Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Nox1+knockdown+led+to+a+loss+of+directional+migration+which+takes+place+through+a+RhoA-dependent+alpha2%2Falpha3+integrin+switch. assertion.
- assertion asSentence RhoA+regulates+the+induction+of+alpha-smooth+muscle+actin+expression+during+epithelial+to+mesenchymal+transition. assertion.
- assertion asSentence In+intestinal+crypt+cells%2C+integrin+alpha8beta1+is+closely+involved+in+the+regulation+of+adhesion%2C+migration+and+cell+proliferation+via+a+predominant+RhoA%2FROCK-dependent+mechanism. assertion.
- assertion asSentence In+amyloid-beta+protein+precursor+mice%2C+RhoA+appears+sequestered+by+neurofibrillary+tangles+and+hyper-phosphorylated+tau+inclusions. assertion.
- assertion asSentence Mechanical+stimulation+of+the+cytoskeleton+and+Rho+activation+are+key+upstream+events+in+mechanotransduction-associated+alveolar+epithelial+cell+differentiation. assertion.
- assertion asSentence Smad3+regulates+RhoA+activation+and+cytoskeletal+reorganization+by+controlling+NET1+in+TGF-beta1-induced+ARPE-19+cells. assertion.
- assertion asSentence The+TNF-alpha-induced+activation+of+the+ERK%2FGEF-H1%2FRhoA+pathway+in+tubular+cells+is+mediated+through+Src-+and+TACE-dependent+EGFR+activation. assertion.
- assertion asSentence RhoA%2FRho+kinase+regulation+by+Notch+signaling+in+endothelial+cells+triggers+a+senescence+phenotype+associated+with+endothelial+barrier+dysfunction. assertion.
- assertion asSentence Existence+of+a+functional+Net1%2FRhoA+signaling+pathway+within+the+nucleus+of+the+cell+and+this+implicates+them+in+the+DNA+damage+response. assertion.
- assertion asSentence The+RhoA%2FROCK+signal+pathway+modulates+the+TLR-2-mediated+secretion+of+chemokines+in+rheumatoid+arthritis+fibroblast-like+synoviocytes. assertion.
- assertion asSentence RhoA+signaling+mediates+plasticity+of+scirrhous+gastric+carcinoma+motility. assertion.
- assertion asSentence RHOA+overexpression+correlates+with+progression+of+non-small+cell+lung+cancer. assertion.
- assertion asSentence Lipopolysaccharide-induced+ICAM-1+synthesis+in+human+umbilical+vein+endothelial+cells+is+regulated+by+GEF-H1%2FRhoA-dependent+signaling+pathway+via+activation+of+p38+and+NF-kappaB. assertion.
- assertion asSentence Protein+kinase+D+regulates+RhoA+activity+via+phosphorylation+rhotekin+at+Ser-435. assertion.
- assertion asSentence Histone+deacetylase+1+represses+the+small+GTPase+RhoB+expression+in+human+nonsmall+lung+carcinoma+cell+line. assertion.
- assertion asSentence WISP3+and+RhoC+genes+expression+status+defines+a+molecular+signature+of+inflammatory+breast+cancer+%28IBC%29. assertion.
- assertion asSentence A+p27%28kip1%29-binding+protein%2C+p27RF-Rho%2C+promotes+cancer+metastasis+via+activation+of+RhoA+and+RhoC. assertion.
- assertion asSentence p38gamma+mitogen-activated+protein+kinase+regulates+breast+cancer+cell+motility+and+metastasis%2C+in+part%2C+by+controlling+expression+of+the+metastasis-associated+small+GTPase+RhoC. assertion.
- assertion asSentence RhoE+inhibits+4E-BP1+phosphorylation+and+eIF4E+function+impairing+cap-dependent+translation. assertion.
- assertion asSentence The+activation+of+RhoG+recruits+its+effector+ELMO2+and+a+Rac+GEF+Dock4+to+form+a+complex+with+EphA2+at+the+tips+of+cortactin-rich+protrusions+in+migrating+breast+cancer+cells. assertion.
- assertion asSentence A+network+consisting+of+ezrin%2C+RhoGDI1%2C+RhoA%2C+F-actin+and+membrane+proteins+functions+to+influence+the+modifications+that+occur+on+the+membrane+of+the+sperm+head+during+human+sperm+capacitation. assertion.
- assertion asSentence RhoH+plays+a+critical+role+in+prosurvival+chronic+lymphocytic+leukemia+cell-cell+and+cell-microenvironment+interactions+with+this+agent. assertion.
- assertion asSentence The+alpha3+subunit+is+expressed+in+every+terminally+differentiated+ganglionic+cell%2C+this+is+the+first+example+of+a+%22pan-autonomic%22+gene+whose+expression+is+regulated+by+PHOX2+proteins. assertion.
- assertion asSentence PHOX2A+and+PHOX2B+genes+are+highly+co-expressed+in+human+neuroblastoma. assertion.
- assertion asSentence The+G+proteins+Arl3+acts+in+a+GTP-dependent+manner+as+allosteric+release+factors+for+farnesylated+cargo. assertion.
- assertion asSentence The+role+of+ARNT%2FHIF1beta+and+altered+gene+expression+in+impaired+beta+cell+function+and+the+pathogenesis+of+human+type+2+diabetes. assertion.
- assertion asSentence Subtypes+of+VHL+mutations+support+an+intermediate+level+of+HIF-1alpha+and+HIF-2alpha+regulation+via+a+remnant+VBC+complex. assertion.
- assertion asSentence Crystal+structures+of+the+heterodimer+formed+by+the+C-terminal+PAS+domains+from+the+HIF2alpha+and+ARNT+subunits+of+the+HIF2+transcription+factor%2C+both+in+the+absence+and+presence+of+an+artificial+ligand. assertion.
- assertion asSentence The+expression+of+miR-101+is+also+modulated+at+different+physiological+conditions%2C+such+as+androgen+stimulation+and+HIF-1alpha%2FHIF-1beta+induction. assertion.
- assertion asSentence The+homozygote+variant+genotype+of+AHR+Lys554Lys+is+associated+with+a+significantly+lower+AHR%2C+ARNT+and+CYP1B1+mRNA+expression. assertion.
- assertion asSentence The+regulators+of+clock-controlled+transcription+PER2%2C+CRY1+and+CRY2+differ+in+their+capacity+to+interact+with+each+single+component+of+the+BMAL1-CLOCK+heterodimer+and%2C+in+the+case+of+BMAL1%2C+also+in+their+interaction+sites. assertion.
- assertion asSentence Regulation+of+arrestin-3+phosphorylation+by+casein+kinase+II. assertion.
- assertion asSentence The+A189+V+FSHR+stably+expressed+in+HEK293N+cells+provoked+ERK+MAP+kinases+phosphorylation+through+beta-arrestins%2C+independently+of+the+canonical+cAMP%2FPKA+pathway. assertion.
- assertion asSentence Neurotensin+triggers+dopamine+D2+receptor+desensitization+through+a+protein+kinase+C+and+beta-arrestin1-dependent+mechanism. assertion.
- assertion asSentence The+beta-arrestin+pathway-selective+type+1A+angiotensin+receptor+%28AT1A%29+agonist+%5BSar1%2CIle4%2CIle8%5Dangiotensin+II+regulates+a+robust+G+protein-independent+signaling+network. assertion.
- assertion asSentence Arrestin2+and+arrestin3+in+striatal+homogenates+bind+to+the+third+cytoplasmic+loop+of+the+D2+receptor. assertion.
- assertion asSentence Agonist-controlled+association+and+dissociation+of+beta-arrestins+from+prephosphorylated+receptors+should+permit+rapid+control+of+receptor+sensitivity. assertion.
- assertion asSentence RACK1+and+beta-arrestin+compete+to+sequester+distinct+%27pools%27+of+PDE4D5. assertion.
- assertion asSentence Agonist-selective%2C+receptor-specific+interaction+of+human+P2Y+receptors+with+beta-arrestin-1+and+-2. assertion.
- assertion asSentence %7Bbeta%7D-Arrestin-2+Mediates+Anti-apoptotic+Signaling+through+Regulation+of+BAD+Phosphorylation. assertion.
- assertion asSentence Beta-Arrestins+play+a+negative+regulatory+role+in+hydroegn+peroxide-induced+apoptosis+signaling+through+associating+with+ASK1+and+CHIP+and+facilitating+ASK1+degradation. assertion.
- assertion asSentence Over-expression+of+TXNRD2%2C+COMT+and+ARVCF+affects+incentive+learning+and+working+memory+in+transgenic+mice. assertion.
- assertion asSentence A+mechanism+through+which+genistein+promotes+sphingolipid+metabolism+and+support+a+role+for+ASAH1+in+breast+cancer+cell+growth. assertion.
- assertion asSentence The+expression+of+HIOMT+in+epithelial+cells+of+striated+ducts+in+human+submandibular+glands. assertion.
- assertion asSentence TRC40%2FAsna-1+interacts+posttranslationally+with+tail-anchored+proteins+in+a+transmembrane+domain-dependent+manner+for+delivery+to+a+proteinaceous+receptor+at+the+endoplasmic+reticulum+membrane. assertion.
- assertion asSentence Asna1+can+mediate+membrane+insertion+of+RAMP4+and+Sec61beta+without+the+participation+of+other+cytosolic+proteins+by+a+mechanism+that+depends+on+the+presence+of+ATP+or+ADP+and+a+protease-sensitive+receptor+in+the+endoplasmic+reticulum+membrane. assertion.
- assertion asSentence Asna1+is+required+for+efficient+histocompatibility+%28HLA%29+class+I+downregulation+mediated+by+viral+protein+BNLF2a. assertion.
- assertion asSentence Under+mild+heating+conditions%2C+purified+antithrombin+London+recruited+WT+monomers+into+growing+polymers%2C+reducing+the+anticoagulant+activity. assertion.
- assertion asSentence ATF1+plays+an+important+role+in+the+trans-activation+of+the+MHC+class+II+trans-activator+%28CIITA%29+promoter+III+in+B+cells. assertion.
- assertion asSentence Initial+increase+in+RNA+pol+II+%28RNA+polymerase+II%29+binding+to+the+promoter+and+in+the+transcription+rate+from+the+ATF3+gene. assertion.
- assertion asSentence Activating+transcription+factor+3+activates+p53+by+preventing+E6-associated+protein+from+binding+to+E6. assertion.
- assertion asSentence The+loss+of+the+major+reactive+oxygen+species+scavenger%2C+glutathione%2C+during+SAIS+directly+correlates+with+an+increase+in+the+expression+of+activating+transcription+factor+3. assertion.
- assertion asSentence PHD-dependent+oxygen-sensing+recruits+both+the+hypoxia-inducible+factor+%28HIF%29+and+ATF-4+systems. assertion.
- assertion asSentence The+ATF4-mediated+up-regulation+of+Ape1+and+other+genes+plays+a+key+role+against+arsenite-mediated+toxicity+and+mutagenesis. assertion.
- assertion asSentence TFIIA+gamma+together+with+ATF4+and+Runx2+stimulates+osteocalcin+promoter+activity+and+endogenous+mRNA+expression. assertion.
- assertion asSentence TRIF-mediated+signals+from+toll-like+receptors+selectively+attenuate+translational+activation+of+ATF4+and+its+downstream+target+gene+CHOP. assertion.
- assertion asSentence ATF4+has+a+key+role+in+the+regulation+of+autophagy+in+response+to+ER+stress+and+is+a+direct+link+between+endoplasmic+stress+response+and+autophagic+machinery. assertion.
- assertion asSentence Coexistence+of+PHD1+stabilized+ATF4%2C+as+opposed+to+the+destabilization+of+ATF4+by+PHD3. assertion.
- assertion asSentence ATF4+facilitated+multidrug+resistance+in+gastric+cancer+cells+through+direct+binding+to+the+SIRT1+promoter. assertion.
- assertion asSentence Polymorphisms+of+reduced+folate+carrier%2Caminoimidazole+carboxamide+ribonucleotide+transformylase%2Cand+thymidylate+synthase+genes+contribute+to+the+therapeutic+response+in+rheumatoid+arthritis+patients+to+methotrexate. assertion.
- assertion asSentence ATM+mutations+in+Finnish+breast+cancer+patients. assertion.
- assertion asSentence Aberrant+methylation+of+the+ATM+promoter+correlates+with+increased+radiosensitivity+in+a+human+colorectal+tumor+cell+line. assertion.
- assertion asSentence ATM+protein+plays+a+critical+role+in+the+signal+transduction+of+cell+cycle+checkpoint%2C+the+repair+of+damaged+DNA+and+the+apoptosis. assertion.
- assertion asSentence ATM+is+involved+in+histone+acetylation-mediated+gene+regulation. assertion.
- assertion asSentence Hexavalent+chromium-induced+activation+of+ATM+involves+the+formation+of+S+phase-dependent+double+stranded+breaks. assertion.
- assertion asSentence Chk2+activity+is+triggered+by+a+greater+number+of+double+strand+breaks%2C+implying+that%2C+below+a+certain+threshold+level+of+lesions%2C+DNA+repair+can+occur+through+ATM%2C+without+enforcing+Chk2-dependent+checkpoints. assertion.
- assertion asSentence Reduced+ATM+expression+in+breast+carcinomas+correlated+with+tumor+differentiation+and+increased+microvascular+parameters%2C+supporting+its+role+in+neoangiogenesis+and+tumor+progression+in+breast+carcinogenesis. assertion.
- assertion asSentence Plk3+is+in+a+pathway+linking+ATM%2C+Plk3%2C+Chk2%2C+Cdc25C+and+Cdc2+in+cellular+response+to+DNA+damage. assertion.
- assertion asSentence Heterozygous+mutations+within+the+ATM+gene+are+associated+with+the+risk+of+breast+cancer. assertion.
- assertion asSentence Wip1+phosphatase+is+an+integral+component+of+an+ATM-dependent+signaling+pathway. assertion.
- assertion asSentence Lead+contamination+generates+late+unrepairable+double+strand+breaks+that+impact+upon+the+ATM-dependent+stress+signaling+pathway+by+favoring+propagation+of+errors. assertion.
- assertion asSentence Polymorphisms+within+the+ATM+gene+are+associated+with+increased+risk+of+chromosomal+damage+due+to+polycyclic+aromatic+hydrocarbon+exposure. assertion.
- assertion asSentence Common+9+bp+deletion+in+the+ataxia-telangiectasia-mutated+gene+is+not+associated+with+oral+cancer. assertion.
- assertion asSentence Phosphorylation+of+tyrosyl-DNA+phosphodiesterase+%28TDP1%29+at+serine81+is+mediated+by+the+protein+kinases+ataxia-telangiectasia-mutated+%28ATM%29+and%2For+DNA-dependent+protein+kinase+%28DNA-PK%29. assertion.
- assertion asSentence 53BP1+promotes+ATM+activity+through+direct+interactions+with+the+MRN+complex. assertion.
- assertion asSentence Increased+ATM+expression+is+associated+with+colorectal+tumor+progression. assertion.
- assertion asSentence Inhibition+of+topo+II+induces+ATM+to+phosphorylate+selected+targets+that+contribute+to+a+G2+arrest+independently+of+DNA+damage. assertion.
- assertion asSentence Interaction+between+BRCA1%2FBRCA2+and+ATM%2FATR+associate+with+breast+cancer+susceptibility. assertion.
- assertion asSentence ATM+prevents+RNA+polymerase+II+elongation-dependent+chromatin+decondensation+at+regions+distal+to+DNA+double-strand+breaks. assertion.
- assertion asSentence Polymorphisms+of+the+ataxia+telangiectasia+mutated+gene+is+associated+with+breast+cancer. assertion.
- assertion asSentence ATM+executes+essential+functions+outside+the+nucleus+in+response+to+DNA+double-stranded+breaks. assertion.
- assertion asSentence Ataxia+telangiectasia+mutated+gene+polymorphisms+are+associated+with+colorectal+adenomas. assertion.
- assertion asSentence Phosphorylation+of+Rad50+plays+a+key+regulatory+role+as+an+adaptor+for+specific+ATM-dependent+downstream+signaling+through+SMC1+for+DNA+repair+and+cell+cycle+checkpoint+control+in+the+maintenance+of+genome+integrity. assertion.
- assertion asSentence Loss+of+ATM+gene+is+associated+with+chronic+lymphocytic+leukemia. assertion.
- assertion asSentence ATM+and+PCNA+physically+interact+both+in+vivo+and+in+vitro. assertion.
- assertion asSentence ATM+phosphorylates+a+subset+of+its+substrates+for+proper+repair+control+without+exogenous+damage. assertion.
- assertion asSentence Hath1+is+one+of+the+transcriptional+regulators+for+MUC6+and+MUC5AC+in+gastric+cancer+cells. assertion.
- assertion asSentence In+the+chimeric+environment%2C+genotypically+wild-type+cells+that+possess+Math1+have+the+competence+to+differentiate+into+hair+cells+by+providing+appropriate+environmental+interactions. assertion.
- assertion asSentence Adult+Atoh1-conditional+knock-out+mice+are+behaviorally+deaf%2C+have+diminished+auditory+brainstem+responses+and+disrupted+auditory+nuclei+morphology. assertion.
- assertion asSentence Conserved+residues+modulate+copper+release+in+human+copper+chaperone+Atox1. assertion.
- assertion asSentence Inhibition+of+phosphorylation+of+na%2B%2Ck%2B-ATPase+by+mutations+causing+familial+hemiplegic+migraine. assertion.
- assertion asSentence An+interaction+between+agrin+and+alpha3-Na%2BK%2B-ATPase+is+of+functional+importance+in+newly+generated+neurons+in+the+adult+olfactory+bulb. assertion.
- assertion asSentence Retinoschisin%2C+the+protein+involved+in+the+pathogenesis+of+X-linked+juvenile+retinoschisis%2C+membrane+association+is+severely+impaired+in+the+absence+of+ATP1A3+and+ATP1B2. assertion.
- assertion asSentence The+coexistence+of+SERCA1+and+-2%2C+together+with+complex+mixtures+of+MyHCs+in+most+of+the+fibers+provide+the+human+EOMs+with+a+unique+molecular+portfolio+that+allows+a+highly+specific+fine-tuning+regimen+of+contraction+and+relaxation. assertion.
- assertion asSentence ATP2A2+mutation+found+in+a+patient+with+severe+Darier+disease. assertion.
- assertion asSentence Increased+skeletal+muscle+SR+ATPase+activity+contributes+to+reduced+exercise+tolerance+in+CHF+patients. assertion.
- assertion asSentence The+primary+role+of+SERCA2b+in+this+process+is+to+act+as+a+Ca%282%2B%29+sensor+in+the+vicinity+of+active+translocons%2C+integrating+protein+folding+with+local+fluctuations+of+ER+Ca%282%2B%29+levels. assertion.
- assertion asSentence Polymorphism+near+the+ATP2B1+gene+is+associated+with+hypertension+risk+in+East+Asians. assertion.
- assertion asSentence PMCA4+is+strongly+expressed+in+rabbit+CE+and+its+immunolocalization+exhibits+marked+changes+in+distribution+during+the+wound+healing+process. assertion.
- assertion asSentence Gastric+H%2B%2FK%2B-ATPase+activities+are+not+associated+with+H+pylori+status+in+patients+with+chronic+gastritis. assertion.