Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence There+are+distinct+roles+for+cmlc1+and+cmlc2+during+zebrafish+cardiogenesis. assertion.
- assertion asSentence Tbx5a+confers+anterior+lateral+plate+mesodermal+cells+the+competence+to+respond+to+Bmp+signals+and+initiate+proepicardial+organ+development. assertion.
- assertion asSentence Maintenance+of+szl+expression+is+dependent+on+bmp2b. assertion.
- assertion asSentence Timely+differentiation+of+the+mesoderm+requires+the+maintenance+of+non-axial+mesoderm+identity+by+Wnt8+and+BMP2b. assertion.
- assertion asSentence Dkk3r+regulates+p38a+phosphorylation+to+maintain+Smad4+stability%2C+in+turn+enabling+the+Smad2.Smad3a.Smad4+complex+to+form+and+activate+the+myf5+promoter. assertion.
- assertion asSentence A+newly+developed+highly+active+GSK3beta+inhibitor+AR-534%2C+reduced+human+TAU+phosphorylation+in+TAU+transgenic+zebrafish. assertion.
- assertion asSentence Nkx+genes+are+essential+to+establish+the+original+dimensions+of+the+linear+heart+tube.Nkx+genes+regulate+heart+tube+extension+and+exert+differential+effects+on+ventricular+and+atrial+cell+number. assertion.
- assertion asSentence Canonical+Wnt+signaling+through+Lef1+is+required+for+hypothalamic+neurogenesis. assertion.
- assertion asSentence Domain-specific+regulation+of+foxP2+CNS+expression+by+lef1. assertion.
- assertion asSentence Lef1+sustains+proliferation+of+leading+zone+progenitors%2C+maintaining+the+primordium+size+and+defining+neuromast+deposition+rate. assertion.
- assertion asSentence Fgfr+expression+is+directly+or+indirectly+regulated+by+FGF+signaling+during+epiboly+and+at+the+end+of+somitogenesis. assertion.
- assertion asSentence her8a+is+positively+regulated+by+Su%28H%29-dependent+Notch+signaling+as+revealed+by+a+Notch-defective+mutant+and+injection+of+variants+of+the+Notch+intracellular+regulator%2C+Su%28H%29. assertion.
- assertion asSentence Zebrafish+scl+has+a+role+in+hematopoietic+and+endothelial+development%2C+downstream+of+hemangioblast+development. assertion.
- assertion asSentence Scl%2FTal1+is+an+indispensable+component+of+the+molecular+hierarchy+that+controls+endocardium+morphogenesis. assertion.
- assertion asSentence Ets1-related+protein+plays+a+critical+role+in+the+initiation+of+definitive+hematopoiesis+by+controlling+the+expression+of+2+stem+cell+leukemia+%28scl%29+isoforms+%28scl-alpha+and+scl-beta%29+in+angioblasts. assertion.
- assertion asSentence The+role+of+stat1b+in+zebrafish+hematopoiesis. assertion.
- assertion asSentence Cellular+correlates+of+Notch-delta+gene+expression+in+the+regenerating+zebrafish+retina. assertion.
- assertion asSentence Zic2a+and+zic5+as+crucial+players+in+the+genetic+network+linking+patterned+gene+expression+to+morphogenetic+changes+during+neurulation. assertion.
- assertion asSentence A+loss+of+Pbx2+and+Pbx4+causes+a+significant+reduction+of+hindbrain+and+spinal+cord+expression+of+lbx1+genes. assertion.
- assertion asSentence Forms+a+complex+with+Gata5+through+the+carboxyl+region+and+can+repress+Gata5-mediated+transcription. assertion.
- assertion asSentence Staggered+cell-intrinsic+timing+of+ath5+expression+underlies+the+wave+of+ganglion+cell+neurogenesis+in+the+zebrafish+retina. assertion.
- assertion asSentence pax5+works+in+conjunction+with+fgf3+and+pax2a+to+establish+and%2For+maintain+the+utricular+macula+and+is+essential+for+vestibular+function. assertion.
- assertion asSentence The+Pax6b+homeodomain+is+dispensable+for+pancreatic+endocrine+cell+differentiation+in+zebrafish. assertion.
- assertion asSentence The+positive+function+of+Foggy%2FSpt5+is+required+for+gata1+expression+during+zebrafish+embryonic+hematopoiesis. assertion.
- assertion asSentence There+are+distinct+roles+for+cmlc1+and+cmlc2+during+zebrafish+cardiogenesis. assertion.
- assertion asSentence Vox+plays+a+critical+role+in+the+establishment+of+the+dorsoventral+axis. assertion.
- assertion asSentence cdk5+plays+a+critical+role+in+spinal+and+cranial+motor+neuron+development. assertion.
- assertion asSentence Slit3+%28and+slit-2%29+coordinate+neuron+axonal+pathfinding+within+the+embryonic+axon+tracts+along+with+Robo2+and+Dcc-Netrin1. assertion.
- assertion asSentence Dihydrofolate+reductase+is+required+for+the+development+of+heart+and+outflow+tract+in+zebrafish. assertion.
- assertion asSentence Required+for+interrenal+differentiation+and+activation+of+the+differentiated+gene+cyp11a1. assertion.
- assertion asSentence Nkx2.2+coordinately+activates+NeuroD1+with+Ngn3+in+the+endocrine+progenitor+cell+and+plays+a+role+in+the+maintenance+of+NeuroD1+expression+to+regulate+beta+cell+function+in+the+mature+islet. assertion.
- assertion asSentence Hindbrain+patterning+requires+fine-tuning+of+early+krox20+transcription+by+Sprouty+4. assertion.
- assertion asSentence Edn1+from+the+pharyngeal+ectoderm+signals+through+Ednra+proteins+to+direct+early+dorsoventral+patterning+of+the+skeletogenic+neural+crest. assertion.
- assertion asSentence mab21l2+is+an+early+downstream+effector+of+rx3+and+is+critical+for+survival+of+eye+progenitors. assertion.
- assertion asSentence Despite+the+absence+of+conserved+non-coding+elements%2C+a+4.9-kb+mab21l2+promoter+is+sufficient+to+recapitulate+expression+in+tissues+unique+to+mab21l1+or+mab21l2. assertion.
- assertion asSentence Heart+and+soul%2FPRKCi+and+nagie+oko%2FMpp5+regulate+myocardial+coherence+and+remodeling+during+cardiac+morphogenesis. assertion.
- assertion asSentence Redundant+activities+of+Tfap2a+and+Tfap2c+are+required+for+neural+crest+induction+and+development+of+other+non-neural+ectoderm+derivatives+in+zebrafish+embryos. assertion.
- assertion asSentence An+evolutionarily+conserved+PTEN-C%2FEBPalpha-CTNNA1+axis+controls+myeloid+development+and+transformation. assertion.
- assertion asSentence Bmi1+acts+immediately+downstream+of+CCAAT+enhancer+binding+protein-alpha+to+regulate+the+survival+and+self-renewal+of+hematopoietic+stem+cells+and+contribute+to+the+erythropoietic+dysplasia. assertion.
- assertion asSentence Ptpra+protein%2C+zebrafish%2C+signaling+is+essential+for+convergence+and+extension+cell+movements+during+gastrulation. assertion.
- assertion asSentence Mil+encodes+Edg5%2C+a+sphingosine-1-phosphate+receptor. assertion.
- assertion asSentence The+phosphorylation+of+p53+by+CK1+is+an+isoform-specific+reaction+to+the+K%28221%29RQK%28224%29+loop. assertion.
- assertion asSentence Mutation+in+the+delta-subunit+of+the+nAChR+suppresses+the+muscle+defects+caused+by+lack+of+Dystrophin. assertion.
- assertion asSentence TRPP2+utilizes+TRPV4+to+form+a+mechano-+and+thermosensitive+molecular+sensor+in+the+cilium. assertion.
- assertion asSentence Hypoxia-inducible+carbonic+anhydrase+IX+%28CAIX%29+expression+is+insufficient+to+alleviate+intracellular+metabolic+acidosis+in+the+muscle+of+zebrafish%2C+Danio+rerio. assertion.
- assertion asSentence Activation+of+PKCgamma+is+necessary+for+the+activity-dependent+trafficking+of+AMPARs+in+embryonic+zebrafish+and+is+NMDA+and+SNARE-dependent+and+requires+AMPARs+to+associate+with+both+NSF+and+PICK1. assertion.
- assertion asSentence Rpgr2+is+required+for+normal+retinal+development+and+plays+a+role+in+dynein-based+retrograde+transport+processes. assertion.
- assertion asSentence zfMC2R+is+not+functional+in+the+absence+of+MRAP+expression. assertion.
- assertion asSentence Ancestral+roles+for+Wnt9s+in+early+patterning+of+neural%2Foral-pharyngeal+ectoderm+and+mesendoderm+derivatives. assertion.
- assertion asSentence The+central+cleft+of+the+zebrafish+hatching+enzyme+1+%28ZHE1%29+represents+the+active+site+of+the+enzyme+that+is+crucial+for+substrate+recognition+and+catalysis. assertion.
- assertion asSentence miR-196+regulates+pectoral+fin+bud+initiation. assertion.
- assertion asSentence Msw%2C+by+controlling+Kupffer%27s+vesicle+morphogenesis%2C+controls+lateralized+behaviors+related+to+diencephalic+asymmetries. assertion.
- assertion asSentence The+gene+knockdown+of+CaM+Kinase+I+delta+using+morpholino-based+antisense+oligonucleotides+induced+significant+morphological+abnormalities+in+zebrafish+embryos. assertion.
- assertion asSentence Progesterone+and+adipoQ+receptor+11+%28PAQR11%29+plays+a+critical+role+in+heart+morphogenesis+via+ras+signaling. assertion.
- assertion asSentence MTF1+is+a+master+regulator+of+gene+expression+during+development. assertion.
- assertion asSentence Ectopic+expression+of+gbx2+by+mRNA+injection+caused+cyclopia+or+truncation+of+the+fore-+and+midbrain+and+severely+affected+isthmic+and+cerebellar+structures. assertion.
- assertion asSentence Carboxypeptidase+A5+%28cpa5%29%2C+a+mast+cell-specific+enzyme%2C+is+expressed+in+zebrafish+blood+cells+beginning+at+24+hours+post+fertilization+%28hpf%29. assertion.
- assertion asSentence Heart+and+soul%2FPRKCi+and+nagie+oko%2FMpp5+regulate+myocardial+coherence+and+remodeling+during+cardiac+morphogenesis. assertion.
- assertion asSentence The+p63+transcription+factor+is+upregulated+to+initiate+this+apoptotic+pathway+and+directly+activates+puma+transcription+in+response+to+ER+stress. assertion.
- assertion asSentence Vbg+encodes+activin+receptor-like+kinase+1+%28acvrl1%29%2C+a+TGFbeta+type+I+receptor+that+is+expressed+predominantly+in+the+endothelium+of+the+vessels+that+become+dilated+in+vbg+mutants. assertion.
- assertion asSentence Trpm7+regulates+exocrine+pancreatic+development+via+the+Mg%282%2B%29-sensitive+Socs3a+pathway. assertion.
- assertion asSentence TRPM7+plays+a+role+within+sensory+neurons+in+modulating+neutrotransmitter+release+at+central+synapses%2C+similar+to+the+role+proprosed+for+mammalian+TRPM7+at+peripheral+synapses. assertion.
- assertion asSentence Heat-shock+protein+60+is+required+for+blastema+formation+and+maintenance+during+regeneration. assertion.
- assertion asSentence Cilia+localization+is+essential+for+in+vivo+functions+of+the+Joubert+syndrome+protein+arl13b. assertion.
- assertion asSentence The+insulin-like+growth+factor+binding+protein+1+%2829-31kDa%29is+similarities+to+mammalian. assertion.
- assertion asSentence Some+distinctive+features+of+zebrafish+myogenesis+based+on+unexpected+distributions+of+the+muscle+cytoskeletal+proteins+actin%2C+myosin%2C+desmin%2C+alpha-actinin%2C+troponin+and+titin. assertion.
- assertion asSentence Neural+crest+cells+are+coattracted+via+the+complement+fragment+C3a+and+its+receptor+C3aR%2C+revealing+an+unexpected+role+of+complement+proteins+in+early+vertebrate+development. assertion.
- assertion asSentence A+mutation+in+silva+leads+to+defects+in+melansome+biogenesis+and+alterations+in+the+visual+system+in+the+mutant+fading+vision. assertion.
- assertion asSentence Bmi1+acts+immediately+downstream+of+CCAAT+enhancer+binding+protein-alpha+to+regulate+the+survival+and+self-renewal+of+hematopoietic+stem+cells+and+contribute+to+the+erythropoietic+dysplasia. assertion.
- assertion asSentence HMGB1+is+a+critical+factor+for+brain+development%2C+enabling+survival+and+proliferation+of+neural+progenitors+that+will+form+the+forebrain+structures. assertion.
- assertion asSentence Knockdown+of+zebrafish+ak2+also+leads+to+aberrant+leukocyte+development%2C+stressing+the+evolutionarily+conserved+role+of+AK2. assertion.
- assertion asSentence The+nucleolar+GTP-binding+proteins+Gnl2+and+nucleostemin+are+required+for+retinal+neurogenesis+in+developing+zebrafish. assertion.
- assertion asSentence prmt1+gene+is+actively+and+ubiquitously+expressed+at+both+RNA+and+protein+levels+at+the+early+developmental+stages+of+zebrafish. assertion.
- assertion asSentence IP6K2+is+a+positive+regulator+of+Hh+signaling. assertion.
- assertion asSentence Gbetagamma+signaling+controls+the+polarization+of+zebrafish+primordial+germ+cells+by+regulating+Rac+activity. assertion.
- assertion asSentence Function+for+Bhmt+involving+modulation+of+Shh+signaling+to+control+beta-cell+development. assertion.
- assertion asSentence Motor+function+is+an+innovation+of+therian+prestin+and+is+concurrent+with+diminished+transporter+capabilities. assertion.
- assertion asSentence TIF1gamma+couples+the+blood-specific+transcriptional+complex+with+Pol+II+elongation+machinery+to+promote+the+transcription+elongation+of+erythroid+genes+by+counteracting+Pol+II+pausing. assertion.
- assertion asSentence sp5-like+is+a+direct+target+of+Wnt%2Fbeta-catenin+signaling+during+gastrulation+and%2C+together+with+sp5%2C+acts+as+a+required+mediator+of+the+activities+of+wnt8+in+patterning+the+mesoderm+and+neuroectoderm. assertion.
- assertion asSentence nlz2+is+expressed+in+the+presumptive+hindbrain+and+midbrain%2Fhindbrain+boundary%2Cwhere+expression+of+nlz1+is+dependent+on+pax2a. assertion.
- assertion asSentence Ship2a+attenuates+the+FGF+signaling+pathway+in+vivo+and+functions+in+the+establishment+of+normal+tissue+patterning+in+the+early+embryo. assertion.
- assertion asSentence Ofd1+is+required+for+ciliary+motility+and+function+in+zebrafish. assertion.
- assertion asSentence Ndel1b+is+expressed+predominantly+in+the+somites+in+developing+zebrafish. assertion.
- assertion asSentence stau1+is+required+for+the+survival+and+migration+of+primordial+germ+cells. assertion.
- assertion asSentence Zebrafish+possess+two+genes%2C+sept9a+and+sept9b+that%2C+like+humans%2C+express+multiple+transcripts. assertion.
- assertion asSentence Spt6+is+essential+for+the+transcriptional+response+to+activation+of+the+Notch+pathway. assertion.
- assertion asSentence Binding+of+CV2+to+Chordin+promotes+BMP-2+signaling. assertion.
- assertion asSentence Mib+encodes+a+RING+ubiquitin+ligase+that+promotes+ubiquitylation+and+internalization+of+Delta. assertion.
- assertion asSentence Isotocin+stimulates+the+proliferation+of+epidermal+stem+cells+and+differentiation+of+ionocyte+progenitors+by+regulating+the+P63+and+Foxi3a+transcription+factors%2C+consequently+enhancing+the+functional+activities+of+ionocytes. assertion.
- assertion asSentence Gli1+regulates+the+maintenance+of+neural+progenitors+at+the+midbrain-hindbrain+boundary+in+concert+with+E%28Spl%29+factor+activity. assertion.
- assertion asSentence Expression+of+Cxcl12+and+Cxclr4+in+radial+glial+cells+of+the+adult+zebrafish+brain+supports+important+roles+for+the+Cxcl12%2FCxcr4+pair+in+brain+development+and+functioning. assertion.
- assertion asSentence Neuropilin+1+can+facilitate+downstream+signaling+to+promote+angiogenesis. assertion.
- assertion asSentence The+ventralized+ogon+mutant+phenotype+is+caused+by+a+mutation+in+the+zebrafish+homologue+of+szl%2C+a+secreted+frizzled-related+protein. assertion.
- assertion asSentence Retinoic+acid+signaling+from+the+somitic+mesoderm+leads+to+activation+of+wnt2b+expression+in+the+intermediate+mesoderm. assertion.
- assertion asSentence GnRH+loss-of-function+affects+early+brain+and+eye+formation+during+development. assertion.
- assertion asSentence IGF+signaling+affects+the+spatial+distribution+of+newborn+GnRH3+neurons+by+influencing+neural+crest+cell+migration+and%2For+differentiation. assertion.
- assertion asSentence Tdrd1+acts+as+a+molecular+scaffold+for+Ziwi. assertion.
- assertion asSentence Activation+of+PKCgamma+is+necessary+for+the+activity-dependent+trafficking+of+AMPARs+in+embryonic+zebrafish+and+is+NMDA+and+SNARE-dependent+and+requires+AMPARs+to+associate+with+both+NSF+and+PICK1. assertion.
- assertion asSentence Exocrine+differentiation+and+proliferation+factor+%28exdpf%29+is+a+direct+target+gene+of+pancreas-specific+transcription+factor+1a+%28Ptf1a%29. assertion.
- assertion asSentence Ras+activity+levels+control+the+repopulation+and+expansion+of+adult+melanocyte+precursors+after+tissue+loss%2C+enabling+the+recovery+of+patterned+melanocyte+stripes+during+zebrafish+appendage+regeneration. assertion.