Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Mucin+1+and+adenomatous+polyposis+coli+co-immunoprecipitate+in+breast+cancer+cells. assertion.
- assertion asSentence The+tumor+suppressor+gene%2C+APC%2C+is+an+independent+prognostic+parameter+with+poor+outcome+in+breast+cancer+patients. assertion.
- assertion asSentence APC+forms+complex+with+AP-2alpha+and+beta-catenin+and+sequesters+beta-catenin+away+from+TCF%2FLEF+transcription+factors. assertion.
- assertion asSentence Truncating+APC+mutations+have+dominant+effects+on+cell+proliferation%2C+spindle+checkpoint+control%2C+survival+and+chromosome+stability. assertion.
- assertion asSentence Large+deletions+in+the+APC+gene+are+a+common+cause+of+typical+familial+adenomatous+polyposis. assertion.
- assertion asSentence APC+regulates+mitotic+spindle+function+and+how+errors+in+chromosome+segregation+are+tolerated+in+tumor+cells. assertion.
- assertion asSentence Desmoid+tumors+occurring+in+the+background+of+familial+adenomatous+polyposis+%28FAP%29+usually+contain+inactivating+germline+mutations+in+the+adenomatous+polyposis+coli+%28APC%29+gene. assertion.
- assertion asSentence Two+cancer-free+dysmorphic+patients+with+karyotypes+that+confer+susceptibility+to+familial+Adenomatous+polyposis+and+von-Hippel-Lindau+syndrome. assertion.
- assertion asSentence Multiple+rare+nonsynonymous+variants+in+APC+play+a+significant+role+in+predisposing+to+colorectal+adenomas. assertion.
- assertion asSentence APC+promoter+methylation+and+altered+nuclear+beta-catenin+localization+is+associated+with+digestive+endocrine+tumours. assertion.
- assertion asSentence The+middle+region+of+APC+is+sufficient+to+recruit+Nup358+to+the+plus+ends+of+microtubules. assertion.
- assertion asSentence Mutations+in+adenomatous+polyposis+coli+protein+is+associated+with+Colorectal+Carcinoma. assertion.
- assertion asSentence APC+mutation+at+codon+1309+is+associated+with+familial+adenomatous+polyposis. assertion.
- assertion asSentence Single-nucleotide+polymorphisms+in+the+adenomatous+polyposis+coli+gene+are+associated+with+prostate-specific+antigen+recurrence+after+radical+prostatectomy+in+prostate+cancer. assertion.
- assertion asSentence Amino-terminal+segment+of+APC+promotes+cell+sensitivity+to+apoptosis+modulated+through+its+binding+to+40-+and+43-kilodalton+hTID-1+isoforms. assertion.
- assertion asSentence Hypermethylation+of+APC+promoter+1A%2C+instead+of+mutations+involving+APC+and+beta-catenin%2C+contributes+to+moderate+activation+of+Wnt+signalling+in+a+subset+of+serrated+adenomas. assertion.
- assertion asSentence APC+mutations+encompassing+at+least+two+beta-catenin+down-regulating+motifs+are+significantly+more+frequent+in+microsatellite+unstable+than+in+microsatellite+stable+colorectal+cancers. assertion.
- assertion asSentence Mutations+in+the+APC+gene+is+associated+with+familial+adenomatous+polyposis. assertion.
- assertion asSentence EBV-positive+gastric+carcinomas+revealed+significantly+more+often+gene+hypermethylation+of+p16%2C+p14+and+APC. assertion.
- assertion asSentence APC+gene+mutations+are+associated+with+familial+adenomatous+polyposis. assertion.
- assertion asSentence Serum+amyloid+p+component+binds+to+late+apoptotic+cells+and+is+involved+in+the+phagocytosis+of+these+cells+by+human+monocyte-derived+macrophages. assertion.
- assertion asSentence AIRE+regulates+gene+expression+by+recruiting+components+of+the+transcription+complex+to+specific+regions+of+the+genome+via+interactions+with+nuclear+matrix. assertion.
- assertion asSentence The+autoimmune+regulator+PHD+finger+binds+to+non-methylated+histone+H3K4+to+activate+gene+expression. assertion.
- assertion asSentence The+amino+terminal+portion+of+HSP70+stimulates+the+activity+of+HAP1. assertion.
- assertion asSentence Ape1+is+involved+in+the+nucleotide+incision+repair+pathway+%28NIR%29%2C+it+incises+DNA+containing+5%2C6-dihydro-2%27-pyrimidines%2C+5-hydroxy-2%27-deoxyuridine%2C+alpha-2%27-deoxyadenosine+and+alpha-thymidine+adducts%2C+generating+3%27-hydroxyl+and+5%27-phosphate+termini. assertion.
- assertion asSentence APE%2Fref-1+plays+a+significant+role+in+gemcitabine+resistance+in+some+pancreatic+cancer+cells. assertion.
- assertion asSentence APE1+is+the+major+activity+involved+in+the+repair+of+3%27-8-oxoguanine+lesions+in+human+cells. assertion.
- assertion asSentence Replication+protein+A+selectively+suppresses+the+nontemplated+ss+cleavage+activity+of+Ape1+in+vivo%2C+particularly+at+sites+of+ongoing+replication%2Frecombination%2C+by+coating+the+ssDNA. assertion.
- assertion asSentence Purified+recombinant+Cockayne+syndrome+B+protein+and+the+major+human+apurinic%2Fapyrimidinic+endonuclease%2C+APE1%2C+physically+and+functionally+interact. assertion.
- assertion asSentence Expression+of+VEGF+and+Ref-1+is+associated+with+Trx-1+overexpression+and+poor+prognosis+in+patients+with+liver+metastases+from+colorectal+cancer. assertion.
- assertion asSentence The+unexpected+involvement+of+Cys99+in+APE1%27s+substrate+binding+and+catalysis+provides+an+example+of+involvement+of+a+residue+far+from+the+active+site. assertion.
- assertion asSentence The+APE1+-656T%3EG+polymorphism+has+an+influence+on+the+APE1+promoter+activity+and+is+significantly+associated+with+a+reduced+risk+for+lung+cancer. assertion.
- assertion asSentence Under+conditions+for+which+alkyladenine+DNA+glycosylase+%28AAG%29+is+stable%2C+APE1+stimulates+the+multiple-turnover+glycosylase+activity+of+AAG%2C+specifically+by+increasing+the+rate+of+its+dissociation+from+the+abasic+DNA+product. assertion.
- assertion asSentence The+human+E3+ubiquitin+ligase+UBR3+has+a+major+activity+that+polyubiquitylates+APE1+at+multiple+lysine+residues+clustered+on+the+N-terminal+tail. assertion.
- assertion asSentence Apurinic%2Fapyrimidinic+endonuclease+1%2FRef-1+is+unregulated+in+recurrent+stage+I+lung+adenocarcinoma. assertion.
- assertion asSentence X-linked+XIAP+is+present+in+Chronic+lymphocytic+leukemia+cells+and+is+up-regulated+in+conditions+where+apoptosis+is+prevented. assertion.
- assertion asSentence cIAP1+and+cIAP2+promote+cancer+cell+survival+by+functioning+as+E3+ubiquitin+ligases+that+maintain+constitutive+ubiquitination+of+the+RIP1+adaptor+protein. assertion.
- assertion asSentence Immortalized+cell+lines+from+human+gingival+mucosal+keratinocytes+with+epithelial+mesenchymal+transition+%28EMT%29+expressed+significantly+elevated+levels+of+cIAP-1%2C+Bclx+and+p27%28kip%29+higher+than+non-EMT+cells. assertion.
- assertion asSentence The+structure+of+the+caspase+recruitment+domain+%28CARD%29+of+cIAP1+is+required+for+cIAP1+autoregulation. assertion.
- assertion asSentence cIAP1%2F2+are+important+regulators+of+inflammatory+processes+in+endothelial+cells. assertion.
- assertion asSentence BIRC2+is+amplified+in+a+subset+of+squamous+cell+carcinoma+of+the+uterine+cervix. assertion.
- assertion asSentence Cellular+inhibitors+of+apoptosis+1+and+2+are+ubiquitin+ligases+for+the+apoptosis+inducer+Smac%2FDIABLO. assertion.
- assertion asSentence X-linked+XIAP+is+present+in+Chronic+lymphocytic+leukemia+cells+and+is+up-regulated+in+conditions+where+apoptosis+is+prevented. assertion.
- assertion asSentence Detachment-induced+upregulation+of+XIAP+and+cIAP2+delays+anoikis+of+intestinal+epithelial+cells. assertion.
- assertion asSentence TRAF2+interaction+is+critical+for+c-IAP2%2FMALT1-mediated+increases+in+the+NF-kappaB+activity%2C+increased+expression+of+endogenous+NF-kappaB+target+genes+and+resistance+to+apoptosis. assertion.
- assertion asSentence Genetically+modified+human+islets+expressing+XIAP+are+resistant+to+the+negative+effects+of+immunosuppressive+drugs+on+insulin+secretion+and+cell+viability. assertion.
- assertion asSentence Increased+XIAP+protein+level+contributes+to+the+drug+resistance+in+HL-60+cells+induced+by+adhesion+to+fibronectin. assertion.
- assertion asSentence Preservation+of+XIAP+proteins+represents+a+key+mechanism+by+which+PGI2+protects+endothelial+cells+from+oxidant-induced+apoptosis. assertion.
- assertion asSentence The+inhibition+of+XIAP+activity+proved+to+be+crucial+for+full+effector+caspase+activity+and+clonogenic+execution. assertion.
- assertion asSentence XIAP+inhibits+multiple+aspects+of+protein+degradation+in+skeletal+muscle+during+chronic+kidney+disease. assertion.
- assertion asSentence Expression+of+XIAP+is+highly+increased+by+post-transcriptional+regulation+in+C-ALL+and+is+associated+with+poor+in+vivo+glucocorticoid+response+and+outcome+in+T-cell+ALL+. assertion.
- assertion asSentence Inhibition+of+Bcl-2+and+XIAP+has+a+non-linear+effect+on+sensitization+towards+apoptosis+in+leukemia+and+lymphoma+cells. assertion.
- assertion asSentence IKKepsilon+regulated+Sendai+virus-induced+apoptosis+via+the+phosphorylation-dependent+turnover+of+XIAP. assertion.
- assertion asSentence Hsp90%2C+a+molecular+chaperone+that+is+central+to+the+cellular+stress+response%2C+associates+with+survivin%2C+an+apoptosis+inhibitor+and+essential+regulator+of+mitosis. assertion.
- assertion asSentence STAT3+signaling+supports+gastric+cancer+cell+survival+in+association+with+survivin+expression. assertion.
- assertion asSentence Depletion+of+survivin+by+small+interfering+RNAs+%28siRNAs%29+increased+both+the+number+of+microtubules+nucleated+by+centrosomes+and+the+incidence+of+microtubule+catastrophe%2C+the+transition+from+microtubule+growth+to+shrinking. assertion.
- assertion asSentence Antisense+survivin+RNA+can+induce+apoptosis+and+inhibit+the+proliferation+of+Hep-2+cells+by+down-regulating+the+expression+of+endogenous+survivin+in+vitro. assertion.
- assertion asSentence Survivin+is+a+critical+modulator+of+atherosclerotic+macrophage+apoptosis+under+dual+control+by+growth+factors+and+oxidized+lipids+accumulating+in+atheroma. assertion.
- assertion asSentence Survivin+expression+in+Hepa1-6+cells+increases+in+response+to+mitomycin+treatment+at+low+doses. assertion.
- assertion asSentence Wild-type+survivin+mRNA+expression+level+is+significantly+associated+with+docetaxel-resistance+in+gastric+cancer. assertion.
- assertion asSentence Survivin+immunohistochemical+staining+can+be+a+useful+adjunct+tool+for+the+grading+of+challenging+cases+of+papillary+urothelial+carcinoma. assertion.
- assertion asSentence Smac%2FDIABLO+interacts+in+a+similar+way+with+both+XIAP+and+survivin+through+its+amino+terminal+residues. assertion.
- assertion asSentence Adenoviral+activity+is+facilitated+by+abrogation+of+multiple+cell+cycle+checkpoints+and+can+be+enhanced+by+expression+of+survivin+within+the+nucleus. assertion.
- assertion asSentence Hedyotis+diffusa+wild+injection+suppresses+Bcl2+and+survivin+expression+which+inhibits+the+growth+of+HL-60+cells. assertion.
- assertion asSentence High+expression+of+BIRC5+is+associated+with+breast+cancer. assertion.
- assertion asSentence Higher+expression+of+cortactin+and+survivin+significantly+correlated+with+advanced+clinicopathological+stage+in+renal+cell+carcinomas. assertion.
- assertion asSentence Polymorphisms+of+survivin+promoter+are+associated+with+esophageal+squamous+cell+carcinoma. assertion.
- assertion asSentence Upregulation+of+survivin+expression+in+KSHV-associated+human+cells+contributes+to+cell+proliferation. assertion.
- assertion asSentence Quercetin+inhibits+human+SW480+colon+cancer+growth+in+association+with+inhibition+of+cyclin+D1+and+survivin+expression+through+Wnt%2Fbeta-catenin+signaling+pathway. assertion.
- assertion asSentence Decreasing+trend+for+BIRC5+expression+is+associated+with+early+to+advanced+stages+of+myelodysplastic+syndrome. assertion.
- assertion asSentence Survivin+RNAi+can+partly+suppress+the+expression+of+survivin+in+SKOV3%2FDDP+cells%2C+inhibit+the+cell+proliferation+and+promote+cell+apoptosis. assertion.
- assertion asSentence High+Survivin+and+its+spliced+isoform+gene+expression+is+associated+with+proliferation+of+renal+cancer+cells+and+clinical+stage+of+renal+cancer. assertion.
- assertion asSentence Survivin-c-erbB2-cox2+co-expression+score+has+independent+prognostic+value+for+endometrial+cancer. assertion.
- assertion asSentence Arsenic+trioxide+suppresses+transcription+of+survivin+mRNA+in+NB-4+cells. assertion.
- assertion asSentence Upregulated+p27kip1+can+downregulate+survivin+expression+and+inhibit+telomerase+activity+in+gastric+carcinoma+cells. assertion.
- assertion asSentence TNF+signaling+activates+Notch2+that+sensitizes+endothelial+cells+to+apoptosis+via+modulation+of+the+key+apoptosis+regulator+survivin. assertion.
- assertion asSentence Survivin+physically+binds+to+polo-like+kinase+1+domain. assertion.
- assertion asSentence Survivin+is+a+critical+factor+for+cell+division+and+cell+viability+in+primary+human+osteoblastic+cells. assertion.
- assertion asSentence LMP1+upregulated+survivin+protein+expression+and+its+phosphorylation+by+p53+due+to+the+transactivation+of+the+survivin+promoter+in+nasopharyngeal+carcinoma+cells. assertion.
- assertion asSentence Survivin+knockdown+induced+morphological+features+of+neuronal+differentiation+in+neuroblastoma+cell+lines. assertion.
- assertion asSentence Sustained+levels+of+APP+and+the+elevated+levels+of+APLP2%2C+in+spite+of+the+reduced+mRNA+expression%2C+are+due+to+altered+proteolytic+processing+of+these+proteins. assertion.
- assertion asSentence APLP2%2FMHC+association+is+influenced+by+multiple+domains+of+the+MHC+class+I+heavy+chain+and+by+beta%282%29m%27s+effects+on+the+conformation+of+the+heavy+chain. assertion.
- assertion asSentence Translocation+of+cholesterol+and+phospholipid+into+the+cytosol+is+related+to+the+apo+A-I-mediated+HDL+assembly+in+astrocytes+through+functional+association+with+caveolin-1+and+a+cyclosporin+A-sensitive+cyclophilin+protein%28s%29. assertion.
- assertion asSentence Apo+A-I+mutations+cannot+be+firmly+establihed+in+samll+number+of+patients+with+severe+HDL+deficiency. assertion.
- assertion asSentence The+orphan+nuclear+receptor+liver+receptor+homolog-1+regulates+APOAI+transcription+and+affects+cholesterol+homeostasis. assertion.
- assertion asSentence The+protective+behavior+of+apo+A-I+against+vesicle+aggregation+and+cholesterol+nucleation+in+the+presence+of+phospholipase+C+%28PLC%29+depends+on+the+relative+concentrations+of+lipids+%28cholesterol+and+lecithin%29+and+proteins+%28apo+A-I+and+PLC%29. assertion.
- assertion asSentence Exhaustive+lysine+acetoacetylation+lowered+apoAI%27s+isoelectric+point%2C+profoundly+disrupted+its+secondary+and+tertiary+structure. assertion.
- assertion asSentence Amyloid+in+the+knee+joint+menisci+is+formed+from+Apo+A-I+that+is+produced+by+chondrocytes+within+the+meniscal+cartilage. assertion.
- assertion asSentence Liver+transplantation+in+a+patient+with+hereditary+variant+apolipoprotein+AI+%28apoAI%29+amyloidosis+associated+with+a+50%25+decrease+in+production+of+variant+apoAI. assertion.
- assertion asSentence Pathways+of+cholesterol+efflux+using+apoA-I+as+an+acceptor+make+a+predominant+contribution+to+cholesterol+export+from+macrophages+in+vivo. assertion.
- assertion asSentence Apolipoprotein+A-I+tryptophan+substitution+leads+to+resistance+to+myeloperoxidase-mediated+loss+of+function. assertion.
- assertion asSentence Levels+of+apo+A-I+and+apo+H+are+elevated+in+the+vitreous+fluid+of+diabetic+patients+and+a+higher+expression+of+apo+A-I+and+apo+H+mRNAs+exists+in+the+diabetic+retina. assertion.
- assertion asSentence Increased+ApoB%2FApoA-I+ratio+and+hs-CRP+levels+are+independently+associated+with+occurrence+of+IS+and+PAD+in+young+patients. assertion.
- assertion asSentence Major+effect+of+LY518674+on+the+production+and+clearance+of+apoA-I+and+high+density+lipoproteins+despite+no+change+in+the+plasma+concentration. assertion.
- assertion asSentence Increased+apoB%2FapoA-I+ratio+is+predictive+of+peripheral+arterial+disease+in+initially+healthy+58-year-old+men+during+8.9+years+of+follow-up. assertion.
- assertion asSentence Retinol-binding+protein+is+elevated+in+nondiabetic+stage+5+chronic+kidney+disease+and+correlates+weakly+with+HbA1c+and+ApoA1. assertion.
- assertion asSentence Very+low+density+lipoprotein+metabolism+and+plasma+adiponectin+as+predictors+of+high-density+lipoprotein+apolipoprotein+A-I+kinetics+in+obese+and+nonobese+men. assertion.
- assertion asSentence High+apoAI+is+associated+with+the+manifestation+of+asthma+and+atopy. assertion.
- assertion asSentence CETP+I405V+polymorphism+contributes+to+the+unfavorable+changes+of+apoA-I+and+HDL-C+in+a+low+polyunsaturated+fat+diet. assertion.
- assertion asSentence ApoB+and+ApoB%2FApoA-I+ratio+increased+in+adolescents+frequently+exposed+to+tobacco+smoke. assertion.