Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Rab5+activation+via+amyloid+precursor+protein+signal+pathway+mediates+neuronal+apoptosis. assertion.
- assertion asSentence Stable+insertion+of+ABETA+peptide+into+the+ER+membrane+strongly+correlates+with+its+length. assertion.
- assertion asSentence Soluble+circulating+LRP+%28sLRP%29+provides+key+endogenous+peripheral+%27sink%27+activity+for+amyloid+beta+in+humans. assertion.
- assertion asSentence Exclusion+of+the+native+alpha-helix+from+the+amyloid+fibrils+of+a+mixerd+alpha%2Fbeta+protein. assertion.
- assertion asSentence Cellular+localization+of+Nicastrin+affects+amyloid+beta+species+production. assertion.
- assertion asSentence The+amyloid+beta+peptide+pattern+in+cerebrospinal+fluid+is+able+to+predict+Alzheimer%27s+disease+in+patients+with+mild+cognitive+impairment+with+a+sensitivity+of+91%25+and+specificity+of+64%25. assertion.
- assertion asSentence Androgen+regulation+of+Abeta+involves+an+androgen+receptor-dependent+mechanism+requiring+up-regulation+of+the+Abeta+catabolizing+enzyme+neprilysin. assertion.
- assertion asSentence CD147+expression+influences+Abeta+levels+by+an+indirect+mechanism+involving+MMPs+that+can+degrade+extracellular+Abeta. assertion.
- assertion asSentence Beta-amyloid+peptide+stimulates+endozepine+release+from+rat+astrocytes+through+an+N-formyl+peptide+receptor+positively+coupled+to+protein+kinase+A+and+protein+kinase+C. assertion.
- assertion asSentence Intracellular+Ass+accumulation+is+an+early+pathological+alteration+contributing+to+cell+death+in+Alzheimer%27s+disease. assertion.
- assertion asSentence Amyloid-beta+and+Tau+affected+aging-prone+astrocyte+cell+death%2C+metabolism+and+cytoskeleton. assertion.
- assertion asSentence BRI3+inhibits+the+various+processing+of+amyloid+protein+precursor+by+blocking+the+access+of+alpha-+and+beta-secretases. assertion.
- assertion asSentence Amyloid+beta+protein+up-regulates+CC-type+chemokine+receptor+5+%28CCR5%29+expression+and+promotes+T+cell+transendothelial+migration+via+receptor+for+advanced+glycation+end+products+%28RAGE%29+on+brain+endothelial+cells. assertion.
- assertion asSentence JNK+and+p38MAPK+inhibition+prevented+both+Abeta+1-40-mediated+down-regulation+of+occludin+and+the+increase+in+paracellular+permeability+in+hCMEC%2FD3+cells. assertion.
- assertion asSentence Amyloid+beta+peptides+trigger+CD47-dependent+mast+cell+secretory+and+phagocytic+responses. assertion.
- assertion asSentence Estrogen+stimulates+degradation+of+beta-amyloid+peptide+by+up-regulating+neprilysin. assertion.
- assertion asSentence Endothelial+APP+regulates+immune+cell+adhesion+and+stimulates+a+tyrosine+kinase-dependent+response+driving+acquisition+of+a+reactive+endothelial+phenotype. assertion.
- assertion asSentence In+mice+overexpressing+amyloid-beta+protein+precursor%2C+RhoA+decreases+in+synaptic+terminals+and+increases+in+dystrophic+neurites. assertion.
- assertion asSentence Morin+destabilizing+Abeta%2842%29+by+binding+to+the+ends+of+the+fibrils+to+block+the+attachment+of+an+incoming+peptide. assertion.
- assertion asSentence Beta-amyloid+1-40+induces+HIPK2+degradation+and+alters+HIPK2+binding+activity+to+DNA%2C+in+turn+regulating+the+p53+conformational+state+and+vulnerability+to+a+noxious+stimulus. assertion.
- assertion asSentence Abeta%2C+PrP+and+tau+all+play+a+role+in+the+neurodegenerative+process+via+their+connection+to+the+cell+cycle+and+cell+death. assertion.
- assertion asSentence The+effect+of+mevalonate+pathway+blockade+on+neurite+outgrowth+is+strikingly+enhanced+by+over-expression+of+human+amyloid+precursor+protein+in+cultured+neuroblastoma+cells. assertion.
- assertion asSentence Selective+translational+control+of+the+Alzheimer+amyloid+precursor+protein+transcript+by+iron+regulatory+protein-1. assertion.
- assertion asSentence Amyloid-beta+peptide+alteration+of+tau+exon-10+splicing+is+related+to+its+activation+of+GSK-3beta+which+in+turn+phosphorylates+SC35. assertion.
- assertion asSentence Soluble+Abeta42+peptide+can+invoke+non-pathological+and+anti-viral+effects+through+inactivation+of+an+HSV-1+challenge+to+human+brain+cells+by+simple+viral+sequestration%2C+viral+destruction%2C+or+by+complex+neurogenetic+mechanisms. assertion.
- assertion asSentence Amyloid+beta-induced+dysfunction+of+gap+junctional+communication+in+cultured+astrocytes+does+not+reflect+the+maintenance+of+dye+transfer+through+astrocytic+syncytial+networks+in+transgenic+mice. assertion.
- assertion asSentence Neurotoxicity+of+Alzheimer%27s+disease+Abeta+peptides+is+induced+by+small+changes+in+the+Abeta42+to+Abeta40+ratio. assertion.
- assertion asSentence MEGF10+is+involved+in+the+uptake+of+amyloid-beta+peptide+%28Abeta42%29+in+the+brain. assertion.
- assertion asSentence Upregulation+of+presenilin+%28PS%291+leads+to+Abeta+overproduction+and+accumulation+in+sporadic+Alzheimer%27s+disease. assertion.
- assertion asSentence Electroencephalography+readings%2C+locomotor+activity+and+sleep+architecture+are+abnormal+in+transgenic+amyloid-beta+protein+precursor+mice. assertion.
- assertion asSentence Abeta42+neurotoxicity+is+mediated+by+ongoing+nucleated+polymerization+process+rather+than+by+discrete+Abeta42+species. assertion.
- assertion asSentence Expression+of+Abeta%281-42%29+in+rat+motor+cortex+leads+to+an+increase+in+Tar+DNA-binding+protein+%28TDP%29-43+pathology+identical+to+the+pathological+changes+seen+in+Alzheimer%27s+disease. assertion.
- assertion asSentence Patients+with+mild+cognitive+impairment+and+low+Abeta42+peptide+fragment%2C+plus+high+tau+levels+in+the+cerebrospinal+fluid%2C+have+a+substantially+increased+risk+of+developing+Alzheimer%27s+disease%2C+even+after+adjustment. assertion.
- assertion asSentence Abeta+impairs+the+assembly+and+maintenance+of+the+mitotic+spindle. assertion.
- assertion asSentence The+Abeta42-induced+presenilin-1+%28PS1%29+increase+is+abolished+by+small+interfering+RNA+acetylcholinesterase+%28AChE%29+pretreatment%2C+demonstrating+its+participation+in+the+pathological+feedback+loop+between+PS1+and+Abeta. assertion.
- assertion asSentence Promoter+mutations+or+common+allelic+variation+in+the+AbetaPP+gene+do+not+have+a+major+contribution+to+cortical+or+cerebrovascular+Abeta+deposition%2C+or+very+late-onset+Alzheimer+disease. assertion.
- assertion asSentence Amyloid+beta-peptide+binds+to+the+extracellular+domain+of+neuroligin-1+with+a+K%28d%29+in+the+nanomolar+range. assertion.
- assertion asSentence Factors+that+control+initial+proteolysis+of+APP+at+the+epsilon-cutting+site+of+proteolytic+activity+apparently+differ+significantly+from+factors+affecting+subsequent+trimming+and+distribution+of+APP+beta-peptides. assertion.
- assertion asSentence Disordered+binding+of+small+molecules+to+Abeta%2812-28%29. assertion.
- assertion asSentence Regulation+of+the+amyloidbeta-induced+formation+of+autophagic+vacuoles+by+the+RAGE-calcium-CaMKKbeta-AMPK+pathway. assertion.
- assertion asSentence Amyloid-beta+is+differentially+implicated+in+Alzheimer%27s+disease+with+microbleeds+and+vascular+dementia. assertion.
- assertion asSentence The+carboxyl-terminal+fragment+Abeta%2839-42%29+inhibits+full-length+amyloidbeta-induced+toxicity+by+a+unique+mechanism%2C+modulating+early+assembly+into+nontoxic+hetero-oligomers%2C+without+preventing+fibril+formation. assertion.
- assertion asSentence Lacmoid+binds+Abeta%281-40%29+in+a+surfactant-like+manner+and+counteracts+the+formation+of+all+types+of+Abeta%281-40%29+and+Abeta%281-42%29+aggregates. assertion.
- assertion asSentence Influence+both+the+aggregation+and+disaggregation+of+amyloid-beta%281-40%29+peptide+by+sequestration+of+the+amyloid+beta+oligomers. assertion.
- assertion asSentence Amyloid+beta+production%2Faccumulation+in+the+retina+is+common+to+different+degenerative+retinal+pathologies. assertion.
- assertion asSentence Biochemical+inhibition+of+the+acetyltransferases+ATase1+and+ATase2+reduces+beta-secretase+%28BACE1%29+levels+and+Abeta+generation. assertion.
- assertion asSentence Soluble+amyloid+precursor+protein-alpha+modulates+BACE1+activity+and+amyloid-beta+generation. assertion.
- assertion asSentence Due+to+the+K16N+mutation+APP+secretion+is+affected+and+a+higher+amount+of+Abeta+peptides+is+being+produced. assertion.
- assertion asSentence Specific+soluble+oligomers+of+amyloid-beta+peptide+undergo+replication+and+form+non-fibrillar+aggregates+in+interfacial+environments. assertion.
- assertion asSentence BRICHOS+domains+efficiently+delay+fibrillation+of+amyloid+beta-peptide. assertion.
- assertion asSentence Molecular+basis+of+beta-amyloid+oligomer+recognition+with+a+conformational+antibody+fragment. assertion.
- assertion asSentence PSA+has+a+functional+role+in+the+progression+of+prostate+cancer+through+their+promotion+of+tumour+cell+migration. assertion.
- assertion asSentence Human+seminal+proteinase+and+prostate-specific+antigen+are+identical+proteins. assertion.
- assertion asSentence PSA-RP2+is+upregulated+in+prostate+cancer+compared+with+benign+prostatic+hyperplasia+tissues. assertion.
- assertion asSentence The+serum+PSA+level+correlates+directly+with+age+in+Chinese+men+older+than+40+years%2C+not+in+Chinese+men+younger+than+40+years+old. assertion.
- assertion asSentence Kallikrein-related+peptidase+3+single+nucleotide+polymorphisms+is+associated+with+ovarian+cancer. assertion.
- assertion asSentence Butyrate+induced+apoptosis+via+the+Fas%2FFas+L+system+and+potentiated+Fas-triggered+apoptosis+in+MCF-7+cells. assertion.
- assertion asSentence Mature+dendritic+cells+are+protected+from+Fas%2FCD95-mediated+apoptosis+by+upregulation+of+Bcl-X%28L%29. assertion.
- assertion asSentence Caspase-10+is+recruited+to+and+activated+at+the+native+CD95+death-inducing+signalling+complex+in+a+FADD-dependent+manner. assertion.
- assertion asSentence Dysfunction+of+the+Fas+apoptotic+signaling+pathway+in+persistent+polyclonal+B-cell+lymphocytosis. assertion.
- assertion asSentence Increased+expression+of+Fas+antigen+on+CD4%2B+subset+and+increased+serum+sFas+level+are+valuable+markers+of+clinical+activity+in+multiple+sclerosis. assertion.
- assertion asSentence Expression+of+a+functional+Fas+death+receptor+by+human+foetal+motoneurons. assertion.
- assertion asSentence The+Fas+signal+mediates+transcription+of+IL-10+in+Jurkat+cells+upon+contact+with+glioma+cells+via+a+protein+kinase+A-independent+pathway. assertion.
- assertion asSentence There+is+no+significant+contribution+of+common+genetic+Fas+variants+to+the+genetic+risk+of+developing+Hashimoto%27s+thyroiditis+or+Graves%27+disease. assertion.
- assertion asSentence Deoxycholate+induces+apoptosis+in+colon+cancer+cell+lines+via+a+CD95+receptor-independent+mechanism. assertion.
- assertion asSentence Ability+of+Hsp72+to+inhibit+Fas-mediated+apoptosis+is+limited+to+type+II+cells+where+involvement+of+the+intrinsic+pathway+is+required+for+efficient+effector+caspase+activation. assertion.
- assertion asSentence The+A%28-670%29G+polymorphisms+in+the+promoter+region+of+Fas+and+high+levels+of+sFas+are+associated+with+the+presence+of+anti-ganglioside+antibodies+in+Guillain-Barre+syndrome. assertion.
- assertion asSentence Expression+of+P-glycoprotein+does+not+induce+resistance+to+caspase-8+and+-3+activation+or+anti-Fas-induced+cell+apoptosis. assertion.
- assertion asSentence C-FLIP+confers+Tax-mediated+resistance+toward+CD95-mediated+apoptosis. assertion.
- assertion asSentence Fas+ligation+suppresses+CD3%2FCD28-initiated+NF-kappaB+activity+by+decreasing+the+levels+of+the+NF-kappaB+p65+subunit+through+a+caspase-dependent+mechanism. assertion.
- assertion asSentence CD95+alters+NOSI+expression+to+contribute+to+diabetic+gastroparesis. assertion.
- assertion asSentence Patients+with+active+and+inactive+juvenile-onset+systemic+lupus+erythematosis+have+a+different+profile+of+Fas+and+Bcl-2+expression. assertion.
- assertion asSentence The+frequent+expression+and+coexpression+of+Fas%2C+FasL+and+c-FLIP+in+colorectal+carcinoma+implicates+c-FLIP+as+an+inhibitor+of+the+Fas-FasL-induced+death+pathway+in+these+tumours. assertion.
- assertion asSentence Paeoniflorin+inhibits+A549+cell+proliferation+via+Fas%2FFasL+apoptosic+pathway. assertion.
- assertion asSentence Resistance+to+Ara-c+up-regulates+FAS+activity. assertion.
- assertion asSentence Cytochrome+C+up-regulates+expressions+of+fas+to+induce+apoptosis+of+HL-60+cells. assertion.
- assertion asSentence In+transgenic+mice+with+mutations+in+the+Fas%2FFasL+pathways%2C+impaired+function+of+memory+CD8%2B+T+cells+increases+their+susceptibility+to+recurrent%2Flatent+infections. assertion.
- assertion asSentence A+functional+link+between+HuR+as+repressor+of+alternative+Fas+splicing+and+the+molecular+mechanisms+modulating+programmed+cell+death. assertion.
- assertion asSentence Up-regulation+of+Fas+expression+in+CD8%2B+T+cells+is+related+to+increased+apoptosis+of+circulating+CD8%2B+T+cells+in+patients+with+gastric+cancer. assertion.
- assertion asSentence There+is+an+association+of+a+Fas+Antigen+%28Fas%29-670+%28A%2FG%29+gene+polymorphism+with+the+risk+of+cervical+cancer+in+a+North+Indian+population. assertion.
- assertion asSentence Fas+undergoes+a+change+in+its+functionality+in+oxaliplatin-resistant+cells+inducing+survival+pathways+instead+of+apoptotic+signals. assertion.
- assertion asSentence The+combination+of+FK228+and+FU+can+up-regulate+the+Fas+mRNA+level+in+hepatoma+cell+lines. assertion.
- assertion asSentence Interference+with+Puma+induction+or+expression+of+MCL1+or+BCL2+significantly+reduced+both+glucocorticoid-+and+FAS-induced+cell+death+in+p16INK4A-reconstituted+leukemia+cells. assertion.
- assertion asSentence The+FAS+-670A%3EG+polymorphism+plays+a+role+in+limited+cutaneous+systemic+sclerosis+susceptibility. assertion.
- assertion asSentence miR-200c+sensitizes+cells+to+apoptosis+mediated+by+CD95. assertion.
- assertion asSentence Polymorphisms+of+FAS+is+associated+with+nasopharyngeal+carcinoma. assertion.
- assertion asSentence The+elevations+of+IL-18+and+sFas%28Apo%2F1-CD95%29+serum+concentrations+in+SLE+patients+are+significantly+correlated. assertion.
- assertion asSentence Stable+over-expression+of+extrinsic+Fas+gene+can+significantly+ameliorate+the+sensitivity+to+Fas-mediated+apoptosis+in+human+malignant+T-cell. assertion.
- assertion asSentence Celastrol+can+induce+apoptosis+of+human+non-small-cell+lung+cancer+A549+cells+through+activation+of+both+mitochondria-+and+Fas%2FFasL-mediated+pathways. assertion.
- assertion asSentence Sialylation+of+the+Fas+death+receptor+by+ST6Gal-I+provides+protection+against+Fas-mediated+apoptosis+in+colon+carcinoma+cells. assertion.
- assertion asSentence The+Ret+oncoprotein+exerts+opposing+controls+on+Fap-1+and+CD95%2C+increasing+Fap-1+expression+and+decreasing+CD95+cell+surface+expression. assertion.
- assertion asSentence Overexpression+of+gastrokine+1+in+gastric+cancer+cell+lines+stimulates+the+expression+of+the+Fas+receptor. assertion.
- assertion asSentence Functional+variant+in+the+core+promoter+of+the+CD95+cell+death+receptor+gene+is+associated+with+acute+promyelocytic+leukemia. assertion.
- assertion asSentence The+interaction+of+LC3B+and+Fas+pathways+requires+cav-1. assertion.
- assertion asSentence High+IL-7+concentration+can+prime+resting+B+cells+to+CD95-mediated+apoptosis+via+an+indirect+mechanism. assertion.
- assertion asSentence Apoptosis+markers+sFas%2C+FasL+or+sFas%2FFasL+ratio+are+associated+with+high+sequential+organ+failure+assessment+score+%28SOFA%29+in+bacteremia. assertion.
- assertion asSentence ATG-induced+apoptosis+in+T+cells+involves+both+Fas+and+TNF+pathways+and+TNF-alpha+is+produced+much+earlier+than+Fas+and+FasL+expression. assertion.
- assertion asSentence Supernatants+from+T+cell+blasts%2C+pulse-stimulated+with+phytohemagglutinin+contained+FasL+expressed+on+microvesicles+. assertion.
- assertion asSentence Effect+of+hibuscus+polyphenol+extracs+in+human+gastric+carcinoma+cells+is+mediated+via+p53+signaling+and+p38+MAPK%2FFasL+cascade+pathway. assertion.
- assertion asSentence FASL+polymorphisms+contribute+to+susceptibility+of+lung+cancer. assertion.