Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _4 value "In this paper, we show that ROS may activate aldose reductase, induce diacylglycerol, activate PKC, induce advanced glycation end product formation, and activate the pleiotropic transcription factor nuclear factor-kappa B (NF-kappaB)" provenance.
- _3 value "Ariadne: Furthermore, in the same cell system, leptin has been reported to upregulate the expression of acyl-CoA oxidase (ACO), carnitine palmitoyl transferase-1 (CPT1), and peroxisome proliferator- activated receptor-alpha (PPAR-alpha) [ 15 ], and to increase glucose decarboxylation [ 14 ] and lipolysis [ 13 , 15 , 17 , 18 ]." provenance.
- _5 value "The results show that the cytochrome c\" promoter is modulated by both E2F1 and E2F6; being activated by the former and suppressed by the latter." provenance.
- _3 value "Transfection of insulin-like growth factor-binding protein-3 (IGFBP-3) cDNA in human breast cancer cell lines expressing either mutant p53 (T47D) or wild-type p53 (MCF-7) induces apoptosis" provenance.
- _4 value "GPR66/FM-3 is specifically stimulated by NmU, causing the mobilization of intracellular calcium." provenance.
- _5 value "Moreover, no difference in IL-5-induced survival of mature eosinophils between Syk(-/-) and wild-type eosinophils could be demonstrated, suggesting that the antiapoptotic effect of IL-5 does not require Syk despite the activation of this tyrosine kinase upon IL-5 receptor ligation." provenance.
- _3 value "ABC1 was upregulated in RAW cells by cAMP, concurrent with the cAMP induction of lipid efflux to apolipoprotein A1." provenance.
- _3 value "the cellular level of unesterified arachidonic acid is a general mechanism by which apoptosis is regulated and that COX-2 and FACL4 promote carcinogenesis by lowering this level." provenance.
- _4 value "However, under hypoxia AK1-deficient hearts, compared with the wild type, had a blunted AK-catalyzed phosphotransfer response, lowered intracellular ATP levels, increased P(i)/ATP ratio, and suppressed generation of adenosine" provenance.
- _4 value "TNF-alpha stimulation resulted in an increase in the production of PTHrP from 3.5 to 4 fold." provenance.
- _4 value "mRNA expression of fibrillin-1, emilin, and elastin was strong in quiescent mesangial cells; their gene expression was further up-regulated by transforming growth factor-beta1, while it was transiently reduced when cells were exposed to mitogenic 10% fetal calf serum and platelet-derived growth factor" provenance.
- _4 value "ATP is cosecreted with hormones from endocrine cells and stimulates NO production by FS cells" provenance.
- _2 value "Our cytophysiological analyses of Tpit/F1 cells revealed that intracellular Ca2+ increased dose dependently on ATP administration (0-100 microM)," provenance.
- _4 value "In acute (16- to 18-h) NGF exposure experiments (endogenous gene in Fig. 3 ; transfected promoter in Fig. 7B ), NGF activated chromogranin B expression." provenance.
- _3 value "Both GH and lipopolysaccharide induced the three SOCS messenger RNAs (mRNAs) (SOCS-3, CIS, and SOCS-2) in vivo" provenance.
- _6 value "Modified assertion" provenance.
- _4 value "BRCA1 functions as a co-regulator to enhance AR transactivation. Addition of BRCA1 enhances the activity of wild type AR. Further addition of ARA70N, ARA55 and CBP could increase AR transactivation from 5-fold to 28-fold, 33-fold and 12-fold, respectively." provenance.
- _2 value "Here, we report that BRCA1 interacts with androgen receptor (AR) and enhances AR target genes, such as p21((WAF1/CIP1)), that may result in the increase of androgen-induced cell death in prostate cancer cells." provenance.
- _4 value "Modified assertion" provenance.
- _5 value "We now show that the phosphorylation of these two residues is critical for determining the stability of Myc. Phosphorylation of Ser 62 is required for Ras-induced stabilization of Myc, likely mediated through the action of ERK." provenance.
- _6 value "Modified assertion" provenance.
- _6 value "To elucidate the role of MAPKs in keratinocyte differentiation, activation of ERK, JNK, and p38 in response to stimulation with extracellular calcium was analyzed. We provide evidence that calcium-induced differentiation of keratinocytes is associated with rapid and transient activation of the Raf/MEK/ERK pathway. Stimulation of keratinocytes with extracellular calcium resulted in activation of Raf isozymes and their downstream effector ERK within 10-15 min, but did not increase JNK or p38 activity" provenance.
- _3 value "The polyphenols quercetin and resveratrol at a micromolar range suppressed iNOS gene expression and NO production, as determined by reverse transcription-polymerase chain reaction and nitrite assay." provenance.
- _5 value "Upon stimulation with epidermal growth factor, similar translocation of ectopically expressed PLCepsilon is observed, which is inhibited by coexpression of dominant negative Ha Ras." provenance.
- _4 value "up-regulation of keratin 19 gene expression by estrogen. Suppression of E2-induced K19 gene expression by the antiestrogen ICI 182,780 s" provenance.
- _4 value "The 5'-NF-KB high affinity binding site and AP-1 element contribute most to the enhancement of alpha1-antichymotrypsin gene transcription in response to TNF-alpha treatment. Mutation at 5'-NF-KB and AP-1 resulted in 60% and 50% reduction respectively, in responsiveness induced by TNF-alpha." provenance.
- _4 value "The expression of alpha(1)-antichymotrypsin (ACT) is significantly enhanced in affected brain regions in Alzheimer's disease. This serine proteinase inhibitor specifically colocalizes with filamentous beta-amyloid deposits and recently has been shown to influence both formation and destabilization of beta-amyloid fibrils. In the brain, ACT is expressed in astrocytes, and interleukin-1 (IL-1), tumor necrosis factor alpha (TNF), oncostatin M (OSM), and IL-6/soluble IL-6 receptor complexes control synthesis of this inhibitor. Here, we characterize a molecular mechanism responsible for both IL-1 and TNF-induced expression of ACT gene in astrocytes. We identify the 5' distal IL-1/TNF-responsive enhancer of the ACT gene located 13 kb upstream of the transcription start site. This 413-bp-long enhancer contains three elements, two of which bind nuclear factor kB (NF-kB) and one that binds activating protein 1 (AP-1). All of these elements contribute to the full responsiveness of the ACT gene to both cytokines, as determined by deletion and mutational analysis. The 5' NF-kB high-affinity binding site and AP-1 element contribute most to the enhancement of gene transcription in response to TNF and IL-1. In addition, we demonstrate that the 5' untranslated region of the ACT mRNA does not contribute to cytokine-mediated activation. Finally, we find that overexpression of the NF-kB inhibitor (IkB) totally inhibits any activation mediated by the newly identified IL-1/TNF enhancer of the ACT gene." provenance.
- _5 value "Modified assertion" provenance.
- _2 value "The p54 isoform of c-jun N-terminal kinase-stress-activated kinase (JNK- SAPK) coimmunoprecipitated with Akt from me-v macrophages, and treatment of me-v cells with the specific phosphatidylinositol 3-kinase inhibitor LY294002 decreased cell survival, Akt and JNK kinase activities, ets-2 phosphorylation, and Bcl-x mRNA expression." provenance.
- _9 value "Furthermore, Cam kinase II blocked nuclear accumulation of a Smad2 and induced Smad2-Smad4 hetero-oligomerization independently of TGF-beta receptor activation, while preventing TGF-beta-dependent Smad2-Smad3 interactions." provenance.
- _3 value "Table 1. Genes with decreased expression with obesity in each mouse strain" provenance.
- _3 value "Table 1. Genes with decreased expression with obesity in each mouse strain" provenance.
- _3 value "Table 1. Genes with decreased expression with obesity in each mouse strain" provenance.
- _3 value "Table 1. Genes with decreased expression with obesity in each mouse strain" provenance.
- _3 value "Table 1. Genes with decreased expression with obesity in each mouse strain" provenance.
- _3 value "Table 1. Genes with decreased expression with obesity in each mouse strain" provenance.
- _3 value "Table 1. Genes with decreased expression with obesity in each mouse strain" provenance.
- _3 value "Table 1. Genes with decreased expression with obesity in each mouse strain" provenance.
- _3 value "Table 1. Genes with decreased expression with obesity in each mouse strain" provenance.
- _3 value "Table 2. Genes with increased expression with obesity" provenance.
- _3 value "Table 2. Genes with increased expression with obesity" provenance.
- _3 value "Table 2. Genes with increased expression with obesity" provenance.
- _3 value "Table 2. Genes with increased expression with obesity" provenance.
- _3 value "Table 2. Genes with increased expression with obesity" provenance.
- _3 value "Table 2. Genes with increased expression with obesity" provenance.
- _3 value "Table 2. Genes with increased expression with obesity" provenance.
- _3 value "Table 2. Genes with increased expression with obesity" provenance.
- _3 value "Table 2. Genes with increased expression with obesity" provenance.
- _3 value "Table 2. Genes with increased expression with obesity" provenance.
- _3 value "Table 2. Genes with increased expression with obesity" provenance.
- _3 value "Table 2. Genes with increased expression with obesity" provenance.
- _3 value "Table 2. Genes with increased expression with obesity" provenance.
- _4 value "IL-10 also reduces the expression of major histocompatibility complex class II, B7.1/B7.2 antigens and clonal designator (CD)23 by these cells, thereby decreasing their accessory cell function (30). In contrast, IL-10 upregulates the release of another antiinflammatory cytokine, IL-1 receptor antagonist (30)." provenance.
- _4 value "IL-10 inhibits the release of ROS by macrophages (30)," provenance.
- _3 value "Cells differentiate in response to various extracellular stimuli. This cellular response requires intracellular signaling pathways. The mitogen-activated protein (MAP) kinase cascade is a core signal transduction pathway that determines the fate of many kinds of cell. MAP kinase kinase kinase activates MAP kinase kinase, which in turn activates MAP kinase. Apoptosis signal-regulating kinase (ASK1) was identified as a MAP kinase kinase kinase involved in the stress-induced apoptosis-signaling cascade that activates the SEK1-JNK and MKK3/MKK6-p38 MAP kinase cascades. Expression of the constitutively active form of ASK1 (ASK1-DeltaN) in keratinocytes induced significant morphological changes and differentiation markers, transglutaminase-1, loricrin, and involucrin. A transient increase in p21(Cip1/WAF1) reduced DNA synthesis, and cell cycle analysis verified the differentiation. p38 MAP kinase inhibitors, SB202190 and SB203580, abolished the induction of differentiation markers, transglutaminase-1, loricrin, and involucrin. In turn, the induction of differentiation with ceramide in keratinocytes caused an increase in ASK1 expression and activity. Furthermore, normal human skin expresses ASK1 protein in the upper epidermis, implicating ASK1 in in vivo keratinocyte differentiation. We propose that the ASK1-p38 MAP kinase cascade is a new intracellular regulator of keratinocyte differentiation." provenance.
- _5 value "We also showed that an increase in CDK2-bound p27 and CDK4-bound p18 are caused by treatment with ATRA and a decrease in CDK6-bound cyclin D3 is induced synergistically by treatment with both reagents." provenance.
- _6 value "Altered patterns of transcription in tissues and cells derived from N-CoR gene-deleted mice block at specific points in CNS, erythrocyte, and thymocyte development indicated that N-CoR was a required component of short-term active repression by nuclear receptors and MAD and of a subset of long-term repression events mediated by REST/NRSF" provenance.
- _5 value "Through direct cloning of p53 binding sequences from human genomic DNA, we have isolated a novel gene, designated p53AIP1 (p53-regulated Apoptosis-Inducing Protein 1), whose expression is inducible by wild-type p53. Ectopically expressed p53AIP1, which is localized within mitochondria, leads to apoptotic cell death through dissipation of mitochondrial A(psi)m. We have found that upon severe DNA damage, Ser-46 on p53 is phosphorylated and apoptosis is induced. In addition, substitution of Ser-46 inhibits the ability of p53 to induce apoptosis and selectively blocks expression of p53AIP1. Our results suggest that p53AIP1 is likely to play an important role in mediating p53-dependent apoptosis, and phosphorylation of Ser-46 regulates the transcriptional activation of this apoptosis-inducing gene." provenance.
- _3 value "In this study, we show that Bin1 engages a caspase-independent cell death process similar to type II apoptosis," provenance.
- _5 value "Here we report that alphaSYN2 interacts specifically with Tat binding protein 1, a subunit of the 700-kDa proteasome activator (PA700), the regulatory complex of the 26S proteasome and of the modulator complex, which enhances PA700 activation of the proteasome." provenance.
- _3 value "Our data demonstrate that Pnck expression in vitro is inversely correlated with cellular proliferation. Specifically, decreasing the proliferative status of mammary epithelial cells in vitro resulted in increased Pnck expression." provenance.
- _5 value "Ref-1 expression was down-regulated by DA but up-regulated by Grx2, while treatment of neurons with Ref-1 antisense oligonucleotide reduced the ability of Grx2 to activate NF-kappaB binding activity." provenance.
- _3 value "Ref-1 expression was down-regulated by DA but up-regulated by Grx2, while treatment of neurons with Ref-1 antisense oligonucleotide reduced the ability of Grx2 to activate NF-kappaB binding activity." provenance.
- _6 value "5-LO-activating protein (FLAP)" provenance.
- _5 value "Here, we show that serine 21 in GSK-3 alpha and serine 9 in GSK-3 beta are also physiological substrates of cAMP-dependent protein kinase A. Protein kinase A physically associates with, phosphorylates, and inactivates both isoforms of GSK-3" provenance.
- _6 value "Here, we show that serine 21 in GSK-3 alpha and serine 9 in GSK-3 beta are also physiological substrates of cAMP-dependent protein kinase A. Protein kinase A physically associates with, phosphorylates, and inactivates both isoforms of GSK-3" provenance.
- _3 value "ESE-1 is induced in response to inflammatory cytokines and lipopolysaccharide in vascular smooth muscle cells, endothelial cells, and cells of the monocyte-macrophage lineage. This induction occurs within hours of stimulation and is mediated by NF-kappaB transactivation of the ESE-1 promoter." provenance.
- _6 value "activator. Since many transcription factors are known to form functional complexes, we searched for proteins that interact with the DNA-binding domain of Maf using the phage display method and identified two homeodomain-containing proteins, Hoxd12 and MHox/Prx1/Phox1/Pmx1." provenance.
- _5 value "Modified assertion" provenance.
- _3 value "Human interleukin-1beta (5-10 ng/mL) induced nitric oxide, prostaglandin E2 and matrix metalloprotease production in bovine or human chondrocytes, which could be inhibited by 500 pg/mL of Type II interleukin-1 receptor." provenance.
- _5 value "CD19 tyrosine phosphorylation is modulated by the Lyn protein-tyrosine kinase" provenance.
- _5 value "SHP-1 dephosphorylates the Lyn autophosphorylation site" provenance.
- _5 value "Modified assertion" provenance.
- _3 value "High glucose and high calcium also up-regulated the expression of c-Myc, but only the high glucose group showed significant difference from control (39% +/- 10% vs 24% +/- 8%, p < 0.05)." provenance.
- _5 value "The induction of NFATL1 protein, as well as NFATL1-dependent transcription, is inhibited by cyclosporin A and FK506, and expression of constitutively active calcineurin induces NFATL1-dependent transcription" provenance.
- _4 value "we demonstrate that follicular TG transcriptionally represses all NFI RNAs (NFI-A, -B, -C, and -X)" provenance.
- _4 value "we demonstrate that follicular TG transcriptionally represses all NFI RNAs (NFI-A, -B, -C, and -X)" provenance.
- _5 value "The ability of activated PKA to reduce the state of phosphorylation of DARPP-32-Thr-75 is apparently attributable to increased protein phosphatase-2A activity, with Cdk5 being unaffected." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _6 value "Phosphorylation by protein kinase A in the presence of ATP activates the CFTR-mediated chloride conductance of the apical membranes." provenance.
- _4 value "The cystic fibrosis transmembrane conductance regulator (CFTR) gene encodes a chloride channel protein that belongs to the superfamily of ATP binding cassette (ABC) transporters. Phosphorylation by protein kinase A in the presence of ATP activates the CFTR-mediated chloride conductance of the apical membranes. We have identified a novel hydrophilic CFTR binding protein, CAP70, which is also concentrated on the apical surfaces. CAP70 consists of four PDZ domains, three of which are capable of binding to the CFTR C terminus. Linking at least two CFTR molecules via cytoplasmic C-terminal binding by either multivalent CAP70 or a bivalent monoclonal antibody potentiates the CFTR chloride channel activity. Thus, the CFTR channel can be switched to a more active conducting state via a modification of intermolecular CFTR-CFTR contact that is enhanced by an accessory protein." provenance.
- _3 value "RA stimulated gene expression in both cell types in a time- and dose-dependent manner" provenance.
- _3 value "The transcription factor Elk1 is activated during thapsigargin-induced pip92 expression." provenance.
- _4 value "On the other hand, inactivation of phosphorylase by insulin is mediated through the PI-3 kinase pathway involving a rapamycin-sensitive p70(s6k) and PP-1G." provenance.
- _6 value "On the other hand, inactivation of phosphorylase by insulin is mediated through the PI-3 kinase pathway involving a rapamycin-sensitive p70(s6k) and PP-1G." provenance.
- _4 value "These data suggest that stimulation of glycogen synthase by insulin in HepG2 cells is mediated through the PI-3 kinase pathway by activating PKB and PP-1G and inactivating GSK-3beta." provenance.
- _5 value "These data suggest that stimulation of glycogen synthase by insulin in HepG2 cells is mediated through the PI-3 kinase pathway by activating PKB and PP-1G and inactivating GSK-3beta." provenance.
- _5 value "Thus, mTOR also controls eIF4E function, which is particularly important in the translation of mRNAs containing a highly structured 5' untranslated region (UTR), such as the transcripts encoding cyclin D1 and the c-myc oncogene ([82])." provenance.
- _4 value "indicate a direct physical and functional interplay between two negative regulators of cell proliferation, Smad3 and P/CAF." provenance.
- _5 value "U-87 MG cells treated with FTI-277 (farnesyltransferase inhibitor), which block the Ras activity, decreased VEGF mRNA expression to approximately 30% of baseline. Also, cells transfected with dominant negative form of Ras, showed a decreased VEGF promoter activity in U-87 and U87/T691cells MG cells." provenance.
- _6 value "Modified assertion" provenance.
- _6 value "It has been shown through electrophoretic mobility shift assay that Ras promoted the PKCzeta-induced binding of Sp1 to the VPF/VEGF promoter." provenance.
- _5 value "HTGL is homologous to HL" provenance.
- _6 value "\"Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.\" Here we report that MKK4 shows a striking preference for the tyrosine residue (Tyr-185), and MKK7 a striking preference for the threonine residue (Thr-183)" provenance.
- _5 value "Here we report that MKK4 shows a striking preference for the tyrosine residue (Tyr-185), and MKK7 a striking preference for the threonine residue (Thr-183) in three SAPK1/JNK1 isoforms tested (JNK1 alpha 1, JNK2 alpha 2 and JNK3 alpha 1)" provenance.
- _5 value "Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase (MKK)4 and MKK7." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _7 value "# Ariadne: Activation of NF-kappaB by TNF alpha is attenuated by RhoB. [Regulation]" provenance.
- _5 value "CnA* muscles displayed threefold higher calcineurin activity and enhanced dephosphorylation of the calcineurin targets NFATc1, MEF2A, and MEF2D." provenance.
- _5 value "CnA* muscles displayed threefold higher calcineurin activity and enhanced dephosphorylation of the calcineurin targets NFATc1, MEF2A, and MEF2D." provenance.