Matches in Nanopublications for { ?s <http://purl.org/dc/terms/description> ?o ?g. }
- NP129961.RAZSAeSuaQMcmqJ2Dn-OppRAfpwFbUpSkXJ68mzZhpM4c130_assertion description "[The inhibitory effect of human TNF on osterix expression in murine pre-osteoblastic cells suggests a potential decrease of osteoblast differentiation in arthritis and osteoporosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP129961.RAZSAeSuaQMcmqJ2Dn-OppRAfpwFbUpSkXJ68mzZhpM4c130_provenance.
- NP129963.RAfAm2Lx23Uj88wkTjz35YJWBeKwAKt4rKt_wfGVp14PA130_assertion description "[TNF-dependent arthritis in the absence of osteoclasts ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP129963.RAfAm2Lx23Uj88wkTjz35YJWBeKwAKt4rKt_wfGVp14PA130_provenance.
- NP129967.RAX_G2BxwllQ-5Ko7u-WY7OsXjJ4HHkyCqoe21lpeRl1c130_assertion description "[Potential role for activation through TLR-2 in the inflammation and joint destruction of rheumaatoid arthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP129967.RAX_G2BxwllQ-5Ko7u-WY7OsXjJ4HHkyCqoe21lpeRl1c130_provenance.
- NP129969.RATyeijY4FH9qgOK_Z-iNU8whVY6hwnuDulXHCnf4W86E130_assertion description "[Blau syndrome and its sporadic counterpart, early-onset sarcoidosis, share an identical phenotype featuring the classic triad of arthritis, dermatitis, and uveitis and are associated with mutations of CARD15 in 50-90% of cases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP129969.RATyeijY4FH9qgOK_Z-iNU8whVY6hwnuDulXHCnf4W86E130_provenance.
- NP129970.RAegqkEgy4QaG1tBTJ4ux0kqwq6mECAw7aBUh6WCkTKsg130_assertion description "[Polymorphisms in MTHFR is associated with the efficacy and toxicity of methotrexate used for the treatment of rhematoid arthritis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP129970.RAegqkEgy4QaG1tBTJ4ux0kqwq6mECAw7aBUh6WCkTKsg130_provenance.
- NP129974.RAcryR49qoZTipP1SUjx6gk6swCiSK8gcUk2RLzjFIn6M130_assertion description "[sTNFR1 and sTNFR2 were found at increased plasma concentrations in active Behcet's disease (BD), with the highest concentration in active BD with arthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP129974.RAcryR49qoZTipP1SUjx6gk6swCiSK8gcUk2RLzjFIn6M130_provenance.
- NP129978.RASVS1iXn8CfrA4ekg_2LpeTZH9cnIIBS1awnudcpNDTY130_assertion description "[These findings identify PAR-2 as a novel upstream regulator of proinflammatory cytokine production in RA and indicate its potential as a novel therapeutic target in inflammatory arthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP129978.RASVS1iXn8CfrA4ekg_2LpeTZH9cnIIBS1awnudcpNDTY130_provenance.
- NP129981.RAaIGluuQBw2n2QVYahEQtAKEzYpbajTn2JagtxkGZ-TI130_assertion description "[NPY contributes to atherosclerosis pathogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP129981.RAaIGluuQBw2n2QVYahEQtAKEzYpbajTn2JagtxkGZ-TI130_provenance.
- NP129985.RASp4AgObdP_iM7F7p7IJ99KQTBZyCOi-vBgm9CL1oo2M130_assertion description "[In a large population-based sample, elevated IL-18 plasma levels associated with risk factors for atherosclerosis and with the metabolic syndrome ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP129985.RASp4AgObdP_iM7F7p7IJ99KQTBZyCOi-vBgm9CL1oo2M130_provenance.
- NP129986.RAfBolb3BBHtCxTU5I7QNq0Yd1xRY5ntRb815OCT-sDSQ130_assertion description "[Higher serum IL-18 levels appear to be associated with greater carotid intima-media thickness, suggesting the link between IL-18 and atherosclerosis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP129986.RAfBolb3BBHtCxTU5I7QNq0Yd1xRY5ntRb815OCT-sDSQ130_provenance.
- NP129990.RAbiwrU8shVd23nPpII5cAlThF1c_t_MEdTnYaV-ne6Ho130_assertion description "[gp130 modulates atherosclerosis in mice and human ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP129990.RAbiwrU8shVd23nPpII5cAlThF1c_t_MEdTnYaV-ne6Ho130_provenance.
- NP129991.RAXsH9lwMF_7bKLXBkLxylKphlD3OLV71ABHqLDNozacI130_assertion description "[HNF-1 alpha gene locus is associated with serum HDL-c level, and Ile27 allele is a risk marker for atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP129991.RAXsH9lwMF_7bKLXBkLxylKphlD3OLV71ABHqLDNozacI130_provenance.
- NP129998.RAduhq1pzwHrpGWXfaATy81uPAmTCzP7R2u_fcWYcYR-M130_assertion description "[the KLOTHO gene is a candidate gene of atherosclerosis in humans ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP129998.RAduhq1pzwHrpGWXfaATy81uPAmTCzP7R2u_fcWYcYR-M130_provenance.
- NP130003.RAeIHJxYW3LJo69vCDAniGya_ZJtVUCRoABUxSEWQ_o8k130_assertion description "[expression of human MPO in macrophages promotes atherosclerosis in hypercholesterolemic mice ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130003.RAeIHJxYW3LJo69vCDAniGya_ZJtVUCRoABUxSEWQ_o8k130_provenance.
- NP130009.RAba832IfeDd6GXxp0Z0OEZXnfgTlzmAjSrFqeoJNNUWc130_assertion description "[The ecNOS Glu298Asp polymorphism is associated with reduced basal NO production and might therefore have functional implications in the development of atherosclerosis or hypertension.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130009.RAba832IfeDd6GXxp0Z0OEZXnfgTlzmAjSrFqeoJNNUWc130_provenance.
- NP130014.RAT-bc0YLoaaeKoiXi1Uq2F6jrOvrAmsvdlRbZv6IldlI130_assertion description "[APOE*4 allele has an age-dependent association with atherosclerosis, increasing susceptibility among young to middle age Argentine males ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130014.RAT-bc0YLoaaeKoiXi1Uq2F6jrOvrAmsvdlRbZv6IldlI130_provenance.
- NP130019.RAX7WLuTdXKrHmdTsrzCnVZ5UOTgtiC0RxjLpX9IfVk4U130_assertion description "[Akt and its downstream targets FoxO3a and GSK3 regulate a survival pathway in VSMCs and that their deregulation due to a reduction of IGF1R signaling may promote apoptosis in atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130019.RAX7WLuTdXKrHmdTsrzCnVZ5UOTgtiC0RxjLpX9IfVk4U130_provenance.
- NP130022.RAXdopj3WnnZLj-hKZplBFe5z7xKXLdcaWcRSqQmnTXKQ130_assertion description "[The TF and TFPI levels depend significantly on the renal function; elevated TF and TFPI levels may be related to thrombosis and atherosclerosis in chronic renal failure patients on peritoneal dialysis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130022.RAXdopj3WnnZLj-hKZplBFe5z7xKXLdcaWcRSqQmnTXKQ130_provenance.
- NP130029.RAXp4RD1fPqHJLTN9BHPrKouj3q3AjVvcSdaPxsT4r4kU130_assertion description "[observed in other protein oxidation parameters in the groups leading to decreasing PON1 activity might, we think, create a predisposition to atherosclerosis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130029.RAXp4RD1fPqHJLTN9BHPrKouj3q3AjVvcSdaPxsT4r4kU130_provenance.
- NP130030.RAY6pZRMXF9_mgroSqjkaTmp_KZyj8GQOlZdiSwz3MA0o130_assertion description "[The PON1 genotype clearly determined the oxidative modification of lipoproteins and may play a role in the pathogenesis of atherosclerosis via its protective effect against lipoprotein oxidation in Japanese subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130030.RAY6pZRMXF9_mgroSqjkaTmp_KZyj8GQOlZdiSwz3MA0o130_provenance.
- NP130039.RASiwKg1aSsRffZxS9ivsKFG9-0oH1zxuYrYc4hjE6tvQ130_assertion description "[The ABCA1 gene -565C > T polymorphism was associated with coronary atherosclerosis severity/variant had an effect on ABCA1 promoter activity/ABCA1 variants contribute to interindividual variability in atherosclerosis susceptibility & severity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130039.RASiwKg1aSsRffZxS9ivsKFG9-0oH1zxuYrYc4hjE6tvQ130_provenance.
- NP130040.RATarp_pVsgwK_QeKx27nTZfUTOOPF-tH2i9BmJJpNpCo130_assertion description "[ABC-A1 may be more than a determinant of HDL-cholesterol which may provide a link between components of the metabolic syndrome and atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130040.RATarp_pVsgwK_QeKx27nTZfUTOOPF-tH2i9BmJJpNpCo130_provenance.
- NP130042.RAaSVUWN1ID72Dht10_MriXf4Wcf6KjWXbcKZLXrf-Hxo130_assertion description "[Taken together, the current study demonstrates that APN might protect against atherosclerosis by increasing HDL assembly through enhancing ABCA1 pathway and apoA-1 synthesis in the liver.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130042.RAaSVUWN1ID72Dht10_MriXf4Wcf6KjWXbcKZLXrf-Hxo130_provenance.
- NP130053.RAUYL5fRqu-FLXqBkj-X1a50SQfBXD0UjC5_7uOOjcTfU130_assertion description "[Acute elevation of PLTP activity destabilizes atherosclerotic lesions and aggravates pre-existing atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130053.RAUYL5fRqu-FLXqBkj-X1a50SQfBXD0UjC5_7uOOjcTfU130_provenance.
- NP130054.RAYhuBJM-1M6IqK6GdOqWbZkd4NX8WpdkcaRKIFDpk0A0130_assertion description "[The -493T MTP promoter polymorphism is associated with a less atherogenic lipoprotein profile and lower carotid tunica intima/media thickness in obese patients/may play a role in the development of obesity-induced dyslipidemia and atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130054.RAYhuBJM-1M6IqK6GdOqWbZkd4NX8WpdkcaRKIFDpk0A0130_provenance.
- NP130058.RAZe-cDQfkjKCU6clMFN0QrPPjrImT5KY3YE2gYTKAwqQ130_assertion description "[human atherosclerosis is characterized by senescence of VSMCs, accelerated by oxidative stress-induced DNA damage, inhibition of telomerase and marked telomere shortening.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130058.RAZe-cDQfkjKCU6clMFN0QrPPjrImT5KY3YE2gYTKAwqQ130_provenance.
- NP130063.RAU5ARNKmePNKnS5DMydG1QSNrdMWwt0kpDB7v_e2Yl_s130_assertion description "[further evidence is provided for the role of CD14 C (-260) -- > T promoter polymorphism as a genetic susceptibility marker of atherosclerosis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130063.RAU5ARNKmePNKnS5DMydG1QSNrdMWwt0kpDB7v_e2Yl_s130_provenance.
- NP130065.RAe08hJ2C3QhsUs1AJ6j1Ax02H_95LKerNc1alzqdQCB4130_assertion description "[the c.-292C > T polymorphism was associated with higher enzyme activity in heterozygous carriers; this polymorphism also showed a tendency to be protective against atherosclerosis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130065.RAe08hJ2C3QhsUs1AJ6j1Ax02H_95LKerNc1alzqdQCB4130_provenance.
- NP130068.RAZ2EuWyu9D7czlbGVf68Gdn-8fE320TNbq3Txae5CObo130_assertion description "[In atherogenic aortas, an imbalance between PAF-AH and transacetylase activity, as well as lyso-PAF accumulation, may lead to unregulated PAF formation and to progression of atherosclerosis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130068.RAZ2EuWyu9D7czlbGVf68Gdn-8fE320TNbq3Txae5CObo130_provenance.
- NP130069.RARyrL_qo4iqVhjnYPGqmdW6IJQU600XOeepKJRP9B2zc130_assertion description "[Overexpression of hPLA2G7 by adenoviral gene transfer in mice diminished the neointima formation (restenosis) induced by a wire-guided denudation of endothelium of the common left carotid and spontaneous atherosclerosis in aortic roots.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130069.RARyrL_qo4iqVhjnYPGqmdW6IJQU600XOeepKJRP9B2zc130_provenance.
- NP130072.RAfgiY6Am22YjJX-XIL8UcvJLl6RE68Jgd_xZ5iXwtKEY130_assertion description "[Data identify ORP8 as a negative regulator of ABCA1 expression and macrophage cholesterol efflux/may, thus, modulate the development of atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130072.RAfgiY6Am22YjJX-XIL8UcvJLl6RE68Jgd_xZ5iXwtKEY130_provenance.
- NP130073.RAfhSela41CRjyzjk2b1HGGo5Kc6wgRrGtGGVPxGWpIcs130_assertion description "[Ghrelin inhibits proinflammatory cytokine production, mononuclear cell binding, and nuclear factor-kappaB activation in human endothelial cells in vitro/could play a modulatory role in atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130073.RAfhSela41CRjyzjk2b1HGGo5Kc6wgRrGtGGVPxGWpIcs130_provenance.
- NP130074.RAapoKHgIMmPXyoPW2dwAtGR8B4v2L0LLWFe8RiFQ28M8130_assertion description "[Low ghrelin is associated with metablolic syndrome and type 2 diabetes in the presence of insulin and leptin resistance; Ghrelin-leptin relation is associated with early atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130074.RAapoKHgIMmPXyoPW2dwAtGR8B4v2L0LLWFe8RiFQ28M8130_provenance.
- NP130079.RAb59jEUOt6kjhQ8QlLQGicRkGrClKVFYhlVH5EdOGigc130_assertion description "[TL1A and DR3 is involved in atherosclerosis via the induction of pro-inflammatory cytokines/chemokines ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130079.RAb59jEUOt6kjhQ8QlLQGicRkGrClKVFYhlVH5EdOGigc130_provenance.
- NP130083.RASKeu9zEOPsT9werNOIuKJ_mNJnM-QYgqinhvCXJXhuw130_assertion description "[PON1 directly reduced macrophage and aortic oxidative status associated with decreased superoxide anion production and increased glutathione/be responsible for attenuated atherosclerosis development in PON1Tg mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130083.RASKeu9zEOPsT9werNOIuKJ_mNJnM-QYgqinhvCXJXhuw130_provenance.
- NP130086.RAT9BpQ8_9rz0OwTd7iGGSnHygHq0bvJPKjv9M12QAgLk130_assertion description "[Uncreased macrophage colony stimulating factor is associated with the process of atherosclerosis in hemodialysis patients ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130086.RAT9BpQ8_9rz0OwTd7iGGSnHygHq0bvJPKjv9M12QAgLk130_provenance.
- NP130090.RAfwkVKsGUcNuqIg4cQ86H_K9JeQQqbWefXYMiF_Vpia4130_assertion description "[SelS protein may be involved in insulin resistance in Chinese with type 2 diabetes mellitus (T2DM) by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130090.RAfwkVKsGUcNuqIg4cQ86H_K9JeQQqbWefXYMiF_Vpia4130_provenance.
- NP130096.RAV78X0HBngnfDAVvE4RAX4Pzb4S1z7DzQLzGY9krb3Y8130_assertion description "[Measures of inflammation, such as CRP, and indices of atherosclerosis, such as coronary calcium store, are likely to provide distinct information regarding cardiovascular risk ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130096.RAV78X0HBngnfDAVvE4RAX4Pzb4S1z7DzQLzGY9krb3Y8130_provenance.
- NP130097.RAULVohoigZAvkq9PvgRKQj0qEH2snSGVSc5MMBUofYv4130_assertion description "[Recombinant and natural C-reactive protein have opposite effects on atherosclerosis in apolipoprotein E-deficient mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130097.RAULVohoigZAvkq9PvgRKQj0qEH2snSGVSc5MMBUofYv4130_provenance.
- NP130099.RAV8a0DggJOR7ky0W-uqUvcJNyjDxUY5ifIPnkulSFND0130_assertion description "[investigated the association of CRP with extent and progression of atherosclerosis in multiple vessel beds in a large, population-based cohort study ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130099.RAV8a0DggJOR7ky0W-uqUvcJNyjDxUY5ifIPnkulSFND0130_provenance.
- NP130102.RASVevnK2cMQlobU4D07r9Ro0CUrEGuaa806cNYL5UXhM130_assertion description "[CRP 1059G > C polymorphism is one possible genetic determinant for the difference between intra- and extracranial atherosclerosis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130102.RASVevnK2cMQlobU4D07r9Ro0CUrEGuaa806cNYL5UXhM130_provenance.
- NP130103.RASQFOhyEJz0zZwlUqep2iiGi3-aijzLR2CwKMc6lRF0o130_assertion description "[Single-nucleotide polymorphisms (SNPs) of the human CRP gene and the T-T-G haplotype are genetic markers for elevated basal CRP levels and appear to be susceptibility markers for atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130103.RASQFOhyEJz0zZwlUqep2iiGi3-aijzLR2CwKMc6lRF0o130_provenance.
- NP130114.RAXahbkLOQC_x5RQO9Z8cNGICpPX0ATN-RMhAlMCpu9Rs130_assertion description "[sFcgammaRIIIa (Mphi) may be used as a predictive marker for atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130114.RAXahbkLOQC_x5RQO9Z8cNGICpPX0ATN-RMhAlMCpu9Rs130_provenance.
- NP130119.RAdASGMhthWgNbUMXMw7b6U5RfBAwLbDXJLz9j6-EzA3w130_assertion description "[Increased fasting CETP activity may contribute to increased risk of atherosclerosis in subjects with impaired glucose tolerance ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130119.RAdASGMhthWgNbUMXMw7b6U5RfBAwLbDXJLz9j6-EzA3w130_provenance.
- NP130120.RAXFKq6uat9FhQ1mJFol0sJKvbnPFKXdIhkkT0yWrMzAk130_assertion description "[attenuates atherosclerosis in ovariectomized mice [Cholesteryl ester transfer protein]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130120.RAXFKq6uat9FhQ1mJFol0sJKvbnPFKXdIhkkT0yWrMzAk130_provenance.
- NP130126.RATexaqbHqRBOxryZ8RUZxCwq7gvl6_zq0Ns1R3brbsAo130_assertion description "[IL-10 has roles in atherosclerosis, possibly contributing to plaque stabilization ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130126.RATexaqbHqRBOxryZ8RUZxCwq7gvl6_zq0Ns1R3brbsAo130_provenance.
- NP130129.RARrFIJbncjTRCT6mDfRxjVDH3ToZBRhBpbKk-40k3qfs130_assertion description "[The IL-6 -174G > C polymorphism combined with IL-6 plasma levels may chronically predispose an individual to develop atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130129.RARrFIJbncjTRCT6mDfRxjVDH3ToZBRhBpbKk-40k3qfs130_provenance.
- NP130137.RAT4LhX_tGSGlf5pRhr5WF6nvor0aqrgehHF9dw60vslc130_assertion description "[the particular combination of MMP3 and MMP9 genotypes present at susceptibility loci may contribute to heterogeneity in the presentation of atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130137.RAT4LhX_tGSGlf5pRhr5WF6nvor0aqrgehHF9dw60vslc130_provenance.
- NP130138.RAfa0SDApur4VpuWRnTXRlgZU59yGarF9b2yt1sOxf3us130_assertion description "[enhanced cell cycle entry, increased MAPK signaling, and downregulated MMP-1 and MMP-3 seen in diabetic arterial vasculature could have a role in progressive atherosclerosis and postangioplasty restenosis in diabetic patients ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130138.RAfa0SDApur4VpuWRnTXRlgZU59yGarF9b2yt1sOxf3us130_provenance.
- NP130139.RAXYxk0vOOsd7_NYKN5fGOGIiOykejHiH9rADv1r2zkwM130_assertion description "[the particular combination of MMP3 and MMP9 genotypes present at susceptibility loci may contribute to heterogeneity in the presentation of atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130139.RAXYxk0vOOsd7_NYKN5fGOGIiOykejHiH9rADv1r2zkwM130_provenance.
- NP130141.RAZSLhkkssuTulEVCQ0FjLbUUV8AHlKOmEVQV_BzxvVZY130_assertion description "[IGF-II metabolism may play a role in atherogenesis in in schizophrenic Arab subjects ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130141.RAZSLhkkssuTulEVCQ0FjLbUUV8AHlKOmEVQV_BzxvVZY130_provenance.
- NP130144.RAZrjO7d3dRODdLgej1o_YxCGkaj28K0pCS4gOZSCxhU8130_assertion description "[ICAM-1 variants may modulate atherosclerosis in humans/gene polymorphisms may influence atherosclerosis independent of plasma levels of their gene products.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130144.RAZrjO7d3dRODdLgej1o_YxCGkaj28K0pCS4gOZSCxhU8130_provenance.
- NP130150.RAU0a183KU1T7lPIw5YF2j5KOGhor95or72b8_sehFFWA130_assertion description "[Taken together, the current study demonstrates that APN might protect against atherosclerosis by increasing HDL assembly through enhancing ABCA1 pathway and apoA-1 synthesis in the liver.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130150.RAU0a183KU1T7lPIw5YF2j5KOGhor95or72b8_sehFFWA130_provenance.
- NP130153.RAbyI54qiSxB3UoJ3kUW6M-OEmLxXjGloxLkgwH0PEOnI130_assertion description "[vWF and tPAag but not thrombomodulin in the present population are independent markers of atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130153.RAbyI54qiSxB3UoJ3kUW6M-OEmLxXjGloxLkgwH0PEOnI130_provenance.
- NP130157.RAQKpAGp8nvcDjVvw3axjAYUlw5HYeDwrUOCuw-HslfHQ130_assertion description "[hypoxia and hypoxia-induced VEGF expression are involved in the pathogenesis of progressive atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130157.RAQKpAGp8nvcDjVvw3axjAYUlw5HYeDwrUOCuw-HslfHQ130_provenance.
- NP130159.RAWZEKLDGtPulV0tkcMGd-vjCpxutpMW-EOOs2JoiX1tQ130_assertion description "[The LTA 252A/G polymorphism is moderately associated with sub-clinical atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130159.RAWZEKLDGtPulV0tkcMGd-vjCpxutpMW-EOOs2JoiX1tQ130_provenance.
- NP130160.RAcvtGhWjz4b7hwmfHoujMhHgx9wLsbuIPRXVfHBXwVSs130_assertion description "[LRP was involved essentially for the cell-mediated LDL oxidation by 12/15-lipoxygenase expressed in J774A.1 cells, suggesting an important pathophysiological role of this receptor-enzyme system as the initial trigger of the progression of atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130160.RAcvtGhWjz4b7hwmfHoujMhHgx9wLsbuIPRXVfHBXwVSs130_provenance.
- NP130165.RAY9PrZbZFWccaTCR4MGMVUhucaAg71eUj-E1X8rT3U9U130_assertion description "[hyperinsulinaemia could accelerate atherosclerosis by directly enhancing neutrophil transendothelial migration through increasing endothelial PECAM-1 expression via mitogen-activated protein kinase activation ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130165.RAY9PrZbZFWccaTCR4MGMVUhucaAg71eUj-E1X8rT3U9U130_provenance.
- NP130170.RAWH5wTvdssT7jHO1t9l8SI4Cx9rFNVklMdQa_UeweLMo130_assertion description "[In an in vitro atherosclerosis model neutrophil infiltration was mediated via IL-8-signalling and accompanied by release of elastase and induction of endothelial cell apoptosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130170.RAWH5wTvdssT7jHO1t9l8SI4Cx9rFNVklMdQa_UeweLMo130_provenance.
- NP130176.RAUO066vwiYwTEHF9Lwrxp2aiC7bk0UcbM-XGy0A7KLVI130_assertion description "[possible roles of CXCL4 in monocyte arrest and macrophage foam cell formation in atherosclerosis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130176.RAUO066vwiYwTEHF9Lwrxp2aiC7bk0UcbM-XGy0A7KLVI130_provenance.
- NP130178.RAU8AodFD4GlWwcsoGKWwl5u4FD4UdxdCc4pwrj79DWyk130_assertion description "[This study introduces IL-32 as a critical regulator of endothelial function, expanding the properties of this cytokine relevant to coagulation, endothelial inflammation, and atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130178.RAU8AodFD4GlWwcsoGKWwl5u4FD4UdxdCc4pwrj79DWyk130_provenance.
- NP130184.RAV5ek2K9qrn02ZQTZUGPBbvbM7tlF_rfBZANZOpaprvw130_assertion description "[The loss of RGS5 in the fibrous cap is of particular interest because of its role in vessel development and physiology and loss in fibrous cap of atherosclerosis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130184.RAV5ek2K9qrn02ZQTZUGPBbvbM7tlF_rfBZANZOpaprvw130_provenance.
- NP130186.RAWPetiTcDckdrnR9znakPEzaSjnugtfSIhgc7qQNOM8g130_assertion description "[TRAIL may play an important role in atherosclerosis by regulating IGF1R expression in VSMC in an NF-kappaB-dependent manner.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130186.RAWPetiTcDckdrnR9znakPEzaSjnugtfSIhgc7qQNOM8g130_provenance.
- NP130187.RAdDzNVYZKw7evWV84fsx5km9_pIq2241TM2RnT7nQNRc130_assertion description "[Akt and its downstream targets FoxO3a and GSK3 regulate a survival pathway in VSMCs and that their deregulation due to a reduction of IGF1R signaling may promote apoptosis in atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130187.RAdDzNVYZKw7evWV84fsx5km9_pIq2241TM2RnT7nQNRc130_provenance.
- NP130188.RAb7ETkb83d3Xq0iLvVawlFLVz_4AWcVDUcjSy1DYjVlA130_assertion description "[REVIEW of involvement of MIF in the inflammatory pathogenesis of atherosclerosis and its consequences ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130188.RAb7ETkb83d3Xq0iLvVawlFLVz_4AWcVDUcjSy1DYjVlA130_provenance.
- NP130189.RAU05xwihijvSGTh_PHVmr7Ziwdzk7K23nI78Q8GB3Krg130_assertion description "[This study introduces IL-32 as a critical regulator of endothelial function, expanding the properties of this cytokine relevant to coagulation, endothelial inflammation, and atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130189.RAU05xwihijvSGTh_PHVmr7Ziwdzk7K23nI78Q8GB3Krg130_provenance.
- NP130192.RAU7tevVNbV5zI0mwQwiuOI9_jqOjdTZnCPpb6yLKsllc130_assertion description "[We show that the diabetes gene calpain-10 (CAPN10) plays a role in atherosclerosis, insulin sensitivity and insulin secretion in a population enriched for atherosclerosis and insulin resistance.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130192.RAU7tevVNbV5zI0mwQwiuOI9_jqOjdTZnCPpb6yLKsllc130_provenance.
- NP130198.RAVMjG16SN9y9Uw7kqkFjuxQfL1RHIJk83Sng7N7pU8rE130_assertion description "[Novel androgen receptor/NF-kappaB mediated mechanism for VCAM-1 expression and monocyte adhesion operating in male endothelial cells that may represent an important unrecognized mechanism for the male predisposition to atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130198.RAVMjG16SN9y9Uw7kqkFjuxQfL1RHIJk83Sng7N7pU8rE130_provenance.
- NP130207.RAcAPHow5jYmDl9SwWf1ayY3hxnf1URIcgPKvEI9sfxCc130_assertion description "[USF1 contributes to atherosclerosis, the pathological arterial wall phenotype resulting in coronary heart disease and in its most dramatic consequence-sudden cardiac death.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130207.RAcAPHow5jYmDl9SwWf1ayY3hxnf1URIcgPKvEI9sfxCc130_provenance.
- NP130210.RAbMVzLXUqLIa7FUd_2QjM3F3J9v6c7lfZlg7SDr6tPBs130_assertion description "[HO-1 expression and activity in endothelial cells are present only in advanced atherosclerosis, whereas VEGF expression is present in early as well as in advanced atherosclerosis and the degree of expression increases with severity of atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130210.RAbMVzLXUqLIa7FUd_2QjM3F3J9v6c7lfZlg7SDr6tPBs130_provenance.
- NP130211.RAaWISF23q5UitmfGXDTA-yxvTMdTY8lOgPc6oh9YC7Rs130_assertion description "[Elucidation of the molecular mechanisms which control HO-1 gene expression will allow us to develop therapeutic strategies to enhance the cytoprotective potential of HO-1 in atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130211.RAaWISF23q5UitmfGXDTA-yxvTMdTY8lOgPc6oh9YC7Rs130_provenance.
- NP130212.RAW-9IroD1rwXW_7w7FBvQqFN9FRvtyOJvvE2NOnqOwOQ130_assertion description "[CX3CR1 and CX3CL1 mediate heterotypic anchorage of foam cells to coronary artery smooth muscle cells in the context of atherosclerosis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130212.RAW-9IroD1rwXW_7w7FBvQqFN9FRvtyOJvvE2NOnqOwOQ130_provenance.
- NP130215.RAaxOwRdWl_BlKirYd5R1CLPyTV0Bne_9P13PzBat2nBQ130_assertion description "[TWEAK and Fn14 are expressed in atherosclerotic plaques and could be novel mediators of atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130215.RAaxOwRdWl_BlKirYd5R1CLPyTV0Bne_9P13PzBat2nBQ130_provenance.
- NP130216.RAeG1T149JrH-_VjwofKXErnJ_nMB26NxcX4-ofqSAh4I130_assertion description "[Increased circulating IGF-1 and IGFBP-3 may be stimulators of atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130216.RAeG1T149JrH-_VjwofKXErnJ_nMB26NxcX4-ofqSAh4I130_provenance.
- NP130217.RATL1VdK7whn29R6wDCfKLk4w3initDna6lE-YDvquc-A130_assertion description "[Hypertensive subjects who have low IGF-I levels because of a genetic polymorphism in the IGF-I gene are at increased risk of developing atherosclerosis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130217.RATL1VdK7whn29R6wDCfKLk4w3initDna6lE-YDvquc-A130_provenance.
- NP130218.RAQsBhacjImEs41FGu0rt7jww4TO-X4HvL0ct56fzECHo130_assertion description "[Review/is implicated in angiogenesis, wound healing, blastocyst implantation, atherosclerosis, & tumor formation/is the diphtheria toxin receptor.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130218.RAQsBhacjImEs41FGu0rt7jww4TO-X4HvL0ct56fzECHo130_provenance.
- NP130220.RATQFPB7uFy-MHlE_dUcvxS9VWAkrvgRnRzKcCJZpUMGs130_assertion description "[a potential functional link between PLA2G3 and atherosclerosis, as has recently been proposed for PLA2G5 and PLA2G10.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130220.RATQFPB7uFy-MHlE_dUcvxS9VWAkrvgRnRzKcCJZpUMGs130_provenance.
- NP130226.RAatlWJpWCd8xdDXWi_z8Yk3I-dKqK1yrJUDcILTdapOo130_assertion description "[High glucose concentrations enhance LOX-1 expression in human monocyte-derived macrophages & this is associated with foam cell formation/of patients with type 2 diabetes overexpress LOX-1 supporting its involvement in diabetic atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130226.RAatlWJpWCd8xdDXWi_z8Yk3I-dKqK1yrJUDcILTdapOo130_provenance.
- NP130227.RAZFZLXP1a-91rhySILro_wfzw8I1Cq61u5_d-rErvwYY130_assertion description "[TL1A and DR3 is involved in atherosclerosis via the induction of pro-inflammatory cytokines/chemokines ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130227.RAZFZLXP1a-91rhySILro_wfzw8I1Cq61u5_d-rErvwYY130_provenance.
- NP130230.RAdhDKzi859fW4xK7WOSLLmJKkGNnBI_i8VmfQ2i1NXug130_assertion description "[C242T mutation in p22 phox gene is associated with progression of asymptomatic atherosclerosis in type 2 diabetes and is also associated with insulin resistance in nondiabetic subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130230.RAdhDKzi859fW4xK7WOSLLmJKkGNnBI_i8VmfQ2i1NXug130_provenance.
- NP130231.RAdSG_uHziBmB5bT5vQqtG4MSI--mvwNPrT1DzlZUOpu4130_assertion description "[study clearly demonstrates that NAD (P) H oxidase-derived reactive oxygen species (ROS) plays a significant role in the development of atherosclerosis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130231.RAdSG_uHziBmB5bT5vQqtG4MSI--mvwNPrT1DzlZUOpu4130_provenance.
- NP130234.RAdF7PPJx8zeoWDCI-hcs6EkoPSWAisVXfmOPilbFOUoE130_assertion description "[Patients with AAA were less frequently carriers of short repeats in the HO-1 gene promoter than patients with atherosclerosis or healthy subjects/alleles facilitating upregulation of HO-1 may be a protective anti-inflammatory factor against AAA.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130234.RAdF7PPJx8zeoWDCI-hcs6EkoPSWAisVXfmOPilbFOUoE130_provenance.
- NP130245.RAXT8e-1thrf-ucoPRMVgvITgcaluB7QH6Zezr34xvXAc130_assertion description "[Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130245.RAXT8e-1thrf-ucoPRMVgvITgcaluB7QH6Zezr34xvXAc130_provenance.
- NP130252.RAfbWfpjAp35lL0BPiyGwsPFZNZYadUAmTNATkzOmpPn4130_assertion description "[Alphavbeta5 integrin may play a role in the adhesion and migration of VSMCs during the pathogenesis of atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130252.RAfbWfpjAp35lL0BPiyGwsPFZNZYadUAmTNATkzOmpPn4130_provenance.
- NP130254.RAZ3Dyb3_6efZtJ8Okx7kCEn9SVzSzO33f9vkp92FoFaI130_assertion description "[Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130254.RAZ3Dyb3_6efZtJ8Okx7kCEn9SVzSzO33f9vkp92FoFaI130_provenance.
- NP130257.RAbD7Venp61yOKqtW6WEjQXvCjx6Svlck9XivwVngq6V0130_assertion description "[ABCA1-independent but apoa1-dependent cholesterol removal pathway may help to prevent early atherosclerosis in Tangier disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130257.RAbD7Venp61yOKqtW6WEjQXvCjx6Svlck9XivwVngq6V0130_provenance.
- NP130260.RAXtGRM736-2lh6yZFdT1Ey3Qdnkp2iBQDT44jp-UyT8Y130_assertion description "[In an LDL receptor-deficient mouse model of familial hypercholesterolemia, helper-dependent adenovirus gene transfer of human apoA-I causes long-term overexpression of apoA-I and retards atherosclerosis progression ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130260.RAXtGRM736-2lh6yZFdT1Ey3Qdnkp2iBQDT44jp-UyT8Y130_provenance.
- NP130262.RAZdgXTVG-OfsG6YTW8_OVvHGn0U1UQHf4ldxccsgKYtg130_assertion description "[Suppression of TLR4 signaling pathway may be an effective treatment for atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130262.RAZdgXTVG-OfsG6YTW8_OVvHGn0U1UQHf4ldxccsgKYtg130_provenance.
- NP130263.RARaN8I_vZWIVnEge7d8SJTrK8FehCNDYsTqeZCo49Yic130_assertion description "[TLR2 and TLR4 agonists have a significant role in diseases such as atherosclerosis and DIC, but our research suggests that this is through a mechanism other than direct platelet activation or by modification of platelet responses to other agonists.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130263.RARaN8I_vZWIVnEge7d8SJTrK8FehCNDYsTqeZCo49Yic130_provenance.
- NP130268.RATVyP63R4iPkS2oN-KWVeTFhjwZVRTOVAkYf6l60kIdk130_assertion description "[Review.the role of the anti-inflammatory cytokine transforming growth factor beta in atherosclerosis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130268.RATVyP63R4iPkS2oN-KWVeTFhjwZVRTOVAkYf6l60kIdk130_provenance.
- NP130270.RAbIZV684vDGFQXMjo1-VE7eQxO4lWw6h0uvMbrxyFZnA130_assertion description "[EPHX2 has an emerging role as a risk factor for atherosclerosis, whose effects are influenced by smoking ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130270.RAbIZV684vDGFQXMjo1-VE7eQxO4lWw6h0uvMbrxyFZnA130_provenance.
- NP130271.RAblkFFICQJLxKcobNKfgL6CtWW8gnUgLDVSXeP67uk2M130_assertion description "[although activation of PPARgamma appears to have beneficial effects on atherosclerosis and heart failure, it is still largely uncertain whether PPARgamma ligands prevent the development of cardiovascular diseases-REVIEW ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130271.RAblkFFICQJLxKcobNKfgL6CtWW8gnUgLDVSXeP67uk2M130_provenance.
- NP130275.RAe-gdsyjIVW57lz1PXSj6ZGsR8tfPmJA2db196U5KDO4130_assertion description "[MCP-1 is involved in the pathogenesis of human atherosclerosis and myocardial infarction ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130275.RAe-gdsyjIVW57lz1PXSj6ZGsR8tfPmJA2db196U5KDO4130_provenance.
- NP130281.RAZ6t5kMwbibQU9OkDBsTo03jza0Lr9wvq0J_VvCQOm-s130_assertion description "[TNF-alpha could cause intracellular iron sequestration, which may participate importantly in the pathophysiology of atherosclerosis and cardiovascular disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130281.RAZ6t5kMwbibQU9OkDBsTo03jza0Lr9wvq0J_VvCQOm-s130_provenance.
- NP130298.RAYCxJMVVxM-SguitpKYzez9zsDdfPiJchzWoRu81vvaM130_assertion description "[We demonstrate that PON2 mRNA and protein are decreased in plaques versus plaque-adjacent tissue, mammary arteries, and fetal carotids/data indicate that the protective effect of PON2 could fail during atherosclerosis exacerbation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130298.RAYCxJMVVxM-SguitpKYzez9zsDdfPiJchzWoRu81vvaM130_provenance.
- NP130299.RATGktuXYkBsyHh8fLfqe2z_YTaBBn58gBeqwKEjtQFuY130_assertion description "[Plays a protective role against atherosclerosis in vivo.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130299.RATGktuXYkBsyHh8fLfqe2z_YTaBBn58gBeqwKEjtQFuY130_provenance.
- NP130301.RAYsSBzcsKkV03T7LIFcfZUE_ryYyswjDKVln3TRwEd4Y130_assertion description "[Data suggest that CD36 signaling in response to oxLDL alters cytoskeletal dynamics to enhance macrophage spreading, inhibiting migration, and possibly inducing trapping of macrophages in the arterial intima and promoting atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130301.RAYsSBzcsKkV03T7LIFcfZUE_ryYyswjDKVln3TRwEd4Y130_provenance.
- NP130302.RAcWKd8s2LL3XeCJ7FMdfPtGxgoT_7e29-hd7gLf5CSTE130_assertion description "[Patients with diabetes show increased coexpression of CD40 system, especially CD40L, which may create a proinflammatory and prothrombotic milieu for aggravating the development of atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130302.RAcWKd8s2LL3XeCJ7FMdfPtGxgoT_7e29-hd7gLf5CSTE130_provenance.
- NP130306.RAWbmgq-GELk06FNEVZ5jMxJ7Btc-hjKsvm-oo66s46vk130_assertion description "[Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130306.RAWbmgq-GELk06FNEVZ5jMxJ7Btc-hjKsvm-oo66s46vk130_provenance.
- NP130323.RAejDg5JPsyusyuSToDJHxyj_JDnOjn4xApVuYC_Fb07A130_assertion description "[Effect of long-term hormone replacement therapy (HRT) on the progression of atherosclerosis in a 5-yr follow-up observational study of 88 postmenopausal women with different hepatic lipase genotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP130323.RAejDg5JPsyusyuSToDJHxyj_JDnOjn4xApVuYC_Fb07A130_provenance.