Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Selective+exon+sequencing+can+allow+a+definitive+diagnosis+in+50%25+of+PH1+patients. assertion.
- assertion asSentence The+molecular+mechanism+of+recognition+by+the+peroxisomal+receptor+Pex5p%2C+in+complex+with+alanine-glyoxylate+aminotransferase+revealed+by+X-ray+crystallography. assertion.
- assertion asSentence An+alternate+translation+initiation+site+circumvents+an+amino-terminal+DAX1+nonsense+mutation+%28Q37X%29+leading+to+a+mild+form+of+X-linked+adrenal+hypoplasia+congenita. assertion.
- assertion asSentence In+comparison+to+DAX-1A%2C+DAX-1+is%2C+by+far%2C+the+predominant+mRNA+isoform+found+in+human+adrenal+glands+and+gonads. assertion.
- assertion asSentence DAX1+gene+mutations+are+associated+with+primary+adrenal+insufficiency. assertion.
- assertion asSentence AhR%2C+a+transcription+factor%2C+can+bind+specifically+to+AD1+in+the+C-terminal+region+of+BRCA1+and+affect+BRCA1%27s+ability+to+regulate+transcription+activity. assertion.
- assertion asSentence Reduction+in+VEGF+correlates+with+inhibited+prostate+carcinogenesis+in+Ahr+transsgenic+mice. assertion.
- assertion asSentence Aryl+hydrocarbon+receptor+regulates+cell+cycle+progression+in+breast+cancer+cells+through+functional+interaction+with+cyclin-dependent+kinase+4. assertion.
- assertion asSentence AhR+agonists+inhibited+cell+invasiveness+and+anchorage-independent+growth+in+human+breast+cancer+cells+regardless+of+ER%2C+PR%2C+or+HER2+status. assertion.
- assertion asSentence There+is+an+independent+and+significant+association+between+reduced+serum+fetuin-A+levels+and+multi-site+cardiovascular+calcification+in+hemodialysis. assertion.
- assertion asSentence The+acceleration+of+arterial+wall+stiffness+in+CKD+is+associated+with+additional+factors%2C+i.e.+fetuin+A+deficiency+and+higher+CRP+and+IL-6. assertion.
- assertion asSentence Low+levels+of+circulating+fetuin-A+are+associated+with+increased+mortality+in+dialysis+patients. assertion.
- assertion asSentence Serum+AHSG+levels+are+significantly+increased+in+adult+patients+with+biopsy-proven+non-alcoholic+fatty+liver+disease+and+are+associated+with+insulin+resistance. assertion.
- assertion asSentence AKT1+activation+disrupts+breast+acinar+architecture+and+enhances+proliferation+in+an+mTOR-dependent+manner. assertion.
- assertion asSentence Expression+of+constitutively+active+PKB+alpha+abrogates+dexamethasone+stimulation+of+hPDK4+promoter+activity. assertion.
- assertion asSentence ET-1+enhances+the+ability+of+lung+fibroblasts+to+contract+extracellular+matrix+through+the+Akt%2Fphosphoinositide+3-kinase+%28PI3-kinase%29+pathway+to+induce+de+novo+protein+synthesis+of+proteins+that+contribute+to+a+contractile+phenotype. assertion.
- assertion asSentence CKIepsilon-induced+down-regulation+of+PI3K%2FAkt+signaling+through+PTEN+leads+to+amplified+sensitivity+to+apoptosis. assertion.
- assertion asSentence Both+activation+of+JNK+and+inhibition+of+Akt+play+a+role+in+translocation+of+Nur77+from+the+nucleus+to+the+cytoplasm. assertion.
- assertion asSentence Akt+activation+is+not+associated+with+differences+in+survival+or+smoking+status+in+bronchioalveolar+carcinoma. assertion.
- assertion asSentence Par6alpha-mediated+inhibition+of+insulin-dependent+glycogen+synthesis+in+C2C12+cells+depends+on+the+direct+interaction+of+Par6alpha+with+aPKC+and+on+aPKC-mediated+T34+phosphorylation+of+Akt1. assertion.
- assertion asSentence Fak%2FSrc+signaling+to+the+PI3-K%2FAkt-1+and+MEK%2FErk+pathways+undergoes+a+differentiation+state-specific+uncoupling+in+enterocytes. assertion.
- assertion asSentence KGF+triggers+negative+feedback+between+ERK1%2F2+and+AKT+pathways+to+regulate+cell+proliferation%2Fdifferention. assertion.
- assertion asSentence Lipid+raft+cholesterol+regulates+apoptotic+cell+death+in+prostate+cancer+cells+through+EGFR-mediated+Akt+and+ERK+pathways. assertion.
- assertion asSentence The+inhibition+of+Akt+and+S6K1+phosphorylation+by+PRR5+knock+down+correlates+with+reduction+in+the+expression+level+of+platelet-derived+growth+factor+receptor+beta+%28PDGFRbeta%29. assertion.
- assertion asSentence In+the+absence+of+EGF%2C+p38MAPK-activated+AKT+is+necessary+for+HER-2+overexpressing+human+breast+cancer+cells+to+survive+and+to+form+colonies+in+soft+agar. assertion.
- assertion asSentence Cutaneous+human+papillomaviruses+down-regulate+AKT1. assertion.
- assertion asSentence Akt+inhibition+primes+TRAIL-resistant+cells+to+TRAIL-induced+apoptosis. assertion.
- assertion asSentence PKB%5Balpha%5D+and%2For+PKB%5Bgamma%5D+and+not+PKB%5Bbeta%5D+alone+are+involved+in+gemcitabine+resistance+mechanisms. assertion.
- assertion asSentence HER-2%2Fneu+transcriptionally+activates+Jab1+expression+via+the+AKT%2Fbeta-catenin+pathway+in+breast+cancer+cells. assertion.
- assertion asSentence Akt+and+Mcl-1+are+major+components+of+a+survival+pathway+that+can+be+activated+in+CLL+B+cells+by+antigen+stimulation. assertion.
- assertion asSentence miR-214+induces+cell+survival+and+cisplatin+resistance+primarily+through+targeting+the+PTEN%2FAkt+pathway. assertion.
- assertion asSentence AKT+is+activated+in+an+ataxia+telangiectasia+and+Rad3-related-dependent+manner+in+response+to+temozolomide+and+confers+protection+against+drug-induced+cell+growth+inhibition. assertion.
- assertion asSentence The+lack+of+Par-4+dramatically+enhances+Ras-induced+lung+carcinoma+formation+in+vivo%2C+acting+as+a+negative+regulator+of+Akt+activation. assertion.
- assertion asSentence PAK1-specific+paxillin+phosphorylation+at+Ser%28273%29+is+critically+involved+in+the+positive-feedback+regulation+of+the+Rac-PAK1+pathway. assertion.
- assertion asSentence DIDS-sensitive+Cl-+channels+play+a+key+role+in+the+Low-density+lipoprotein-induced+cell+proliferation+of+human+aortic+smooth+muscle+cells+via+the+activation+of+Erk1%2F2+and+PI3K%2FAkt+and+the+upregulation+of+Egr-1. assertion.
- assertion asSentence Gate+control+for+cell+polarization+can+explain+how+Rac+can+be+employed+for+both+PI3K-dependent+and+-independent+signaling+pathways+coexisting+in+the+same+cell. assertion.
- assertion asSentence H.+pylori+infection+of+gastric+epithelial+cells+induced+phosphorylation+of+Akt+at+Ser+473+and+Thr+308. assertion.
- assertion asSentence Activation+of+the+Akt-mTOR-p70S6K+pathway+plays+a+significant+role+in+HCC+progression+by+promoting+neoangiogenesis. assertion.
- assertion asSentence AKT1+inhibits+homologous+recombination+by+inducing+cytoplasmic+retention+of+BRCA1+and+RAD51. assertion.
- assertion asSentence NGF+induces+Mac-2BP+expression+via+the+PI3K%2FAkt%2FNF-kappaB+pathway. assertion.
- assertion asSentence The+prosurvival+effect+of+NADPH+oxidase+inhibitor+parabutoporin+depends+on+activation+of+protein+kinase+B%2FAkt+via+lipid+raft+signaling. assertion.
- assertion asSentence Akt%2FmTOR-dependent+translation+of+HIF-1alpha+plays+a+critical+role+in+the+postirradiation+up-regulation+of+intratumoral+HIF-1+activity+in+response+to+radiation-induced+alterations+of+glucose+and+oxygen+availability+in+a+solid+tumor. assertion.
- assertion asSentence Pneumococci+exploit+the+vitronectin-alphavbeta3-integrin+complex+as+a+cellular+receptor+for+invasion+and+this+integrin-mediated+internalization+requires+the+cooperation+between+the+host+signalling+molecules+ILK%2C+PI3K+and+Akt. assertion.
- assertion asSentence Tubulin+acetylation+stimulates+the+binding+and+the+signaling+function+of+the+kinase+Akt%2FPKB. assertion.
- assertion asSentence ET-1+and+TGF-beta1+independently+promote+fibroblast+resistance+to+apoptosis+through+signaling+pathways+involving+PI3K%2FAKT. assertion.
- assertion asSentence VEGF-A+signalling+acts+on+tumour+cells+as+a+stimulator+of+the+AKT%2FmTOR+pathway. assertion.
- assertion asSentence Leptin+exerts+an+anti-apoptotic+effect+on+human+dendritic+cells+via+the+PI3K-Akt+signaling+pathway. assertion.
- assertion asSentence Akt-mediated+transactivation+of+the+S1P1+receptor+in+caveolin-enriched+microdomains+regulates+endothelial+barrier+enhancement+by+oxidized+phospholipids. assertion.
- assertion asSentence AKT+activity+is+downregulated+when+Tsc1%2FTsc2+function+is+reduced. assertion.
- assertion asSentence Apoptotic+body+engulfment+by+hepatic+stellate+cells+promotes+their+survival+by+the+JAK%2FSTAT+and+Akt%2FNF-kappaB-dependent+pathways. assertion.
- assertion asSentence PTEN%2FAkt%2Fbeta-catenin+signaling+pathway+plays+an+importatn+role+in+regulation+of+normal+and+malignant+mammary+stem%2Fprogenitor+cell+populations. assertion.
- assertion asSentence Interaction+of+Akt-phosphorylated+SRPK2+with+14-3-3+mediates+cell+cycle+and+cell+death+in+neurons. assertion.
- assertion asSentence The+Akt+pathway+is+involved+in+peptidoglycan-induced+interleukin-6+production+in+rheumatoid+arthritis+synovial+fibroblasts. assertion.
- assertion asSentence BMP-2+promotes+motility+and+invasion+of+gastric+cancer+cells+by+activating+the+PI-3+kinase%2FAkt+signal+pathway. assertion.
- assertion asSentence There+is+an+intensive+relationship+between+pAKT+and+CD44v6+expression+in+breast+cancer+tissues. assertion.
- assertion asSentence CNK1+promotes+oncogenic+signalling+through+Akt+in+breast+cancer+cell+lines+and+tumours. assertion.
- assertion asSentence Glutamine%2C+leucine+and+proline+increase+Akt+phosphorylation+in+HepG2+cells. assertion.
- assertion asSentence Role+of+germ+line+genetic+variations+in+the+PI3K-AKT-mTOR+pathway+genes+as+predictors+of+bladder+cancer+metastasis+and+invasiveness. assertion.
- assertion asSentence PDCD4+regulates+TRAIL+sensitivity+in+gastric+cancer+cells+by+inhibiting+the+PI3K%2FAkt+signaling+pathway. assertion.
- assertion asSentence P21-activated+kinase+1+stimulates+colon+cancer+cell+growth+and+migration%2Finvasion+via+ERK-+and+AKT-dependent+pathways. assertion.
- assertion asSentence Nuclear+p-AKT+expression+together+with+stage+and+grade+constitute+independent+prognostic+factors+for+tumour+progression+and+cancer-specific+survival. assertion.
- assertion asSentence Recent+development+of+anticancer+therapeutics+targeting+Akt. assertion.
- assertion asSentence Autophagy+and+Akt+promote+survival+in+glioma. assertion.
- assertion asSentence Dependence+of+Evi1-expressing+leukemic+cells+on+AKT%2FmTOR+signaling+provides+the+first+example+of+targeted+therapeutic+modalities+that+suppress+the+leukemogenic+activity+of+Evi1. assertion.
- assertion asSentence PI3K-activating+hormones+inhibit+ROMK+by+enhancing+its+endocytosis+via+a+mechanism+that+involves+phosphorylation+of+WNK1+by+Akt1+and+SGK1. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+in+AKT+gene+is+not+associated+with+colorectal+cancer. assertion.
- assertion asSentence Insulin+inhibits+amyloid-beta42-induced+intracellular+reactive+oxygen+species+generation+via+Akt+activation. assertion.
- assertion asSentence A+cell+penetrating+peptide+derived+from+azurin+inhibits+angiogenesis+and+tumor+growth+by+inhibiting+phosphorylation+of+VEGFR-2%2C+FAK+and+Akt. assertion.
- assertion asSentence Angiopoietin-2%2C+an+angiogenic+regulator%2C+promotes+initial+growth+and+survival+of+breast+cancer+metastases+to+the+lung+through+the+integrin-linked+kinase+%28ILK%29-AKT1%2C2-B+cell+lymphoma+2+%28Bcl-2%29+pathway. assertion.
- assertion asSentence Administration+of+a+Toll-like+receptor+%28TLR%29-2+ligand+attenuates+focal+cerebral+perfusion+injury+via+a+transgenic+TLR2-+and+phosphatidylinositol+3-kinase%2FAkt-dependent+mechanism. assertion.
- assertion asSentence TGF-beta1+undergo+a+switch+into+mesenchymal+cells+and+PI3K%2FAkt+and+MAPK%2FErk1%2F2+signaling+pathways+serve+to+regulate+TGF-beta1-induced+epithelial-to-mesenchymal+transition+of+A549+cells. assertion.
- assertion asSentence FGF2+and+EGF+affect+the+motor+neuron+fate+decision+in+human+fetal+neural+stem+cells+differently+through+a+fine+tuning+of+the+PI3K%2FAKT%2FGSK3beta+pathway. assertion.
- assertion asSentence IKBKE+protein+activates+Akt+independent+of+phosphatidylinositol+3-kinase%2FPDK1%2FmTORC2+and+the+pleckstrin+homology+domain+to+sustain+malignant+transformation. assertion.
- assertion asSentence Proliferation+of+human+IVD+cells+is+regulated+by+exogenous+and+autocrine+growth+factors+mainly+via+the+MEK%2FERK+and+PI-3K%2FAkt+pathways. assertion.
- assertion asSentence miR-7+functions+as+a+tumor+suppressor+and+plays+a+substantial+role+in+inhibiting+the+tumorigenesis+and+reversing+the+metastasis+of+hepatocellular+carcinoma+through+the+PI3K%2FAkt%2FmTOR-signaling+pathway+in+vitro+and+in+vivo. assertion.
- assertion asSentence Akt%2FmTOR+is+a+key+signaling+component+through+which+c-Met+protects+multiple+myeloma+cells+from+chemotherapy-induced+growth+inhibition+and+apoptosis. assertion.
- assertion asSentence Overexpression+of+hyaluronan-binding+protein+1+%28HABP1%2Fp32%2FgC1qR%29+in+HepG2+cells+leads+to+increased+hyaluronan+synthesis+and+cell+proliferation+by+up-regulation+of+cyclin+D1+in+AKT-dependent+pathway. assertion.
- assertion asSentence FKBP5+as+a+selection+biomarker+for+gemcitabine+and+Akt+inhibitors+in+treatment+of+pancreatic+cancer. assertion.
- assertion asSentence In+renal+tubular+epithelial+cell%2C+Akt+phosphorylation+is+up-regulated+in+an+effort+to+minimize+cell+death. assertion.
- assertion asSentence PKB%5Balpha%5D+and%2For+PKB%5Bgamma%5D+and+not+PKB%5Bbeta%5D+alone+are+involved+in+gemcitabine+resistance+mechanisms. assertion.
- assertion asSentence Polymorphisms+in+two+components+of+the+insulin+signaling+pathway%2C+AKT2+and+GSK3B%2C+are+associated+with+polycystic+ovary+syndrome. assertion.
- assertion asSentence Akt2+is+a+negative+regulator+of+NFAT+activation+through+its+ability+to+inhibit+calcium+mobilization+from+the+endoplasmic+reticulum. assertion.
- assertion asSentence Hypoxia+induces+erythroid-specific+5-aminolevulinate+synthase+expression+in+human+erythroid+cells+through+transforming+growth+factor-beta+signaling. assertion.
- assertion asSentence Albumin+is+the+major+component+of+plasma+that+blocks+CLL+cell+killing+by+chlorambucil+or+radiation. assertion.
- assertion asSentence Synthesis+of+albumin+and+fibrinogen+is+upregulated+in+type+2+diabetic+patients+with+increased+urinary+albumin+excretion. assertion.
- assertion asSentence Changes+of+net+charge+and+alpha-helical+content+affect+the+pharmacokinetic+properties+of+human+serum+albumin. assertion.
- assertion asSentence Investigate+the+movement+of+intravitreal+human+serum+albumin+nanoparticles+in+the+vitreous+and+retina. assertion.
- assertion asSentence Low+albumin+is+associated+with+lymphomatous+adult+T-cell+leukemia%2Flymphoma. assertion.
- assertion asSentence Hypoalbuminemia+is+a+predictor+of+poor+surgical+outcomes+of+colon+cancer. assertion.
- assertion asSentence ALCAM+is+expressed+on+human+endometrial+epithelial+cells+and+blastocysts. assertion.
- assertion asSentence Elevated+levels+of+ALCAM+in+serum+is+associated+with+breast+cancer. assertion.
- assertion asSentence Breast+cancers+with+ALDH1%2B+cancer+stem+cells+posses+biologically+aggressive+phenotypes+that+tend+to+have+a+poor+prognosis. assertion.
- assertion asSentence Upregulation+of+aldehyde+dehydrogenase+is+associated+with+thyroid+cancer. assertion.
- assertion asSentence EZH2+and+ALDH-1+mark+breast+epithelium+at+risk+for+breast+cancer+development. assertion.
- assertion asSentence ALDH+2%2A1%2A2+polymorphisms+are+associated+with+pancreatic+cancer. assertion.
- assertion asSentence ALDH1+expression+in+carcinoma+cells+is+an+independent+prognostic+factor+in+triple+negative+breast+cancer+patients. assertion.
- assertion asSentence ALDH1+expression+is+frequent+in+tumour-associated+stromal+cells+of+triple+negative+breast+cancer+and+is+associated+with+better+outcome. assertion.
- assertion asSentence ALDH2+genotype+is+significantly+associated+with+acetaldehyde-induced+micronuclei+and+alcohol-induced+facial+flushing. assertion.
- assertion asSentence Polymorphisms+of+the+alcohol+metabolism-related+ALDH2+gene+are+significantly+different+in+Korean+patients+with+alcoholism+and+Korean+control+subjects+without+alcoholism. assertion.
- assertion asSentence Aldehyde+dehydrogenase+2+%28ALDH2%29+genotype+is+associated+with+essential+hypertension+independently+of+alcohol+consumption. assertion.