Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Accelerated+oxidative+damage+to+plasma+ApoA-1+in+patients+with+type+1+diabetes. assertion.
- assertion asSentence The+inter-helical+segment+%28residues+35-49%29+plays+a+role+in+the+adaptation+of+apoA-I+to+the+particle+size+of+HDL. assertion.
- assertion asSentence Adipocyte+recycling+of+apoA-I+is+a+selective+process+that+involves+the+ectopically+expressed+beta-subunit+of+ATP+synthase. assertion.
- assertion asSentence A+pair+of+amphipathic+alpha-helical+repeats+with+a+particular+insertion+topology+in+the+central+region+of+ApoA1+predicts+that+an+intermolecular%2C+deeply+located+Y-helix+bundle+penetrates+ApoA1+membrane+perpendicularly+to+the+membrane+surface. assertion.
- assertion asSentence Apolipoprotein+A1%2C+the+major+protein+of+sHDL%2C+forms+a+hollow+structure+that+cradles+a+central+compact+lipid+core. assertion.
- assertion asSentence Treatment+with+apoA-I+stabilized+atherosclerotic+plaques+and+prevented+plaque+rupture. assertion.
- assertion asSentence MPO+chlorinates+and+nitrates+specific+tyrosine+residues+of+apoA-I%2C+the+major+HDL+protein. assertion.
- assertion asSentence ApoA-II+adopts+a+beltlike+structure+in+which+the+protein+helices+wrap+around+the+lipid-+bilayer+reconstituted+high+density+lipoprotein+%28rHDL%29+disc. assertion.
- assertion asSentence ApoA-II+is+associated+with+a+decreased+risk+of+future+coronary+artery+disease+in+apparently+healthy+people%2C+implying+that+apoA-II+itself+exerts+effects+on+specific+antiatherogenic+pathways. assertion.
- assertion asSentence ApoA-II+plays+a+crucial+role+in+triglyceride+catabolism+by+regulating+lipoprotein+lipase+activity%2C+at+least+in+part%2C+through+HDL+proteome+modulation. assertion.
- assertion asSentence Apolipoprotein+A-II-mediated+conformational+changes+of+apolipoprotein+A-I+in+discoidal+high+density+lipoproteins. assertion.
- assertion asSentence HNF-4alpha+and+gamma+functionally+interact+with+a+second+hormone-responsive+element+present+in+the+proximal+region+of+the+human+apoA-IV+promoter. assertion.
- assertion asSentence Codon+9%2C+Msp+I+and+VNTR+polymorphisms+in+the+apo+A-IV+gene+are+associated+with+type-IV+hyperlipoproteinaemia+in+a+Chinese+population. assertion.
- assertion asSentence Red+wine+polyphenolics+down+regulate+the+production+of+chylomicron+and+apo+B48+in+intestinal+CaCo-2+cells. assertion.
- assertion asSentence APO+B+gene+polymorphism+is+strongly+related+to+the+incidence+of+coronary+artery+diseases+and+myocardial+infarction. assertion.
- assertion asSentence Overexpressed+human+apoB-100+protein+significantly+increases+the+level+of+serum+lipids+in+transgenic+mice%2C+leading+to+cerebrovascular+lesions+and+subsequently+induces+apoptosis+and+neurodegeneration. assertion.
- assertion asSentence ApoB+gene+is+predictive+factor+of+cardiocerebrovascular+diseases+in+elderly. assertion.
- assertion asSentence Glycated+apolipoprotein+B+is+associated+with+serum+triglycerides+in+both+diabetic+and+non-diabetic+subjects. assertion.
- assertion asSentence Increased+apoB%2FapoA-I+ratio+is+predictive+of+peripheral+arterial+disease+in+initially+healthy+58-year-old+men+during+8.9+years+of+follow-up. assertion.
- assertion asSentence Feedback+inhibition+of+hepatic+lipogenesis+in+conjunction+with+post-ER+degradation+of+misfolded+apoB+proteins+can+contribute+to+reduce+fat+accumulation+in+the+familial+hypobetalipoproteinemia+liver. assertion.
- assertion asSentence Human+granulosa+cells+assemble+and+secrete+apoB100-containing+lipoproteins. assertion.
- assertion asSentence Increased+level+and+content+of+sialic+acid+in+apoB-containing+lipoproteins+do+not+correlate+with+any+markers+of+alcohol+abuse+and+lipid+status+in+alcoholic+subjects. assertion.
- assertion asSentence Subcutaneous+infusion+of+adjuvant-free+human+ApoB100-derived+peptides+to+Apoe-%2F-+mice+reduces+atherosclerosis+through+the+induction+of+a+specific+Treg+cell+response. assertion.
- assertion asSentence Catechin+prevents+severe+dyslipidemia-associated+changes+in+wall+biomechanics+of+cerebral+arteries+in+LDLr-%2F-+hApoB%2B%2F%2B+mice+and+improves+cerebral+blood+flow. assertion.
- assertion asSentence Antisense+inhibition+of+apoB+synthesis+reduced+plasma+concentrations+of+apoC-III+and+apoC-III-containing+lipoproteins. assertion.
- assertion asSentence Knockdown+of+hepatocyte+aquaporin-8+by+RNA+interference+induces+defective+bile+canalicular+water+transport. assertion.
- assertion asSentence Aquaporin+8+has+a+role+in+intramembranous+water+transport+and+the+balance+of+amniotic+fluid. assertion.
- assertion asSentence The+ozone+oxidation+product+of+cholesterol%2C+3beta-hydroxy-5-oxo-5%2C6-secocholestan-6-al%2C+rapidly+promotes+human+apolipoprotein+%28apo%29+C-II+amyloid+fibril+formation+in+vitro. assertion.
- assertion asSentence Phospholipid+interaction+induces+molecular-level+polymorphism+in+APOC2+amyloid+fibrils+via+alternative+assembly+pathways. assertion.
- assertion asSentence APO+CIII+metabolism+is+disturbed+in+type+2+diabetes. assertion.
- assertion asSentence Expression+of+apoC-III+in+McA-RH7777+cells+enhances+hepatic+triacylglycerol-rich+VLDL+assembly+and+secretion+under+lipid-rich+conditions. assertion.
- assertion asSentence The+polymorphisms+C-482T+and+T-455C+in+APOC3+are+associated+with+nonalcoholic+fatty+liver+disease+and+insulin+resistance. assertion.
- assertion asSentence Altered+plasma+apoC-III+metabolism+is+a+feature+of+dyslipidemia+in+moderate+chronic+kidney+disease. assertion.
- assertion asSentence The+decrease+in+plasma+ApoD+concentration+during+pregnancy+is+an+adaptive+response+aimed+at+maintaining+fetal+lipid+homeostasis. assertion.
- assertion asSentence Apolipoprotein+E-epsilon+4+protects+against+severe+liver+disease+caused+by+hepatitis+C+virus. assertion.
- assertion asSentence APOE+isoproteins+are+inefficient+at+complexing+with+synthetic+Alzheimer+disease+amyloid-beta+protein+in+vitro. assertion.
- assertion asSentence Discontinuation+and+poor+adherence+to+therapy+with+statins+is+dependent+on+APO+E+genotype. assertion.
- assertion asSentence HFE+and+APOE+genotypes+are+different+between+Alzheimer%27s+disease+patients%2C+high+cognitive+impairment+and+low+cognitive+impairment+controls. assertion.
- assertion asSentence Lack+of+an+association+of+apolipoprotein+E+gene+polymorphisms+with+familial+age-related+macular+degeneration. assertion.
- assertion asSentence APOE+is+not+associated+with+the+risk+of+Alzheimer+disease. assertion.
- assertion asSentence Accelerated+memory+decline+in+Alzheimer%27s+disease+with+apolipoprotein+epsilon4+allele. assertion.
- assertion asSentence There+is+no+linkage+between+Apo+E+polymorphism+and+autism. assertion.
- assertion asSentence Chronic+anxiety+is+associated+with+significantly+greater+decline+in+problem+solving+skills+in+cognitively+normal+APOE+e4+homozygotes. assertion.
- assertion asSentence A+peptide+derived+from+the+low+density+lipoprotein+receptor-binding+domain+of+apoE+mediates+an+efficient%2C+energy-dependent+translocation+of+liposomes+across+the+membrane+of+primary+rat+brain+capillary+endothelial+cells. assertion.
- assertion asSentence Parkinson%27s+disease+patients+who+carry+the+APOE+epsilon4+allele+develop+psychosis+earlier. assertion.
- assertion asSentence The+increase+in+phospholipid+transfer+protein+lipid+transfer+protein+in+type+2+diabetes+is+partly+related+to+the+changes+in+apolipoprotein+E. assertion.
- assertion asSentence Significant+interaction+between+cholesterol%2C+APOE-epsilon4+and+the+risk+of+Alzheimer+disease+in+the+Yoruba. assertion.
- assertion asSentence ApoE+polymorphism+is+related+to+coronary+disease+in+the+Chinese+Han+population%2C+with+smoking+and+alcohol+drinking+increasing+the+genetic+predisposition+to+disease. assertion.
- assertion asSentence Intravenous+administration+of+AAV2%2F7-+and+AAV2%2F8-apoE+vectors+effectively+mediated+robust+and+sustained+hepatic-specific+expression+of+apoE+and+completely+prevented+atherosclerosis+at+1+year. assertion.
- assertion asSentence APOE+epsilon4%2B+%28epsilon4%2B%2Fepsilon4+%2B+or+epsilon4%2B%2Fepsilon4-%29+genotype+is+more+frequent+in+Alzheimer+disease+and+Lewy+body+dementia. assertion.
- assertion asSentence Apolipoprotein+E+epsilon4+allele+is+associated+with+Parkinson+disease+risk+in+a+Mexican+Mestizo+population. assertion.
- assertion asSentence In+patients+with+subarachnoid+hemorrhage%2C+the+expression+of+the+E4+allele+is+associated+with+a+higher+risk+of+a+negative+outcome+and+delayed+ischemia. assertion.
- assertion asSentence Overweight+exhibited+an+inverse+association+with+APOE4+and+associated+with+decreased+non-APOE4+Alzheimer%27s+disease+onset+age. assertion.
- assertion asSentence Hypertriglyceridemia+is+closely+associated+with+APOE%2A2+allele+and+with+an+early+onset+of+liver+cirrhosis. assertion.
- assertion asSentence APOE+has+an+influence+on+nonverbal+cognition+in+old+age+and+interacts+with+childhood+IQ+to+influence+processing+speed. assertion.
- assertion asSentence Impact+of+an+ApoE-deficient+diet+on+mice+expressing+human+ApoE2%2C+E3%2C+or+E4+allele+demonstrates+that+E2+is+more+protective+for+dietary+deficiency+than+murine+ApoE+or+E3+and+E4. assertion.
- assertion asSentence Cyclosporin+A+decreases+apolipoprotein+E+secretion+from+human+macrophages+via+a+protein+phosphatase+2B-dependent+and+ATP-binding+cassette+transporter+A1+%28ABCA1%29-independent+pathway. assertion.
- assertion asSentence The+presence+of+the+epsilon4+allele+increases+the+risk+for+CVE+and+cardiac+death+in+patients+with+T2DM+and+ESRD. assertion.
- assertion asSentence High+density+lipoproteins+%28HDL%29+apolipoproteins+A-I%2C+A-II+and+E+have+distinct+intracellular+and+post-secretory+pathways+of+hepatic+lipidation+and+dimerization+in+the+process+of+HDL+formation. assertion.
- assertion asSentence Healthy+individuals+the+broad+range+of+neurobiological+mechanisms+associated+with+APOE+is+consistent+with+effects+on+non-memory+cognitive+subsystems. assertion.
- assertion asSentence APOE+gene+polymorphism+influences+the+short-term+outcome+of+CSM+patients+after+surgical+decompressive+and+stabilizing+therapy+in+the+way+that+the+presence+of+the+APOE+epsilon4+allele+is+an+independent+predictor+for+a+no+improvement. assertion.
- assertion asSentence After+every+meal%2C+VLDL+fluidity+is+increased+causing+apoE4+into+a+more+expanded+conformation. assertion.
- assertion asSentence The+significance+of+the+temporal+order+of+MAPT+biomarker+abnormalities+in+Alzheimer+disease+correlates+with+hippocampal+volume+and+radial+distance+compared+with+apolipoprotein+E4+carriers+and+noncarriers. assertion.
- assertion asSentence The+cholesterol+transporters+apolipoprotein+E+%28APOE%29%2C+APOC1+and+APOJ+are+recognized+major+genetic+risk+factors+for+common+Alzheimer%27s+disease. assertion.
- assertion asSentence Renal+transplant+recipients+are+liable+to+develop+hyperlipidemia%2C+particularly+hypertriglyceridemia+among+recipients+with+ApoE+genotypes. assertion.
- assertion asSentence Young+adult+carriers+of+APOE+epsilon4+allele+have+lower+mitochondrial+cytochrome+oxidase+activity+than+noncarriers+in+posterior+cingulate+cortex. assertion.
- assertion asSentence Single+nucleotide+polymorphisms+are+found+in+APOepsilon4+associated+with+dementia+of+Alzheimer%27s+disease+in+subjects+with+Down+syndrome. assertion.
- assertion asSentence APOE4+allele+carriers+%28E4%2B%29+differed+significantly+from+E4-in+functional+connectivity+of+the+precuneus+to+several+brain+regions. assertion.
- assertion asSentence ApoE+epsilon4+allele+is+associated+with+a+twofold+increased+risk+of+developing+hypertension+in+Chinese. assertion.
- assertion asSentence APOE+rs439401+TT-genotype+is+associated+with+an+adverse+metabolic+profile+in+a+population+of+psychologically+stressed+Danish+men. assertion.
- assertion asSentence APOE+epsilon4+is+not+associated+with+significant+hippocampal%2C+hemispheric%2C+or+whole+brain+atrophy+in+patients+with+medically+intractable+temporal+lobe+epilepsy. assertion.
- assertion asSentence CV+risk+factors+influence+age-related+memory+decline+in+APOE+epsilon+4+homozygotes. assertion.
- assertion asSentence ApoE+signaling+via+VLDL-R+or+apoER2+promotes+macrophage+conversion+from+the+proinflammatory+M1+to+the+antiinflammatory+M2+phenotype. assertion.
- assertion asSentence In+ApoE+e4+carriers%2C+the+negative+association+between+the+ratio+of+campesterol+to+cholesterol+and+memory+reached+borderline+significance. assertion.
- assertion asSentence Polymorphism+within+the+ApoE+gene+is+associated+with+serum+LDL+cholesterol+in+postmenopausal+women+with+obesity+and+metabolic+syndrome. assertion.
- assertion asSentence Decreased+in-phase+connectivity+in+regions+of+the+posterior+default+mode+network+are+found+in+APOE+epsilon4+carriers+relative+to+APOE+epsilon4+noncarriers. assertion.
- assertion asSentence SIGMAR1+and+APOE+interact+to+influence+Alzheimer%27s+disease+severity+across+ethnic+populations. assertion.
- assertion asSentence Apolipoprotein+E2+mutation+is+associated+with+lipoprotein+glomerulopathy. assertion.
- assertion asSentence The+APOepsilon4+allele+enhances+electroencephalographic+abnormalities+at+the+early+stage+of+traumatic+brain+injury. assertion.
- assertion asSentence Mutations+in+apolipoprotein+E3+is+not+associated+with+its+structural+variation+and+type+III+hyperlipoproteinemia. assertion.
- assertion asSentence ApoE-containing+astrocyte+lipoproteins+exhibit+the+most+robust+interactions+with+Abeta. assertion.
- assertion asSentence LRP1+enables+apoE+to+accumulate+in+an+early+endosomal+recycling+compartment+that+serves+as+a+pool+for+the+intracellular+formation+and+subsequent+re-secretion+of+apoE-enriched+HDL+particles. assertion.
- assertion asSentence The+SNP+genotype+pattern+at+the+APOE+gene+is+associated+with+episodic+memory. assertion.
- assertion asSentence Prevalence+and+clinical+significance+of+anticardiolipin+and+anti-beta2-glycoprotein-I+antibodies+in+patients+with+non-Hodgkin%27s+lymphoma. assertion.
- assertion asSentence Women+with+high+serum+aCLbeta2GPI+titers+experienced+severe+maternal-fetal+complications. assertion.
- assertion asSentence Beta%282%29-GPI%2Fplasmin-nicked+beta%282%29-GPI+ratio+controls+extrinsic+fibrinolysis+via+a+negative+feedback+pathway+loop. assertion.
- assertion asSentence Anti-beta2GPI+antibodies+are+a+significant+risk+factor+for+myocardial+infarction+in+young+premenopausal+women+independently+of+other+risk+factors. assertion.
- assertion asSentence Levels+of+apo+A-I+and+apo+H+are+elevated+in+the+vitreous+fluid+of+diabetic+patients+and+a+higher+expression+of+apo+A-I+and+apo+H+mRNAs+exists+in+the+diabetic+retina. assertion.
- assertion asSentence Direct+binding+of+beta+2-glycoprotein+I+on+the+endothelial+cell+surface+occurs+through+direct+interaction+with+toll-like+receptor+TLR2. assertion.
- assertion asSentence Increased+complexes+of+beta%282%29-glycoprotein+I+with+lipoprotein%28a%29is+associated+with+coronary+artery+disease. assertion.
- assertion asSentence %5Breview%5D+Val%2FVal+genotype+of+beta2-GPI+gene+is+associated+with+antiphospholipid+syndrome+%28APS%29%2C+by+patients+with+APS%2C+with+production+of+anti-beta2-GPI+antibodies. assertion.
- assertion asSentence Insulin-degrading+enzyme+rapidly+removes+the+beta-amyloid+precursor+protein+intracellular+domain+%28AICD%29. assertion.
- assertion asSentence Munc18a+acts+through+direct+and+indirect+interactions+with+X11+proteins+and+powerfully+regulates+APP+metabolism+and+Abeta+secretion. assertion.
- assertion asSentence Presenilin+1+stabilizes+the+C-terminal+fragment%28C99%29+of+the+amyloid+precursor+protein+independently+of+gamma-secretase+activity. assertion.
- assertion asSentence A713T+in+Amyloid+A+Precursor+is+implicated+in+the+pathogenesis+of+Early+Onset+Alzheimer+Disease+. assertion.
- assertion asSentence An+APP+T174I+mutation+is+associated+with+early-onset+Alzheimer+disease+in+an+African+American+kindred. assertion.
- assertion asSentence Parenchymal+and+vascular+amyloid+deposits+in+the+cerebral+cortex+are+associated+with+a+different+array+of+Abeta+peptide+species. assertion.
- assertion asSentence Transfected+into+transgenic+mice%2C+involved+in+induction+of+tau+pathology%2C+making+the+interference+of+Abeta+oligomerization+a+valid+therapeutic+target+in+Alzheimer+disease. assertion.
- assertion asSentence alphaB-crystallin+competes+efficiently+for+Abeta+monomer-monomer+interactions. assertion.
- assertion asSentence GxxxG+motifs+within+the+amyloid+precursor+protein+transmembrane+sequence+are+critical+for+the+etiology+of+Abeta42. assertion.