Matches in Nanopublications for { ?s <http://purl.org/dc/terms/description> ?o ?g. }
- NP124826.RAeEklBFvOoq8gECSbo0mWQ_0Gwt5PgUcfpGk2WTI-7ZE130_assertion description "[Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124826.RAeEklBFvOoq8gECSbo0mWQ_0Gwt5PgUcfpGk2WTI-7ZE130_provenance.
- NP124827.RAbGXuIqUHhyTZpUEm4S-y0xFk6r4ScjUjBQni-NHgFJ4130_assertion description "[Data suggest that increased MIP-1alpha/beta production enhances multiple myeloma cell binding to stromal cells by VLA-4-VCAM-1 adhesion, forming a " vicious cycle " between MM cell adhesion to stromal cells and MIP-1 production via VLA-4-VCAM-1 interaction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124827.RAbGXuIqUHhyTZpUEm4S-y0xFk6r4ScjUjBQni-NHgFJ4130_provenance.
- NP124832.RAVOxS1-F-Vv5P2fbEmgffruDOQOM0baoWVsNCITuRGxY130_assertion description "[BAFF has a role as a survival factor in multiple myeloma ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124832.RAVOxS1-F-Vv5P2fbEmgffruDOQOM0baoWVsNCITuRGxY130_provenance.
- NP124833.RAQYSCX5286i65RDvKTKss0AKFW2abNQkHyhizxNJf920130_assertion description "[BAFF secretion is 3- to 10-fold higher in bone marrow stromal cell than in multiple myeloma cells; tumor cell adhesion to BMSCs augments BAFF secretion by 2- to 5-fold, confirmed by both ELISA and immunoblotting.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124833.RAQYSCX5286i65RDvKTKss0AKFW2abNQkHyhizxNJf920130_provenance.
- NP124834.RAT22RRjNrYYMh41k856Puz8TFnSUil_q73IbR3k-v2kA130_assertion description "[Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124834.RAT22RRjNrYYMh41k856Puz8TFnSUil_q73IbR3k-v2kA130_provenance.
- NP124835.RAWVYCRO99xfdTGW3xEg2_K4IeqmfMiw96xpg11qh8nDM130_assertion description "[results place the Erk5 route as a new regulatory signaling pathway that affects multiple myeloma proliferation and apoptosis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124835.RAWVYCRO99xfdTGW3xEg2_K4IeqmfMiw96xpg11qh8nDM130_provenance.
- NP124840.RARNe-sy58dDAJZIseRBQkE7K3H-ZbMsP-c9okebt8YOU130_assertion description "[Polymorphisms of the tumor necrosis factor-alpha gene promoter predict for outcome after thalidomide therapy in relapsed and refractory multiple myeloma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124840.RARNe-sy58dDAJZIseRBQkE7K3H-ZbMsP-c9okebt8YOU130_provenance.
- NP124846.RAYLQ7Dh3uwMKOdHDNaozZFyCShqba07T-vT_GGfN3NWM130_assertion description "[Data suggest that increased MIP-1alpha/beta production enhances multiple myeloma cell binding to stromal cells by VLA-4-VCAM-1 adhesion, forming a " vicious cycle " between MM cell adhesion to stromal cells and MIP-1 production via VLA-4-VCAM-1 interaction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124846.RAYLQ7Dh3uwMKOdHDNaozZFyCShqba07T-vT_GGfN3NWM130_provenance.
- NP124847.RAY4VewoHqYE-VThoKnKWzQ2Y6wGw6S-AdBUrg6YU19L0130_assertion description "[Alpha (v) beta (3) integrin engagement enhances cell invasiveness in human multiple myeloma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124847.RAY4VewoHqYE-VThoKnKWzQ2Y6wGw6S-AdBUrg6YU19L0130_provenance.
- NP124849.RASWW0pkPptvsNGufnCRK5maY7RBK3lojZV_AjSkooScA130_assertion description "[Alterations in the NKG2D pathway are associated with progression from monoclonal gammopathy of undetermined significance to full-blown multiple myeloma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124849.RASWW0pkPptvsNGufnCRK5maY7RBK3lojZV_AjSkooScA130_provenance.
- NP124851.RAbN0WBukBs0dg36xxPjIpLUfhk5UYQTq0bjbRj8klUqk130_assertion description "[IAP family proteins may the prognosis of multiple myeloma patients in association with chemotherapy-induced overexpression of MDR1 or LRP.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124851.RAbN0WBukBs0dg36xxPjIpLUfhk5UYQTq0bjbRj8klUqk130_provenance.
- NP124855.RAYfzHO4VRfeNQpeI0s6ICBptlMIcV7IZkSwv7pntIbLg130_assertion description "[Low expression is an independent adverse prognostic factor in patients with multiple myeloma ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124855.RAYfzHO4VRfeNQpeI0s6ICBptlMIcV7IZkSwv7pntIbLg130_provenance.
- NP124857.RAe7mW1kpV8zdDaqA8ZolWmGfLxqJxS3pe2RIrEy8TmCM130_assertion description "[IL-6r and TNF-alpha increase in parallel to VEGF and FGF-2 with increasing stage of multiple myeloma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124857.RAe7mW1kpV8zdDaqA8ZolWmGfLxqJxS3pe2RIrEy8TmCM130_provenance.
- NP124858.RARZhWFbqklDegiz27KglBQATspAT3EE_cwP680on7KB0130_assertion description "[Regulation of most IL-6 target genes in a multiple myeloma cell line required the activation of Stat3, underscoring its central role for IL-6 signal transduction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124858.RARZhWFbqklDegiz27KglBQATspAT3EE_cwP680on7KB0130_provenance.
- NP124862.RAX-ndvwaKWDqDiiqGw7Fk-MYddOzh2hXwxHGBG7KjcME130_assertion description "[MMP-2 overproduction is associated with bone marrow stromal cells in multiple myeloma ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124862.RAX-ndvwaKWDqDiiqGw7Fk-MYddOzh2hXwxHGBG7KjcME130_provenance.
- NP124877.RAe6Vlc0gBOXL9zD4eAEK9ojd1Fs6_YaxSN6XePOQu6jo130_assertion description "[The Mcl-1, which has been shown to be essential for the survival of human myeloma cells in vitro, is overexpressed in vivo in MM in relation with relapse and shorter survival/represents a potential therapeutical target in multiple myeloma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124877.RAe6Vlc0gBOXL9zD4eAEK9ojd1Fs6_YaxSN6XePOQu6jo130_provenance.
- NP124879.RAWMjklHNud0snpjhKt1Nz-mrNrFV_F3b025vY49MRX_Q130_assertion description "[Strong cyclin D1 mRNA overexpression was detected in mantle cell lymphomas, hairy cell leukemias, and multiple myelomas/transcript levels were found in some multiple myelomas and hairy cell leukemias.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124879.RAWMjklHNud0snpjhKt1Nz-mrNrFV_F3b025vY49MRX_Q130_provenance.
- NP124881.RAZqbgtx-PfVt-7i0mLnD-IhJyhvuMNyuelfKys7G1H4o130_assertion description "[Ectopic cyclin D1 overexpression increases chemosensitivity but not cell proliferation in multiple myeloma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124881.RAZqbgtx-PfVt-7i0mLnD-IhJyhvuMNyuelfKys7G1H4o130_provenance.
- NP124885.RAfFXPzDv_ag3SCO9EXcevKM0ZEIz_wIIA16hKU7afJJ8130_assertion description "[the human nucleotide excision repair gene, hHR23B, is epigenetically silenced in interleukin-6-responsive multiple myeloma KAS-6/1 cells ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124885.RAfFXPzDv_ag3SCO9EXcevKM0ZEIz_wIIA16hKU7afJJ8130_provenance.
- NP124897.RAXbW4HaodW8Nt6NRgZuShmymVE9MsZzD-MNLGNgXq2HM130_assertion description "[MAGE-C1 is cancer-testis antigen suitable for immune targeting in multiple myeloma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124897.RAXbW4HaodW8Nt6NRgZuShmymVE9MsZzD-MNLGNgXq2HM130_provenance.
- NP124898.RAYLn_5KA-g5hkHhv-gssmALNCDKlp-kE-Ffyo5JKRygc130_assertion description "[bone marrow sera from 21 multiple myeloma patients significantly suppressed Wnt3a-induced OPG expression and enhanced RANKL expression in osteoblasts in a DKK1-dependent manner ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124898.RAYLn_5KA-g5hkHhv-gssmALNCDKlp-kE-Ffyo5JKRygc130_provenance.
- NP124900.RAYlmyMk3Z6YFhG8ZvqXUK6ABu6vZZnuwP2CCOz61C2YY130_assertion description "[data suggested a longer overall survival for multiple myeloma patients with C/T and T/T genotypes (log-rank test, P = 0.02) compared with patients with C/C genotype ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124900.RAYlmyMk3Z6YFhG8ZvqXUK6ABu6vZZnuwP2CCOz61C2YY130_provenance.
- NP124905.RAZ-QT6MiKSdXEEwCfRo7S5hdFkVaPPBtrpMchN_GZT6g130_assertion description "[the only factor useful in identifying multiple myeloma patients benefiting from anthracycline/thalidomide-based therapy ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124905.RAZ-QT6MiKSdXEEwCfRo7S5hdFkVaPPBtrpMchN_GZT6g130_provenance.
- NP124906.RAe2_guF6QoajPPC7_--7PGF5OpsYkVW91vKsvTPiop_U130_assertion description "[IL-6 related gene variations influence susceptibility to multiple myeloma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124906.RAe2_guF6QoajPPC7_--7PGF5OpsYkVW91vKsvTPiop_U130_provenance.
- NP124915.RASdW4HWzPZjM8XKjJXl64X6inXyAafGJ6hTcy1IhkUTI130_assertion description "[cells from multiple myeloma patients express constitutively active NF-kappaB and STAT3, and suppression of these transcription factors inhibits the survival of the cells ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124915.RASdW4HWzPZjM8XKjJXl64X6inXyAafGJ6hTcy1IhkUTI130_provenance.
- NP124921.RAdvP2UVKkRnO7y9bq8CBCxK3J958cLHuSZaNdHgDsyHo130_assertion description "[Results show that OPN is not valuable as a clinical marker for monitoring the treatment response in multiple myeloma patients because of inconsistency in its levels in multiple myeloma patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124921.RAdvP2UVKkRnO7y9bq8CBCxK3J958cLHuSZaNdHgDsyHo130_provenance.
- NP124922.RAc-D1mJL_FXIShqW0YCFq2092AAzm4tUaDoVxL-q2lW8130_assertion description "[different transcripts detected, multiple myeloma SET domain containing protein (MMSET I), MMSET II, Exon 4a/MMSET III, and response element II binding protein (RE-IIBP), are produced by alternative splicing ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124922.RAc-D1mJL_FXIShqW0YCFq2092AAzm4tUaDoVxL-q2lW8130_provenance.
- NP124924.RAQdp7fOmaMbZLCG4_wrjI-CBD__d2JeUFvEYbQ79scrI130_assertion description "[data indicate that t (4; 14) (p16; q32) and loss of fibroblast growth factor receptor 3 occurred at a very early stage of multiple myeloma and suggest that activation of multiple myeloma SET domain protein may be transforming event of this translocation ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124924.RAQdp7fOmaMbZLCG4_wrjI-CBD__d2JeUFvEYbQ79scrI130_provenance.
- NP124926.RATDerR1scEwZqi9-8PGIBiU7jrS8Isl5MH9CxAlfVz9c130_assertion description "[ATM mutation may play a role in the pathogenesis of a subset of multiple myelomas ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124926.RATDerR1scEwZqi9-8PGIBiU7jrS8Isl5MH9CxAlfVz9c130_provenance.
- NP124936.RAWQ2gCvKloI_w3xCoh21wdXWFRM83ODtIiLYE7QjOd3c130_assertion description "[Hsp27 is overexpressed in both dexamethasone resistant multiple myeloma cell lines and primary patient cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124936.RAWQ2gCvKloI_w3xCoh21wdXWFRM83ODtIiLYE7QjOd3c130_provenance.
- NP124939.RAUsRubIXGehGvgJQK88LXri4vLAlqMdagWKL003tlGKM130_assertion description "[In multiple myeloma cells mTOR inhibition results a more complete abrogation of VEGF translation, and ultimately, angiogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124939.RAUsRubIXGehGvgJQK88LXri4vLAlqMdagWKL003tlGKM130_provenance.
- NP124942.RAafwgBHK8dF8pB4ULuAB4u2ejZXWvMJ8Gf8N1c2EUnMI130_assertion description "[Data suggest that increased MIP-1alpha/beta production enhances multiple myeloma cell binding to stromal cells by VLA-4-VCAM-1 adhesion, forming a " vicious cycle " between MM cell adhesion to stromal cells and MIP-1 production via VLA-4-VCAM-1 interaction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124942.RAafwgBHK8dF8pB4ULuAB4u2ejZXWvMJ8Gf8N1c2EUnMI130_provenance.
- NP124949.RAf2iORo1H7HmBoPOwMGU5SvSfUMAZs49j35he51r3xi4130_assertion description "[a selective induction of cox-2 in multiple myeloma cells containing RAS mutations, results in heightened binding to extracellular matrix protein and chemotherapeutic drug resistance ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124949.RAf2iORo1H7HmBoPOwMGU5SvSfUMAZs49j35he51r3xi4130_provenance.
- NP124953.RAecwuEgUiCXHExyede9T4H6mS8w-qgEB41aUnSpYCQ30130_assertion description "[multiple myeloma cells (but not B-cell chronic lymphocytic leukemia cells) induced a dramatic increase in expression of VEGFR-1 and VEGFR-3 on human bone marrow endothelial cells ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124953.RAecwuEgUiCXHExyede9T4H6mS8w-qgEB41aUnSpYCQ30130_provenance.
- NP124954.RATCkvRUSa4yzwuFERwg2tpwpaN5-gtP0hGIfY3ztZCu8130_assertion description "[AREG gene expressed by purified primary myeloma cells, and expression higher than in normal bone marrow (BM) plasma cells or plasmablastic cells; AREG plays an important role in biology of multiple myeloma ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124954.RATCkvRUSa4yzwuFERwg2tpwpaN5-gtP0hGIfY3ztZCu8130_provenance.
- NP124955.RAYUtSmQ066U2RArMZO-QZeCmq16kH1n5VL4Alf9rAA9E130_assertion description "[multiple myeloma cells (but not B-cell chronic lymphocytic leukemia cells) induced a dramatic increase in expression of VEGFR-1 and VEGFR-3 on human bone marrow endothelial cells ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124955.RAYUtSmQ066U2RArMZO-QZeCmq16kH1n5VL4Alf9rAA9E130_provenance.
- NP124961.RAWnpLf13GxeXeH9jF_V8ufNKP2UOGTCtCyieG4mq5uWY130_assertion description "[VEGF receptors are found on plasma cells from all groups of patients with multiple myeloma with the lowest expression on plasma cells from normal individuals ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124961.RAWnpLf13GxeXeH9jF_V8ufNKP2UOGTCtCyieG4mq5uWY130_provenance.
- NP124962.RAV3bkWl9X8EgaeliGhqqKi8sAGgYn_cM1ya9W4ajcQn0130_assertion description "[Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124962.RAV3bkWl9X8EgaeliGhqqKi8sAGgYn_cM1ya9W4ajcQn0130_provenance.
- NP124971.RAdkxgfCxxXzCyWpT_fiCfWHji5gU7FZCVc85R75HfD3k130_assertion description "[Rituximab may be effective in patients with multiple myeloma expressing this antigen.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124971.RAdkxgfCxxXzCyWpT_fiCfWHji5gU7FZCVc85R75HfD3k130_provenance.
- NP124972.RAbkWj5A5QgWUehZ1JONpP-vDe8LO4x35-EelbNkOlmG0130_assertion description "[The induction of apoptosis by a combined 1, 25 (OH) 2D3 analog, EB1089 and TGF-beta1 in NCI-H929 multiple myeloma cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124972.RAbkWj5A5QgWUehZ1JONpP-vDe8LO4x35-EelbNkOlmG0130_provenance.
- NP124975.RAT7TTjaJVv6KyjhuGCDXFZKthwyf5r9N_orzsL55QQVQ130_assertion description "[Up-regulation of nuclear factor kappaB is associated with multiple myeloma ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124975.RAT7TTjaJVv6KyjhuGCDXFZKthwyf5r9N_orzsL55QQVQ130_provenance.
- NP124981.RAevH1uoeuZ9WujQDVLvghojHyVdZ8Dl5SRHGFuz83JY0130_assertion description "[variant isoforms involved in plasma cell adhesion to bone marrow stromal cells and in the multiple myeloma disease process ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124981.RAevH1uoeuZ9WujQDVLvghojHyVdZ8Dl5SRHGFuz83JY0130_provenance.
- NP124984.RAbbLPUWMhSqhhXqdx-S6xbSmDq46to5Dwv5lRbYQ_Fh8130_assertion description "[NY-ESO-1 is frequently expressed in multiple myeloma with cytogenetic abnormality ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124984.RAbbLPUWMhSqhhXqdx-S6xbSmDq46to5Dwv5lRbYQ_Fh8130_provenance.
- NP124988.RAVmZiPn-TRN0ODL2pivOyP05cK33Npg_FNEnvZqaaG0U130_assertion description "[Oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124988.RAVmZiPn-TRN0ODL2pivOyP05cK33Npg_FNEnvZqaaG0U130_provenance.
- NP124990.RAcCtT8rBKclLlWC-BZzHYlzgZCuuthhOOkIg1flci5zI130_assertion description "[there is an FGFR3 mutation with a demonstrated deregulatory mechanism and alternative splicing in the absence of t (4; 14) in multiple myeloma patients ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124990.RAcCtT8rBKclLlWC-BZzHYlzgZCuuthhOOkIg1flci5zI130_provenance.
- NP124993.RAcjI-FL6162KBzbavPUUsb-7H4ScTyb-hRVi7vLe2kG8130_assertion description "[Inactivation of TRAF3 is associated with multiple myeloma ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124993.RAcjI-FL6162KBzbavPUUsb-7H4ScTyb-hRVi7vLe2kG8130_provenance.
- NP124994.RAQmj7l6cZWPWhzqq3D_0Bo7iA7ji0NEXTZqDf6J8JCgI130_assertion description "[serum levels of BAFF and APRIL were increased about 5-fold in patients with multiple myeloma as compared with healthy donors ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124994.RAQmj7l6cZWPWhzqq3D_0Bo7iA7ji0NEXTZqDf6J8JCgI130_provenance.
- NP124996.RAZkb-Qa5uPHViC8VCKzbVpY-nFcKYlSpl0T9SPhaqHco130_assertion description "[accumulated evidence indicated an association between MTHFR C677T polymorphism and multiple myeloma in Caucasians under a dominant model ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124996.RAZkb-Qa5uPHViC8VCKzbVpY-nFcKYlSpl0T9SPhaqHco130_provenance.
- NP124998.RAQcwTmjzIYXf2fhAuvAEdF6XMegUN2w8ZKdku7owUID4130_assertion description "[polymorphism associated with an increased risk of multiple myeloma ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124998.RAQcwTmjzIYXf2fhAuvAEdF6XMegUN2w8ZKdku7owUID4130_provenance.
- NP124999.RAbzI8H-4qsd_2cMI4W5D7DStboJbL6wxOCXpohUxTZhU130_assertion description "[FGFR3 is an important cell survival and antiapoptotic factor for multiple myeloma cells ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP124999.RAbzI8H-4qsd_2cMI4W5D7DStboJbL6wxOCXpohUxTZhU130_provenance.
- NP125002.RAbF5uguofg05awKSRjMze1np5e3LDKdo7qOqY5eWTMnc130_assertion description "[PPARgamma negatively controls multiple myeloma growth and viability in part through inhibition of interleukin-6 production by bone marrow stromal cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125002.RAbF5uguofg05awKSRjMze1np5e3LDKdo7qOqY5eWTMnc130_provenance.
- NP125003.RAcjhWH1aZ50ucu3OgBYPXKUHNafXYdnqKJiJR8vJR-Ak130_assertion description "[CD74 represents a novel and promising target for treatment of multiple myeloma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125003.RAcjhWH1aZ50ucu3OgBYPXKUHNafXYdnqKJiJR8vJR-Ak130_provenance.
- NP125004.RAWe3-9qXjc0vN0QYFglkFiB419-goNeH9NMMH2pbJQjY130_assertion description "[Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of MCL1 and BIM and a decrease in the MCL1/BIM complex.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125004.RAWe3-9qXjc0vN0QYFglkFiB419-goNeH9NMMH2pbJQjY130_provenance.
- NP125005.RAck-p-uLuQ79GbNLoNpBXjiCq9-5kQJuTt6fF68OwCio130_assertion description "[skeletrophin is a novel ubiquitin ligase that targets the intracellular region of Jagged-2 and is aberrantly overexpressed in multiple myeloma cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125005.RAck-p-uLuQ79GbNLoNpBXjiCq9-5kQJuTt6fF68OwCio130_provenance.
- NP125008.RAQLbmWiTMaHojcXO5N5fcKFbG5XZKoxczDAqXcc8rAOk130_assertion description "[VEGF-A, STAT5 and AKT are downregulated in acute myeloid leukemia blasts of patients treated with SU5416 ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125008.RAQLbmWiTMaHojcXO5N5fcKFbG5XZKoxczDAqXcc8rAOk130_provenance.
- NP125010.RAeann8-wiONawOmGjtMeTL7LR4W7CuQk95E7IS45aAp0130_assertion description "[Transfecting CCN3 into BCR-ABL+ cells inhibited proliferation and decreased clonogenic potential in acute myeloid leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125010.RAeann8-wiONawOmGjtMeTL7LR4W7CuQk95E7IS45aAp0130_provenance.
- NP125011.RAdAbLCPx6LW6MQ-l4GvRVtis0E2lrZJKQZ6FKvKqM1x4130_assertion description "[acute myeloid leukemia cells expressed the NKG2D receptor and its signal-transducing adaptator DAP 10, which were functional as confirmed by redirected lysis experiments ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125011.RAdAbLCPx6LW6MQ-l4GvRVtis0E2lrZJKQZ6FKvKqM1x4130_provenance.
- NP125013.RAfW7B5F7yzYU_MK9-H0r1DjXiTgI7HZr0IYsTGplsrrU130_assertion description "[MRP3, BCRP, and P-glycoprotein have roles in progression of adult acute myeloid leukemia ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125013.RAfW7B5F7yzYU_MK9-H0r1DjXiTgI7HZr0IYsTGplsrrU130_provenance.
- NP125015.RAc9r2PSAU9zk6IPS4UJZUM_xQvUXyffEZNwkPJ9cIkfs130_assertion description "[Increased expression in relapsed or refractory acute myeloid leukemia compared to level at diagnosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125015.RAc9r2PSAU9zk6IPS4UJZUM_xQvUXyffEZNwkPJ9cIkfs130_provenance.
- NP125017.RAUSse6LKYkTiuEVAaCq8cRLMfGl2mLOezm6aorntkvpQ130_assertion description "[BCRP mRNA levels, antibody staining and function correlated strongly in cell lines but not in acute myeloid leukemia samples, suggesting complex biology of BCRP in AML and incomplete modeling by cell lines ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125017.RAUSse6LKYkTiuEVAaCq8cRLMfGl2mLOezm6aorntkvpQ130_provenance.
- NP125018.RATU-opNvFI3qZkdjZP69SYT18l3_1LjcXqrNn4Qr06m0130_assertion description "[BCRP was over-expressed in 24 patients and was significantly co-expressed with P-glycoprotein in acute myeloid leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125018.RATU-opNvFI3qZkdjZP69SYT18l3_1LjcXqrNn4Qr06m0130_provenance.
- NP125020.RAbdTUU3OHYhXzcGmBh0vtTBXGrbkex03BWVcxCmG7i6w130_assertion description "[relationship between soluble resistance-related calcium-binding protein (sorcin) gene and multidrug resistance gene (mdr1), and their significance in clinical drug resistance and prognosis of acute myeloid leukemia (AML) ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125020.RAbdTUU3OHYhXzcGmBh0vtTBXGrbkex03BWVcxCmG7i6w130_provenance.
- NP125022.RASYDpToM7LoT5fP98TXiflKIbArXe3meM6jxhaV-yg9o130_assertion description "[MDR1 promoter polymorphism is not associated with its activity and protein expression in acute myeloid leukemia ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125022.RASYDpToM7LoT5fP98TXiflKIbArXe3meM6jxhaV-yg9o130_provenance.
- NP125023.RAdIp_5HSKTnBZIAu4Vh33K-HW8zttPMjkJqNvXzP3BIo130_assertion description "[REVIEW: potential signaling pathways leading to modulation of mdr1 expression in acute myeloid leukemia and, particularly, potential possibilities of Ras influence on mdr1 activity ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125023.RAdIp_5HSKTnBZIAu4Vh33K-HW8zttPMjkJqNvXzP3BIo130_provenance.
- NP125027.RAa7kZsGxZ7JkGtP2IhdKzNrvPBGJfKjv4kd08G78hEOA130_assertion description "[MDR1 overexpression is an unfavorable prognostic factor in acute myeloid leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125027.RAa7kZsGxZ7JkGtP2IhdKzNrvPBGJfKjv4kd08G78hEOA130_provenance.
- NP125031.RAVTkMyM4B0odFZ7iq_HadXych3J9NRfui0PzVho3dO-w130_assertion description "[Present in acute myeloid leukemia of M2 subtype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125031.RAVTkMyM4B0odFZ7iq_HadXych3J9NRfui0PzVho3dO-w130_provenance.
- NP125033.RAX-Aweiy4ixj62D5HXhuCuPl_7JnNb4G_vrWASe45kHc130_assertion description "[RT-PCR for the detection of AML1/ETO in children with acute non-lymphoid leukemia (ANLL) was quick, convenient and sensitive, and could be regarded as a useful method for the diagnosis and prognosis of ANLL.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125033.RAX-Aweiy4ixj62D5HXhuCuPl_7JnNb4G_vrWASe45kHc130_provenance.
- NP125034.RAWggb13W8zQPx_8vuLA-L8ggT59ZOGXa0-s0o3E8J3n0130_assertion description "[AML1-ETO and JAK2 may have a role in leukemogenesis, as shown by a myeloproliferative syndrome progressing to acute myeloid leukemia [case report]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125034.RAWggb13W8zQPx_8vuLA-L8ggT59ZOGXa0-s0o3E8J3n0130_provenance.
- NP125036.RAfoLk83udvtfW7v0Ch1aHBvXgM4P8X35xmYlbdIcHf7s130_assertion description "[Trisomy 13 is strongly associated with AML1/RUNX1 mutations and increased FLT3 expression in acute myeloid leukemia ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125036.RAfoLk83udvtfW7v0Ch1aHBvXgM4P8X35xmYlbdIcHf7s130_provenance.
- NP125039.RAecZNyLy_u2NXmCjqPN5RUUvBZc_zITQABeOb-4g4y5U130_assertion description "[Potential involvement of the AML1-MTG8 fusion protein in the granulocytic maturation characteristic of the t (8; 21) acute myelogenous leukemia cell ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125039.RAecZNyLy_u2NXmCjqPN5RUUvBZc_zITQABeOb-4g4y5U130_provenance.
- NP125041.RAbhVMxfz1uuW1a8D3vVVqcMpXSaGzU66x-dA4v2i0bdw130_assertion description "[Present in acute myeloid leukemia of M2 subtype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125041.RAbhVMxfz1uuW1a8D3vVVqcMpXSaGzU66x-dA4v2i0bdw130_provenance.
- NP125044.RAQ5NrQnUqQyhpEuDbV222RCeUjkN1r89qO3_wUvK1ZDE130_assertion description "[AML1 mutations were identified in 6.3% of acute myeloid leukemia patients with chromosomal translocations involving CBF, PML-RARalpha, HOX, or ETS transcription factor (TF) gene families ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125044.RAQ5NrQnUqQyhpEuDbV222RCeUjkN1r89qO3_wUvK1ZDE130_provenance.
- NP125047.RAfcKkHZ5ImPJafE-lQXyAoKrLy57oG70yBYuPFVo36Ok130_assertion description "[Double trisomy 8 and 21, one with rearrangement of the RUNX1 gene, in acute myelocytic leukemias ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125047.RAfcKkHZ5ImPJafE-lQXyAoKrLy57oG70yBYuPFVo36Ok130_provenance.
- NP125060.RAVBph2X71-GL-DCwaV5QoyiGOHk_0ORUxrgWDyObkShg130_assertion description "[The HP196-197 insertion is not a mutation but a polymorphism and does not appear related to acute myeloid leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125060.RAVBph2X71-GL-DCwaV5QoyiGOHk_0ORUxrgWDyObkShg130_provenance.
- NP125061.RAU62Qc9cd0ewiEHtqH9Ce_QBoCTMsgwCZ6DAM3fQjSdg130_assertion description "[Mutant CEBPA predicts favorable prognosis and may improve risk stratification in acute myeloid leukemia patients with normal cytogenetics.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125061.RAU62Qc9cd0ewiEHtqH9Ce_QBoCTMsgwCZ6DAM3fQjSdg130_provenance.
- NP125065.RAVRtFV0a52EEyN35Sp0mfYgYvBYwiDxCq-yT5toxnM2Q130_assertion description "[its deficiency in acute myeloid leukemia may be one of the explanations for susceptibility to infection among these patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125065.RAVRtFV0a52EEyN35Sp0mfYgYvBYwiDxCq-yT5toxnM2Q130_provenance.
- NP125068.RASkdBMGhhD_NZTHuoIpCrjY69y0LL5noChbgXEwlXorM130_assertion description "[Differential effects of FGF4, EGF and TGFB1 on functional development of stromal layers (progenitor cell-outputs) in acute myeloid leukemia ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125068.RASkdBMGhhD_NZTHuoIpCrjY69y0LL5noChbgXEwlXorM130_provenance.
- NP125070.RAdv7vP9u_AAh8o_W6tfWz11yKjg3Xd8hPJZXFCP7e76w130_assertion description "[up-regulated by the AML1-MTG8 fusion protein, suggesting a role in the granulocytic maturation characteristic of the t (8; 21) acute myelogenous leukemia ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125070.RAdv7vP9u_AAh8o_W6tfWz11yKjg3Xd8hPJZXFCP7e76w130_provenance.
- NP125072.RAdtPk28_0mgLR6FRxu9PQ3Hks2qQhbjHEtR6YQ4UUh00130_assertion description "[MMP-9 abnormal expression may play a role in the increased vessel density notoriously found in bone marrow of acute myeloid leukemia (AML) patients at diagnosis and thus it may be involved in the leukemogenic process and in myelodysplastic syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125072.RAdtPk28_0mgLR6FRxu9PQ3Hks2qQhbjHEtR6YQ4UUh00130_provenance.
- NP125082.RAT_UhkVag1CZuPuKw9KfjtYZsI-D2tes46pt8vHKsiH0130_assertion description "[NPM1 mutations were observed in 7 of 51 patients presenting as overt therapy-related acute myeloid leukemia as compared to only 3 of 89 patients presenting as therapy-related myelodysplasia ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125082.RAT_UhkVag1CZuPuKw9KfjtYZsI-D2tes46pt8vHKsiH0130_provenance.
- NP125086.RAW_58fpneCkTHUDz_PLgTpvGpW6aMJHAI22Jxla6mK5g130_assertion description "[NPM1 mutations were not detected in the 28 patients with myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125086.RAW_58fpneCkTHUDz_PLgTpvGpW6aMJHAI22Jxla6mK5g130_provenance.
- NP125087.RAbaRyt-JF7NFcUQtxGqOvTj2RhKzoigNTLioB5KCfRWQ130_assertion description "[NPM1 mutations are associated with residual disease of acute myeloid leukemia ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125087.RAbaRyt-JF7NFcUQtxGqOvTj2RhKzoigNTLioB5KCfRWQ130_provenance.
- NP125090.RAXBcyN5wa_fNPfCk8TiTIunpdRi3TeP478et5y_o2TJ8130_assertion description "[Ski is expressed in patients with acute myeloid leukemia treated with all-trans retinoic acid ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125090.RAXBcyN5wa_fNPfCk8TiTIunpdRi3TeP478et5y_o2TJ8130_provenance.
- NP125091.RAY8LlvmBHGGT-VRAVSwJ8o3J8j1ayT-fQzUk-9vO9OrI130_assertion description "[Results indicate the expression of functional B7.2 molecule may facilitate progression of acute myeloid leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125091.RAY8LlvmBHGGT-VRAVSwJ8o3J8j1ayT-fQzUk-9vO9OrI130_provenance.
- NP125103.RAXdG6OCNyb1rPjjRdEfowxhrYhmjVA2dxv_Wr0e5Si9c130_assertion description "[amplification in acute nonlymphocytic leukemia ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125103.RAXdG6OCNyb1rPjjRdEfowxhrYhmjVA2dxv_Wr0e5Si9c130_provenance.
- NP125109.RAVgiZwllPWJO8fppcFANZAE0mDYBdqX5JnUNapCKf-YQ130_assertion description "[Different clones of t (1; 12)/t (12; 12) involving the ETV6 gene in a case of acute myeloid leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125109.RAVgiZwllPWJO8fppcFANZAE0mDYBdqX5JnUNapCKf-YQ130_provenance.
- NP125111.RAfObIuxj1cJIeZXJ28YcKuPXUsHUDO8P_POpGuR93I4c130_assertion description "[Acquisition of N-ras mutation is frequently associated with progression of myelodysplastic syndrome to acute myeloid leukemia ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125111.RAfObIuxj1cJIeZXJ28YcKuPXUsHUDO8P_POpGuR93I4c130_provenance.
- NP125112.RAWR2VAQLVSOqjoek1sqjhUfraxFVbvaPvr8sr9sCC_u8130_assertion description "[NRAS mutations are frequent in acute myeloblastic leukemia with normal karyotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125112.RAWR2VAQLVSOqjoek1sqjhUfraxFVbvaPvr8sr9sCC_u8130_provenance.
- NP125114.RARB9dfvyMbOJ4Bbgwx6HXmysphb6Ev49JIkd5nG8Jbnk130_assertion description "[Increased monocyte chemoattractant protein 1 serum level is associated with acute myeloid leukemia ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125114.RARB9dfvyMbOJ4Bbgwx6HXmysphb6Ev49JIkd5nG8Jbnk130_provenance.
- NP125117.RATF91ZJ01RSZB9YXXvkOfWxZ3LgbjL4TZKtFJtF0yqe4130_assertion description "[Aberrant methylation of ESR1 promoter is associated with acute myeloid leukemia ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125117.RATF91ZJ01RSZB9YXXvkOfWxZ3LgbjL4TZKtFJtF0yqe4130_provenance.
- NP125119.RAZiGtlRiM9L32gs6GlaHI0-jurcePCGru5bF6QeRbJAA130_assertion description "[Overexpression of hERG1 channels mediate the FLT-1-dependent cell migration and invasion, and hence confer a greater malignancy in acute myeloid leukemia ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125119.RAZiGtlRiM9L32gs6GlaHI0-jurcePCGru5bF6QeRbJAA130_provenance.
- NP125121.RAUX78DHl-BGsr_JC5aAoK77I7JwQc19lPbw9gheVnZnc130_assertion description "[JAK2-V617F activating mutation may have a role in acute myeloid leukemia ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125121.RAUX78DHl-BGsr_JC5aAoK77I7JwQc19lPbw9gheVnZnc130_provenance.
- NP125127.RAXZdJRHIOleMdsouMuYyV0se7Mh_shCVBddZFxR4-xNY130_assertion description "[Superior outcome of t (8; 21) acute myeloid leukemia patients is partly due to an activated p53 pathway, and that loss of the p53 response pathway is associated with disease progression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125127.RAXZdJRHIOleMdsouMuYyV0se7Mh_shCVBddZFxR4-xNY130_provenance.
- NP125136.RASmGf-aroEBMYOi0NsS6OcEd01Ve6tMj9fA235wsj3wo130_assertion description "[CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 were observed in patients with acute myeloid leukemia, and not in controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125136.RASmGf-aroEBMYOi0NsS6OcEd01Ve6tMj9fA235wsj3wo130_provenance.
- NP125137.RAS_Rij7f5bZW6Cor5KeplQGqGRyaSISjx6956AXswW_U130_assertion description "[monocytic differentiation and a poor prognosis may also be associated with acute myeloid leukemia with the variant MLL/SEPT9 fusion transcript ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125137.RAS_Rij7f5bZW6Cor5KeplQGqGRyaSISjx6956AXswW_U130_provenance.
- NP125141.RAdvNof0P4ckdvtRFHINk8chBjI88hKYSJi2PRyZift-A130_assertion description "[Genetic abnormality in the KIT gene, particularly at codon 816, might contribute to the progression of myelodysplastic syndromes to acute myelocytic leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125141.RAdvNof0P4ckdvtRFHINk8chBjI88hKYSJi2PRyZift-A130_provenance.
- NP125147.RAVQsmdmagQxm5jogn6iXi8qFnLnt828LWdeHZyFUF4MU130_assertion description "[GSTT1 deletions confers interindividual variability of response to treatment in patients with acute myeloid leukemia ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125147.RAVQsmdmagQxm5jogn6iXi8qFnLnt828LWdeHZyFUF4MU130_provenance.
- NP125151.RAYnCB2MDXCzTzHktNlN2c440qrbDJGAZcy3gNk5iEt8E130_assertion description "[Deleterious G-CSFR-mediated signaling events, such as aberrant Stat3 activation demonstrated in a subset of acute myeloid leukemia (AML) patients with poor prognosis, could be exploited for the treatment of AML patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125151.RAYnCB2MDXCzTzHktNlN2c440qrbDJGAZcy3gNk5iEt8E130_provenance.
- NP125154.RAYiiEfc7KTa3ZCPDuNot9JzZbekSSokcVPjvpZNsXUbU130_assertion description "[MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125154.RAYiiEfc7KTa3ZCPDuNot9JzZbekSSokcVPjvpZNsXUbU130_provenance.
- NP125157.RATsUUAKOPePQqlAZMbfSYAHmRRri4mean-KGyFUhtsoM130_assertion description "[This study provides evidence for a novel role for NPM as a negative regulator of CXCR4 signaling induced by CXCL12 that may be relevant to the biology of acute myelogenous leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP125157.RATsUUAKOPePQqlAZMbfSYAHmRRri4mean-KGyFUhtsoM130_provenance.