Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Plasma+MDK+level+is+a+prognostic+factor+for+human+neuroblastoma. assertion.
- assertion asSentence Midkine+promotes+self-renewal+and+proliferation+of+human+embryonic+stem+cells. assertion.
- assertion asSentence Akt+enhances+Mdm2-mediated+ubiquitination+and+degradation+of+p53. assertion.
- assertion asSentence Cirrhotic+livers+reveal+genetic+changes+in+the+MDM2-P14ARF+system+of+cell+cycle+regulators. assertion.
- assertion asSentence p14ARF+promotes+accumulation+of+%28H%29Mdm2+conjugated+to+the+small+ubiquitin-like+protein+SUMO-1. assertion.
- assertion asSentence No+correlation+between+p53+accumulation+and+survival+in+bilharziasis+associated+bladder+squamous+cell+carcinoma. assertion.
- assertion asSentence The+RING+domain+of+MDM2+mediates+histone+ubiquitylation+and+transcriptional+repression. assertion.
- assertion asSentence HIPK2+contributes+to+drug-induced+modulation+of+MDM2+activity+at+transcriptional+%28through+p53Ser46+phosphorylation%29+and+posttranscriptional+%28through+p53-independent+subcellular+re-localization+and+proteasomal+degradation%29+levels. assertion.
- assertion asSentence PCNA%2C+L2DTL+and+the+DDB1-CUL4A+complex+play+critical+and+differential+roles+in+regulating+the+protein+stability+of+p53+and+MDM2%2FHDM2+in+unstressed+and+stressed+cells. assertion.
- assertion asSentence Gene+amplifications+are+important+prognostic+markers+for+soft+tissue+sarcomas. assertion.
- assertion asSentence Arrestins+recruit+ERK1%2F2+and+the+E3+ubiquitin+ligase+Mdm2+to+microtubulesin+cells%2C+similar+to+the+arrestin-dependent+mobilization+of+these+proteins+to+the+receptor. assertion.
- assertion asSentence The+WNV+capsid+%28WNVCp%29+is+capable+of+binding+to+and+sequestering+HDM2+into+the+nucleolus. assertion.
- assertion asSentence MDM2+single-nucleotide+polymorphism+is+associated+with+the+early+development+of+hepatocellular+carcinoma+in+Korean+patients+with+chronic+HBV+infection. assertion.
- assertion asSentence Mdm2+regulates+p53+levels+also+by+targeting+ribosomal+protein+L26+for+polyubiquitylation+and+proteasomal+degradation. assertion.
- assertion asSentence PI3K%2FAkt%2Fmdm2+signalling+pathway+can+be+activated+by+doxorubicin+and+suppress+apoptosis+by+promoting+phosphorylation+of+mdm2+in+a+gastric+cancer+cell+line. assertion.
- assertion asSentence ALK+signaling+leads+to+the+functional+inactivation+and%2For+degradation+of+p53+in+JNK+and+MDM2+dependent+manners. assertion.
- assertion asSentence Nucleostemin+is+a+target+for+Mdm2-mediated+ubiquitination+and+degradation+when+not+bound+to+GTP. assertion.
- assertion asSentence SNP+genotyping+of+a+sclerosing+rhabdomyosarcoma+reveals+high+aneuploid+profile+and+a+specific+MDM2+amplification. assertion.
- assertion asSentence AP-4+participates+in+a+transcriptional-regulating+complex+at+the+HDM2-P2+promoter+in+response+to+DNA+damage. assertion.
- assertion asSentence MDM2+SNP309+polymorphism+is+not+associated+with+prostate+cancer. assertion.
- assertion asSentence Genetic+variants+in+p14ARF%2C+alone+or+in+combination+with+MDM2+Del1518+polymorphism%2C+contribute+to+the+development+of+chronic+benzene+poisoning+in+occupational+exposure+to+benzene+in+a+Chinese+population. assertion.
- assertion asSentence MDM-2+is+overexpressed+in+a+significant+number+of+childhood+acute+lymphoblastic+leukemia%2C+it+is+more+frequent+in+relapsed+cases+and+its+frequency+is+not+related+to+p53+status. assertion.
- assertion asSentence MDM2+promotes+Itch-mediated+degradation+of+p73+through+the+interaction+with+Itch+in+HeLa+cells. assertion.
- assertion asSentence Caspase-2+directly+cleaves+the+E3+ubiquitin+ligase+Mdm2+at+Asp+367%2C+leading+to+loss+of+the+C-terminal+RING+domain+responsible+for+p53+ubiquitination. assertion.
- assertion asSentence The+MDM2+oncogene+is+amplified+in+a+substantial+proportion+of+ER%2B+early-stage+breast+carcinomas+and+an+independent+parameter+for+poor+patient+outcome+in+this+subgroup. assertion.
- assertion asSentence MDMX+dramatically+inhibits+the+acetylation+of+p53+induced+by+both+endogenous+and+ectopically+expressed+p300%2FCBP. assertion.
- assertion asSentence Structure+of+the+human+Mdmx+protein+bound+to+the+p53+tumor+suppressor+transactivation+domain. assertion.
- assertion asSentence MDM4+gain+is+associated+with+the+early+transition+from+normal+retina+to+retinoma. assertion.
- assertion asSentence Male+Rett+phenotypes+in+T158M+and+R294X+MeCP2-mutations. assertion.
- assertion asSentence The+International+Rett+Syndrome+Association+%28IRSA%29+North+American+database+is+the+first+comprehensive+compilation+of+information+in+the+United+States+and+Canada+on+individuals+with+Rett+syndrome+or+another+diagnosis+in+association+with+MECP2+mutations. assertion.
- assertion asSentence MECP2+gene+duplications+can+occur+by+fork+stalling+and+template+switching. assertion.
- assertion asSentence Rett+syndrome+patients+with+nonsense+mutations+located+in+the+methyl-CpG-binding+domain+tend+to+develop+a+more+severe+phenotype. assertion.
- assertion asSentence A+common+MECP2+haplotype+associates+with+reduced+cortical+surface+area+in+humans+in+two+independent+populations. assertion.
- assertion asSentence MeCP2+cooperates+with+HIPK2+in+induction+of+apoptosis+and+Ser+80+phosphorylation+is+required+together+with+the+DNA+binding+of+MeCP2. assertion.
- assertion asSentence Rett+syndrome+%28RTT%29+is+a+pervasive+development+disorder%2C+mainly+caused+by+mutations+in+the+methyl-CpG+binding+protein+2+%28MeCP2%29+gene. assertion.
- assertion asSentence MYCN+and+MeCP2+protein+interact+and+co-localize+to+similar+genomic+sites+at+very+high+frequency. assertion.
- assertion asSentence MEF2+proteins+are+an+important+component+in+Galpha13-mediated+angiogenesis. assertion.
- assertion asSentence MEF2A+is+not+a+susceptibility+gene+for+coronary+artery+disease+and+premature+myocardial+infarction+in+the+Italian+population. assertion.
- assertion asSentence MEF2A+and+MEF2D+play+dual+roles+in+human+macrophages+differentiation%2C+as+activators+and+as+repressors+of+c-jun+transcription. assertion.
- assertion asSentence MEF2+positively+regulates+the+expression+of+HZF1. assertion.
- assertion asSentence Prevalence+of+MEFV+gene+mutations+and+their+clinical+correlations+in+Turkish+children+with+Henoch-Schonlein+purpura. assertion.
- assertion asSentence A+link+is+established+between+the+restless+legs+syndrome-associated+MEIS1+gene+and+iron+metabolism. assertion.
- assertion asSentence Structural+details+of+MEKK3+PB1+and+its+binding+properties+with+mitogen-activated+protein+kinase+kinase+5%2C+human+PB1. assertion.
- assertion asSentence Reactive+oxygen+species+generated+by+Nox4%2C+at+least+in+part%2C+transmit+cell+survival+signals+through+the+AKT-ASK1+pathway+in+pancreatic+cancer+cells+and+their+depletion+leads+to+apoptosis. assertion.
- assertion asSentence Apoptosis+signal-regulating+kinase+%28ASK%29+2+functions+as+a+mitogen-activated+protein+kinase+kinase+kinase+in+a+heteromeric+complex+with+ASK1. assertion.
- assertion asSentence Beta-Arrestins+play+a+negative+regulatory+role+in+hydroegn+peroxide-induced+apoptosis+signaling+through+associating+with+ASK1+and+CHIP+and+facilitating+ASK1+degradation. assertion.
- assertion asSentence Stimulation+of+human+aortic+endothelial+cells+with+TNF-alpha+led+to+an+increased+expression+of+p73+protein+and+a+reduction+in+the+levels+of+p53+involving+apoptosis+signal-regulating+kinase+1+%28ASK1%29. assertion.
- assertion asSentence DCDC5+colocalizes+with+Rab8+and+links+it+to+dynein+during+cytokinesis. assertion.
- assertion asSentence Pigmentary+retinopathy+in+patients+with+the+MELAS+mutation+3243A--%3EG+in+mitochondrial+DNA. assertion.
- assertion asSentence Loss+of+one+MEN1+allele+in+pancreatic+tumors+and+monohormonal+endocrine+cell+clusters+in+Multiple+endocrine+neoplasia+type+1. assertion.
- assertion asSentence Multiple+Endocrine+Neoplasia+type+1+%28MEN-1%29+and+is+caused+by+a+germ-line+mutation+in+MEN-1+gene+encoding+a+tumour+suppressor+protein%2C+menin. assertion.
- assertion asSentence Lens+epithelium-derived+growth+factor+critically+associates+with+mixed-lineage+leukemia+protein+and+menin+at+the+nexus+of+transcriptional+pathways+that+are+recurrently+targeted+in+diverse+diseases. assertion.
- assertion asSentence Recapitulation+of+pancreatic+neuroendocrine+tumors+in+human+multiple+endocrine+neoplasia+type+I+syndrome+via+Pdx1-directed+inactivation+of+Men1. assertion.
- assertion asSentence Menin+is+an+important+factor+in+PPARgamma-mediated+adipogenesis. assertion.
- assertion asSentence Exon+2+mutation+of+the+MEN1+gene+is+associated+with+bilateral+adrenal+carcinomas+in+multiple+endocrine+neoplasia+type+1+syndrome. assertion.
- assertion asSentence Menin+mutant+exhibits+selective+loss+of+the+TGF-beta+signaling+pathway+and+loss+of+cell+proliferation+control+contributing+to+the+development+of+MEN1. assertion.
- assertion asSentence Type+of+epimutation+at+the+PEG1%2FMEST+locus+does+not+play+a+relevant+role+in+Silver-Russell+syndrome. assertion.
- assertion asSentence Radiation+stimulates+HGF+receptor%2Fc-Met+expression+that+leads+to+amplifying+cellular+response+to+HGF+stimulation+via+upregulated+receptor+tyrosine+phosphorylation+and+MAP+kinase+activity+in+pancreatic+cancer+cells. assertion.
- assertion asSentence Ki-ras+mutations+and+HGF+signaling+cooperate+to+enhance+tumor+growth+by+increased+duration+of+MAPK+activation+and+decreased+apoptosis+in+human+carcinoma+cells. assertion.
- assertion asSentence Role+of+the+HGF+receptor+in+proliferation+and+invasive+behavior+of+osteosarcoma+cell+lines. assertion.
- assertion asSentence Retroviral+ribozyme+transgenes+targeting+HGF%2FSF+in+fibroblasts+or+its+receptor+cMET+in+mammary+cancer+cells+can+reduce+the+growth+of+mammary+cancer+and+associated+angiogenesis+by+inhibiting+paracrine+stromal-tumor+cell+interactions. assertion.
- assertion asSentence The+role+of+HGFR+signal+in+colon+tumorigenesis+is+associated+to+progression+of+adenoma+into+carcinoma. assertion.
- assertion asSentence C-Met+is+overexpressed+in+esophageal+adenocarcinoma. assertion.
- assertion asSentence C-met-siRNA+can+down-regulate+the+expression+of+c-met+and+inhibit+hepatocellular+carcinoma+cell+proliferation%2C+motility+and+invasiveness. assertion.
- assertion asSentence Mimp+expression+reduces+hepatocyte+growth+factor%2Fscatter+factor-induced+proliferation+and+scattering+by+attenuating+and+altering+the+downstream+signaling+of+met+proto-oncogene. assertion.
- assertion asSentence p100+MET%2C+corresponding+to+the+entire+extracellular+region+of+the+MET+receptor+still+spanning+the+membrane+is+able+to+bind+HGF%2FSF+and+to+prevent+HGF-dependent+signaling+downstream+of+full+MET%2C+demonstrating+its+function+as+a+decoy+receptor. assertion.
- assertion asSentence The+epithelial+expression+of+HGFR+is+elevated+in+mildly+active+UC. assertion.
- assertion asSentence MET+as+a+target+of+YB-1+that+work+in+concert+to+promote+Basal-like+breast+cancers+%28BLBC%29+growth. assertion.
- assertion asSentence Link+between+the+PAR%282%29+and+Met+receptor+tyrosine+kinase+signaling+in+promoting+hepatocellular+carcinoma+%28HCC%29+cell+invasion. assertion.
- assertion asSentence Exploring+the+roles+of+c-met+in+modulating+the+motility+of+cell%2C+by+silencing+c-met+expression+in+a+human+hepatoma+cell+line. assertion.
- assertion asSentence Both+binding+and+orientation+is+dictated+by+the+c-MET+phosphorylated+tyrosine+and+an+adjacent+arginine+forming+intra-peptide+hydrogen+bonds+and+aligning+unidirectionally+with+complementary+charges+in+the+phosphotyrosine+binding+pocket+of+c-Cbl. assertion.
- assertion asSentence Increased+neuronal+Met+in+amyotrophic+lateral+sclerosis+met-transgenic+mice+prolongs+life+span%2C+retards+motor+neuron+and+delay+disease+onset+loss. assertion.
- assertion asSentence RPTP-beta+is+a+key+regulator+of+Met+function. assertion.
- assertion asSentence Ovarian+carcinomas%2C+the+amplification+of+the+MET+proto-oncogene+is+highly+selective+and+commonly+occurs+in+clear-cell+adenocarcinoma. assertion.
- assertion asSentence Protein-tyrosine+phosphatase+1B+modulates+early+endosome+fusion+and+trafficking+of+Met+and+epidermal+growth+factor+receptors. assertion.
- assertion asSentence Plasma+cell+membrane+localization+of+c-MET+is+associated+with+malignant+mesothelioma. assertion.
- assertion asSentence Fas+ligand+enhances+malignant+behavior+of+tumor+cells+through+interaction+with+Met%2C+hepatocyte+growth+factor+receptor%2C+in+lipid+rafts. assertion.
- assertion asSentence An+N-glycosylation+site+on+the+beta-propeller+domain+of+the+integrin+alpha5+subunit+plays+key+roles+in+both+its+function+and+site-specific+modification+by+beta1%2C4-N-acetylglucosaminyltransferase+III. assertion.
- assertion asSentence Low+GnT-V+expression+is+associated+with+shorter+survival+and+poor+prognosis+in+pStage+I+overall+Non-small+cell+lung+cancer. assertion.
- assertion asSentence Glycosylation+caused+by+GnT-V+directs+integrin+beta1+stability+and+more+delivery+to+plasma+membrane%2C+subsequently+promotes+Fn-based+cell+migration+and+invasion. assertion.
- assertion asSentence Mammaglobin+is+a+sensitive+marker+of+breast+carcinoma%2C+it+defines+a+subgroup+of+patients+with+better+prognosis+and+is+a+useful+method+to+detect+breast+cancer+metastases. assertion.
- assertion asSentence Detection+of+Mammaglobin+as+part+of+a+3-marker+RT-PCR+for+early+diagnosis+of+breast+cancer. assertion.
- assertion asSentence Stem+cell+factor+has+%22late%22+effects+on+fetal+hemoglobin+modulation+during+erythropoiesis%2C+related+to+the+expression+pattern+of+CD117. assertion.
- assertion asSentence Airway+smooth+muscle+cells+maintain+human+lung+mast+cell+survival+in+vitro+by+a+direct+cooperative+interaction+between+the+two+cell+types+via+a+mechanism+dependent+upon+stem+cell+factor%2C+interleukin-6+and+cell+adhesion+molecule+%28CADM%291. assertion.
- assertion asSentence MIF-mediated+melanogenesis+occurs+mainly+through+the+activation+of+PAR-2+and+SCF+expression+in+keratinocytes+after+exposure+to+ultraviolet-B+radiation. assertion.
- assertion asSentence Variants+in+KITLG+predispose+to+testicular+germ+cell+cancer+independently+from+spermatogenic+function. assertion.
- assertion asSentence The+modified+human+DNA+repair+enzyme+O%286%29-methylguanine-DNA+methyltransferase+is+a+negative+regulator+of+estrogen+receptor-mediated+transcription+upon+alkylation+DNA+damage. assertion.
- assertion asSentence Glutathione+S-transferase+P1+and+NADPH+quinone+oxidoreductase+polymorphisms+are+associated+with+aberrant+promoter+methylation+of+P16%28INK4a%29+and+O%286%29-methylguanine-DNA+methyltransferase+in+sputum. assertion.
- assertion asSentence Polymorphism+in+MGMT+increases+the+susceptibility+of+women+to+cervical+carcinoma%2C+especially+in+those+with+high-risk+sexual+and+reproductive+histories. assertion.
- assertion asSentence Temozolomide+significantly+improves+survival+of+human+glioma-bearing+mice+by+silencing+the+O6-methylguanine-DNA+methyltransferase+promoter. assertion.
- assertion asSentence Pseudoprogression+after+radiochemotherapy+in+glioblastoma+patients+is+significantly+correlated+with+MGMT+status. assertion.
- assertion asSentence Immunohistochemistry+revealed+moderate+to+high+level+expression+of+MGMT+in+the+primary+endometrial+tumors. assertion.
- assertion asSentence MGMT+promoter+methylation+and+gene+expression+is+associated+with+glioblastomas. assertion.
- assertion asSentence Histone+H3-K9+di-methylation%2C+H3-K4+di-methylation%2C+H3-K9+acetylation+and+DNA+methylation+work+in+combination+to+silence+MGMT. assertion.
- assertion asSentence The+MGMT+-535G%3ET+polymorphism+is+correlated+with+poor+prognosis+in+patients+with+advanced+colorectal+cancer+treated+with+oxaliplatin-based+chemotherapy. assertion.
- assertion asSentence Chronic+kidney+disease+and+hemodialysis+patients+have+a+different+distribution+of+MGP+gene+polymorphism+as+compared+to+the+normal+population. assertion.
- assertion asSentence Uncarboxylated+matrix+Gla+protein+%28ucMGP%29+is+associated+with+coronary+artery+calcification+in+haemodialysis+patients. assertion.
- assertion asSentence Examine+circulating+Matrix+Gla-Protein+and+anticoagulation+status+in+patients+with+aortic+valve+calcification. assertion.
- assertion asSentence Promoter+polymorphism+rs3087456+in+the+MHC+class+II+transactivator+gene+is+not+associated+with+susceptibility+for+selected+autoimmune+diseases+in+German+patient+groups. assertion.
- assertion asSentence Elevated+soluble+MICB+levels+exist+in+serum+of+multiple+sclerosis+patients+related+with+disease+activity. assertion.