Nanopublications LDF server

Matches in Nanopublications for { ?s <http://purl.org/dc/terms/description> ?o ?g. }

• NP134562.RAd3SxI91jcadqG7QtX2TWKgdhstaWHWrvm9GhKI4bB0U130_assertion description "[NADH: ubiquinone oxidoreductase gene may have a role in the regulation of molecular changes during the global cardiac ischemia/reperfusion injury during CPB ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134562.RAd3SxI91jcadqG7QtX2TWKgdhstaWHWrvm9GhKI4bB0U130_provenance.
• NP134563.RAatVBtv2vbgVZlDrSKMIdnkl_TL6EP5lx4G3Aipw5FjE130_assertion description "[Data show that Ngal protects the kidney and mitigates azotemia during ischemia-reperfusion injury.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134563.RAatVBtv2vbgVZlDrSKMIdnkl_TL6EP5lx4G3Aipw5FjE130_provenance.
• NP134571.RAft3gkG1plSVRo7adfHJCIBPQ9j19MXfxrtn8YPLxiyM130_assertion description "[The proposed type 1 autism includes autism cases with the originally described premature stop codon CNTNAP2, along with other CNTNAP2 mutations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134571.RAft3gkG1plSVRo7adfHJCIBPQ9j19MXfxrtn8YPLxiyM130_provenance.
• NP134573.RAV_ZOQhpFGMWTu6vJBgLN0IcL26EJ1AvAu5XvbqD1Kbc130_assertion description "[We found significant reductions in 410 kDa Reelin species in autistic twins, their fathers, mothers, and phenotypically normal siblings versus controls, suggesting that Reelin 410 deficiency may be a vulnerability factor in the pathology of autism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134573.RAV_ZOQhpFGMWTu6vJBgLN0IcL26EJ1AvAu5XvbqD1Kbc130_provenance.
• NP134582.RAVIt2DLcB77tsptudU-vca0fuCaPZ4lQRgPb4o_QuSnU130_assertion description "[Linkage and association of the glutamate receptor 6 gene with autism ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134582.RAVIt2DLcB77tsptudU-vca0fuCaPZ4lQRgPb4o_QuSnU130_provenance.
• NP134584.RAbByTlyYSO3onKsJ3ZGNU88fhUATcSA1Wew4ByNS7uEw130_assertion description "[Polymorphism of tryptophan 2, 3 dioxygenase gene is associated with autism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134584.RAbByTlyYSO3onKsJ3ZGNU88fhUATcSA1Wew4ByNS7uEw130_provenance.
• NP134585.RAUCcu5TJuQHtHv0aI2PeK-f10B6r2-l17seqfzdj_J7o130_assertion description "[Dysregulation of EGR2 and MeCP2 plays roles in in Rett syndrome and autism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134585.RAUCcu5TJuQHtHv0aI2PeK-f10B6r2-l17seqfzdj_J7o130_provenance.
• NP134599.RAXL4BVGrueUtFm_w3DdVKkZVPsA9de1nhXWbARDMVwMc130_assertion description "[Mutation screening of the RAB3A gene in 47 individuals with autism provided no evidence that DNA variants in this gene are associated with autism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134599.RAXL4BVGrueUtFm_w3DdVKkZVPsA9de1nhXWbARDMVwMc130_provenance.
• NP134604.RAWkV3PwY-UEAFSvGw0uLUJPeg7EEfme5Df4YRXRW4c9k130_assertion description "[Data indicate that coding mutations in neuroligin 3 are very rarely associated to autism spectrum disorders.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134604.RAWkV3PwY-UEAFSvGw0uLUJPeg7EEfme5Df4YRXRW4c9k130_provenance.
• NP134606.RAY-HSAzHJ-YLCfahuvxExKwNYMaRom36rxWQsr9zVKqw130_assertion description "[These results suggest that PECAM-1 plays a role in the pathophysiology of high-functioning autism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134606.RAY-HSAzHJ-YLCfahuvxExKwNYMaRom36rxWQsr9zVKqw130_provenance.
• NP134608.RAZMfqB2fEFBFv62_IqDcMp0Wek4UaceBgV__B0EDXqP0130_assertion description "[Data suggest that oxytocin improves the ability to infer the mental state of others from social cues of the eye region/might play a role in autism spectrum disorder, characterized by severe social impairment.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134608.RAZMfqB2fEFBFv62_IqDcMp0Wek4UaceBgV__B0EDXqP0130_provenance.
• NP134627.RAXCPp3O4nQ_WQ2tC7vnkiiXRH2XayGGVaRvlKiI8Kh1c130_assertion description "[investigation of role of specific mutations in autism ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134627.RAXCPp3O4nQ_WQ2tC7vnkiiXRH2XayGGVaRvlKiI8Kh1c130_provenance.
• NP134628.RARTpHb4_hbP0TLgO1ni3I3S4_f8MbHbrJHiA5iD8erBg130_assertion description "[Levels of Bcl-2 are decreased in three important brain tissues, i.e.frontal, parietal, and cerebellar cortices of autistic subjects, alluding to impaired apoptotic mechanisms in autism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134628.RARTpHb4_hbP0TLgO1ni3I3S4_f8MbHbrJHiA5iD8erBg130_provenance.
• NP134633.RAZKbRdWrPNIMS0G29KTkPSdDgygaNFifYTeuGXEsUxTc130_assertion description "[These data suggest that changes are apparent in markers for abnormal glial-neuronal communication (connexin 43 and aquaporin 4) in brains of subjects with autism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134633.RAZKbRdWrPNIMS0G29KTkPSdDgygaNFifYTeuGXEsUxTc130_provenance.
• NP134648.RATR9UmFaehB0U3N7mv7946qxFMcxzjWTxUtXwt_o8Z7g130_assertion description "[Data indicate that coding mutations in neuroligin 4 are very rarely associated to autism spectrum disorders.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134648.RATR9UmFaehB0U3N7mv7946qxFMcxzjWTxUtXwt_o8Z7g130_provenance.
• NP134663.RAaM0M7C8wVlcgtnXlMS7lyxmBCIrNPRKpKCpld7ufu7E130_assertion description "[Lactic acidosis after cardiac surgery is associated with polymorphisms in interleukin 10 gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134663.RAaM0M7C8wVlcgtnXlMS7lyxmBCIrNPRKpKCpld7ufu7E130_provenance.
• NP134668.RAYyF6S0sWu5WHeh8KXn6ZVRiRYR3aqvBzAJOBfT68jaY130_assertion description "[Mutations are rare in adult myelodysplastic syndromes and chronic myelomonocytic leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134668.RAYyF6S0sWu5WHeh8KXn6ZVRiRYR3aqvBzAJOBfT68jaY130_provenance.
• NP134670.RAWRWQeK1z0yeId1x4zfpMO5bv0oa5BbihUG0t0qjbm8s130_assertion description "[Survivin overexpression, by disrupting the balance between cell proliferation/differentiation and apoptosis, may play an important role in chronic myelomonocytic leukemia's pathophysiology.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134670.RAWRWQeK1z0yeId1x4zfpMO5bv0oa5BbihUG0t0qjbm8s130_provenance.
• NP134683.RAf0L_6Y9NgE-5Jmp0JkI1KxcN2_OCV3P1t_OAEmM1Wys130_assertion description "[A multifunctional domain in CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134683.RAf0L_6Y9NgE-5Jmp0JkI1KxcN2_OCV3P1t_OAEmM1Wys130_provenance.
• NP134686.RATRgFlo7WwD_HWLT6vF2Pm35jmYIPD6fIj9tiEjHSzJI130_assertion description "[Data suggest that the constitutive expression of IL-32 mRNA as well as the predominant production of a smaller sized IL-32 isoform in Jurkat cells may implicate a role for IL-32 in human T cell leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134686.RATRgFlo7WwD_HWLT6vF2Pm35jmYIPD6fIj9tiEjHSzJI130_provenance.
• NP134689.RATubt4VWAcwLMmBFA8EuH21SZt3obWImAuUomkxzFVa0130_assertion description "[PTEN posttranslational inactivation and hyperacivation of the PI3K/Akt pathway sustain primary T cell leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134689.RATubt4VWAcwLMmBFA8EuH21SZt3obWImAuUomkxzFVa0130_provenance.
• NP134690.RAVjhEC1QPqK9-9XTVq8Ga4f7tcmBeNOsM6Jl6o7CA6G8130_assertion description "[Involved in the pathogenesis of mature leukemias and lymphomas: mature T-cell leukemia and chronic lymphocytic leukemia (review) ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134690.RAVjhEC1QPqK9-9XTVq8Ga4f7tcmBeNOsM6Jl6o7CA6G8130_provenance.
• NP134692.RAY--_wDNXafkYPMshTmjmP6NcZeQZkrwa6gjI5UjbpzM130_assertion description "[Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134692.RAY--_wDNXafkYPMshTmjmP6NcZeQZkrwa6gjI5UjbpzM130_provenance.
• NP134693.RAURyAnBZ7VNJjlk0ZsA8HXTTENP_AedNJYsD9j6MeCvo130_assertion description "[interference with the binding of the human T cell leukemia virus type 1 rex regulatory protein to its response element ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134693.RAURyAnBZ7VNJjlk0ZsA8HXTTENP_AedNJYsD9j6MeCvo130_provenance.
• NP134697.RASbrd6HYLOhwbKcwXrukFSP3AKARsj1KP01P6CSG0DHI130_assertion description "[required for Tax protein induction of TRail expression in HTLV-1 infected T-cell lines and adult T cell leukemia cells ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134697.RASbrd6HYLOhwbKcwXrukFSP3AKARsj1KP01P6CSG0DHI130_provenance.
• NP134698.RAYY9jQfs2LMiOr5iyuD9iHcH7SuiK26g-99jRHmSETyk130_assertion description "[activation of APC (Cdc20) by Tax provides an explanation for the mitotic abnormalities in HTLV-I-infected cells and is likely to play an important role in the development of adult T cell leukemia ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134698.RAYY9jQfs2LMiOr5iyuD9iHcH7SuiK26g-99jRHmSETyk130_provenance.
• NP134703.RAQDE0hSBxASDyRQrX3Jr-JXNMDE17YZkx3AV9VVYB-qM130_assertion description "[In the case of cell death after in vitro influenza viral infection, both C-terminal and N-terminal regions of MxA were shown to be involved in cell death promotion.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134703.RAQDE0hSBxASDyRQrX3Jr-JXNMDE17YZkx3AV9VVYB-qM130_provenance.
• NP134706.RARJZgx9Or_JRTB4j2WgEeEx1WD5sjmatC2HjO5qOsgic130_assertion description "[released from lung epithelial cells rendered necrotic by influenza A virus infection ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134706.RARJZgx9Or_JRTB4j2WgEeEx1WD5sjmatC2HjO5qOsgic130_provenance.
• NP134707.RAUfno8OLxp5loHMN1EjWV4FozDk18gRvu-QAF78X6pmo130_assertion description "[released from lung epithelial cells rendered necrotic by influenza A virus infection ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134707.RAUfno8OLxp5loHMN1EjWV4FozDk18gRvu-QAF78X6pmo130_provenance.
• NP134711.RAX6xXajl4Kdc0gybpqxzmlCWM6lR5a6h1oN5wXmgbPTQ130_assertion description "[Hsc70 is directly associated with Influenza virus matrix protein 1 and therefore is required for viral production ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134711.RAX6xXajl4Kdc0gybpqxzmlCWM6lR5a6h1oN5wXmgbPTQ130_provenance.
• NP134714.RAYe7PEvzlC9ROcQpP79zshFjzBLYaHoziPkxfUNs2f-c130_assertion description "[Triggering of cytosolic RNA recognition pathway with poly (I: C) transfection or influenza A virus infection resulted in caspase-1- and -3-mediated proteolytic processing of pro-IL-18 and secretion of biologically active IL-18.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134714.RAYe7PEvzlC9ROcQpP79zshFjzBLYaHoziPkxfUNs2f-c130_provenance.
• NP134724.RAagO71VfuIpXckeYj0c5Jgupx4Jt1z3dqzVC4m3gQQkk130_assertion description "[A possible role of SAP in either host resistance or viral virulence was investigated during influenza infection in vivo/virus infection is not affected by serum amyloid P component.Human SAP binds much more avidly than mouse SAP to the virus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134724.RAagO71VfuIpXckeYj0c5Jgupx4Jt1z3dqzVC4m3gQQkk130_provenance.
• NP134727.RAX2JuKLnwsiNSCrP8DpkP2lYccAHqBTuiFY8rBehpXEM130_assertion description "[Increased binding to influenza virus-infected cells is observed in leukocyte Ig-like receptor-1 (LIR1) that is functional and possibly results from the generation of complexes of class I MHC proteins after influenza virus infection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134727.RAX2JuKLnwsiNSCrP8DpkP2lYccAHqBTuiFY8rBehpXEM130_provenance.
• NP134729.RAZtRACTOEQRzOCRkADHIazfqGQWXZ3PLvZoYwPb0Gj8k130_assertion description "[Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral and opsonic activities related to influenza virus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134729.RAZtRACTOEQRzOCRkADHIazfqGQWXZ3PLvZoYwPb0Gj8k130_provenance.
• NP134730.RAXa2CTDExA7GZ2p-lNPxJFNXlBiSDs6OvWnr1iP-LzJs130_assertion description "[A recombinant trimeric fragment of surfactant protein D chemically cross-linked to the Fab'of anti-Fc alpha receptor monoclonal antibody markedly enhances the uptake of influenza A virus, Candida albicans, and Escherichia coli by neutrophils in vitro.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134730.RAXa2CTDExA7GZ2p-lNPxJFNXlBiSDs6OvWnr1iP-LzJs130_provenance.
• NP134734.RAcFh-epwIVlNM6cw3Aq-L-1bph2vwEHNmqQPTZkhp0VU130_assertion description "[We report a mutation causing a premature termination triplet in exon 17 of the Krit1 gene in a family with diagnoses of cerebral cavernous angioma ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134734.RAcFh-epwIVlNM6cw3Aq-L-1bph2vwEHNmqQPTZkhp0VU130_provenance.
• NP134736.RAQCcNT5dbxiTGkL_hF1U91eh4uQc56lb4P7-ZJtq58_Q130_assertion description "[The USP26 gene might be of importance in male reproduction/in this gene might be associated with male infertility, and might negatively affect testicular function.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134736.RAQCcNT5dbxiTGkL_hF1U91eh4uQc56lb4P7-ZJtq58_Q130_provenance.
• NP134737.RAUl_Pn7gg14_iXWXoCr-1XexWWBjeR-I4qdZHMksMVxE130_assertion description "[Alterations in the USP26 gene may be involved in male infertility or might increase the risk of male infertility/patients showed 370-371insACA, 494T > C and 1423C > T causing T123-124ins, L165S and H475Y, respectively ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134737.RAUl_Pn7gg14_iXWXoCr-1XexWWBjeR-I4qdZHMksMVxE130_provenance.
• NP134739.RAShs1IFSCXrALwtho0S_OTu9A8gFprHjle9_hntkwM7E130_assertion description "[Potential role for CatSper in sperm motility and fertility in mouse and human/is therefore implicated as a potential target to explore the molecular mechanisms of male infertility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134739.RAShs1IFSCXrALwtho0S_OTu9A8gFprHjle9_hntkwM7E130_provenance.
• NP134742.RAWwBm1E57mXa8S3PD57fKMznq4uO14P4WoHfXfswSY80130_assertion description "[Screening of a substantial number of patients would be required to clarify whether observed combinations of genetic changes in the CREM gene might explain some forms of male infertility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134742.RAWwBm1E57mXa8S3PD57fKMznq4uO14P4WoHfXfswSY80130_provenance.
• NP134743.RAdb0PibFJvgb9MGqGhGSayckW9bu4YFw5wC2EjMmv5EA130_assertion description "[The AZFc variation was detected in five cases of male infertility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134743.RAdb0PibFJvgb9MGqGhGSayckW9bu4YFw5wC2EjMmv5EA130_provenance.
• NP134750.RAUdGY-CYt1E_nRz0N5f36EGtSj_ao6jpq-n6GbuSzxaw130_assertion description "[Loss of only some copies of DAZ is sufficient to lead to severe male infertility, but it is not a frequent finding in cryptorchid men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134750.RAUdGY-CYt1E_nRz0N5f36EGtSj_ao6jpq-n6GbuSzxaw130_provenance.
• NP134755.RAb63WF3K2hh8HTwgUvuDQCBf8SnhL1k3fCKpjVyNk5sM130_assertion description "[Radiation hybrid mapping places the human tauCstF-64 gene at 10q22-q23, which is the site of a translocation that has been associated with human neurological problems and male infertility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134755.RAb63WF3K2hh8HTwgUvuDQCBf8SnhL1k3fCKpjVyNk5sM130_provenance.
• NP134760.RAUtK2R9bh8JgzQN8zNiEyJIJjzVIP3pBhfqpPbP225Qo130_assertion description "[The codon72 and IVS7+72C > T polymorphisms of the p53 gene are unlikely to contribute to the pathogenesis of idiopathic male infertility with spermatogenetic failure.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134760.RAUtK2R9bh8JgzQN8zNiEyJIJjzVIP3pBhfqpPbP225Qo130_provenance.
• NP134763.RAUHEOj-QkScv7P2EMSYi50-eL0It7Lke6sH022NEZ3-k130_assertion description "[mutations in the PCSK9 gene cause autosomal dominant hypercholesterolemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134763.RAUHEOj-QkScv7P2EMSYi50-eL0It7Lke6sH022NEZ3-k130_provenance.
• NP134766.RAYXeHK_HnWQIHYl108uL2TXZ8Jv0PTyz15fvkuJ3mJDU130_assertion description "[Mutations in the PCSK9 gene are associated with variable phenotype of autosomal dominant hypercholesterolemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134766.RAYXeHK_HnWQIHYl108uL2TXZ8Jv0PTyz15fvkuJ3mJDU130_provenance.
• NP134767.RASRgyV5_T44812oKuh9Xtk05XtlBvPj3roHxFgbmMwkA130_assertion description "[A new mutation that could cause autosomal dominant hypercholesterolemia by increasing the transcription of PCSK9.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134767.RASRgyV5_T44812oKuh9Xtk05XtlBvPj3roHxFgbmMwkA130_provenance.
• NP134769.RAbYDPxRnXAOsBBOuSpjvxd8bLB-5ia4BNeUd3ZDXqK1A130_assertion description "[The 664A allele of the Atrial Natriuretic Peptide (ANP) polymorphism is associated with lower levels of ApoA1 and HDL-C in Familial Hypercholesterolemia patients, but not with Coronary Artery Disease risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134769.RAbYDPxRnXAOsBBOuSpjvxd8bLB-5ia4BNeUd3ZDXqK1A130_provenance.
• NP134774.RAWE63HWM50SkVNEidV5lj_i-6V4DlyHxPqaw_xmbHvhc130_assertion description "[2 novel mutations were identified in the LDLR gene of a family with a member suffering from severe Familial hypercholesterolemia; 1 was W165X, G > A substitution and IVS5-1G > A, was also a G > A substitution at the acceptor splice site of intron 5.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134774.RAWE63HWM50SkVNEidV5lj_i-6V4DlyHxPqaw_xmbHvhc130_provenance.
• NP134778.RAS-_cNVPIF1prmfH_9TfsGJGbCFwmjtYEjFwgMzC7ZT4130_assertion description "[In familial hypercholesterolemia children, the null allele genotype was associated with a greater carotid intima-media thickness, higher HDL cholestserol levels and attenuated response to cholesterol lowering agents.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134778.RAS-_cNVPIF1prmfH_9TfsGJGbCFwmjtYEjFwgMzC7ZT4130_provenance.
• NP134780.RAQWQa-201fXHAsvPF8CUndcQaOFOm7skqyEdVVTxD65U130_assertion description "[HDL cholesterol levels in patients with molecularly defined familial hypercholesterolemia/receptor gene mutation (81T > G, 858C > A, 1285G > A, 1646G > A, and 1775G > A,) did not significantly influence HDL cholesterol levels.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134780.RAQWQa-201fXHAsvPF8CUndcQaOFOm7skqyEdVVTxD65U130_provenance.
• NP134781.RATvT3Mg7ol8aSMgKoLVrM9_SsaqXsb9d8rPIaNtBgh98130_assertion description "[75 different LDL receptor mutations in 645 children with heterozygous familial hypercholesterolemia; in these children, null alleles were clearly associated with more elevated LDL cholesterol levels compared to receptor-defective mutations ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134781.RATvT3Mg7ol8aSMgKoLVrM9_SsaqXsb9d8rPIaNtBgh98130_provenance.
• NP134783.RAWObTV-cxX9rC_LPJh6ilHHBDIi9peKFojBjA5nQGBLQ130_assertion description "[A novel sequence change in repeat 3 of the promoter of the low-density lipoprotein receptor gene has been identified in a female patient with familial hypercholesterolemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134783.RAWObTV-cxX9rC_LPJh6ilHHBDIi9peKFojBjA5nQGBLQ130_provenance.
• NP134785.RAd6_WvPOp3prjzZN1TmptoQP1p_tDl-PYxOE8oAIcHyw130_assertion description "[Homozygous familial hypercholesterolemia patients exhibited significantly elevated level of active MMP-9.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134785.RAd6_WvPOp3prjzZN1TmptoQP1p_tDl-PYxOE8oAIcHyw130_provenance.
• NP134788.RARsNdz4V8h8087uWDm-q1wmW9ecJY3h_fxE_gM74vYMQ130_assertion description "[low plasma adiponectin is associated with an increased risk of premature Coronary artery disease over and above the already exaggerated risk seen in Familial Hypercholesterolemia patients ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134788.RARsNdz4V8h8087uWDm-q1wmW9ecJY3h_fxE_gM74vYMQ130_provenance.
• NP134789.RAU_M5uOKR7ubspkWlPFbIJUNoL0xzEYC7Z_fmpkzFFVI130_assertion description "[In familial hypercholesterolemia there was no correlation between plasma myeloperoxidase levels and atherosclerosis progression ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134789.RAU_M5uOKR7ubspkWlPFbIJUNoL0xzEYC7Z_fmpkzFFVI130_provenance.
• NP134795.RAQCgRwIGgu-1GeR1OWODzAndJMbu2zTtXEN0SmIjQ_9U130_assertion description "[In an LDL receptor-deficient mouse model of familial hypercholesterolemia, helper-dependent adenovirus gene transfer of human apoA-I causes long-term overexpression of apoA-I and retards atherosclerosis progression ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134795.RAQCgRwIGgu-1GeR1OWODzAndJMbu2zTtXEN0SmIjQ_9U130_provenance.
• NP134805.RAVtHL09-wjpK0cx2lZPoEC3D1X6-GL_V1X3UjW3hjh5M130_assertion description "[increases in IL-6, MMP-13, and RANKL (receptor activator of nuclear factor kappa B ligand) expression in osteoarthritis (OA) subchondral bone osteocytes suggest that in subchondral bone OA progression involves abnormal osseous tissue remodeling.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134805.RAVtHL09-wjpK0cx2lZPoEC3D1X6-GL_V1X3UjW3hjh5M130_provenance.
• NP134807.RAck1s-cBiZvefutxW7DBXpzG60KkVmP9K_fqoJfihwnU130_assertion description "[This study further highlighted the significance of asporin in osteoarthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134807.RAck1s-cBiZvefutxW7DBXpzG60KkVmP9K_fqoJfihwnU130_provenance.
• NP134808.RAWiW9MC2uQcHLdJn1GDX_P6YcM1Afq7QmeuUZXKaJaSY130_assertion description "[ASPN is a lumbar-disc degeneration (LDD) gene in Asians, and common risk factors may be considered for osteoarthritis and LDD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134808.RAWiW9MC2uQcHLdJn1GDX_P6YcM1Afq7QmeuUZXKaJaSY130_provenance.
• NP134816.RAcrQovln6Lew7iQPfUmoGFpPbLRA84O-xm87bxgNDGHc130_assertion description "[in the IL1B (interleukin 1 beta) T-31C T/T genotype, the rate of radiographis osteoarthritis was significantly higher than that with the C/C and C/T genotypes ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134816.RAcrQovln6Lew7iQPfUmoGFpPbLRA84O-xm87bxgNDGHc130_provenance.
• NP134817.RASzQHAkZ_LpAMRDuQMWrwIdO0ZXedLkwf5iDB61dvDmM130_assertion description "[IL-1 gene cluster polymorphisms may play a significant role in the pathogenesis of osteoarthritis of the hip.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134817.RASzQHAkZ_LpAMRDuQMWrwIdO0ZXedLkwf5iDB61dvDmM130_provenance.
• NP134820.RAbXY_KMLGQ29F0THK6VC39jHO3e0-KM51_dOFtfYUKUI130_assertion description "[Aggrecanase-1 is expressed by fibroblast-like synoviocytes from rheumatoid arthritis and osteoarthritis patients and is induced by cytokines, especially TGF-beta.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134820.RAbXY_KMLGQ29F0THK6VC39jHO3e0-KM51_dOFtfYUKUI130_provenance.
• NP134821.RAVKigsZC771464jar17aKhfJ3KMSgbsyxJjhY6i-aGhc130_assertion description "[PKCzeta is involved in regulation of IL-1beta-induced NF-kappaB signaling in human osteoarthritis chondrocytes, which regulates downstream expression of ADAMTS-4 and NOS2 via NF-kappaB.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134821.RAVKigsZC771464jar17aKhfJ3KMSgbsyxJjhY6i-aGhc130_provenance.
• NP134822.RAc9R1TvEK3tbpzVQ3Fu8HADZwwtgTZXWCgIfPL_CmmgI130_assertion description "[Our data suggest that both ADAMTS-4 and ADAMTS-5 contribute to the structural damage that characterizes human osteoarthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134822.RAc9R1TvEK3tbpzVQ3Fu8HADZwwtgTZXWCgIfPL_CmmgI130_provenance.
• NP134825.RAU9BSfPKxY3A1YYOvXxDHz8XFpONwZdjb-62SlnBszTU130_assertion description "[fibroblast-like synoviocytes of knees of rheumatoid arthritis and osteoarthritis patients express cannabinoid receptor (CB) 1 and CB2 ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134825.RAU9BSfPKxY3A1YYOvXxDHz8XFpONwZdjb-62SlnBszTU130_provenance.
• NP134830.RAaTQO45AlWcGHYkFOXt9f_2tObaSc_Uy6RwcxJdcUE8c130_assertion description "[LIGHT was upregulated in both synovial fluid and synovium of rheumatoid arthritis patients compared with osteoarthritis patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134830.RAaTQO45AlWcGHYkFOXt9f_2tObaSc_Uy6RwcxJdcUE8c130_provenance.
• NP134833.RAXgD9TVrkmtNwGzsX5kg_qdxpupveagtB6pOr_AAmRNQ130_assertion description "[temporomandibular joint (TMJ) osteoarthritis (OA) patients with PX haplotype had higher risk of moderate or severe pain compared to those without the haplotype; suggests ERalpha polymorphism may be associated with pain susceptibility in females with TMJ OA ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134833.RAXgD9TVrkmtNwGzsX5kg_qdxpupveagtB6pOr_AAmRNQ130_provenance.
• NP134835.RAcIbwhmnViZt7id2hLxdDFNDikRV2AtC0-i0u2N6N2hU130_assertion description "[The IValpha cytosolic phospholipase A2 at protein levels in articular cartilage from patients with rheumatoid arthritis, osteoarthritis and patients with non-arthritic joints.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134835.RAcIbwhmnViZt7id2hLxdDFNDikRV2AtC0-i0u2N6N2hU130_provenance.
• NP134838.RAfiz1wd2cE_Oe50uPjwOn9kcg1j9Gl9DhGSmaNy89z6E130_assertion description "[HIF1A is upregulated in rheumatoid arthritis and osteoarthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134838.RAfiz1wd2cE_Oe50uPjwOn9kcg1j9Gl9DhGSmaNy89z6E130_provenance.
• NP134841.RAUuXUrz6622WDt1qhzYQLJigvcjQ7o4Lv_npioPKb1H8130_assertion description "[knee synovial fluid levels of CXCL 13 were higher in Rheumatoid arthritis and Behcets disease patients compared to Osteoarthritis patients ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134841.RAUuXUrz6622WDt1qhzYQLJigvcjQ7o4Lv_npioPKb1H8130_provenance.
• NP134844.RAc19BTcXw7YSwONHIl3y9jBjMh6v0BZtVNq6648TznXE130_assertion description "[IL-7 may contribute to cartilage destruction in joint diseases, including osteoarthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134844.RAc19BTcXw7YSwONHIl3y9jBjMh6v0BZtVNq6648TznXE130_provenance.
• NP134857.RAbv1THKihqIUwdPv1sVmeWW-SpsYccMVVYLw2l8LEdTk130_assertion description "[Accumulation of AGE may have a role in the development of osteoarthritis by increasing MMP-1, -3, and -13, and TNF-alpha.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134857.RAbv1THKihqIUwdPv1sVmeWW-SpsYccMVVYLw2l8LEdTk130_provenance.
• NP134860.RAfNw_DV9ANiXdn53zllz2LJlvGmDhB_Mnl2Rda8LPw54130_assertion description "[In comparison with healthy cartilage, Osteoarthritis articular chondrocytes exhibit increased in vivo synthesis of collagen prolyl-4-hydroxylase type II, a pivotal enzyme in collagen triple helix formation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134860.RAfNw_DV9ANiXdn53zllz2LJlvGmDhB_Mnl2Rda8LPw54130_provenance.
• NP134861.RAUO4iVuiXheSz6531sUOHmVlLNjtVPTK1geSHGdoN-Co130_assertion description "[BMP-4 is expressed in normal synovial tissue and was decreased in osteoarthritis and rheumatoid arthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134861.RAUO4iVuiXheSz6531sUOHmVlLNjtVPTK1geSHGdoN-Co130_provenance.
• NP134867.RAZf5P414o6k7FY4HoIx3UVa54LUsJ54VjMnAtxFaw3G0130_assertion description "[SOX9 signaling is not essential for LE135-induced chondrogenesis in mesenchymal stem cells derived from osteoarthritis patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134867.RAZf5P414o6k7FY4HoIx3UVa54LUsJ54VjMnAtxFaw3G0130_provenance.
• NP134873.RAVmyYkk0qJc3jVTs6jdamG5A6iF0dM3vJQwJJ5e34eOc130_assertion description "[small but persistent imbalance of GDF5 expression throughout life therefore appears to render an individual more susceptible to osteoarthritis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134873.RAVmyYkk0qJc3jVTs6jdamG5A6iF0dM3vJQwJJ5e34eOc130_provenance.
• NP134874.RASuZ4JAtbQf6pUlSdOrkB6T7LPCtYAdHWEvSB2C3hwuE130_assertion description "[present work shows that the functional GDF5 polymorphism associated with osteoarthritis risk demonstrates a similar role in rheumatoid arthritis susceptibility ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134874.RASuZ4JAtbQf6pUlSdOrkB6T7LPCtYAdHWEvSB2C3hwuE130_provenance.
• NP134888.RAaCHWTHGVntqAoohTm_x-eXhzhjcTndWUgsoKq8suBjM130_assertion description "[Results indicate a new susceptibility gene (DIO2) conferring risk to osteoarthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134888.RAaCHWTHGVntqAoohTm_x-eXhzhjcTndWUgsoKq8suBjM130_provenance.
• NP134890.RARypq317o-0pw6ovll2YF8QIFkE5yaguV9PDUSyvuYC8130_assertion description "[Expression of GRP78 in macrophages was increased significantly in the affected peripheral joints of ankylosing spondylitis compared with osteoarthritis patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134890.RARypq317o-0pw6ovll2YF8QIFkE5yaguV9PDUSyvuYC8130_provenance.
• NP134894.RAQjE9ddrhNNWXw8KLK1j_hqlewPXM7X7T-0P2ztA2rKk130_assertion description "[the perpetuation of DDR-2 expression and activation can be seen as a vicious circle that ultimately leads to cartilage destruction in osteoarthritis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134894.RAQjE9ddrhNNWXw8KLK1j_hqlewPXM7X7T-0P2ztA2rKk130_provenance.
• NP134901.RAbfhccb5jvdD_KC4bJ8iQo5uaOWBYruZ4CUqZ-BwQnyg130_assertion description "[VIP (Vasoactive intestinal peptide) expression was decreased in Rhematoid Arthritis (RA) synovial fibroblasts (FLS) compared with Osteoarthritis (OA) FLS; in RA FLS, VPAC2 (VIP receptor type 2) mediates the antiinflammatory effects of VIP ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134901.RAbfhccb5jvdD_KC4bJ8iQo5uaOWBYruZ4CUqZ-BwQnyg130_provenance.
• NP134916.RAWtpctTGZq74VKWZWRbTIEaghW3MmW-jOXxjJHDGva34130_assertion description "[Data suggest that IL-1beta is involved in the regulation of various cytoskeletal components in human chondrocytes including the multifunctional protein FHL2, which might be relevant for the pathogenesis of osteoarthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134916.RAWtpctTGZq74VKWZWRbTIEaghW3MmW-jOXxjJHDGva34130_provenance.
• NP134925.RAcW11puKAiEVYig_aPDOyFcNDmFtXaeNu7eC16br1Cbk130_assertion description "[These studies identify F-spondin as a novel protein in osteoarthritis cartilage, where it may act in situ at lesional areas to activate latent TGF-beta and induce cartilage degradation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134925.RAcW11puKAiEVYig_aPDOyFcNDmFtXaeNu7eC16br1Cbk130_provenance.
• NP134928.RActlTKWTWptvBkhBarWxgeR4Vf7GHDMVfQjt-pK5Bils130_assertion description "[Mesenchymal stem cells from patients with osteoarthritis showed significantly increased total TGF-beta, TGF-beta1 isoform, TBR-II, and TBR-III mRNA expression compared to controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134928.RActlTKWTWptvBkhBarWxgeR4Vf7GHDMVfQjt-pK5Bils130_provenance.
• NP134934.RAdTGImTVnPtgW16AMYMJEEZXUe5nn10ctecqP59xAV-U130_assertion description "[fibroblast-like synoviocytes of knees of rheumatoid arthritis and osteoarthritis patients express cannabinoid receptor (CB) 1 and CB2 ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134934.RAdTGImTVnPtgW16AMYMJEEZXUe5nn10ctecqP59xAV-U130_provenance.
• NP134935.RAVt6c-E6Ek9DiyGGeIv0ZO9-9mf-H7n4ghAEO4q6GRUQ130_assertion description "[Heparanase (HPSE) activity was dramatically higher in Synovial fluid (SF) and Synovial tissue (ST) of rheumatoid arthritis (RA) patients than in SF and ST from Osteoarthritis patients and asymptomatic donors; HPSE RNA was upregulated in ST of RA patients ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134935.RAVt6c-E6Ek9DiyGGeIv0ZO9-9mf-H7n4ghAEO4q6GRUQ130_provenance.
• NP134937.RAfX4zxSePYa43pjey--j4IHh6r8ljdR3FtS5huizRk8Q130_assertion description "[NGAL protects MMP-9 activity and is relevant to cartilage matrix degradation in OA, may represent mechanism by which NGAL contributes to the loss of cartilage matrix proteins in osteoarthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134937.RAfX4zxSePYa43pjey--j4IHh6r8ljdR3FtS5huizRk8Q130_provenance.
• NP134938.RAZPT1f9jaNgN9H182FM8iP-oxz_PVcDCpdYcZwyZfQjQ130_assertion description "[IgG-type anti-TPI autoantibodies were detected in 24.7% of the serum samples and 24.1% of the synovial fluid samples from the patients with osteoarthritis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134938.RAZPT1f9jaNgN9H182FM8iP-oxz_PVcDCpdYcZwyZfQjQ130_provenance.
• NP134940.RAcAmHvry73UtvLrFCUUck9PzkdjQsO4gKz-_EWTXFY8Y130_assertion description "[Results show that human chondrocytes express eotaxin-1, that its expression is induced by treatment with interleukin-1beta and TNF-alpha, and suggest that it plays an important role in cartilage degradation in osteoarthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134940.RAcAmHvry73UtvLrFCUUck9PzkdjQsO4gKz-_EWTXFY8Y130_provenance.
• NP134941.RASQMUxOrEHbwUsTxuzpB8qincZIkyru-_C3yGWrQ-0LM130_assertion description "[Accumulation of AGE may have a role in the development of osteoarthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134941.RASQMUxOrEHbwUsTxuzpB8qincZIkyru-_C3yGWrQ-0LM130_provenance.
• NP134943.RAbM_fBOnU3WkCzZ05oTuB_nmyxG3mmYMLrcKEmxYqY0s130_assertion description "[EphB4 receptor activation by ephrin B2 in osteoarthritis subchondral bone could affect abnormal metabolism in this tissue by inhibiting resorption factors and their activities ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134943.RAbM_fBOnU3WkCzZ05oTuB_nmyxG3mmYMLrcKEmxYqY0s130_provenance.
• NP134946.RAcvLEpod-MgIhYE_rj6suXM2Iw6g6K47U0ld_guz4SMA130_assertion description "[deregulation of cross-talk between mitogen-activated protein kinases and PKCdelta signaling may contribute to the etiology of osteoarthritis in human patients ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134946.RAcvLEpod-MgIhYE_rj6suXM2Iw6g6K47U0ld_guz4SMA130_provenance.
• NP134950.RATjP5fAoRQV99UACMtXd-u55p05OrumfydE0sY99NlWA130_assertion description "[MMP-13, uPA, and PAI-1 antigen levels were determined in the synovium of patients with osteoarthritis ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134950.RATjP5fAoRQV99UACMtXd-u55p05OrumfydE0sY99NlWA130_provenance.
• NP134957.RAVd3NG_AEAcbGIL45g8Ob2oqLcPRwvwig7nUI7xATWKw130_assertion description "[Expression of active FAPalpha on chondrocyte membrane and elevated levels in cartilage from osteoarthritis patients/have important pathological role in cartilage turnover prevalent in arthritic diseases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134957.RAVd3NG_AEAcbGIL45g8Ob2oqLcPRwvwig7nUI7xATWKw130_provenance.
• NP134964.RAXMhv0229_QAhDvwABssBHQ74NhJfFAayooUzPSc7p44130_assertion description "[A regulatory role for GNE shifting between the nuclear and the Golgi compartment is proposed/insight into GNE regulation may promote the understanding of hereditary inclusion body myopathy pathogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134964.RAXMhv0229_QAhDvwABssBHQ74NhJfFAayooUzPSc7p44130_provenance.
• NP134966.RAYuTFcFw8m5St9L8Wq8n-Ok5ZOC8Y1epybUEIT4ipgiI130_assertion description "[Two siblings heterozygous for the mutations A460V and V572L/sibs had Nonaka myopathy (OMIM 605820).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134966.RAYuTFcFw8m5St9L8Wq8n-Ok5ZOC8Y1epybUEIT4ipgiI130_provenance.
• NP134973.RARIamrd10z06JmyKADXzIUyRGXd-x8d6k69MpWsbexY8130_assertion description "[Bethlem myopathy is an autosomal dominantly inherited myopathy with contractures caused by mutations in the COL6A1 gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134973.RARIamrd10z06JmyKADXzIUyRGXd-x8d6k69MpWsbexY8130_provenance.
• NP134976.RAdOF3-98f7B_1XjBzXfd236xjiP4R8J1mJVmrBoP6bV8130_assertion description "[A 8328G > A tRNALys mutation was detected in a 59 year old man with myopathy and exercise intolerance.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134976.RAdOF3-98f7B_1XjBzXfd236xjiP4R8J1mJVmrBoP6bV8130_provenance.
• NP134978.RARfbQ-K-ogVrS4voQF44avri1Gcfk4RCAYCCLascMdFs130_assertion description "[Study characterized a new disorder, X-linked myopathy with postural muscle atrophy (XMPMA), and identified FHL1 as the causative gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP134978.RARfbQ-K-ogVrS4voQF44avri1Gcfk4RCAYCCLascMdFs130_provenance.

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