis+and+angiogenesis-dependent+tumor+growth. assertion.
- assertion asSentence Apolipoprotein%28a%29%2C+through+its+strong+lysine-binding+site+in+KIV%2810%27%29%2C+mediates+increased+endothelial+cell+contraction+and+permeability+via+a+Rho%2FRho+kinase%2FMYPT1-dependent+pathway. assertion.
- assertion asSentence Genotype-phenotype+relationship+and+impact+on+atherogenic+risk. assertion.
- assertion asSentence Lipoprotein%28a%29+and+homocysteine+as+genetic+risk+factors+for+vascular+and+neuropathic+diabetic+foot+in+type+2+diabetes+mellitus. assertion.
- assertion asSentence Basal+bolus+insulin+therapyenhances+preheparin+LPL+mass%2C+accompanied+by+antiatherogenic+changes+in+glucose+and+lipid+metabolism+in+type+2+diabetes. assertion.
- assertion asSentence In+insulin-resistant+conditions+of+obesity.+diabetics+compared+to+obese+subjects+have+increased+postprandial+chylomicron+response+and+reduced+adipose+tissue+LPL+activity. assertion.
- assertion asSentence PPAR-alpha+response+is+generated+by+unbound+fatty+acids+released+locally+by+lipase+activity+and+not+by+circulating+plasma+fatty+acids. assertion.
- assertion asSentence LPL+expression+is+the+strongest+RNA-based+prognostic+marker+in+chronic+lymphocytic+leukemia. assertion.
- assertion asSentence Proper+regulation+of+LPL+is+important+for+controlling+the+delivery+of+lipid+nutrients+to+tissues. assertion.
- assertion asSentence Dendritic+cells+derived+from+patients+with+Kaposi+sarcoma+in+AIDS+retain+the+ability+to+prime+the+adaptive+arm+of+the+immune+system+through+CD91%2C+leading+to+phenotypic+activation+and+stimulation+of+tetramer-positive+CD8%2B+cytotoxic+T+cells. assertion.
- assertion asSentence The+binding+sites+for+VLDLR+%28very+low+density+lipoprotein+receptor%29+and+LRP+%28low-density+lipoprotein+receptor-related+protein%29+within+Factor+VIII+overlap+and+the+A2+site+becomes+exposed+upon+physiological+activation+of+Factor+VIII. assertion.
- assertion asSentence Mediates%2C+in+part%2C+the+transport+of+Kunitz+domain-derived+peptide+angiopep-2+across+the+blood-brain+barrier. assertion.
- assertion asSentence LRP1+stimulates+a+canonical+Wnt5a+signaling+pathway+that+prevents+cholesterol+accumulation. assertion.
- assertion asSentence LRP1+exerts+remarkable+effects+to+retain+the+mature+phenotype+of+chondrocytes+as+a+critical+mediator+of+cell+signaling. assertion.
- assertion asSentence No+defect+in+the+trafficking+or+function+of+megalin+upon+OCRL1+knockdown. assertion.
- assertion asSentence Mesd+and+LRP6+modulate+Wnt+signaling. assertion.
- assertion asSentence A+common+variant+in+low-density+lipoprotein+receptor-related+protein+6+gene+%28LRP6%29+is+associated+with+LDL-cholesterol. assertion.
- assertion asSentence LRP6+protein+regulates+low+density+lipoprotein+%28LDL%29+receptor-mediated+LDL+uptake. assertion.
- assertion asSentence sLRP6E1E2%2C+by+inhibiting+interaction+between+Wnt+and+its+receptor%2C+suppressed+Wnt-induced+cell+proliferation+and+epithelial-to-mesenchymal+transition. assertion.
- assertion asSentence Splice+forms+of+crucial+genes+of+the+Wnt-pathway%2C+beta-Catenin%2C+LRP5%2C+GSK3beta%2C+Axin-1+and+CtBP1+are+expressed+in+human+colorectal+tissue. assertion.
- assertion asSentence Phosphorylated+LRP6%2F5+both+recruits+and+directly+inhibits+GSK3beta+using+two+distinct+portions+of+its+cytoplasmic+sequence. assertion.
- assertion asSentence Low-density+lipoprotein+receptor-related+protein-associated+protein+%28LRPAP1%29+gene+IVS5+insertion%2Fdeletion+polymorphism+is+not+a+risk+factor+for+gallstone+disease+in+a+Polish+population. assertion.
- assertion asSentence MK2-regulated+LSP1+phosphorylation+is+involved+in+stabilization+of+F-actin+polarization+during+neutrophil+chemotaxis. assertion.
- assertion asSentence Functional+T60N+variant+of+LTA+is+associated+with+type+2+diabetes+and+other+features+of+the+metabolic+syndrome+among+Danish+Caucasian+individuals. assertion.
- assertion asSentence The+LTA+252A%2FG+polymorphism+is+moderately+associated+with+sub-clinical+atherosclerosis. assertion.
- assertion asSentence LTA+is+a+major+gene+associated+with+early-onset+leprosy. assertion.
- assertion asSentence TNF+and+LTA+genes+are+not+major+susceptibility+genes+for+endometriosis. assertion.
- assertion asSentence Association+between+15+single+nucleotide+polymorphisms+in+the+coding+and+promoter+regions+of+LTA+and+TNFalpha+geneswith+risk+of+migraine. assertion.
- assertion asSentence A+haplotype-based+association+of+four+lymphotoxin-alpha+gene+polymorphisms+is+found+with+the+risk+of+coronary+artery+disease+in+Han+Chinese. assertion.
- assertion asSentence Single-nucleotide+polymorphisms+in+LTA+is+associated+with+chronic+kidney+disease+in+Type+2+diabetes. assertion.
- assertion asSentence Extracellular+matrix+is+an+important+site+of+deposition+for+LTBP-3+and+LTBP-4. assertion.
- assertion asSentence The+C+allele+of+the+leukotriene+C4+synthase+%28A-444C%29+polymorphism+is+associated+with+asthma+phenotype+or+severity. assertion.
- assertion asSentence Polymorphisms+of+the+PTGDR+and+LTC4S+influence+responsiveness+to+leukotriene+receptor+antagonists+in+Korean+children+with+asthma. assertion.
- assertion asSentence Lactoferrin+contributes+to+the+activation+of+both+the+innate+and+adaptive+immune+responses+by+promoting+the+recruitment+of+leukocytes+and+activation+of+dendritic+cells. assertion.
- assertion asSentence Lactoferrin+%28LF%29+in+solution+at+neutral+pH+is+oligomerized+in+the+absence+of+salt+or+at+physiological+salt+concentrations. assertion.
- assertion asSentence Fecal+lactoferrin+can+be+used+to+effectively+disease+activity+in+patients+with+idiopathic+ulcerative+colitis. assertion.
- assertion asSentence BCAM+glycoproteins+are+the+unique+erythroid+receptors+of+laminin+alpha5+chain%2C+a+major+component+of+the+extracellular+matrix+and+are+involved+in+several+erythrocyte+diseases. assertion.
- assertion asSentence Malignant+cells+can+actively+influence+the+composition+of+the+extracellular+matrix+through+TGFbeta1+and+other+soluble+factors. assertion.
- assertion asSentence Four+polymorphisms+of+the+LUM+promoter+contribute+to+the+pathogenesis+of+high+myopia. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+in+lumican+gene+are+associated+with+systemic+lupus+erythematosus+in+the+Taiwan+Chinese+Han+population. assertion.
- assertion asSentence CD229+is+a+self-ligand%2C+interacting+through+its+N-terminal+V-like+domain+which+contains+three+amino+acid+residues+critical+for+the+homophilic+binding+interaction. assertion.
- assertion asSentence Induction+of+LY75+antigen+is+associated+with+relapsed+chronic+myeloid+leukemia. assertion.
- assertion asSentence Activation+of+Lyn+kinase+is+necessary+for+proliferation+of+CD45%2B+myeloma+cells+by+IL-6. assertion.
- assertion asSentence CD45+tyrosine+phosphatase+inhibits+erythroid+differentiation+of+umbilical+cord+blood+CD34%2B+cells+associated+with+selective+inactivation+of+Lyn. assertion.
- assertion asSentence The+kinase+domain+of+Lyn+plays+a+role+in+Lyn+trafficking+besides+catalysis+of+substrate+phosphorylation. assertion.
- assertion asSentence Geldanamycin-induced+Lyn+dissociation+from+aberrant+Hsp90-stabilized+cytosolic+complex+is+an+early+event+in+apoptotic+mechanisms+in+B-chronic+lymphocytic+leukemia. assertion.
- assertion asSentence PTPIP51+is+phosphorylated+by+Lyn+and+c-Src+kinases+lacking+dephosphorylation+by+PTP1B+in+acute+myeloid+leukemia. assertion.
- assertion asSentence Regulation+of+SLAM-associated+protein+%28SAP%29has+functional+consequences+for+the+stimulation+of+natural+killer+%28NK%29+cell+cytotoxicity+by+2B4+%28CD244%29. assertion.
- assertion asSentence The+chimeric+mRNA+is+a+bicistronic+transcript+of+post+transcriptional+origin+that+independently+translates+the+Cyclin+D1+and+Trop-2+proteins+in+cancer+cells. assertion.
- assertion asSentence EpCAM+is+highly+expressed+in+metastatic+breast+cancers%2C+verifying+that+it+is+a+promising+therapeutic+target. assertion.
- assertion asSentence Deletion+involving+both+EPCAM+and+the+5%27+part+of+MSH2+are+associated+with+Lynch+syndrome. assertion.
- assertion asSentence MARCKS%2C+via+its+myristoylated+aminoterminus%2C+is+a+key+regulator+of+neutrophil+migration+and+adhesion. assertion.
- assertion asSentence The+unusual+two-state+behavior+of+Mad2+is+critical+for+spindle+checkpoint+signaling. assertion.
- assertion asSentence Frequent+mutations+of+MAD2+in+gastric+cancers+cause+defective+mitotic+spindle+checkpoint. assertion.
- assertion asSentence Mad2beta+is+an+alternative+splicing+variant+of+spindle+checkpoint+gene+mad2%2C+related+to+drug+resistance+in+gastric+cancer+cells. assertion.
- assertion asSentence No+somatic+mutations+of+the+Mad2+gene+is+associated+with+tumors. assertion.
- assertion asSentence The+degradation+of+Cdc20+represents+a+critical+control+mechanism+to+ensure+inactivation+of+APC%2FC%28Cdc20%29+in+response+to+the+spindle+assembly+checkpoint. assertion.
- assertion asSentence MAD2+contributes+to+the+pathogenesis+and+development+of+human+osteosarcoma. assertion.
- assertion asSentence BMP9+acts+as+a+proliferative+factor+for+immortalized+ovarian+surface+epithelial+cells+and+ovarian+cancer+cell+lines%2C+signaling+predominantly+through+an+ALK2%2FSmad1%2FSmad4+pathway%2C+the+major+BMP9+receptor+in+endothelial+cells. assertion.
- assertion asSentence Force-specific+activation+of+Smad1%2F5+regulates+vascular+endothelial+cell+cycle+progression+in+response+to+disturbed+flow. assertion.
- assertion asSentence TGF-beta-mediated+up-regulation+of+the+expression+of+the+integrin+subunits+alpha%282%29+and+alpha%286%29+is+mainly+mediated+in+MSC+by+Smad2. assertion.
- assertion asSentence The+Smad2%2F3+pathway+is+the+predominant+TGFbeta1+signaling+pathway+inducing+Il6+and+inhibiting+Il8+release+in+bronchial+epithelial+cells. assertion.
- assertion asSentence Protein+phosphatase+PPM1A+regulates+the+nuclear+export+of+Smad2%2F3+through+targeting+nuclear+exporter+RanBP3. assertion.
- assertion asSentence Smad2+copy-number+variations+are+associated+with+basal+cell+carcinoma%2C+squamous+cell+carcinoma+in+skin+cancers. assertion.
- assertion asSentence HTLV-1+tax+represses+Smad-mediated+TGF-beta+signaling. assertion.
- assertion asSentence Smad3+trimerization%2C+induced+by+phosphorylation%2C+activates+the+TGF-beta+signal+by+driving+Smad3+dissociation+from+SARA+%26+sets+up+the+negative+feedback+mechanism+by+Ski. assertion.
- assertion asSentence The+TGFB%2FSMAD3+signaling+pathway+is+involved+in+butyrate-mediated+vitamin+D+receptor+expression. assertion.
- assertion asSentence SMAD3+is+one+important+transcription+factor+mediating+transforming+growth+factor+beta%27s-+inhibitory+effects+on+IFN-gamma+production+and+antibody-dependent+cellular+cytotoxicity+following+CD16+activation+of+natural+killer+cells. assertion.
- assertion asSentence Sustained+co-cultivation+with+human+placenta-derived+MSCs+enhances+SMAD3+signaling+in+human+breast+epithelial+cells%2C+leading+to+EMT+and+differentiation. assertion.
- assertion asSentence Smad2%2F3+and+p38+MAPK+differentially+regulate+TGFB1-induced+epithelial-mesenchymal+transition+in+pulmonary+epithelial+cells. assertion.
- assertion asSentence Activation+of+peroxisome+proliferator-activated+receptor+gamma+%28PPAR-gamma%29+inhibits+transforming+growth+factor+beta+%28TGF-beta%29-induced+epithelial-mesenchymal+transition+in+lung+cancer+cells+and+prevents+metastasis+by+antagonizing+Smad3+function. assertion.
- assertion asSentence L+type-specific+target+selection+by+combinatorial+binding+of+Smad2%2F3+proteins+and+hepatocyte+nuclear+factor+4alpha+in+HepG2+cells. assertion.
- assertion asSentence Common+deletion+of+SMAD4+in+juvenile+polyposis+is+a+mutational+hotspot. assertion.
- assertion asSentence Smad4+point+mutations+are+prevalent+in+pancreatic+carcinoma%2C+they+are+infrequent+in+early+stages+%28I-III%29+of+colorectal+cancer. assertion.
- assertion asSentence Two+missense+mutations+in+the+C-terminal+domain+of+Smad4%2C+D351H+%28Asp351--%3EHis%29+%26+D537Y+%28Asp537--%3ETyr%29%2C+from+colorectal+cancer+cells+cannot+interact+with+either+TGF-beta-induced+phosphorylated+Smad2+or+Smad3. assertion.
- assertion asSentence mRNA+expressed+in+human+granulosa-luteal+cells+at+oocyte+retrieval. assertion.
- assertion asSentence Cooperates+with+lymphoid+enhancer-binding+factor+1+to+activate+c-myc+expression. assertion.
- assertion asSentence Smad4+mediates+down-regulation+of+E-cadherin+induced+by+TGF-beta+in+PANC-1+cells%2C+at+least+in+part%2C+through+Snail+and+Slug+induction. assertion.
- assertion asSentence Transgenic+Smad4+has+a+role+in+the+maintenance+of+hematopoietic+stem+cell+self-renewal+and+reconstituting+capacity. assertion.
- assertion asSentence Vidence+for+a+cross+talk+between+Smad4+and+the+Wnt%2Fbeta-catenin+pathway+in+pancreatic+carcinoma+cells. assertion.
- assertion asSentence Smad4+is+a+target+molecule+for+functional+inactivation+in+cervical+cancer. assertion.
- assertion asSentence TGF-beta-induced+and+basal+state+spontaneous+nuclear+import+of+Smad4+require+importin+7+and+8. assertion.
- assertion asSentence BMP9+acts+as+a+proliferative+factor+for+immortalized+ovarian+surface+epithelial+cells+and+ovarian+cancer+cell+lines%2C+signaling+predominantly+through+an+ALK2%2FSmad1%2FSmad4+pathway%2C+the+major+BMP9+receptor+in+endothelial+cells. assertion.
- assertion asSentence Smad4+loss+alters+the+tumor%27s+interaction+with+stromal+myeloid+cells+and+the+tumor+cells%27+response+to+the+stromal+chemokine%2C+S100A8. assertion.
- assertion asSentence Smad4+copy-number+variations+are+associated+with+squamous+cell+carcinoma+in+skin+cancers. assertion.
- assertion asSentence Smad6+repressed+bone+morphogenetic+protein-induced+Id1+transcription+through+recruiting+transcriptional+corepressor+C-terminal+binding+protein+%28CtBP%29. assertion.
- assertion asSentence SMAD7+induces+tumorigenicity+by+blocking+TGF-beta-induced+growth+inhibition+and+apoptosis. assertion.
- assertion asSentence Smad7+plays+a+crucial+role+upstream+of+ATM+and+p53+to+protect+the+genome+from+insults+evoked+by+extracellular+stress. assertion.
- assertion asSentence Stable+overexpression+of+Smad7+in+human+melanoma+cells+impairs+bone+metastasis. assertion.
- assertion asSentence Smad+signaling+pathway+plays+in+important+role+in+the+progress+of+glomerular+sclerosis%2C+renal+tubular+injury+and+interstitial+fibrosis+in+children+with+IGA+nephropathy. assertion.
- assertion asSentence Hepatitis+C+virus+impairs+the+induction+of+cytoprotective+Nrf2+target+genes+by+delocalization+of+small+Maf+proteins. assertion.
- assertion asSentence Present%2C+by+immunocytochemistry%2C+in+normal+prostate%2C+prostatic+hypertrophy+and+prostate+cancer. assertion.
- assertion asSentence High+MAGE-3+gene+expression+is+associated+with+metastases+in+hepatitis+C+virus+patients+complicated+by+hepatocellular+carcinoma. assertion.
- assertion asSentence MAGE-A4+expression+in+bladder+transitional+cell+carcinoma. assertion.
- assertion asSentence Present%2C+by+immunocytochemistry%2C+in+normal+prostate%2C+prostatic+hypertrophy+and+prostate+cancer. assertion.
- assertion asSentence High+MAGE-4+gene+expression+is+associated+with+metastases+in+hepatitis+C+virus+patients+complicated+by+hepatocellular+carcinoma. assertion.
- assertion asSentence Disease-associated+bias+in+T+helper+type+1+%28Th1%29%2FTh2+CD4%28%2B%29+T+cell+responses+against+MAGE-6+in+HLA-DRB10401%28%2B%29+patients+with+renal+cell+carcinoma+or+melanoma. assertion.