Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence The+functional+defect+associated+with+an+AR+exon+1+missense+mutation. assertion.
- assertion asSentence Inactivation+of+the+MAL+gene+in+breast+cancer+is+a+common+event+that+predicts+benefit+from+adjuvant+chemotherapy. assertion.
- assertion asSentence High-activity+MAOA+promoter+gene+polymorphisms%2C+as+in+aging%2C+are+a+risk+factor+for+telomeric+shortening. assertion.
- assertion asSentence Lesion+location+and+MAO-A+genotype+interact+in+mediating+aggression+in+PTBI. assertion.
- assertion asSentence Activation+of+human+monoamine+oxidase+B+gene+expression+by+a+protein+kinase+C+MAPK+signal+transduction+pathway+involves+c-Jun+and+Egr-1. assertion.
- assertion asSentence Parkin+degrades+ESRRA%2C+ESRRB+and+ESRRG+to+limit+the+expression+of+MAOA+and+MAOB. assertion.
- assertion asSentence The+light+chain+%28LC1%29+of+microtubule-associated+protein+1B+%28MAP1B%29-5-HT%283A%29+receptor+interaction+contributes+to+a+mechanism+that+regulates+receptor+desensitization+kinetics. assertion.
- assertion asSentence Truncation+of+the+projection+domain+of+MAP4+leads+to+attenuation+of+microtubule+dynamic+instability. assertion.
- assertion asSentence L266V+is+a+pathogenic+tau+mutation+that+is+associated+with+Pick-like+pathology. assertion.
- assertion asSentence Tau+FTDP-mutation+N279K+is+implicated+in+dementias. assertion.
- assertion asSentence Familial+autosomal+dominant+cortico-basal+degeneration+with+the+P301S+mutation+in+the+tau+gene. assertion.
- assertion asSentence In+DMI+Tau+exon+6+is+mis-regulated+only+in+the+brain+tissue. assertion.
- assertion asSentence Overexpression+of+mutant+%28P301L%29+human+tau+in+CHIP-%2F-+mice+is+insufficient+to+promote+either+argyrophilic+or+%22pre-tangle%22+structures%2C+despite+marked+phospho-tau+accumulation+throughout+the+brain. assertion.
- assertion asSentence The+tau-4R+isoform+essentially+contributes+to+hippocampal+development+by+controlling+proliferation+and+differentiation+of+neuronal+precursors. assertion.
- assertion asSentence An+impaired+control+of+glycogen+synthase+kinase-3beta+activity+by+insulin+receptor-mediated+signalling+plays+a+role+in+the+pathogenesis+of+AD%2C+facilitating+tau+protein+phosphorylation+and+neurofibrillary+tangle+formation. assertion.
- assertion asSentence There+is+an+increased+neurogenesis+during+tau+hyperphosphorylation+and+cell+cycle+events+during+abnormal+tau+phosphorylation+and+tau+aggregation+preceding+neuronal+death+and+neurodegeneration. assertion.
- assertion asSentence Amyloid-beta+and+Tau+affected+aging-prone+astrocyte+cell+death%2C+metabolism+and+cytoskeleton. assertion.
- assertion asSentence Sut-2+as+a+gene+required+for+human+tau+neurotoxicity+in+C.+elegans. assertion.
- assertion asSentence The+hyperphosphorylated+transgenic+tau+accumulates+in+the+nerve+fibre+layer+and%2C+from+2+months+of+age%2C+aggregates+into+filamentous+inclusions+in+retinal+ganglion+cells+of+human+P301S+tau+transgenic+mice. assertion.
- assertion asSentence The+significance+of+the+time+course+of+MAPT+biomarker+abnormalities+in+Alzheimer+disease+correlates+with+hippocampal+volume+and+radial+distance+compared+with+apolipoprotein+E4+carriers+and+noncarriers. assertion.
- assertion asSentence Amyloid-beta+peptide+alteration+of+tau+exon-10+splicing+is+related+to+its+activation+of+GSK-3beta+which+in+turn+phosphorylates+SC35. assertion.
- assertion asSentence From+tau+phosphorylation+to+tau+aggregation. assertion.
- assertion asSentence Functional+implications+of+the+association+of+tau+with+the+plasma+membrane. assertion.
- assertion asSentence %5Breview%5D+The+abnormally+hyperphosphorylated+tau+of+Alzheimer%27s+disease+%28AD%29+is+distinguishable+from+both+normal+and+transiently+hyperphosphorylated+taus+and+is+inhibitory+when+in+the+cytosolic%2Foligomeric+state+of+AD+and+related+tauopathies. assertion.
- assertion asSentence The+early+age+at+onset+a+frontotemporal+dementia+reflects+a+marked+pathogenic+effect+of+the+mutation+involving+a+disturbance+of+microtubule+binding%2C+tau+phosphorylation+or+a+major+acceleration+of+tau+aggregation. assertion.
- assertion asSentence In+brain+from+Alzheimer%27s+patients%2C+protein+phosphatase+2B+%28PP2B%29+activity+correlated+positively%2C+rather+than+negatively%2C+to+the+levels+of+tau+phosphorylation+at+several+sites+that+can+be+dephosphorylated+by+PP2B+in+vitro. assertion.
- assertion asSentence A+R406W+mutation+in+TAU+leads+to+impaired+membrane+binding. assertion.
- assertion asSentence Patients+with+mild+cognitive+impairment+and+low+Abeta42+peptide+fragment%2C+with+high+tau+levels+in+the+cerebrospinal+fluid%2C+have+a+substantially+increased+risk+of+developing+Alzheimer%27s+disease%2C+even+after+adjustment. assertion.
- assertion asSentence Variation+in+MAPT+gene+is+associated+with+tauopathy+progressive+supranuclear+palsy. assertion.
- assertion asSentence Addition+of+Hsp70+to+a+mixture+of+oligomeric+and+fibrillar+tau+aggregates+prevents+the+toxic+effect+of+these+tau+species+on+fast+axonal+transport. assertion.
- assertion asSentence LRRK2+plays+an+important+role+as+a+physiological+regulator+for+phosphorylation-mediated+dissociation+of+tau+from+microtubules. assertion.
- assertion asSentence Mutations+in+the+MAT1A+gene+are+the+most+prevalent+cause+of+isolated+hypermethioninemia+in+Taiwanese. assertion.
- assertion asSentence Beta+subunit+associates+with+cirrhosis+and+cancer+providing+a+proliferative+advantage+in+hepatoma+cells+through+its+interaction+with+methionine+adenosyltransferase+II+alpha2+and+down-regulation+of+S-adenosylmethionine+levels. assertion.
- assertion asSentence After+IGF-I+stimulation%2C+CTK+is+recruited+to+IGF-IR+and+its+recruitment+facilitates+CTK%27s+subsequent+association+with+phospho-SHPS-1. assertion.
- assertion asSentence The+tagSNP+rs1149048+polymorphism+in+the+MATN1+promoter+region+is+associated+with+both+susceptibility+and+disease+severity+in+adolescent+idiopathic+scoliosis. assertion.
- assertion asSentence MAZ+and+Sp1+play+important+roles+on+the+transcriptional+activation+of+the+human+edn+promoter+through+specific+binding+to+a+34-nt+segment+present+in+representative+primate+eosinophil+rnase+promoters. assertion.
- assertion asSentence The+SAF-1.c-Fos.c-Jun+ternary+complex+efficiently+promotes+transcription+from+both+SAF-1+and+AP-1+sites+of+human+MMP-1+promoter. assertion.
- assertion asSentence Hypoxia+reprograms+calcium+signaling+and+regulates+myoglobin+expression. assertion.
- assertion asSentence Methyl-CpG+binding+protein+MBD1+binds+to+teneurin+1. assertion.
- assertion asSentence Polymorphism+within+the+MBL+gene+is+not+associated+with+presence+or+extent+of+erosions+by+5+years+in+patients+with+rheumatoid+arthritis+or+inflammatory+polyarthritis. assertion.
- assertion asSentence Mannose+binding+lectin+levels+are+not+altered+by+HIV+infection+or+AIDS. assertion.
- assertion asSentence Development+of+restenosis+depends+on+both+complement+activation+regulated+by+the+MBL2+gene+and+pathologic+processes+leading+to+enhanced+production+of+VEGF+and+PDGF+during+the+very+early+postoperative+period. assertion.
- assertion asSentence Frequent+variants+of+the+MBL+gene%2C+leading+to+low+MBL+concentrations%2C+are+associated+with+the+diagnosis+of+BPD+in+preterm+infants. assertion.
- assertion asSentence MBL2-gene+polymorphisms+play+a+role+in+susceptibility+to+leprosy+per+se+and+in+the+clinical+progression+of+the+disease. assertion.
- assertion asSentence MBL2+mey+considered+candidate+gene+for+sodium-lithium+countertransport%2Fsusceptibility+to+hypertension. assertion.
- assertion asSentence Susceptibility+to+high-risk+HPV+infection+is+influenced+by+functional+MBP2+polymorphisms%2C+especially+in+deficient+genotypes. assertion.
- assertion asSentence The+current+knowledge+of+the+genetics+of+MBL2+is+inadequate+to+predict+serum+MBL+concentration+and+MBL-dependent+lectin+pathway+activity+in+individual+subjects. assertion.
- assertion asSentence MBL+is+indeed+present+on+the+surface+of+fresh+human+monocytes. assertion.
- assertion asSentence MBL+influences+intestinal+epithelial+cell+integrity+in+an+immediate+and+non-complement+dependent+manner+during+ischemia+and+reperfusion. assertion.
- assertion asSentence The+combination+of+fetal+MBL2+haplotypes+and+exposure+to+in+utero+viral+infection+increases+the+risk+of+adverse+pregnancy+outcomes. assertion.
- assertion asSentence In+men+with+proven+coronary+artery+disease%2C+MBL2+secretor+haplotypes+are+not+associated+to+the+rate+of+progression+of+coronary+sclerosis+nor+does+pravastatin+treatment+influence+progression+based+on+MBL2+haplotypes. assertion.
- assertion asSentence Association+of+MBP+tetranucleotide+repeat+and+multiple+sclerosis+is+restricted+to+a+geographically+defined+subpopulation+in+Finland. assertion.
- assertion asSentence MBP+inhibits+the+fibril+assembly+of+cerebral+amyloid+angiopathy+mutant+amyloid+beta-protein+%28Abeta%29. assertion.
- assertion asSentence Myelin+basic+protein+and+p25alpha+colocalize+in+myelin+in+normal+human+brains. assertion.
- assertion asSentence Peripheral+activation+of+myelin+basic+protein-specific+CD4-positive+T+cells+in+draining+lymph+nodes+is+an+early+event+in+the+development+of+autoimmune+encephalitis+%28EAE%29+in+healthy+pre-EAE+transgenic+mice. assertion.
- assertion asSentence The+21.5+kDa+MBP+promotes+the+proliferation+of+HepG-2+cells+and+blocks+apoptosis. assertion.
- assertion asSentence MC1R+isosform+is+a+negative+regulator+of+skin+pigmentation+and+MC1R+isoform-specific+expression+is+closely+related+to+skin+pigmentation+and+photoprotection. assertion.
- assertion asSentence MC1R+variant+is+associated+with+multiple+primary+melanoma. assertion.
- assertion asSentence Specific+factors%2C+missing+in+cells+which+do+not+express+any+melanocortin+receptor%2C+are+involved+in+the+correct+addressing+of+human+MC2R+to+the+cell+membrane. assertion.
- assertion asSentence ACTH+binding+to+MC2R+stimulates+PKA-dependent+p44%2Fp42%28mapk%29+phosphorylation. assertion.
- assertion asSentence Familial+glucocorticoid+deficiency+in+five+Arab+kindreds+with+homozygous+point+mutations+of+the+ACTH+receptor+%28MC2R%29. assertion.
- assertion asSentence Outlining+the+ligand+recognition+sites+in+the+melanocortin+receptors. assertion.
- assertion asSentence Genetic+variation+in+the+transcriptionally+essential+region+of+the+MC4R+promoter+is+not+a+significant+cause+of+severe+obesity+in+humans. assertion.
- assertion asSentence Conserved+sequences+in+the+melanocortin-4+receptor+are+involved+in+alpha-melanocyte-stimulating+hormone+binding+and+signaling. assertion.
- assertion asSentence Prevalence+of+2.4%25+of+MC4R+homozygous+and+heterozygous+mutations+among+Czech+obese+children. assertion.
- assertion asSentence An+important+role+for+the+beta-MSH%2FMC4-R+cascade+in+human+melanocyte+biology. assertion.
- assertion asSentence Autosomal+dominant+mutations+in+the+melanocortin-4+receptor+%28MC4R%29+gene+are+the+leading+cause+of+monogenic+severe+childhood-onset+obesity. assertion.
- assertion asSentence The+combined+effect+of+common+variants+in+two+of+the+most+robustly+obesity-associated+loci%2C+that+is+FTO+and+MC4R%2C+explains+not+more+than+2%25+of+the+variance+in+body+weight+at+the+population+level. assertion.
- assertion asSentence MCAM+expression+doees+not+correlates+with+progression+to+advanced-stage+melanoma. assertion.
- assertion asSentence MCC+regulates+lamellipodia+formation+by+binding+to+Scrib+and+its+downstream+partner+Myosin-IIB+in+a+multiprotein+complex. assertion.
- assertion asSentence Dbl+is+regulated+by+hamartin+through+association+with+ezrin. assertion.
- assertion asSentence MCL-1+is+a+BCR%2FABL-dependent+survival+factor+and+interesting+target+in+chronic+myeloid+leukemia. assertion.
- assertion asSentence Specific+knockdown+of+Mcl-1+gene+expression+by+small+interfering+RNA+yielded+an+increase+in+apoptosis+of+LNCaP-IL-6%2B+cells. assertion.
- assertion asSentence Tribbles+homolog+2-Mcl-1+axis+plays+an+important+role+in+survival+factor+withdrawal-induced+apoptosis+of+TF-1+erythroleukemia+cells. assertion.
- assertion asSentence Mcl-1%28139%29+is+an+HLA-A2-restricted+epitope+from+Mcl-1+recognized+spontaneously+by+cytotoxic+T+cells+in+cancer+patients. assertion.
- assertion asSentence Inhibition+of+the+proteasome+by+cobalt+chloride+leads+to+the+accumulation+of+Mcl-1+which+acts+to+limit+cobalt+chloride+induced+apoptosis. assertion.
- assertion asSentence Late+tumour+stages+of+Kaposi+sarcoma+in+tissues+from+HIV-positive+patients+are+associated+with+high+levels+of+LANA-1%2C+HIF-1alpha+and+of+the+anti-apoptotic+proteins%2C+Bcl-2+and+Mcl-1. assertion.
- assertion asSentence Over-expression+of+miR-133B+increased+apoptosis+in+response+to+gemcitabine+and+reduced+MCL-1+and+BCL2L2+expression. assertion.
- assertion asSentence Mcl-1+binds+with+high+affinity+to+peptides+resembling+natural+BH3+domain+sequences. assertion.
- assertion asSentence Immediate+impact+of+Mcl-1+protein+level+manipulations+on+the+course+of+early+acute+apoptotic+response+of+colon+adenocarcinoma+cells+to+TRAIL. assertion.
- assertion asSentence Overexpression+of+MCL1+is+associated+with+prostate+carcinogenesis. assertion.
- assertion asSentence MCL-1+is+a+stress+sensor+that+regulates+autophagy+in+a+developmentally+regulated+manner. assertion.
- assertion asSentence Mcl-1+is+both+an+upstream+regulator+and+a+downstream+target+of+caspase+activity+in+human+neutrophils. assertion.
- assertion asSentence Quercetin+downregulates+Mcl-1+acting+directly+or+indirectly+on+its+mRNA+stability+and+protein+degradation. assertion.
- assertion asSentence Upregulation+of+myeloid+cell+leukemia+protein-1+by+human+cytomegalovirus+transiently+protects+nonpermissive+myeloid+cells+from+chemical+and+virus+entry-induced+cell+death. assertion.
- assertion asSentence Inhibition+of+Mcl-1+and+A1+strongly+induced+cell+death+in+some+melanoma+cell+lines. assertion.
- assertion asSentence MCL1+expression+levels+inversely+correlate+with+the+responsiveness+of+gastric+cancer+cells+toward+HDACi. assertion.
- assertion asSentence MCM2+is+part+of+the+GINS+complex. assertion.
- assertion asSentence Minichromosome+maintenance+protein+2+is+a+useful+proliferative+marker+of+breast+carcinoma. assertion.
- assertion asSentence Lymphocyte+Mcm-2+expression+is+a+useful+adjunct+to+histology+in+differentiating+between+hepatitis+C+virus+graft+infection+and+acute+cellular+rejection. assertion.
- assertion asSentence Phosphorylation+of+Mcm2+by+Cdc7+kinase+promotes+chromatin+loading+of+Mcm2. assertion.
- assertion asSentence The+subtype+and+MCM6+protein+expression+in+craniopharyngiomas+are+related+to+the+prognosis+of+tumor. assertion.
- assertion asSentence The+molecular+mechanism+of+Mcm2-7+chromatin+loading+and+prereplicative+complex+assembly. assertion.
- assertion asSentence ATM%2FATR-dependent+%28ataxia-telangiectasia-mutated%2FATM-+and+Rad3-related%29+checkpoint+pathways+are+directly+linked+to+three+members+of+the+MCM+complex%28MCM2%2CMCM3%2CMCM7%29. assertion.
- assertion asSentence INT6+stabilizes+chromatin-bound+MCM7+and+alteration+of+this+effect+is+associated+with+replication+deficiency. assertion.
- assertion asSentence Replisome+factors+MCM10%2C+MCM2and+MCM7+helicase%2C+are+the+primary+interaction+partner+proteins+of+human+RECQ4. assertion.
- assertion asSentence DAF+and+MCP+regulate+cell+survival+of+human+cervical+cancer+cells. assertion.
- assertion asSentence Mumps+virus+%28MuV%29+and+vesicular+stomatitis+virus+%28VSV%29+assemble+to+include+CD46+and+CD55%2C+two+host+cell+regulators+which+inhibit+propagation+of+complement+pathways+through+distinct+mechanisms. assertion.
- assertion asSentence The+MDH1+gene+is+not+the+cause+of+RP28-linked+autosomal+recessive+retinitis+pigmentosa. assertion.
- assertion asSentence Midkine+is+expressed+in+astrocytes+during+the+early+period+of+human+brain+ischemia. assertion.