Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Three+heterozygous+missense+mutations+of+the+skeletal+muscle+alpha+actin+gene+%28ACTA1%29+in+three+unrelated+cases+of+congenital+fiber+type+disproportion+%28CFTD%29+from+Japan+and+Australia. assertion.
- assertion asSentence CK2+regulates+vaccinia+virus+dissemination+and+actin+tail+formation. assertion.
- assertion asSentence Missense+mutation+in+ACTA2+gene+is+associated+with+thoracic+aortic+aneurysms+and+dissections. assertion.
- assertion asSentence With+increased+tension+cytoskeletal+stress+fibers+develop+that+contain+alphaSMA+and+alphavbeta3+integrin+that+replaces+alpha2beta1+integrin%2C+consistent+with+cell+switching+from+collagen+to+non-collagen+proteins+interactions. assertion.
- assertion asSentence Interstitial+expression+of+ASMA+is+associated+with+reduced+renal+function+at+time+of+biopsy. assertion.
- assertion asSentence MARCKS+regulates+lamellipodia+formation+induced+by+IGF-I+via+association+with+PIP2+and+beta-actin+at+membrane+microdomains. assertion.
- assertion asSentence Functional+effects+of+nemaline+myopathy+mutations+on+human+skeletal+alpha-actin. assertion.
- assertion asSentence A+missense+mutation+in+the+gamma+actin+1+gene+causes+autosomal+dominant+hearing+loss. assertion.
- assertion asSentence A+major+factor+in+the+deafness+caused+by+gamma-actin+mutations+is+an+altered+ability+of+the+actin+filaments+to+be+properly+regulated+by+actin-binding+proteins+rather+than+an+inability+to+polymerize. assertion.
- assertion asSentence During+cell+membrane+blebbing+actin+recruitment+is+involved+in+cortex+assembly. assertion.
- assertion asSentence A+critical+regulator+of+AKT1+localization+and+function. assertion.
- assertion asSentence Crystal+structure+of+the+actin-binding+domain+of+alpha-actininin-4+Lys255Glu+mutant+implicated+in+focal+segmental+glomerulosclerosis. assertion.
- assertion asSentence Alpha-actinin+plays+a+role+in+regulating+cell+survival+through+stabilization+of+focal+adhesions+and+regulation+of+TNF-alpha-induced+survival+signaling. assertion.
- assertion asSentence Interaction+of+alpha+1+actinin+with+ICAM-1+is+required+for+leukocyte+extravasation. assertion.
- assertion asSentence Spectrin-like+repeats+from+dystrophin+and+alpha-actinin-2+are+not+functionally+interchangeable. assertion.
- assertion asSentence ACTN3+XX+genotype+is+negatively+associated+with+elite+sprint+athlete+status%2C+the+underlying+low+frequency+in+these+populations+eliminates+the+possibility+of+replicating+this+association+in+Jamaican+and+US+African+American+sprinters. assertion.
- assertion asSentence Functional+ACTN3+R577X+genotype+represents+a+genetic+risk+factor+for+falling+in+older+females. assertion.
- assertion asSentence Professional+soccer+athletes+homozygous+to+ACTN3XX+gene+are+more+susceptible+to+eccentric+damage+and+present+a+higher+catabolic+state%2C+demonstrated+by+metabolic%2C+hormonal+and+immune+responses+post+an+eccentric+training. assertion.
- assertion asSentence ALK2+signalling+contributes+to+the+disturbed+folliculogenesis+in+polycystic+ovary+syndrome+%28PCOS%29+patients. assertion.
- assertion asSentence Activin+inhibits+the+growth+of+SNU-16+cells+by+inducing+apoptosis+through+caspase+activation. assertion.
- assertion asSentence Activin+is+growth+suppressive+and+enhances+migration+in+colon+cancer. assertion.
- assertion asSentence It+remains+unclear+what+role%2C+if+any%2C+ACVR2A+polymorphisms+play+in+pre-eclampsia+risk%2C+at+least+in+these+Australian+families. assertion.
- assertion asSentence Exonic+selectivity+for+frameshift+mutation+within+ACVR2+is+specifically+controlled+by+individual+nucleotides+flanking+each+coding+ACVR2+microsatellite. assertion.
- assertion asSentence Missense+mutations+of+ALK-1+cause+pulmonary+hypertension+in+patients+with+hereditary+haemorrhagic+telangiectasia. assertion.
- assertion asSentence Caveolin-1+interacts+and+cooperates+with+the+transforming+growth+factor-beta+type+I+receptor+ALK1+in+endothelial+caveolae. assertion.
- assertion asSentence Relationship+between+plasma+malondialdehyde+levels+and+adenosine+deaminase+activities+in+preeclampsia. assertion.
- assertion asSentence ADAM8+is+up-regulated+upon+formation+of+multinuclear+giant+cells+after+HPIV2+induction. assertion.
- assertion asSentence ADAM10+mediates+cleavage+of+a+receptor+tyrosine+phosphatase+and+regulation+of+beta+catenin%27s+transcriptional+activity. assertion.
- assertion asSentence Cell+migration+in+response+to+the+amino-terminal+fragment+of+urokinase+requires+epidermal+growth+factor+receptor+activation+through+an+ADAM9%2F10-mediated+mechanism. assertion.
- assertion asSentence ADAM-10+has+a+key+role+in+the+sequence+of+events+through+which+N-cadherin+affects+spine+maturation+and+function+of+glutamatergic+synapses. assertion.
- assertion asSentence ADAM10+facilitated+cell+migration+through+modulation+of+CD44+and+L1+cleavage. assertion.
- assertion asSentence ADAR1+is+primarily+responsible+for+editing+HDV+RNA+at+the+amber%2FW+site+during+HDV+infection. assertion.
- assertion asSentence ADAR1+and+not+ADAR2+is+required+for+cell+survival. assertion.
- assertion asSentence Inositol+hexakisphosphate+is+buried+within+the+catalytic+domain+of+ADAR2+and+is+required+for+editing+of+transfer+RNA. assertion.
- assertion asSentence Parathyroid+hormone+communicates+with+IP%283%29R+via+%22cAMP+junctions%22+that+allow+local+delivery+of+a+supramaximal+concentration+of+cAMP+to+IP%283%29R%2C+directly+increasing+their+sensitivity+to+IP%283%29. assertion.
- assertion asSentence The+catalytic+domains+%28C1+and+C2%29+of+adenylate+cyclase+6+play+a+role+in+targeting+adenylate+cyclase+6+to+lipid+rafts. assertion.
- assertion asSentence The+first+cytoplasmic+domain+%28residues+506-584%29+of+adenylyl+cyclase+%28AC%29+type+VII+is+an+internal+regulatory+subunit%2C+interacting+with+a+cardinal+activator+of+AC+%28Gs+alpha%29+and+with+the+conserved+first+catalytic+domain+of+type+VII+AC. assertion.
- assertion asSentence Cyclic+AMP+compartmentation+due+to+increased+cAMP-phosphodiesterase+activity+in+transgenic+mice+expressing+human+adenylyl+cyclase+type+8. assertion.
- assertion asSentence Blood+pressure+in+patients+with+primary+aldosteronism+is+influenced+by+alpha-adducin+gene+polymorphisms. assertion.
- assertion asSentence The+alpha-adducin+G614T+polymorphism+is+associated+with+the+antihypertensive+effect+of+hydrochlorothiazide. assertion.
- assertion asSentence Left+ventricular+diastolic+relaxation+is+modulated+by+genetic+variation+in+ADD1. assertion.
- assertion asSentence ALPHA+AND+BETA+ADDUCIN+POLYMORPHISMS+AFFECT+DECLINE+OF+RENAL+FUNCTION+IN+HUMAN+IGA+NEPHROPATHY. assertion.
- assertion asSentence Mycobacterium+leprae+regulates+ADRP%2Fperilipin+expression+to+facilitate+the+accumulation+of+lipids+within+infected+macrophages+for+intracellular+survival. assertion.
- assertion asSentence ADRP+upregulation+mediated+by+retinol+and+palmitate+promotes+downregulation+of+hepatic+stellate+cells+activation+and+is+functionally+linked+to+the+expression+of+fibrogenic+genes. assertion.
- assertion asSentence Risk+of+cerebral+infarction+is+increased+by+the+ADH2%2A1+allele. assertion.
- assertion asSentence ADH1b47his+allele+frequency+is+different+for+European+regions. assertion.
- assertion asSentence An+interaction+is+found+between+ALDH2%2A2+and+ADH1B%2A2%2C+with+ADH1B%2A2+being+associated+with+heightened+self-reported+sensitivity+to+alcohol+only+in+Asian+Americans+who+also+possess+1+ALDH2%2A2+allele. assertion.
- assertion asSentence The+mean+alcohol-elimination+rate+among+ADH2%2A2+carriers+is+significantly+higher+than+among+ADH2%2A1+homozygotes+in+a+male+Jewish+population. assertion.
- assertion asSentence Single+Nucleotide+Polymorphism+in+ADH7+gene+is+associated+with+upper+aerodigestive+cancer. assertion.
- assertion asSentence ADH7+gene+polymorphisms+are+associated+with+upper+aerodigestive+tract+cancers. assertion.
- assertion asSentence The+mature+form+of+adrenomedullin+is+pathophysiologically+significant+as+a+useful+marker+of+circulating+blood+volume+in+hemodialysis+patients. assertion.
- assertion asSentence Role+for+adrenomedullin+and+ACTH+in+the+regulation+of+the+immune+and+inflammatory+response. assertion.
- assertion asSentence ADM+gene+delivery+protects+against+cerebral+ischemic+injury+by+promoting+astrocyte+migration+and+survival. assertion.
- assertion asSentence Adrenomedullin+%28ADM%29+expression+in+the+anterior+pituitary+is+diminished+in+tumors+as+compared+to+the+normal+gland. assertion.
- assertion asSentence Adrenomedullin+is+a+factor+associated+with+progression+of+IM+in+human+HCC. assertion.
- assertion asSentence Plasma+MR-proADM+correlates+to+BMI+and+decreases+in+relation+to+leptin+after+gastric+bypass+surgery. assertion.
- assertion asSentence AM%2FAMBP-1+elevates+cAMP+levels%2C+followed+by+activating+PKA%2C+to+protect+neural+cells+from+the+injury+caused+by+hypoxia. assertion.
- assertion asSentence High+adrenomedullin+mRNA+expression+is+associated+with+clear-cell+renal+carcinoma. assertion.
- assertion asSentence AM+is+expressed+in+ovarian+epithelial+carcinoma+tissue+and+bFGF+can+induce+the+expression+of+AM+through+the+JNK-AP-1+pathway+in+ovarian+epithelial+carcinoma+cell+line+CAOV%283%29. assertion.
- assertion asSentence Epicardial+fat+adrenomedullin+gene+and+protein+expression+can+be+downregulated+in+coronary+artery+disease+%28CAD%29+subjects+and+intracoronary+adrenomedullin+levels+are+lower+in+CAD. assertion.
- assertion asSentence AM+produced+in+colorectal+tumors+acts+in+concert+with+metalloproteinase-9+in+the+stroma+to+contribute+to+the+pathogenesis+of+colorectal+cancer. assertion.
- assertion asSentence With+300+MBq+of+injected+%2818%29F-CPFPX+a+subject+receives+an+effective+dose+%28ICRP+60%29+of+5.3+mSv. assertion.
- assertion asSentence The+ability+to+increase+synchronized+slow-wave+activity+from+waking+to+slow-wave+sleep+is+significantly+attenuated+by+the+loss+of+adenosine+A1+receptor+expression+in+AdoA1R%28f%2Ff%29+floxed+mice. assertion.
- assertion asSentence Endogenous+activation+of+A%281%29-AR+contributes+to+the+early+development+of+renal+ischaemia%2Freperfusion+injury. assertion.
- assertion asSentence Most+damage+after+hepatic+ischemia+occurs+during+reperfusion+and+can+be+blocked+by+adenosine+A2a+receptor+activation. assertion.
- assertion asSentence At+least+three+A%282A%29+receptors+assemble+into+higher-order+oligomers+at+the+plasma+membrane+in+differentiated+neuronal+cells. assertion.
- assertion asSentence A%282A%29+receptor+activation+suppresses+the+activation-induced+cell+death+of+peripheral+T+cells. assertion.
- assertion asSentence Suppression+of+A2A-receptor-mediated+central+sympathoexcitation+contributes%2C+at+least+partly%2C+to+the+depressant+effect+of+nicotine+on+reflex+chronotropic+responses+to+baroreceptor+unloading. assertion.
- assertion asSentence A%282B%29+receptors+up-regulate+IL-4+through+G%28q%29+signaling+that+is+potentiated+via+cross-talk+with+G%28s%29-coupled+pathways. assertion.
- assertion asSentence Hypoxic+mature+dendritic+cells+predominantly+express+adenosine+receptor+A2b. assertion.
- assertion asSentence Development+of+Chlamydia+trachomatis+is+reversibly+retarded+by+prolonged+exposure+of+infected+cells+to+extracellular+adenosine+mediated+by+the+A2b+adenosine+receptor. assertion.
- assertion asSentence Adenosine+triggers+a+survival+signal+via+A3+receptor+activation+and+it+kills+the+cell+through+A2A+receptor+inducing+a+signaling+pathway+that+involves+protein+kinase+C+and+mitogen-activated+protein+kinases. assertion.
- assertion asSentence Inactivation+of+the+ADORA3+receptor+prevents+the+CXCL16+effect+of+neuroprotection+against+excitotoxic+damage. assertion.
- assertion asSentence PARP-1+does+not+play+a+major+role+in+catalysis+of+DNA+damage+processing+via+either+base+excision+repair+pathway. assertion.
- assertion asSentence Inhibition+of+PARP-1+and+DNA-dependent+protein+kinase+id+a+powerful+strategy+for+tumor+radiosensitization. assertion.
- assertion asSentence Poly%28ADP-ribose%29+polymerase+1+inactivates+the+catalytic+activities+of+the+Werner+syndrome+protein. assertion.
- assertion asSentence Interplay+between+APE1%2C+DNA+polymerase+beta+and+poly%28ADP-ribose%29+polymerase-1+during+base+excision+repair. assertion.
- assertion asSentence PARP-1+plays+an+important+role+in+acute+tubular+necrosis+and+recovery+of+renal+function+and+is+related+to+the+extent+and+severity+of+ATN+and+to+the+renal+allograft+function. assertion.
- assertion asSentence Down-regulation+of+PARP1+in+TUR+leukemia+cells+restores+transcriptional+responsiveness+for+differentiation+and+cell+cycle+arrest. assertion.
- assertion asSentence Physical+interaction+between+the+major+DSB+signaling+kinase%2C+ATM+and+poly%28ADP-ribosyl%29ation+by+PARP-1%2C+a+key+enzyme+of+chromatin+remodeling. assertion.
- assertion asSentence NRF-1+can+also+directly+interact+with+poly%28ADP-ribose%29+polymerase+1+%28PARP-1%29+and+co-purify+the+PARP-1.DNA-PK.Ku80.Ku70.topoisomerase+IIbeta-containing+protein+complex. assertion.
- assertion asSentence gammaH2AX+and+cleaved+PARP-1+as+apoptotic+markers+in+irradiated+breast+cancer+BT474+cellular+spheroids. assertion.
- assertion asSentence PARP1-dependent+PARylation+of+EBNA1+and+adjacently+bound+TRF2+induces+structural+changes+at+the+dyad+symmetry+element+that+reduce+EBNA1+DNA+binding+affinity+and+functional+recruitment+of+origin+recognition+complex. assertion.
- assertion asSentence Utilization+of+beta-lapachone+as+a+radiosensitizer+in+prostate+cancers+that+overexpress+PARP1. assertion.
- assertion asSentence Methylation+of+the+TM+promoter+is+responsible+for+silencing+of+TM+expression+in+MM+tissue%2C+a+process+that+is+regulated+by+PARP1. assertion.
- assertion asSentence Reduced+expression+of+PARP1+is+associated+with+an+impairment+of+CLL+responsiveness+to+cell+death. assertion.
- assertion asSentence The+interaction+between+CHFR+and+PARP-1+plays+an+important+role+in+cell+cycle+regulation+and+cancer+therapeutic+strategies. assertion.
- assertion asSentence Investigate+role+of+ADRA1D+amino+residues+in+binding+of+beta-adrenergic+antagonists+%28prazosin%2Ftamulosin%29. assertion.
- assertion asSentence Ezrin+directly+interacts+with+the+alpha1b-adrenergic+receptor+and+plays+a+role+in+receptor+recycling. assertion.
- assertion asSentence Functional+alpha1-+and+beta2-adrenergic+receptors+in+human+osteoblasts. assertion.
- assertion asSentence Through+beta-D+receptor+heteromers+dopamine+inhibits+adrenergic+receptor+signaling+and+blocks+the+synthesis+of+melatonin+induced+by+adrenergic+receptor+ligands. assertion.
- assertion asSentence Estrogen+attenuates+the+lipolytic+response+through+up-regulation+of+the+number+of+antilipolytic+alpha2A-adrenergic+receptors+only+in+sc+and+not+in+visceral+fat+depots. assertion.
- assertion asSentence Involvement+of+the+ADRA2A+MspI+and+DraI+polymorphisms+in+the+etiology+of+ADHD+in+Korean+subjects. assertion.
- assertion asSentence A+variant+of+the+ADRA2B+gene+is+associated+with+essential+hypertension+with+or+without+type+2+diabetes+in+Malaysian+subjects. assertion.
- assertion asSentence The+alpha%282C%29+Del322-325+polymorphism+exclusively+or+in+combination+with+the+beta%281%29Arg389+allele+is+not+associated+with+an+increased+risk+of+adverse+events+in+HF. assertion.
- assertion asSentence Cyclic+AMP+acts+through+Rap1+and+JNK+signaling+to+increase+expression+of+cutaneous+smooth+muscle+alpha2C-adrenoceptors. assertion.
- assertion asSentence Genotype+polymorphism+frequencies+for+B1+receptor+%28amino+acid+positions+389+and+49%29+and+alpha+2c+receptor+%28deletion+322-325%29+are+not+significantly+different+in+SC+patients+compared+to+female+controls. assertion.
- assertion asSentence The+effects+of+aerobic+fitness+and+beta1-adrenergic+receptor+blockade+on+cardiac+work+during+dynamic+exercise. assertion.
- assertion asSentence Genotype+polymorphism+frequencies+for+B1+receptor+%28amino+acid+positions+389+and+49%29+and+alpha+2c+receptor+%28deletion+322-325%29+are+not+significantly+different+in+SC+patients+compared+to+female+controls. assertion.
- assertion asSentence Marked+interethnic+difference+exist+in+beta%281%29-adrenoceptor+gene+polymorphisms. assertion.