Matches in Nanopublications for { ?s <http://purl.org/nanopub/x/asSentence> ?o ?g. }
- assertion asSentence Higher+levels+of+ATP5a1+expression+are+associated+with+certain+Single+Nucleotide+Polymorphisms+and+with+TP53+mutation. assertion.
- assertion asSentence Nitration+of+tyrosine+residues+368+and+345+in+the+beta-subunit+elicits+FoF1-ATPase+activity+loss. assertion.
- assertion asSentence Neurologic+sparing+in+untreated+occipital+horn+syndrome+is+associated+with+approximately+30%25+residual+functional+activity+of+ATP7A. assertion.
- assertion asSentence Role+of+glutaredoxin1+and+glutathione+in+regulating+the+activity+of+the+copper-transporting+P-type+ATPases%2C+ATP7A+and+ATP7B. assertion.
- assertion asSentence Clusterin+and+COMMD1+independently+regulate+degradation+of+the+mammalian+copper+ATPases+ATP7A+and+ATP7B. assertion.
- assertion asSentence ATP7A+overexpression+played+an+important+role+in+platinum-resistance+of+non-small+cell+lung+cancer. assertion.
- assertion asSentence Frameshift+and+nonsense+mutations+in+the+gene+for+ATPase7B+are+associated+with+severe+impairment+of+copper+metabolism+and+with+an+early+clinical+manifestation+of+Wilson%27s+disease. assertion.
- assertion asSentence Receptors+of+copper+from+HAH1+protein. assertion.
- assertion asSentence Apical+targeting+and+Golgi+retention+signals+reside+within+a+9-amino+acid+sequence+in+the+copper-ATPase%2C+ATP7B. assertion.
- assertion asSentence Several+different+mutations+are+demonstrated+in+the+Wilson+disease+gene+ATP7B. assertion.
- assertion asSentence Clusterin+%28apolipoprotein+J%29%2C+a+molecular+chaperone+that+facilitates+degradation+of+the+copper-ATPases+ATP7A+and+ATP7B. assertion.
- assertion asSentence Polyglutamine-expanded+proteins+strongly+activated+ATR. assertion.
- assertion asSentence ATR-p53+pathway+is+suppressed+in+noncycling+lymphocytes+via+ATR+downregulation. assertion.
- assertion asSentence ATRIP+is+required+for+ATR+accumulation+at+intranuclear+foci+induced+by+DNA+damage. assertion.
- assertion asSentence The+ATR+protein+Deltap53+is+an+essential+element+of+the+ATR-intra-S+phase+checkpoint. assertion.
- assertion asSentence ATR+is+activated+in+a+variety+of+replication-linked+DNA+double-strand+breaks+from+ionizing+radiation+and+leads+to+activation+of+checkpoints+in+a+checkpoint+kinase+%28Chk%291-dependent+manner. assertion.
- assertion asSentence An+important+role+for+the+DNA+damage+response+mediated+by+ATR-Chk2+in+p53+activation+and+renal+cell+apoptosis+during+cisplatin+nephrotoxicity. assertion.
- assertion asSentence Deficiency+in+ATR+is+associatd+with+marked+sensitivity+of+the+cells+to+cisplatin+in+osteosarcoma. assertion.
- assertion asSentence The+ATR-XPA+interaction+mediated+by+the+helix-turn-helix+motif+of+XPA+plays+an+important+role+in+DNA-damage+responses+to+promote+cell+survival+and+genomic+stability+after+UV+irradiation. assertion.
- assertion asSentence Human+CDC6+physically+interacts+with+ATR%2C+a+crucial+checkpoint+kinase%2C+in+a+manner+that+is+stimulated+by+phosphorylation+by+Cdk+and+the+CDC6-ATR+interaction+is+conserved+in+Xenopus. assertion.
- assertion asSentence ATR+deficiency+causes+telomere+instability+both+in+primary+human+fibroblasts+from+Seckel+syndrome+patients+and+in+HeLa+cells. assertion.
- assertion asSentence Tethering+DNA+damage+checkpoint+mediator+proteins+topoisomerase+IIbeta-binding+protein+1+%28TopBP1%29+and+Claspin+to+DNA+activates+ataxia-telangiectasia+mutated+and+RAD3-related+%28ATR%29+phosphorylation+of+checkpoint+kinase+1+%28Chk1%29. assertion.
- assertion asSentence Chk1+and+FANCD2+function+downstream+of+ATR+in+a+non-redundant+manner+for+the+establishment+and+maintenance+of+psoralen+photoactivation-induced+senescence. assertion.
- assertion asSentence Dbf4+is+direct+downstream+target+of+ataxia+telangiectasia+mutated+%28ATM%29+and+ataxia+telangiectasia+and+Rad3-related+%28ATR%29+protein+to+regulate+intra-S-phase+checkpoint. assertion.
- assertion asSentence Atrx+plays+role+in+interneuron+survival+and+differentiation. assertion.
- assertion asSentence RAD54+that+lacks+helicase+activity+is+more+efficient+in+DNA+heterology+bypass+than+BLM+or+REQ1+helicases. assertion.
- assertion asSentence Non-suppressible+release+of+AVP+is+crucially+involved+in+the+impaired+water+excretion+and+hyponatremia+seen+in+elderly+patients+with+secondary+adrenal+insufficiency. assertion.
- assertion asSentence Dominant+pro-vasopressin+mutants+progressively+accumulate+as+endoplasmic+reticulum-associated+aggregates. assertion.
- assertion asSentence Copeptin+in+a+heart+transplant+population+is+independently+associated+with+kidney+function+and+intraventricular+septal+thickness. assertion.
- assertion asSentence Copeptin+has+a+distinct+release+pattern+in+patients+with+ST-elevation+AMI%2C+peaking+within+the+first+hour+after+symptom+onset+before+conventional+cardiac+biomarkers+and+falling+to+normal+ranges+within+the+first+day. assertion.
- assertion asSentence %5Breview%5D+AVP+and+oxytocin+play+parallel+roles+in+modulating+the+recognition+and+avoidance+of+socially+relevant+pathogen+threats+in+both+humans+and+rodents. assertion.
- assertion asSentence Increased+plasma+copeptin+level+is+an+independent+prognostic+marker+of+1-year+mortality%2C+1-year+unfavorable+outcome+and+early+neurological+deterioration+after+intracerebral+hemorrhage. assertion.
- assertion asSentence There+is+an+association+of+the+V1aR+SNP-6951+with+essential+hypertension+in+nonobese+individuals. assertion.
- assertion asSentence Mutations+involved+in+nephrogenic+syndrome+of+inappropriate+antidiuresis+in+men+and+womwen. assertion.
- assertion asSentence Overexpression+of+a+V2R+fragment+corresponding+to+V2R-i3+as+a+fusion+protein+with+thioredoxin+A+at+the+N-terminus+and+a+hexahistidine+tag+between+the+two+proteins. assertion.
- assertion asSentence Interaction+of+Axl+receptor+tyrosine+kinase+with+C1-TEN+%28C1+domain-containing+phosphatase+and+TENsin+homologue%29. assertion.
- assertion asSentence Overexpression+of+Axl+is+associated+with+esophageal+adenocarcinoma. assertion.
- assertion asSentence No+etiological+correlation+between+microdeletions+in+gene+loci+on+the+AZF-a%2C+AZF-b+and+AZF-c+regions+of+the+Y+chromosome+and+cryptorchidism. assertion.
- assertion asSentence Quantitative+fluorescent-PCR+is+a+simple+and+reliable+method+to+detect+rearrangements+in+AZFb+and+AZFc. assertion.
- assertion asSentence High+prevalence+of+AZFb+microdeletion+in+Iranian+patients+with+idiopathic+non-obstructive+azoospermia. assertion.
- assertion asSentence Overexpression+of+AZGP1+is+associated+with+lung+adenocarcinoma. assertion.
- assertion asSentence Treatment+with+TNFalpha+reduced+Zag+gene+expression+in+differentiated+adipocytes. assertion.
- assertion asSentence Signal+transduction+of+beta2m-induced+expression+of+VCAM-1+and+COX-2+in+synovial+fibroblasts. assertion.
- assertion asSentence Besides+beta%282%29m+and+tapasin%2C+an+extra+unidentified+component+is+also+critical+for+the+expression+of+certain+human+class+I+alleles. assertion.
- assertion asSentence Transgenic+expression+of+human+beta2-+microglobulin+alters+self-major+histocompatibility+complex+%28MHC%29+class+I+in+such+a+way+that+it+modulates+the+natural+killer+%28NK%29+cell+phenotype%2C+causing+NK+cells+to+be+partially+self-reactive. assertion.
- assertion asSentence B2M+level+measured+at+first+autologous+hematopoietic+stem+cell+transplantation+is+a+useful+predictor+for+progressin+in+multiple+myeloma. assertion.
- assertion asSentence Serum+beta2M+levels+can+help+predict+outcome+in+patients+greater+than+or+%3D60+years+with+untreated+acute+myeloid+leukemia. assertion.
- assertion asSentence Native-unlike+long-lived+intermediates+along+the+folding+pathway+of+the+amyloidogenic+protein+beta2-microglobulin+revealed+by+real-time+two-dimensional+NMR. assertion.
- assertion asSentence Heme+regulates+gene+expression+by+triggering+CRM1-dependent+nuclear+export+of+BACH1. assertion.
- assertion asSentence Key+role+of+down-regulation+of+Bach1+and+up-regulation+of+heme+oxygenase+1+in+diminishing+cytotoxic+effects+of+hepatitis+C+virus+proteins+in+human+hepatocytes. assertion.
- assertion asSentence ERK%281%2F2%29+and+JNK+are+involved+in+cigarette+smoking-induced+biphasic+HO-1+expression+by+a+specific+regulation+of+Nrf2%2FKeap1-Bach1. assertion.
- assertion asSentence BAD-mediated+sensitivity+of+prosstatic+cancer+cells+to+TRAIL+depends+on+the+phosphorylation+status+of+BAD+WT+and+tBAD. assertion.
- assertion asSentence AKT-induced+BAD+phosphorylation+and+its+subsequent+cytoplasmic+sequestration+by+14-3-3zeta+is+a+major+mechanism+responsible+for+the+postponement+of+UVB-induced+apoptosis+in+human+keratinocytes. assertion.
- assertion asSentence BH3-only+proteins+and+BH3+mimetics+induce+autophagy+by+competitively+disrupting+the+interaction+between+BECN1+and+BAX+and+Bcl-2. assertion.
- assertion asSentence Activated+extracellular+signal-regulated+kinase+in+epithelial+cells+infected+with+N.+gonorrheae+targeted+Bad+and+Bim+for+downregulation+at+the+protein+level. assertion.
- assertion asSentence PTH+induction+of+apoptosis+is+mediated+by+translocation+of+mitochondria+to+the+perinuclear+region%2C+dephosphorylation+of+Akt%2C+dephosphorylation+of+Bad+and+its+movement+to+the+mitochondria%2C+release+of+cytochrome+c+and+Smac%2FDiablo%2C+activating+casp3. assertion.
- assertion asSentence Ginsenoside+Rg3+decreased+both+Pim-3+and+pBad+expressions+in+a+dose-dependent+manner+in+PANC-1+cells. assertion.
- assertion asSentence Overexpression+of+BAG-1+and+p53+plays+an+important+role+in+the+process+laryngeal+squamous+cell+carcinoma+development. assertion.
- assertion asSentence BAG-1L+endogenously+regulates+gene+expression+by+potentiating+nuclear+hormone+receptor+function+and+a+role+for+BAG-1L+in+24-hydroxylase+regulation+of+vitamin+D+metabolism+and+the+cellular+response+of+oral+keratinocytes+to+1alpha%2C25-dihydroxyvitamin+D3. assertion.
- assertion asSentence Bag-1+expression+in+breast+tumors+is+associated+with+improved+outcome+and+steroid+receptor+positivity. assertion.
- assertion asSentence Bag-1+proteins+function+as+regulators+of+the+action+of+selective+transcription+factors. assertion.
- assertion asSentence FPV039+is+a+functional+Bcl-2+homologue+that+inhibits+apoptosis+by+neutralizing+the+proapoptotic+Bcl-2+family+member+Bak. assertion.
- assertion asSentence ABT-737+augments+TRAIL-induced+cell+killing+by+unsequestering+Bim+and+Bak+and+enhancing+a+Bax+conformational+change+induced+by+TRAIL. assertion.
- assertion asSentence Galphas+augments+gamma+ray-induced+apoptosis+by+up-regulation+of+Bak+expression+via+CREB+and+AP-1+in+H1299+lung+cancer+cells. assertion.
- assertion asSentence Heterodimerization+of+BAK+and+MCL-1+activated+by+detergent+micelles. assertion.
- assertion asSentence BRCA1%2FBARD1+heterodimer+formation+is+important+for+optimal+nuclear+targeting+of+BARD1+and+its+role+in+DNA+repair+and+cell+survival. assertion.
- assertion asSentence The+science+behind+BARD1+and+its+role+in+breast+and+ovarian+cancer+is+explained+in+this+article. assertion.
- assertion asSentence Bcl-2+family+member+Bfl-1%2FA1+sequesters+truncated+bid+to+inhibit+is+collaboration+with+pro-apoptotic+Bak+or+Bax. assertion.
- assertion asSentence Poly%28ADP-ribose%29+polymerase+activation+and+changes+in+Bax+protein+expression+associated+with+extracellular+ATP-mediated+apoptosis+in+human+embryonic+kidney+293-P2X7+cells. assertion.
- assertion asSentence NBK+mediated+apoptosis+entirely+by+BAX-dependent+mitochondrial+pathway. assertion.
- assertion asSentence Human+prolactin-G129R-induced+breast+cancer+cell+and%2For+mammary+gland+apoptosis+which+is+mediated%2C+at+least+in+part%2C+through+the+regulation+of+Bax+and+Bcl-2+gene+expression. assertion.
- assertion asSentence Bax+plays+an+important+role+in+UV-induced+apoptosis+and+in+caspase-2+activation. assertion.
- assertion asSentence Alteriations+of+BAX+are+not+responsible+for+cancers+in+TP53+wild-type+Li-Fraumeni+syndrome+families. assertion.
- assertion asSentence Bax+expression+is+comparable+in+verrucous+and+low-grade+squamous+cell+penile+carcinomas. assertion.
- assertion asSentence Bax+gene+therapy+with+cationic+liposomes+will+be+useful+for+osteosarcoma. assertion.
- assertion asSentence Suppression+of+Bax+and+overexpression+of+Bcl-2+protein+is+an+early+event+in+gastric+tumorigenesis%2C+before+gastric+dysplastic+changes+occur. assertion.
- assertion asSentence Androgen+and+androgen+receptor+promote+Bax-mediated+apoptosis+in+prostate+cancer+cells. assertion.
- assertion asSentence No+significant+differences+within+the+expression+of+Bcl-2+family+member+proteins+in+B-cell+chronic+leukemia. assertion.
- assertion asSentence ALK7-induced+apoptosis+is+at+least+in+part+through+two+Smad-dependent+pathways%2C+Bax%2FBcl-2+and+Xiap. assertion.
- assertion asSentence The+structure+reveals+the+conformation+of+the+6A7+peptide+epitope+on+Bax+in+the+activated+form+and+elucidates+the+extensive+structural+changes+that+Bax+must+undergo+during+the+conversion+from+its+native+to+its+activated+conformation. assertion.
- assertion asSentence Two+amino+acids%2C+leucine-70+and+aspartate-71%2C+within+the+BH3+homology+domain+of+Bax+play+a+critical+role+in+regulating+its+multimeric+state%2C+localization+and+activation. assertion.
- assertion asSentence Bax+translocation+by+UV+irradiation+is+a+Bid-independent+event+and+inhibited+by+overexpression+of+Bcl-x%28L%29. assertion.
- assertion asSentence A+critical+role+of+cysteine+62+in+oxidative+stress-induced+Bax+activation+and+subsequent+apoptosis. assertion.
- assertion asSentence Hierarchical+involvement+of+Bak%2C+VDAC1+and+Bax+in+cisplatin-induced+cell+death. assertion.
- assertion asSentence Expressed+in+most+dysmorphic+neurons+in+focal+cortical+dysplasia+type+II. assertion.
- assertion asSentence Dimethylformamide+can+induce+apoptosis+of+cultured+adult+normal+hepatocytes+in+vitro+by+reducing+expression+of+Bax+and+Bcl2+and+cleaving+casp3. assertion.
- assertion asSentence Treatment+of+KG-1+cells+with+Resveratrol+increased+apoptosis%2C+downregulated+Bcl2+and+upregulated+Bax. assertion.
- assertion asSentence There+is+a+mechanism+whereby+reactive+oxygen+species+upregulation+of+Id3+relieves+repression+of+bax+via+E-box-binding+factors. assertion.
- assertion asSentence IL-6+functions+in+a+cytoprotective+manner%2C+in+part%2C+by+suppressing+Bax+translocation+and+dimerization+through+PI3K%2FAkt-mediated+Bax+phosphorylation. assertion.
- assertion asSentence Resveratrol+derivative+2%2C4%2C3%27%2C5%27-tetramethoxystilbene+induces+breast+cancer+cell+death+by+targeting+Bax. assertion.
- assertion asSentence Bcl-2+binds+Bax+through+two+interdependent+interfaces+to+inhibit+the+pro-apoptotic+oligomerization+of+Bax. assertion.
- assertion asSentence Reduced+Bax+expression+after+exposure+to+cisplatin+is+not+sufficient+to+induce+cisplatin-resistance+in+small+cell+lung+ccancer+cells. assertion.
- assertion asSentence At+low+respiratory+chain+activity%2C+unlike+a+mitochondrial+Ca2%2B+upload%2C+Bax%2C+a+pro-apoptotic+Bcl-2-family+protein%2C+is+able+to+trigger+a+massive+release+of+cytochrome+c+from+one+of+six+alternative+ANT1+structures. assertion.
- assertion asSentence Membrane-active+segments+of+Bax+induce+the+release+of+mitochondria-residing+apoptogenic+factors+and+commit+tumor+cells+to+apoptosis. assertion.
- assertion asSentence UVRAG+has+an+essential+role+in+the+intrinsic+mitochondrial+pathway+of+apoptosis+by+regulating+the+localization+of+Bax. assertion.
- assertion asSentence The+ERK%2FELK-1+cascade+is+involved+in+p53-independent+induction+of+p21+and+BAX+gene+expression. assertion.
- assertion asSentence Ceramide%2C+generated+in+the+mitochondrial+outer+membrane+of+mammalian+cells+upon+irradiation%2C+forms+a+platform+into+which+Bax+inserts%2C+oligomerizes+and+functionalizes+as+a+pore. assertion.
- assertion asSentence Fluazinam-induced+apoptosis+of+SH-SY5Y+cells+is+mediated+by+accumulation+of+TP53%2C+reduced+levels+of+Bcl-2+and+increased+levels+of+Bax. assertion.
- assertion asSentence Bax+mutations+are+not+associated+with+the+microsatellite+instability-high+colorectal+cancer. assertion.
- assertion asSentence The+presence+of+three+mutant+alleles+in+the+BBS+family+correlates+with+a+more+severe+Bardet-Biedl+phenotype. assertion.